Typha pollen extract inhibit melanogenesis via α-MSH/MC1R signaling pathway in B16 and melasma mouse model

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 31, 2025

Language: Английский

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Cannabidiol-Based Thiosemicarbazones: A Preliminary Study Evaluating Their Anti-Tyrosinase Properties

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1291 - 1291

Published: March 13, 2025

Cannabidiol (CBD), a non-psychoactive cannabinoid, has attracted significant research interest due to its antioxidant, anti-inflammatory, and neuroprotective properties. As versatile scaffold in drug discovery, CBD been widely explored for developing novel therapeutics. In this study, we synthesized evaluated the anti-tyrosinase activity of CBD-based thiosemicarbazones. Structure–activity relationship (SAR) analyses were conducted assess impact various functional groups on tyrosinase inhibition, including an evaluation inhibitory kinetics selected compounds. The derivatives demonstrated potent with comparable kojic acid, standard inhibitor. Given crucial role melanin biosynthesis, these findings suggest that thiosemicarbazones could serve as promising candidates managing tyrosinase-related disorders, hyperpigmentation melanogenesis-related conditions. Moreover, presence thiosemicarbazone moieties may contribute observed effects, potentially through metal chelation at enzyme’s active site. This study provides valuable insights into design CBD-derived inhibitors targeting tyrosinase. Further optimization in-depth biological are warranted explore their full therapeutic potential.

Language: Английский

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A real-world study to observe the efficacy and safety of Lutai Danshen Baishao Granules for improving melasma

Medicine, Journal Year: 2025, Volume and Issue: 104(6), P. e41394 - e41394

Published: Feb. 7, 2025

Background: Traditional Chinese Medicine categorizes melasma into various syndromes, one of which is the kidney-deficiency and blood-stasis syndrome. Different medicines are used for each syndrome to achieve a personalized treatment approach, resulting in more effective outcome. The study aimed investigate efficacy safety Lutai Danshen Baishao Granules (LDBG) alleviating compare effects LDBG patients with without through real-world, large-sample investigation. Methods: A multicenter, prospective, nonrandomized, observational trial was conducted from December 2021 May 2023, recruiting 1000 female participants melasma. After enrollment, were divided Group (kidney-deficiency syndrome) group B (non-kidney-deficiency based on traditional medicine (TCM) scale. General physical signs, indicators, Dermatology Life Quality Index, TCM scores recorded before after intervention. long-term effectiveness assessed 2 months intervention ended. Results: Following intervention, melasma-related indicators significantly lower than those ( P < .001). Compared B, showed significant reduction total area Melasma Area Severity Index score .05). also pronounced (group A: 425.00 vs B: 312.50, Two intergroup intragroup comparisons revealed that had effect tendency recurrence, better overall incidence adverse events during 1.2%. Conclusion: can reduce facial improve particularly cases associated syndrome, high low risk relapse.

Language: Английский

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Comparative Efficacy of Skin-Lightening Formulations in Suppressing Ultraviolet B (UVB)-Induced Arachidonic Acid, Alpha-Melanocyte-Stimulating Hormone (α-MSH), and Melanin Expression: An In Vitro Keratinocyte-Melanocyte Co-culture Study

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Background: Melasma is a chronic hyperpigmentary disorder exacerbated by sun exposure, characterized asymptomatic hyperpigmented macules and patches. Its pathogenesis involves ultraviolet B (UVB)-induced activation of melanogenesis pathways, including arachidonic acid (AA) metabolism, alpha-melanocyte-stimulating hormone (α-MSH) secretion, melanin synthesis. This study aimed to evaluate the efficacy multi-ingredient skin-lightening formulation (3% tranexamic acid, 2% ascorbyl glucoside, 2.5% arbutin, 5% niacinamide) compared 10% vitamin C preparation 4% hydroquinone (HQ) in suppressing UVB-induced AA, α-MSH, production keratinocyte-melanocyte co-culture model. Methods: Keratinocyte-melanocyte co-cultures were pretreated with formulation, C, or HQ before UVB irradiation (150 mJ/cm2). Distilled water served as negative control. Biomarkers (AA, melanin) quantified using enzyme-linked immunosorbent assay (ELISA) fluorometric assay. Results: significantly increased AA (4.3-fold), α-MSH (3.7-fold), (2.6-fold) levels unirradiated cells (all p < 0.001). All tested formulations reduced control (p 0.001), demonstrating superior over both Only suppressed Regarding reduction, achieved comparable but outperformed 0.05). Conclusion: The demonstrated reducing while achieving reduction HQ. These results are consistent prevailing consensus that effective melasma management necessitates multifaceted approach concurrently targets multiple mechanisms.

Language: Английский

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Efficacy, safety, and cost-effectiveness of glycolic acid vs. azelaic acid in melasma

Journal of Family Medicine and Primary Care, Journal Year: 2025, Volume and Issue: 14(3), P. 990 - 996

Published: March 1, 2025

To compare efficacy, safety, and cost of the treatment among topical glycolic acid (GA) azelaic (AA) in melasma patients. A total 80 patients with were randomized into two groups 40 each received either GA (12%) or AA (20%). Their demographic data, detailed clinical history, systemic complete local skin examination carried out. MASI scoring adverse events recorded at baseline, 2, 4, 6, 8 weeks after compared. The therapy was calculated Most belong to 24-35 years a female preponderance. No statistically significant difference found for risk factors like exposure sunlight, hormonal contraceptives, Fitzpatrick type, affected site both (P > 0.05). mean score groups, respectively, 5.13 4.84 baseline = 0.48) which reduced 4.57 4.86 correspondingly 0.05) first week. In 8th week, 2.82 2.88 There no considerable prevalence side effects between Rs. 1410 430 per patient respectively < is noticeable terms their effectiveness safety profiles while treating but significantly higher acid.

Language: Английский

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QbD-Based Development of Fluocinolone Nanocomposite Transdermal Gel: Optimization, Characterization, and Enhanced Anti-hyperpigmentation Efficacy Assessment

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)

Published: April 2, 2025

Language: Английский

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Minoxidil cyclodextrin inclusion complex-loaded microemulsions and transfersomes for androgen alopecia treatment: a comparative study

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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Margarita (Pearl) Extract Alleviates Melasma by Targeting CAMP‐Responsive Element Binding Protein 1

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(5)

Published: May 1, 2025

ABSTRACT Purpose Margarita (pearl) has detoxifying and skin barrier‐repairing properties. The study was to evaluate the therapeutic effect of pearl on melasma preliminarily explore its possible mechanism action. Methods efficacy patients with evaluated by area severity index (MASI) physician's global assessment (PGA) score. DNA sequencing performed pharyngeal swab samples from obtain gene loci related melasma. active compounds potential targets for were retrieved Integrated Traditional Chinese Medicine HERB databases. relevant genes obtained GeneCards database intersected identify against mapped KEGG pathway in Mapper verified using human melanoma A375 cells that exposed ultraviolet irradiation. Results Pearl significantly improved MASI PGA scores revealed TYR DCT Calcium carbonate, iron, magnesium, manganese, silicon, strontium, zinc pearl. CAMP‐responsive element binding protein 1 (CREB1) target regulated microphthalmia‐associated transcription factors through CREB affected melasma‐related , which turn inhibit cell activity intracellular tyrosinase activity. Conclusion can alleviate targeting CREB1/MITF axis then .

Language: Английский

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Comparative study of different treatment modalities for melasma: introducing a novel nanotechnology-based tranexamic acid microemulsion

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: June 2, 2025

Language: Английский

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Manejo clínico del melasma en la población femenina. Una revisión de la literatura

Polo del Conocimiento, Journal Year: 2024, Volume and Issue: 9(8), P. 585 - 599

Published: Aug. 1, 2024

El melasma es un trastorno común, caracterizado por áreas hiperpigmentadas en zonas fotoexpuestas, principalmente el rostro. Afecta mayoritariamente a mujeres edad fértil, llegando al 40% Asia y 30% Latinoamérica. Los factores etiológicos incluyen la exposición radiación UV, predisposición genética hormonal. Además del impacto estético, afecta calidad de vida está asociado con ansiedad depresión. Se realizó una revisión bibliográfica bases datos como Scielo, Redalyc Science Direct, centrada estudios periodo 2019-2024. tratamientos principales agentes despigmentantes tópicos hidroquinona, retinoides, ácido azelaico, kójico tranexámico. La hidroquinona eficaz reducir pigmentación inhibir tirosinasa, aunque puede causar irritación. retinoides azelaico ayudan renovación celular reducen inflamación, mientras que tranexámico presenta buenos resultados tanto orales. Tratamientos emergentes tiamidol cisteamina ofrecen alternativas viables. peelings químicos terapias láser se utilizan casos más severos. Sin embargo, condición crónica recurrente, requiriendo personalizados expectativas realistas sobre los resultados.

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