Association Between Vitamin D and COVID-19–Related Outcomes: An Umbrella Review of Meta-Analyses

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

COVID-19 remains globally pandemic, and although several meta-analyses have explored the association between vitamin D relative to clinical outcomes, a unified view has not yet emerged. To summarize evidence for associations levels COVID-19-related outcomes assess strength validity of these associations. PubMed, Embase, Web Science, Scopus, Cochrane Database Systematic Reviews databases were searched from January 1, 2020, June 15, 2024. Two reviewers independently extracted data assessed study quality. Low increased risk infection by 1.26- 2.18-fold, severe illness 1.50- 5.57-fold, intensive care unit (ICU) admission more than 2-fold, death 1.22- 4.15-fold. In addition, patients with deficiency had an average increase in length hospital stay 0.54 days compared high levels. Overall, supplementation may reduce severity (eg, ICU admissions, need mechanical ventilation) shorter but nonsignificant effect on mortality rates. there significant differences individuals testing positive those negative (mean difference [MD] = -3.22 ng mL-1; 95% CI, -5.18 -1.25), cases mild (MD -4.60 -5.49 -3.71), nonsurvivors survivors -6.59 CI: -8.94 -4.24). are associated higher rates, disease, rates among COVID-19, whereas patients' disease severity. The beneficial effects remain be further explored, however, higher-quality, randomized controlled studies. Nonetheless, caution is warranted because methodological quality most level very low. PROSPERO registration No. CRD42022385036.

Language: Английский

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Herbal and Dietary Supplements as Adjunctive Treatment for Mild SARS-CoV-2 Infection in Italy

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 230 - 230

Published: Jan. 9, 2025

During the COVID-19 pandemic, several observational studies proved a certain efficacy of nutraceuticals, herbal products, and other dietary supplements as adjuvant therapies used alongside antiviral drugs. Although their use has not been widespread in Italy, according to preliminary evidence, many with demonstrated immunomodulatory effects, such vitamins C D, medicines essential oils, might relieve respiratory symptoms COVID-19, since SARS-CoV-2 can activate inflammasome-mediated inflammatory signaling pathways. Other have shown that treatments, Echinacea purpurea ginseng, help alleviate reduce serum levels cytokines, which are typically overexpressed both adult pediatric patients. Further, D attenuate immune response thanks cytokine suppression ability known antimicrobial activity potential modulate T helper cell response. The strong triggered by infection is responsible for severity disease. Preliminary data also L-arginine, an endothelial-derived relaxing factor, able endothelial damage, appears be one main targets this systemic Finally, some oils isolated compounds, eucalyptol, may helpful reducing although others, menthol, recommended, it lead undervaluation clinical status patient. In narrative review, despite lack evidence field, we aimed give overview current available literature (mainly cross-sectional studies) regarding products treatment mild disease from infection. Obviously, do constitute standardized disease, but they could represent adjunctive useful when together antivirals.

Language: Английский

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The Effect of Vitamin D Supplementation Post COVID-19 Infection and Related Outcomes: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3794 - 3794

Published: Nov. 5, 2024

Vitamin D's role in COVID-19 management remains controversial. This meta-analysis aimed to evaluate the efficacy of vitamin D supplementation patients with SARS-CoV-2 infection, focusing on mortality, intensive care unit (ICU) admissions, intubation rates, and hospital length stay (LOS).

Language: Английский

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Klotho Deficiency in Severe COVID-19: A Unifying Hypothesis

COVID, Journal Year: 2024, Volume and Issue: 4(12), P. 1833 - 1850

Published: Nov. 22, 2024

COVID-19 is characterized by a striking similarity to premature aging. Its clinical manifestations range from asymptomatic critical illness. No single central agent has been demonstrated so far. We present Klotho, an antiaging protein, as key factor in pathophysiology. There epidemiological evidence that both acute and chronic uses of Klotho agonists have beneficial effect reducing severity mortality. A review the PubMed epidemiological, clinical, mechanistic supports role for deficit determinant severe COVID-19. Clinical data support idea use protects against its may be beneficial. propose unifying hypothesis low levels play COVID-19, while increasing can through prevention kidney injury (AKI) potential antiviral effects. Further research needed.

Language: Английский

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