Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway DOI

Qiyuan Su,

Qian Hu,

Songtao Wu

et al.

Natural Products and Bioprospecting, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 30, 2024

Language: Английский

“Shield” Armed Programmable Probiotics Harboring α-Aminoadipate Aminotransferase Gene Regulate Tryptophan Metabolism and Gut Microbiota to Alleviate the Inflammatory Bowel Disease DOI

A Liu,

Jun Ma,

Zengguang Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Current treatment of inflammatory bowel disease (IBD) relies on anti-inflammatory and immunosuppressive agents. However, this concept is considered outdated due to its restricted efficacy unavoidable side effects. Herein, a polynorepinephrine-coated programmable probiotic expressing α-aminoadipate aminotransferase (NE-EcN-pA) was constructed improve the levels kynurenic acid xanthurenic in intestine by modulating endogenous tryptophan metabolism. The NE layer could protect EcN-pA against harsh environment gastrointestinal tract, enhancing survival colonization. In UC mice, oral administration NE-EcN-pA effectively alleviated intestinal inflammation restored epithelial barrier owing activation aryl hydrocarbon receptor pathway. Furthermore, promoted diversity flora, improved imbalance enhanced content short-chain fatty acids colon. Overall, can regulate metabolism gut microbiota, showing promise disorders.

Language: Английский

Citations

0
The biological roles of exosome-encapsulated traditional Chinese medicine monomers in neuronal disorders DOI Creative Commons
Pang Chen, Jie Zhang,

Yujin Gu

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101131 - 101131

Published: Oct. 1, 2024

Language: Английский

Citations

1
Optimal traditional Chinese medicine formulas in treating ulcerative colitis: Choose one or take it all? DOI
Yan Zeng, Junwen Zhang, Jian Yang

et al.

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 12(32), P. 6570 - 6574

Published: Sept. 23, 2024

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that presents significant treatment challenges due to its complexity, especially in terms of the various side effects traditional medications may bring during course disease. Traditional Chinese medicine (TCM) has emerged as promising complementary therapy for UC. Based on latest research, our editorial explored current issues and potential essential research directions TCM treating We anticipate future high-quality will pave way optimization formulas UC their broader global application.

Language: Английский

Citations

0
Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway DOI

Qiyuan Su,

Qian Hu,

Songtao Wu

et al.

Natural Products and Bioprospecting, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 30, 2024

Language: Английский

Citations

0