Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118910 - 118910
Published: Oct. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12091 - 12091
Published: Nov. 11, 2024
The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 14, 2024
Background The interaction between pyroptosis—a form of programmed cell death—and tumor immunity represents a burgeoning field interest. Pyroptosis exhibits dual role in cancer: it can both promote development and counteract by activating immune responses that inhibit evasion encourage death. Current immunotherapy strategies, notably CAR-T therapy checkpoint inhibitors (ICIs), alongside the potential certain traditional Chinese medicinal compounds, highlight intricate relationship pyroptosis cancer immunity. As research delves deeper into mechanisms within therapy, its application enhancing emerges as novel avenue. Purpose This review aims to elucidate underlying pyroptosis, impact on biology, advancements research. Methods A comprehensive literature was conducted across PubMed, Embase, CNKI, Wanfang Database from inception study until August 22, 2023. search employed keywords such “pyroptosis”, “cancer”, “tumor”, “mechanism”, “immunity”, “gasdermin”, “ICB”, “CAR-T”, “PD-1”, “PD-L1”, “herbal medicine”, “botanical “Chinese “traditional “immunotherapy”, linked AND/OR, capture latest findings immunotherapy. Results is governed complex mechanism, with Gasdermin family playing pivotal role. While promising for application, pyroptosis’s effect still evolving. Notably, medicine ingredients have been identified inducers, meriting further exploration. Conclusion consolidates current knowledge It reveals beneficial factor immunotherapeutic landscape, suggesting leveraging developing treatment including those involving medicine, forward-looking approach oncology.
Language: Английский
Citations
4
Cancer Investigation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26
Published: Jan. 6, 2025
Apoptosis, or programmed cell death, is a fundamental biological process essential for maintaining tissue homeostasis. Dysregulation of apoptosis implicated in variety diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. This review provides an in-depth insight into the molecular mechanisms signaling pathways that regulate apoptosis, highlighting both intrinsic extrinsic pathways. Additionally, explains tumor microenvironment's influence on its implications cancer therapy resistance. Understanding complex interplay between apoptotic cellular responses crucial developing targeted therapies can effectively manage diseases associated with dysregulation. The effects conventional therapeutics alternative substances natural sources such as herbal compounds, alongside vitamins, minerals, trace elements homeostasis disease pathogenesis have been thoroughly investigated. Moreover, recent advances therapeutic strategies aimed at modulating are discussed, focus novel interventions nutrition bio shield dietary supplement. These emerging approaches offer potential benefits beyond treatments by selectively targeting to inhibit progression metastasis. By integrating insights from studies, this aims enhance our understanding guide future research innovative approaches.
Language: Английский
Citations
0
Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: Feb. 12, 2025
Objective Chronic liver diseases are accountable for approximately 2 million deaths annually. The current study aimed to test the putative prophylactic role of Kalanchoe pinnata against hepatic stress.
Language: Английский
Citations
0
Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 20, 2025
Abstract Background Steroid-induced hypergluconeogenesis is a significant contributor to hyperglycemia, often complicating the therapeutic use of steroids. This study investigates potential quercetin, naturally occurring flavonoid, mitigate steroid-induced in Saccharomyces cerevisiae . The levels glucose, total proteins, free amino acids, pyruvate, lactate and antioxidants were assessed quercetin-treated yeast cells induced with betamethasone at different time intervals. glucose uptake treated quercetin was also studied effect steroids on cell viability analyzed. Results Our results show that effectively reduces gluconeogenesis by normalizing metabolites involved process alleviates hyperglycemic effects associated steroid exposure. Quercetin-treated demonstrated better glucose. Additionally, found improve overall highlighting its role modulating metabolism. Conclusion These outcomes suggest can serve as promising adjunct therapy for managing metabolic disturbances, providing natural effective approach counteracting hyperglycemia.
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(9), P. 5526 - 5536
Published: Feb. 21, 2025
Silicon dioxide particles (SiO2) have been widely used in food additives. Increasing data demonstrate that SiO2 can cause multisystem damage through oxidative stress. Quercetin (Que) is one of the most popular nutritional antioxidants. Ferroptosis reduces level angiogenesis. However, whether Que alleviates inhibition testicular angiogenesis by relieving SiO2-induced ferroptosis via ROS/PPARγ unclear. Based on this, we established SiO2-exposed mice and C166 cell models added stress activators Sanguinarine chloride (SAN), PPARγ inhibitor GW9662, activator Erastin to vitro. The results showed exposure group had antioxidant dysfunction; was significantly downregulated; levels were increased; reduced. treatment alleviate these changes. addition SAN, reduced effects activating stress, inhibiting PPARγ, ferroptosis, respectively. In general, ROS/PPARγ, thus restoring mice.
Language: Английский
Citations
0
Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100784 - 100784
Published: March 1, 2025
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118055 - 118055
Published: April 26, 2025
Language: Английский
Citations
0
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(3)
Published: May 1, 2025
Abstract Quercetin (Qu), a naturally occurring flavonoid abundant in various fruits, vegetables, and grains, has garnered significant attention due to its potent antioxidant properties wide range of functional activities, including anti‐inflammatory, antibacterial, anti‐tumor, neuroprotective effects. These attributes make Qu promising candidate for extending the shelf‐life food, enhancing human health preventing chronic diseases. However, practical application faces challenges such as poor stability during food processing storage, susceptibility environmental factors, low water solubility, bioavailability, which limit effective potential. To address these challenges, innovative Qu‐based delivery systems are being developed, protect from degradation improve absorption gastrointestinal tract, maximizing efficacy. Additionally, combinations explored enhance activity utilization by integrating their advantages, increasing effectiveness. This review comprehensively summarizes associated with biomedicine applications reviews advanced strategies overcome obstacles. It systematically introduces structure characteristics derivatives, discusses instability processing, digestion, highlights factors contributing degradation. By reviewing recent advances systems, this provides insights into how technologies can stability, targeted efficacy Qu, presenting current future development prospects more safety health‐promoting applications.
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 120025 - 120025
Published: May 1, 2025
Language: Английский
Citations
0