Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging DOI Open Access
Paweł Kordowitzki

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13318 - 13318

Published: Dec. 12, 2024

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause severe and often fatal illness. The zoonotic EEEV enzootic cycle involves of transmission between Culiseta melanura avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans horses. Interestingly, it has been described that the W132G mutation very low-density lipoprotein receptor (VLDLR), EEEV, significantly enhanced VLDLR-mediated cell attachment EEEV. patient’s metabolism plays pivotal role shaping complex landscape viral zoonosis. represents significant public health concern due its clinical outcomes, challenging epidemiological characteristics, certain risk factors heighten susceptibility specific populations or age groups. Age one several predictors impact outcome infection; juvenile animals appear be particularly vulnerable disease. This also observed natural infections, children are most severely impacted humans. aim this piece shed light on intricate relationship human virus.

Language: Английский

Mitochondrial transplantation via injection of exogenous mitochondria into blood reduces bleomycin-induced oxidative damages and mitochondrial dysfunction in lung tissue DOI
Ahmad Salimi, Mohammad Shabani,

Samira Pourmohammad Shahsavar

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: March 10, 2025

Language: Английский

Citations

0
Global research trends and hotspots in mitochondria and asthma: A bibliometric and visualized analysis DOI
Lei Huang, Chuyan Wu, Feng Jiang

et al.

Journal of Asthma, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 11, 2025

Asthma is a complex chronic respiratory disease marked by inflammation, bronchoconstriction, and hyperresponsiveness. Mitochondria, key regulators of energy production, ROS, apoptosis, are increasingly recognized as crucial in asthma pathophysiology. However, comprehensive analysis global research trends this area lacking. This study aims to perform bibliometric visualized on mitochondria asthma. A was conducted using Web Science Core Collection data from 2004 June 2024. CiteSpace VOSviewer software were used examine co-authorship, co-citation, keyword co-occurrence, thematic clusters. total 669 publications identified. The number studies grew significantly after 2015, with the United States, China, UK leading research. Co-citation analyses revealed mitochondrial dysfunction, oxidative stress, airway inflammation major themes. Emerging areas interest include biogenesis, NLRP3 inflammasome, innate immunity. Collaboration among institutions like Harvard University Council Scientific & Industrial Research significant, journals such European Respiratory Journal Nature Medicine highly influential. provides an overview asthma, highlighting emerging biogenesis immune pathways. Future should focus these role environmental triggers offering valuable insights for therapeutic strategies targeting

Language: Английский

Citations

0
Increased TSLP and oxidative stress reflect airway epithelium injury upon cigarette smoke exposure. Is there a role for carbocysteine? DOI Creative Commons

Paola Pinto,

Daniele Donzì,

Serena Di Vincenzo

et al.

Toxicology, Journal Year: 2025, Volume and Issue: 515, P. 154160 - 154160

Published: April 23, 2025

Language: Английский

Citations

0
Urolithin-A supplementation alleviates sepsis-induced acute lung injury by reducing mitochondrial dysfunction and modulating macrophage polarization DOI

Mohd Mohsin,

Almaz Zaki,

Gulnaz Tabassum

et al.

Mitochondrion, Journal Year: 2025, Volume and Issue: unknown, P. 102047 - 102047

Published: May 1, 2025

Language: Английский

Citations

0
Multifaceted roles of mitochondria in asthma DOI Creative Commons
Wei Zhang, Chen‐Yu Zhang, Yi Zhang

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Oct. 9, 2024

Mitochondria are essential organelles within cells, playing various roles in numerous cellular processes, including differentiation, growth, apoptosis, energy conversion, metabolism, and immunity. The phenotypic variation of mitochondria is specific to different tissues cell types, resulting significant differences their function, morphology, molecular characteristics. Asthma a chronic, complex, heterogeneous airway disease influenced by external factors such as environmental pollutants allergen exposure, well internal at the tissue, cellular, genetic levels, lung structural immune granulocytes, mast cells. Therefore, comprehensive understanding responses stimuli changes crucial for elucidating pathogenesis asthma. Previous research on mitochondrial-targeted therapy asthma has primarily focused antioxidants. Consequently, it necessary summarize multifaceted discover additional strategies targeting this context. In review, our goal describe mitochondrial function response exposure across types other relevant context asthma, utilizing new terminology framework that encompasses cell-dependent characteristics, features, activity, behavior.

Language: Английский

Citations

0
Hexavalent chromium exposure induces lung injury via activation of NLRP3 and AIM2 inflammasomes in rats DOI Creative Commons
Ningning Li, Saifei Li, Yue Yu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117181 - 117181

Published: Oct. 22, 2024

Language: Английский

Citations

0
Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging DOI Open Access
Paweł Kordowitzki

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13318 - 13318

Published: Dec. 12, 2024

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause severe and often fatal illness. The zoonotic EEEV enzootic cycle involves of transmission between Culiseta melanura avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans horses. Interestingly, it has been described that the W132G mutation very low-density lipoprotein receptor (VLDLR), EEEV, significantly enhanced VLDLR-mediated cell attachment EEEV. patient’s metabolism plays pivotal role shaping complex landscape viral zoonosis. represents significant public health concern due its clinical outcomes, challenging epidemiological characteristics, certain risk factors heighten susceptibility specific populations or age groups. Age one several predictors impact outcome infection; juvenile animals appear be particularly vulnerable disease. This also observed natural infections, children are most severely impacted humans. aim this piece shed light on intricate relationship human virus.

Language: Английский

Citations

0