Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms

Metabolic Brain Disease, Journal Year: 2021, Volume and Issue: 37(1), P. 51 - 66

Published: Oct. 7, 2021

Language: Английский

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The interactive effects of acute exercise and hypoxia on cognitive performance: A narrative review

Scandinavian Journal of Medicine and Science in Sports, Journal Year: 2019, Volume and Issue: 30(3), P. 384 - 398

Published: Oct. 12, 2019

Acute moderate intensity exercise has been shown to improve cognitive performance. In contrast, hypoxia is believed impair The detrimental effects of on performance are primarily dependent the severity and duration exposure. this review, we describe how acute under alters performance, propose that combined mainly determined by interaction among duration, hypoxia, exposure hypoxia. We discuss physiological mechanism(s) suggest alterations in neurotransmitter function, cerebral blood flow, possibly metabolism primary candidates determine when with Furthermore, acclimatization appears counteract impaired during prolonged although precise responsible for amelioration remain be elucidated. This review implications sporting, occupational, recreational activities at terrestrial high altitude where essential. Further studies required understand mechanisms performed

Language: Английский

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The Brain at High Altitude: From Molecular Signaling to Cognitive Performance

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10179 - 10179

Published: June 15, 2023

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), lower atmospheric pressure inevitably challenges brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims summarize cellular, metabolic, functional alterations in at with a focus on role factors controlling hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, plasticity.

Language: Английский

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A review of methods for assessment of cognitive function in high‐altitude hypoxic environments

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(2)

Published: Feb. 1, 2024

Abstract Hypoxic environments like those present at high altitudes may negatively affect brain function. Varying levels of hypoxia, whether acute or chronic, are previously shown to impair cognitive function in humans. Assessment and prevention such impairment require detection changes using specific assessment tools. This paper summarizes the findings previous research, outlines methods for used a altitude, elaborates need develop standardized systematic tools high‐altitude hypoxia environments.

Language: Английский

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The Study on Effects of Acute Exposure to High Altitude Hypoxia on Cognitive Function in Lowlander

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115515 - 115515

Published: Feb. 1, 2025

Language: Английский

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Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

Language: Английский

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The menstrual cycle minimally affects cardiorespiratory function and body balance control in trained women during acute hypobaric hypoxia exposure (4000 m)

European Journal of Applied Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

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Changes in cognitive function and latent processes of decision-making during incremental ascent to high altitude

Physiology & Behavior, Journal Year: 2019, Volume and Issue: 201, P. 139 - 145

Published: Jan. 3, 2019

Language: Английский

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Memantine ameliorates cognitive impairment induced by exposure to chronic hypoxia environment at high altitude by inhibiting excitotoxicity

Life Sciences, Journal Year: 2021, Volume and Issue: 270, P. 119012 - 119012

Published: Jan. 8, 2021

Language: Английский

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Cognition and Neuropsychological Changes at Altitude—A Systematic Review of Literature

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(12), P. 1736 - 1736

Published: Dec. 19, 2022

High-altitude (HA) exposure affects cognitive functions, but studies have found inconsistent results. The aim of this systematic review was to evaluate the effects HA on functions in healthy subjects. A structural overview applied neuropsychological tests provided with a classification superordinate domains. literature search performed using PubMed up October 2021 according PRISMA guidelines. Eligibility criteria included human cohort exposed altitude field (at minimum 2440 m [8000 ft]) or hypoxic environment laboratory, and an assessment identified 52 (29 these were studies; range: m–8848 [8000–29,029 ft]). Researchers 112 different tests. Attentional capacity, concentration, executive most frequently studied. In ratio altitude-induced impairments (64.7%) twice as high compared results showing no change improved (35.3%), altitudes studied similar chamber studies. field, opposite (66.4 % improvements, 33.6% impairments). Since better acclimatization can be assumed studies, findings support hypothesis that sufficient has beneficial at HA. However, it also becomes apparent research area would benefit if consensus could reached standardized framework freely available neurocognitive

Language: Английский

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