Physiology & Behavior, Journal Year: 2022, Volume and Issue: 250, P. 113785 - 113785
Published: March 26, 2022
Language: Английский
Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14
Published: Jan. 13, 2023
Background: The two main symptoms at high altitude, sleep abnormalities and cognitive impairments, interact with each other. These dysfunctions are also closely related to systemic multisystem diseases, including cerebrovascular psychiatric disorders, immune regulatory diseases. Purpose: To systematically analyze visualize research on disturbances impairment altitudes using a bibliometrics method, determine future directions by analyzing trends the latest hotspots. Methods: Publications from 1990 2022 were retrieved Web of Science. Using R Bibliometrix software Microsoft Excel, all data examined statistically qualitatively. For network visualization, later exported into VOSviewer 1.6.17 CiteSpace 6.1.R6. Results: A total 487 articles in this area published 2022. In period, there was an overall increase number publications. United States has shown considerable importance sector. Bloch Konrad E most prolific valuable author. journal High Altitude Medicine & Biology, it been first choice for publishing field recent years. Analysis keyword co-occurrences suggested that interest clinical manifestations caused altitude hypoxia mainly focused "acute mountain-sickness," "insomnia," "apnea syndrome," "depression," "anxiety," "Cheyne-strokes respiration," "pulmonary hypertension." mechanisms disease development "oxidative stress," "inflammation," "hippocampus," "prefrontal cortex," "neurodegeneration," "spatial memory" brain have focus research. According burst detection analysis, "mood" "memory impairment," as terms strength, expected remain hot topics coming High-altitude-induced pulmonary hypertension is emerging stage research, treatments will continue receive attention future. Conclusion: More being altitudes. This work serve useful reference induced hypobaric
Language: Английский
Citations
9
Travel Medicine and Infectious Disease, Journal Year: 2023, Volume and Issue: 53, P. 102576 - 102576
Published: April 15, 2023
The high-altitude hypoxia environment will cause poor acclimatization in a portion of the population. Remote ischemic preconditioning（RIPC）has been demonstrated to prevent cardiovascular and cerebrovascular diseases under or hypoxic conditions. However, its role improving preventing acute mountain sickness (AMS) at high altitude has undetermined. This study aims estimate effect RIPC on individuals exposed altitude.The project was designed as randomized controlled trial with 82 healthy young males, who received training once day for 7 consecutive days. Then they were transported by aircraft (3680 m) examined 6 Lake Louise Score(LLS) AMS, physiological index, self-reported sleep pattern, Pittsburgh Sleep Quality Index（PSQI）score applied assess altitude. Five neurobehavioral tests conducted cognitive function.The result showed that group had significantly lower AMSscore than control (2.43 ± 1.58 vs 3.29 2.03, respectively; adjusted mean difference-0.84, 95% confidence interval-1.61 -0.06, P = 0.036). there no significant difference AMS incidence between two groups (25.0% 28.57%, 0.555). performed better spatial memory span score (11[9-12] 10[7.5-11], P=0.025) passing digit (7[6-7.5] 6[5-7], P= 0.001). Spatial higher low-altitude (P＜0.01). And obtained quality (P 0.024) PSQI 0.031).The treatment improved subjects exposure this may lead performance
Language: Английский
Citations
9
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 29, 2024
Abstract Background Acute hypobaric hypoxia-induced brain injury has been a challenge in the health management of mountaineers; therefore, new neuroprotective agents are urgently required. Meldonium, well-known cardioprotective drug, reported to have effects. However, relevant mechanisms not elucidated. We hypothesized that meldonium may play potentially novel role hypoxia cerebral injury. Methods initially evaluated neuroprotection efficacy against acute mice and primary hippocampal neurons. The potential molecular targets were screened using drug-target binding Huprot™ microarray chip mass spectrometry analyses after which they validated with surface plasmon resonance (SPR), docking, pull-down assay. functional effects such explored through gene knockdown overexpression. Results study clearly shows pretreatment rapidly attenuates neuronal pathological damage, blood flow changes, mitochondrial damage its cascade response oxidative stress injury, thereby improving survival rates neurons, revealing remarkable pharmacological high-altitude On one hand, we confirmed directly interacts phosphoglycerate kinase 1 (PGK1) promote activity, improved glycolysis pyruvate metabolism ATP production. other also ameliorates by PGK1 translocating mitochondria under regulate activity TNF receptor-associated protein (TRAP1) chaperones. Conclusion These results further explain mechanism as an energy optimizer provide strategy for preventing at high altitudes.
Language: Английский
Citations
3
High Altitude Medicine & Biology, Journal Year: 2019, Volume and Issue: 20(4), P. 361 - 374
Published: Oct. 25, 2019
Background: We investigated altitude effects on different cognitive domains among perennial shift-workers at the Atacama Large Millimeter/submillimeter Array Observatory (5050 m), Chile. Materials and Methods: Twenty healthy male workers were recruited assigned to either a moderate-altitude first (MAF group, Test 1: 2900 m 2: 5050 m) or high-altitude (HAF m). 1 was conducted beginning 2 end of shift-work week. Processing speed (RTI, reaction time), attention (AST, attention-switching task, RVP, rapid visual processing), executive function (OTS, One Touch Stockings Cambridge) assessed. Results: Of three assessed, only processing showed altitude-at-test group interaction (RTI median five choice time: F1, 17 = 6.980, [Formula: see text] 0.291, p 0.017). With acclimatization, there decrease in AST latency mean (t17 -2.155, dz 1.086, 0.046), an increase RVP accuracy 2.733, 1.398, 0.014), OTS -2.375, 1.211, 0.03). Decreased variability observed standard deviation -2.524, 1.282, 0.022) response -2.35, 1.177, 0.03) with acclimatization. At elevation, SpO2 positively correlated MAF (OTS problems solved choice: r(5) 0.839, 0.018) negatively deviations HAF deviation: r(10) -0.618, 0.032). Conclusions: Our findings highlight importance acclimatization improvement blood oxygen level, even high altitude-experienced workers, optimize performance cognitively demanding work reduce altitude-associated health risks.
Language: Английский
Citations
21
Aging and Disease, Journal Year: 2020, Volume and Issue: 11(4), P. 820 - 820
Published: Jan. 1, 2020
Remote ischemic conditioning (RIC) confers protection on major organs from hypoxic/ischemic injuries; however, its impacts attention network function and blood oxygen levels in unacclimatized adults exposed to high altitudes have yet be elucidated. In this study, we recruited 120 healthy male volunteers, of which one was altitude the other low altitude. The two cohorts were further divided into RIC sham control groups. attentional test (ANT) performed evaluate cognitive before after treatment. Other outcomes such as heart rate, pressure, saturation, cerebral tissue oxygenation index (CTOI), cerebrovascular hemodynamic indices also evaluated. Prior treatment, there no significant differences orienting or executive between treatment arms either cohort. Alerting significantly lower high-altitude cohort than low-altitude There reductions both CTOI relative cohort, while pulse (PI) former increased. After a difference alerting group associated control. increased 60.39±3.40% 62.78±4.40%, improved. Furthermore, showed reduction PI. Exposure environments had impact function, oxygen, CTOI, ameliorated changes well suggesting that it potentially alters compliance upon exposure
Language: Английский
Citations
20
Automation in Construction, Journal Year: 2024, Volume and Issue: 160, P. 105307 - 105307
Published: Feb. 8, 2024
Language: Английский
Citations
2
Psychophysiology, Journal Year: 2024, Volume and Issue: 61(6)
Published: Feb. 22, 2024
This study aimed to explore the neural mechanisms underlying high-altitude (HA) adaptation and deadaptation in perceptual processes lowlanders. Eighteen healthy lowlanders were administered a facial S1-S2 matching task that included incomplete face (S1) complete (S2) photographs combined with ERP technology. Participants tested at four time points: shortly before they departed HA (Test 1), twenty-five days after entering 2), one week 3) month 4) returning lowlands. Compared those sea level (SL), shorter reaction times (RTs), latencies of P1 N170, larger amplitudes N170 found HAs. After SL, compared HA, amplitude was smaller week, month. The right hemisphere greater SL than baseline, but it returned baseline Taken together, current findings suggest increases visual cortex excitation accelerate processing. More mental resources are recruited during configural encoding stage faces exposure. affected by exposure reversible low-level processing differs between due compensation mechanisms. is requires more less recover baseline.
Language: Английский
Citations
2
Safety Science, Journal Year: 2024, Volume and Issue: 177, P. 106569 - 106569
Published: June 12, 2024
Language: Английский
Citations
2
Brain and Behavior, Journal Year: 2022, Volume and Issue: 12(12)
Published: Nov. 2, 2022
Inadequate oxygen availability may lead to impairment of neurocognitive functions. The aim the present study was investigate effect acute high-altitude exposure on cerebral hemodynamic response and working memory.The same subjects performed memory exercises with forward backward digit span tasks both under normal conditions in large simulated hypobaric hypoxia chambers, a series physiological parameters were evaluated. Functional near-infrared spectroscopy used measure blood flow changes dorsolateral prefrontal cortex (DLPFC) during tasks.Compared normoxic conditions, hypoxic heart rate pressure increased, saturation decreased significantly, task had similar accuracy time, while lower longer time. Neuroimaging analysis showed increased activation DLPFC deactivation conditions.Acute leads adaptations. abnormal responses at low reveal disruption function by exposure, which compromises complex cognitive functions, provides promising application for functional near infrared exploration neural mechanisms brain exposure.
Language: Английский
Citations
11
Brain Imaging and Behavior, Journal Year: 2020, Volume and Issue: 15(1), P. 147 - 156
Published: March 3, 2020
Language: Английский
Citations
16