Translational research, Journal Year: 2023, Volume and Issue: 264, P. 85 - 96
Published: Oct. 23, 2023
Language: Английский
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Nov. 2, 2022
Diabetic nephropathy (DN) is the most common chronic kidney disease. Accumulation of glucose and metabolites activates resident macrophages in kidneys. Resident play diverse roles on diabetic injuries by releasing cytokines/chemokines, recruiting peripheral monocytes/macrophages, enhancing renal cell (podocytes, mesangial cells, endothelial cells tubular epithelial cells), macrophage-myofibroblast transition. The differentiation cross-talks ultimately result inflammation fibrosis DN. Emerging evidence shows that targeting suppressing macrophage activation/transition, macrophages-cell interactions may be a promising approach to attenuate In review, we summarized other DN, highlighted therapeutic potentials macrophages.
Language: Английский
Citations
65
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8668 - 8668
Published: Aug. 4, 2022
The inflammatory component of diabetic kidney disease has become great interest in recent years, with genetic and epigenetic variants playing a fundamental role the initiation progression disease. Cells innate immune system play major pathogenesis disease, lesser contribution from adaptive cells. Other components such as complement also role, well specific cytokines chemokines. is an active research field, hope to find potential innovative therapeutic targets.
Language: Английский
Citations
54
BMJ Open, Journal Year: 2022, Volume and Issue: 12(12), P. e062188 - e062188
Published: Dec. 1, 2022
Objectives To investigate low-grade inflammation in type 2 diabetes and explore associations to clinical aspects as well microvascular macrovascular complications. Design Cross-sectional analysis. Setting The outpatient clinic at the Department of Endocrinology Aalborg University Hospital, Denmark. Participants 100 participants with confirmed by a haemoglobin A1c (HbA1c)≥6.5% for minimum 1 year 21 healthy controls. Outcome measures Serum levels 27 inflammation-related biomarkers measured immunoassay. Associations complications, body weight, glycaemic control, medication sex were investigated cohort. Results tumour necrosis factor (TNF)-α eotaxin elevated (p<0.05), while interleukin (IL)-7 was decreased (p<0.001). IL-12/IL-23p40, IL-15, macrophage-derived chemokine (MDC) C reactive protein (CRP) increased weight TNF-α HbA1c (p<0.04). Dipeptidyl peptidase-4 inhibitor therapy associated lower induced protein-10, MDC thymus activation regulated (p<0.02), females had higher (p=0.027). Individuals ≥3 diabetic complications IL-6, IL-10, IL-15 CRP compared those ≤3 (p<0.05). Conclusion level is obesity, regulation, therapeutical management, Our results underline importance addressing inflammatory issues diabetes, these may predispose crippling comorbidities.
Language: Английский
Citations
51
Chinese Herbal Medicines, Journal Year: 2023, Volume and Issue: 15(2), P. 222 - 230
Published: March 8, 2023
Kunxian Capsule (KX) is a popular Chinese patent medicine for the treatment of rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus, Henoch-Schönlein purpura, ankylosing spondylitis, psoriatic arthritis and eczema. However, there scarcity comprehensive information on significance KX in clinical application its side effects. Hence, it aimed to provide review KX, with focus pharmacological effects, applications, adverse reactions. This was based published literatures PubMed, China National Knowledge Infrastructure WanFang database. The articles were collected by two independent authors no time limits applied until November 30, 2022. search term includes and/or effect, pharmacology, disease, therapy, effects quality control. has been shown be effective autoimmune inhibiting inflammatory responses inducing apoptosis. Many studies suggest that anti-inflammatory analgesic properties aid improvement joint functions. dispels wind, removes dampness, invigorates kidneys, promotes blood circulation, thereby curing various diseases. also KX-related reactions multiple systems. Overall, this highlights scientific basis or preventing diseases provides novel insights further research applications.
Language: Английский
Citations
31
Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1225 - 1225
Published: Sept. 2, 2022
Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has been great advance in our understanding the pathogenesis DN, no effective managements this chronic kidney disease are currently available. Therefore, continuing to elucidate underlying biochemical and molecular mechanisms DN remains constant need. In regard, animal models indispensable tools. This review article highlights widely used rodent model non-obese type 2 induced by nicotinamide (NA) streptozotocin (STZ). The mechanism induction combining two chemicals involves blunting toxic effect STZ NA so that only percentage β cells destroyed remaining viable can still respond glucose stimulation. NA-STZ model, as platform for testing numerous antidiabetic renoprotective materials, also discussed. comparison with other diabetic models, such high-fat-diet/STZ genetically engineered less time-consuming expensive create. Given unique mimics certain pathological features human should continue find its applications field research.
Language: Английский
Citations
36
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12
Published: Jan. 11, 2022
Diabetes mellitus is a global public health challenge with high morbidity. Type 2 diabetes (T2DM) accounts for 90% of the prevalence diabetes. T2DM featured by combination defective insulin secretion pancreatic β-cells and inability insulin-sensitive tissues to respond appropriately insulin. However, pathogenesis this disease complicated genetic environmental factors, which needs further study. Numerous studies have demonstrated an epigenetic influence on course via altering expression downstream diabetes-related proteins. Further in field epigenetics can help elucidate mechanisms identify appropriate treatments. Histone methylation defined as common histone mark adding methyl group (-CH3) onto lysine or arginine residue, alter proteins affect cellular processes. Thus, tthis study will discuss types functions its role wilsed. We review involvement methyltransferases demethylases progression analyze epigenetic-based therapies. also potential application modification targets treatment T2DM.
Language: Английский
Citations
33
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: July 5, 2022
Diabetic nephropathy (DN), one of the most common and intractable microvascular complications diabetes, is main cause terminal renal disease globally. MicroRNA-21 (miR-21) a kind miRNA early identified in human circulation tissues. Mounting studies have demonstrated that miR-21 plays an important role development progression DN. This collaborative review aimed to present first attempt capture current evidence on relationship between After systematic search, 29 relevant were included for comprehensively thoroughly reviewing. All these eligible reported was up-regulated DN, whether serum or tissues animal models. MiR-21 exhibited its pathogenic roles DN by forming complex network with targeted genes (e.g. MMP-9, Smad7, TIMP3, Cdk6, FOXO1, IMP3, MMP2) signaling cascades Akt/TORC1 axis, TGF-β/NF-κB pathways, TGF-β/SMAD pathway, CADM1/STAT3 signaling, AGE-RAGE regulatory cascade), which resulted epithelial-to-mesenchymal transition, extracellular matrix deposition, cytoskeletal remodeling, inflammation, fibrosis. highlights pivotal factor It may serve as attractive potential diagnostic, prognostic, predictive biomarker clinical practice after further confirmation clinicopathological features molecular mechanisms miR-21-mediated
Language: Английский
Citations
30
Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(3), P. 210 - 222
Published: March 28, 2024
Language: Английский
Citations
7
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: March 8, 2024
Abstract The present study aimed to explore the potential ameliorative effect of apigenin (APG) against diabetes-associated genitourinary complications in rats. A diabetic rat model was induced by intraperitoneal injection streptozotocin (STZ). All experimental animals were treated with vehicle or plus APG at a dose 0.78 mg/kg/day for 10 days, either once diabetes confirmed end 3rd week after confirmation diabetes. Rats sacrificed fifth week. In addition histological assessment, an analysis kidney function tests and serum testosterone performed assess complications. Gene expression mitochondrial fission protein, dynamin related protein 1 ( Drp1 ), measured renal testicular tissues using qRT PCR. can increase body weight, reduce blood glucose levels, improve functions decreased overexpression animals’ kidneys testes. summary, our current work discloses that attenuates lesions rats via suppressing overexpression.
Language: Английский
Citations
6
Membranes, Journal Year: 2022, Volume and Issue: 12(11), P. 1060 - 1060
Published: Oct. 28, 2022
Contradictory results were obtained regarding the effects of extracellular vesicles such as exosomes (EXOs) on diabetes and diabetic nephropathy (DN). Some studies showed that EXOs, including milk involved in pathogenesis DN, whereas other revealed ameliorative effects. Compared to animals, camel had unique components lower blood glucose levels. However, little is known effect its EXOs DN. Thus, present study was conducted evaluate this a rat model DN induced by streptozotocin. Treatment with and/or ameliorated evidenced (1) reduced levels kidney function parameters (urea, creatinine, retinol-binding protein (RBP), urinary proteins), (2) restored redox balance (decreased lipid peroxide malondialdehyde (MDA) increased activity antioxidants enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx)), (3) downregulated expression DN-related genes (transforming growth factor-beta 1 (TGFβ1), intercellular adhesion molecules (ICAM1), transformation specific (ETS1), integrin subunit beta 2 (ITGβ2), tissue inhibitors matrix metalloproteinase (TIMP2), injury molecule-1 (KIM1)), (4) decreased renal damage histological score. These concluded treatment could ameliorate better for combined therapy.
Language: Английский
Citations
22