Starch - Stärke,
Journal Year:
2024,
Volume and Issue:
76(9-10)
Published: March 19, 2024
Abstract
Diabetic
nephropathy
is
a
serious
metabolic
disease
that
usually
caused
by
diabetes
mellitus
and
ends
in
chronic
kidney
renal
failure.
Many
drugs
used
to
treat
diabetic
have
limitations
side
effects.
There
an
urgent
need
find
safe
effective
new
for
the
treatment
of
nephropathy.
The
polysaccharides
from
natural
sources,
including
plants,
fungi,
algae,
good
protective
effects
on
without
In
this
paper,
chemical
composition,
structural
characteristics
are
reviewed.
addition,
study
summarizes
different
mechanisms
improve
nephropathy,
such
as
antioxidative
stress,
regulation
inflammation,
inhibition
apoptosis,
fibrosis.
This
review
provides
theoretical
support
effect
reveals
potential
therapeutic
methods
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(4), P. 633 - 633
Published: March 31, 2023
Diabetic
kidney
disease
(DKD)
is
a
highly
prevalent
condition
worldwide.
It
represents
one
of
the
most
common
complications
arising
from
diabetes
mellitus
(DM)
and
leading
cause
end-stage
(ESKD).
Its
development
involves
three
fundamental
components:
hemodynamic,
metabolic,
inflammatory
axes.
Clinically,
persistent
albuminuria
in
association
with
progressive
decline
glomerular
filtration
rate
(GFR)
defines
this
disease.
However,
as
these
alterations
are
not
specific
to
DKD,
there
need
discuss
novel
biomarkers
its
pathogenesis
which
may
aid
diagnosis,
follow-up,
therapeutic
response,
prognosis
Annals of Medicine,
Journal Year:
2024,
Volume and Issue:
56(1)
Published: April 24, 2024
Diabetic
nephropathy
(DN)
is
a
severe
complication
of
diabetes
mellitus,
causing
substantive
threat
to
the
public,
which
receives
global
concern.
However,
there
are
limited
drugs
targeting
treatment
DN.
Owing
this,
it
highly
crucial
investigate
pathogenesis
and
potential
therapeutic
targets
The
process
ferroptosis
type
regulated
cell
death
(RCD)
involving
presence
iron,
distinct
from
autophagy,
apoptosis,
pyroptosis.
A
primary
mechanism
associated
with
iron
metabolism,
lipid
accumulation
ROS.
Recently,
many
studies
testified
significance
in
kidney
tissue
under
diabetic
conditions
explored
DN
therapy.
Our
review
summarized
most
current
between
DN,
along
investigating
significant
processes
different
cells,
providing
novel
target
option
for
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(2)
Published: Feb. 1, 2025
Diabetic
nephropathy
(DN)
is
the
leading
cause
of
uremia
and
clinical
mortality,
characterized
by
progressive
deterioration
kidney
structure
function
due
to
prolonged
exposure
hyperglycemia.
This
condition
often
necessitates
renal
replacement
therapy
for
patients
with
end-stage-renal-disease
(ESRD).
Consequently,
early
detection,
diagnosis,
treatment
DN
are
crucial
mitigate
disease
progression,
enhance
patient
outcomes,
maintain
a
good
quality
life.
Exploring
relevant
biomarkers
diagnosis
holds
significant
importance.
In
recent
years,
numerous
researchers
have
identified
various
novel
associated
diabetic
nephropathy,
which
critical
predicting
both
onset
progression
disease.
article
aims
provide
comprehensive
overview
related
DN.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 21, 2023
Type
II
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease
characterized
by
prolonged
hyperglycemia
and
insulin
resistance
(IR).
Its
incidence
increasing
annually,
posing
significant
threat
to
human
life
health.
Consequently,
there
an
urgent
requirement
discover
effective
drugs
investigate
the
pathogenesis
of
T2DM.
Autophagy
plays
crucial
role
in
maintaining
normal
islet
structure.
However,
state
high
glucose,
autophagy
inhibited,
resulting
impaired
function,
resistance,
complications.
Studies
have
shown
that
modulating
through
activation
or
inhibition
can
positive
impact
on
treatment
T2DM
its
it
important
note
specific
regulatory
mechanisms
vary
depending
target
organ.
This
review
explores
T2DM,
taking
into
account
both
genetic
external
factors.
It
also
provides
summary
reported
chemical
traditional
Chinese
medicine
autophagic
pathway
for
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6532 - 6532
Published: March 31, 2023
Diabetic
nephropathy
(DN)
is
a
microvascular
complication
of
diabetes
mellitus.
This
study
examined
the
therapeutic
effects
sitagliptin,
dipeptidyl
peptidase
inhibitor,
on
DN
and
explored
underlying
mechanism.
Male
Wistar
albino
rats
(n
=
12)
were
intraperitoneally
administered
single
dose
streptozotocin
(30
mg/kg)
to
induce
diabetes.
Streptozotocin-treated
untreated
further
divided
into
normal
control,
sitagliptin-treated
diabetic
groups
6
in
each).
The
control
received
saline,
whereas
sitagliptin
(100
mg/kg,
p.o.).
We
assessed
serum
levels
inflammatory
biomarkers.
Protein
tyrosine
phosphatase
1
B
(PTP1B),
phosphorylated
Janus
kinase
2
(P-JAK2),
signal
transducer
activator
transcription
(P-STAT3)
kidney
tissues
using
Western
blotting,
sections
histologically.
Sitagliptin
reduced
biomarkers
expression
PTP1B,
p-JAK2,
p-STAT3
(p
<
0.001)
improved
streptozotocin-induced
histological
changes
kidney.
These
results
demonstrate
that
ameliorates
inflammation
by
inhibiting
DPP-4
consequently
modulating
PTP1B-related
JAK/STAT
axis,
leading
alleviation
DN.
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
19(14), P. 4427 - 4441
Published: Jan. 1, 2023
Diabetic
kidney
disease
(DKD)
is
a
global
health
issue
that
presents
complex
pathogenesis
and
limited
treatment
options.To
provide
guidance
for
precise
therapies,
it
crucial
to
accurately
identify
the
of
DKD.Several
studies
have
recognized
mitochondrial
endoplasmic
reticulum
(ER)
dysfunction
are
key
drivers
DKD.The
mitochondria-associated
ER
membrane
(MAM)
dynamic
contact
site
(MSC)
connects
mitochondria
essential
in
maintaining
normal
function
two
organelles.MAM
involved
various
cellular
processes,
including
lipid
synthesis
transport,
calcium
homeostasis,
fusion
fission,
stress.Meanwhile,
recent
confirm
MAM
plays
significant
role
DKD
by
regulating
glucose
metabolism,
inflammation,
stress,
fission
fusion,
autophagy.Herein,
this
review
aims
comprehensive
summary
physiological
MAMs
their
impact
on
progression
DKD.Subsequently,
we
discuss
trend
pharmaceutical
target
resident
proteins
treating
DKD.Furthermore,
also
explore
future
development
prospects
research,
thereby
providing
new
perspective
basic
clinical
DKD.
Chemico-Biological Interactions,
Journal Year:
2023,
Volume and Issue:
385, P. 110711 - 110711
Published: Sept. 26, 2023
Morroniside
(MOR),
a
cyclic
enol
ether
terpene
glycoside
isolated
from
Cornus
officinalis,
has
been
shown
to
inhibit
lipid
accumulation,
although
the
mechanism
of
action
is
uncertain.
The
aim
this
study
was
investigate
potential
pathways
by
which
MOR
affects
renal
deposition
in
diabetic
nephropathy
(DN).
In
vitro
and
vivo
experiments
were
performed
using
PA-induced
HK-2
cell
model
KKAy
animal
model,
respectively.
Network
pharmacological
analysis
used
identify
signaling
for
DN
therapy,
with
results
verified
via
Western
blotting
immunofluorescence
experiments.
effect
on
metabolism
investigated
BODIPY
493/503
staining.
Our
indicate
that
significantly
reduces
accumulation
both
vivo.
According
network
pharmacology
studies,
NF-κB/TNF-α/SREBP1c
pathway
may
be
DN.
found
reducing
phosphorylation
NF-κB
p65
expression
TNF-α
SREBP1c,
similar
effects
Bay11-7082.
Additionally,
inhibited
factors
such
as
ACC,
FAS,
SCD1.
conclusion,
can
regulate
disruption
reduce
suppression
pathway.
Internal and Emergency Medicine,
Journal Year:
2024,
Volume and Issue:
19(5), P. 1473 - 1491
Published: July 6, 2024
Abstract
Autophagy
is
an
evolutionarily
conserved
process
that
plays
a
pivotal
role
in
the
maintenance
of
cellular
homeostasis
and
its
impairment
has
been
implicated
pathogenesis
various
metabolic
diseases
including
obesity,
type
2
diabetes
(T2D),
dysfunction-associated
steatotic
liver
disease
(MASLD).
This
review
synthesizes
current
evidence
from
human
studies
on
autophagy
alterations
under
these
conditions.
In
most
data
point
to
upregulation
during
initiation
phase
autophagosome
formation,
potentially
response
proinflammatory
conditions
adipose
tissue.
Autophagosome
formation
appears
be
enhanced
hyperglycemic
or
insulin-resistant
patients
with
T2D,
possibly
acting
as
compensatory
mechanism
eliminate
damaged
organelles
proteins.
Other
have
proposed
prolonged
hyperglycemia
disrupted
insulin
signaling
hinder
autophagic
flux,
resulting
accumulation
dysfunctional
components
can
contribute
β-cell
dysfunction.
Evidence
MASLD
supports
inhibition
progression.
Nevertheless,
given
available
data,
it
difficult
ascertain
whether
suppressed
because
levels
markers
depend
overall
metabolism
specific
organs,
tissues,
experimental
conditions,
duration.
Owing
constraints,
determining
observed
shifts
activity
precede
result
remains
challenging.
Additionally,
autophagy-modulating
strategies
are
shortly
discussed.
To
conclude,
more
investigating
required
gain
comprehensive
understanding
unveil
novel
therapeutic
for
