Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 244, P. 116126 - 116126
Published: April 1, 2024
Language: Английский
Cell, Journal Year: 2024, Volume and Issue: 187(5), P. 1177 - 1190.e18
Published: Feb. 1, 2024
Language: Английский
Citations
109
Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1476 - 1476
Published: June 1, 2023
Candida albicans is a commensal fungal species that commonly colonizes the human body, but it also pervasive opportunistic pathogen in patients with malignant diseases. A growing body of evidence suggests this fungus not only coincidental oncology patients, may play an active role development cancer. More specifically, several studies have investigated potential association between C. and various types cancer, including oral, esophageal, colorectal possible skin cancer as well. The proposed mechanisms include production carcinogenic metabolites, modulation immune response, changes cell morphology, microbiome alterations, biofilm production, activation oncogenic signaling pathways, induction chronic inflammation. These act together or independently to promote development. Although more research needed fully grasp carcinogenesis, available be contributor underscores importance considering impact on pathogenesis. In narrative review, we aimed summarize current state offer some insights into mechanisms.
Language: Английский
Citations
18
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: Aug. 23, 2023
Senescence is an inevitable biological process. Disturbances in glucose and lipid metabolism are essential features of cellular senescence. Given the important roles these types metabolism, we review evidence for how key metabolic enzymes influence senescence senescence-related secretory phenotypes, autophagy, apoptosis, insulin signaling pathways, environmental factors modulate homeostasis. We also discuss alterations abnormal diseases anti-cancer therapies that target through interventions. Our work offers insights developing pharmacological strategies to combat cancer.
Language: Английский
Citations
16
The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(3)
Published: Jan. 31, 2024
Abstract Small noncoding RNAs (sncRNAs) are implicated in age‐associated pathologies, including sarcopenia and insulin resistance (IR). As potential circulating biomarkers, most studies have focussed on microRNAs (miRNAs), one class of sncRNA. This study characterized the wider sncRNA transcriptome older individuals associations with IR. expression miRNAs, transfer (tRNAs), tRNA‐associated fragments (tRFs), piwi‐interacting (piRNAs) was measured serum from 21 healthy sarcopenic Hertfordshire Sarcopenia Study extension women matched for age (mean 78.9 years) HOMA2‐IR. Associations age, HOMA2‐IR were examined predicted gene targets biological pathways characterized. Of total among controls, piRNAs abundant (85.3%), followed by tRNAs (4.1%), miRNAs (2.7%), tRFs (0.5%). Age associated (FDR < 0.05) 2 58 tRNAs, 14 tRFs, chromatin organization, WNT signaling, response to stress enriched targets. nominally ( p .05) 12 3 6 piRNAs, target genes linked cell proliferation differentiation such as Notch Receptor 1 NOTCH1 ), DISC1 scaffold protein GLI family zinc finger‐2 GLI2 ). (p<0.05) 9 tRF, 19 lysine degradation, circadian rhythm, fatty acid biosynthesis pathways. These findings identify changes human chronological sarcopenia, may clinical utility biomarkers ageing pathologies provide novel therapeutic intervention.
Language: Английский
Citations
6
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115197 - 115197
Published: Feb. 9, 2024
Skin cancer is a heterogeneous disease that can be divided into two main groups, melanoma and nonmelanoma skin cancers. Conventional therapies for have numerous systemic side effects high recurrence rate. Topical treatment an alternative approach, but drug permeability remains challenge. Therefore, nanocarriers appear as important nanotechnology tools reduces both the improves clinical outcomes. This why they are attracting growing interest. In this review, scientific articles on use of topical were collected. Despite promising results presented considering some them already market, there urgent need investment in development manufacturing methods, well suitable toxicological regulatory evaluations, since conventional methods currently used to develop these nanocarriers-based products more time-consuming expensive than products.
Language: Английский
Citations
5
Metabolites, Journal Year: 2024, Volume and Issue: 14(3), P. 133 - 133
Published: Feb. 21, 2024
Traumatic brain injury (TBI) is a significant source of disability in the United States and around world may lead to long-lasting cognitive deficits decreased quality life for patients across severities. Following primary phase, TBI characterized by complex secondary cascades that involve altered homeostasis metabolism, faulty signaling, neuroinflammation, lipid dysfunction. The objectives present study were (1) assess potential correlations between lipidome cytokine changes after closed-head mild (mTBI), (2) examine reproducibility our acute lipidomic profiles following TBI. Cortices from 54 Sprague Dawley male female rats analyzed ultra-high-performance liquid chromatography mass spectrometry (LC-MS) both positive negative ionization modes multiplex analysis single (smTBI) or repetitive (rmTBI) impacts, sham conditions. Tissue age was variable, given two cohorts (
Language: Английский
Citations
4
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 134951 - 134951
Published: June 22, 2024
Language: Английский
Citations
4
Food Chemistry, Journal Year: 2024, Volume and Issue: 465, P. 141918 - 141918
Published: Nov. 5, 2024
Language: Английский
Citations
4
Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 228, P. 251 - 266
Published: Jan. 6, 2025
Language: Английский
Citations
0
Journal of Virology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
ABSTRACT Persons living with HIV experience significant metabolic dysregulation, frequently resulting in immune and other cellular dysfunction. However, our understanding of metabolism its relationship to immunity the context remains incompletely understood, especially as it relates acute early chronic phases infection. Herein, we employed mass spectrometry a simian immunodeficiency virus (SIV)-infected rhesus macaque model characterize changes over 500 plasma metabolites throughout SIV This broad metabolomic approach recapitulated known pathogenic signatures HIV, such perturbed tryptophan/kynurenine ratio, but also identified novel changes. We observed general decrease amino acid concentrations, notable exceptions elevated aspartate glutamate. Acute infection was marked by transient increase lactate dehydrogenase activity, indicating shift toward anaerobic metabolism. Indoleamine 2,3-dioxygenase defined kynurenine/tryptophan significantly increased both strongly correlated viral load. These results provide comprehensive characterization fluctuations during lentiviral infection, furthering crucial interplay between response. Our findings highlight systemic consequences potential targets for therapeutic intervention or biomarkers disease progression. IMPORTANCE Despite advances antiretroviral therapy pre-exposure prophylaxis, global challenge. Understanding underlying mechanisms is critical improving control development. Cellular represents yet underappreciated area system function. Metabolite availability pathway preferences directly influence functional response capacity cells are highly dysregulated To further impacts utilized cutting-edge spectrometry-based metabolome interrogation measure using an macaques. analysis provides insights into dynamic landscape revealing signatures. enhance complex infections, potentially informing new strategies detection, prevention, treatment HIV.
Language: Английский
Citations
0