The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167063 - 167063
Published: Sept. 13, 2023
Language: Английский
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 176897 - 176897
Published: Oct. 12, 2024
Language: Английский
Citations
3
Fishes, Journal Year: 2024, Volume and Issue: 9(2), P. 51 - 51
Published: Jan. 27, 2024
The teleost ATP Binding Cassette (ABC) transporter P-glycoprotein (P-gp) is an active transmembrane that plays a pivotal role in facilitating the movement of both endogenous and xenobiotic substrates (moderately hydrophobic amphipathic compounds) across cell membranes. P-gp exhibits substrate specificity often shared with other ABC transporters solute carrier proteins, thereby ensuring maintenance chemical homeostasis within cells. These are integral to defense systems fish, as they actively expel wide range substrates, primarily unmodified compounds, from This transport process assists preventing absorption (e.g., intestine), safeguarding sensitive tissues brain gonads), effectively excreting substances liver kidney). Upregulated export activity aquatic animals results multi-xenobiotic resistance (MXR) phenotype essential protective survival contaminated environments. Pollutants inhibiting termed chemosensitizers heighten fish sensitivity toxic substrates. While known intrinsic functions encompass steroid hormone bile acid processing, relatively little attention has been given inhibitors. Fish regulation orchestrated by nuclear transcription factors, including pregnane X receptor (PXR) factor erythroid 2-related 2 (Nrf2). comprehensive review provides profound insights into P-gp’s significance diverse species, contributing enhanced understanding physiology, evolution, toxicology, information potential applications, such environmental monitoring.
Language: Английский
Citations
2
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0298213 - e0298213
Published: March 13, 2024
Freshwater salinization poses global challenges for aquatic organisms inhabiting urban streams, impacting their physiology and ecology. However, current research predominantly focuses on mortality endpoints in limited model species, overlooking the sublethal effects a broader spectrum of exploration adaptive mechanisms pathways under natural field conditions. To address these gaps, we conducted high-throughput sequencing transcriptomic analysis gill tissue euryhaline fish Gasterosteus aculeatus , investigating its molecular response to salinity stress highly urbanized river Boye, Germany. We found that stream sections with concentrations chloride costly osmoregulatory systems were activated, evidenced by differential expression genes related osmoregulation. Our enrichment revealed differentially expressed (DEGs) transmembrane transport regulation other osmoregulation pathways, which aligns crucial role maintaining biological homeostasis. Notably, identified candidate involved increased activity stress, including those responsible moving ions across membranes: ion channels, pumps, transporters. Particularly, from solute carrier family SLC, aquaporin AQP1 channel CLC7 ATP-binding cassette transporter ABCE1 ATPases member ATAD2 exhibited prominent expression. These findings provide insights into potential underlying have implications conservation management face freshwater salinization.
Language: Английский
Citations
2
Aquaculture, Journal Year: 2024, Volume and Issue: 590, P. 741047 - 741047
Published: May 9, 2024
Language: Английский
Citations
2
Fish Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 50(6), P. 2149 - 2164
Published: July 19, 2024
Language: Английский
Citations
2
Animals, Journal Year: 2023, Volume and Issue: 13(8), P. 1381 - 1381
Published: April 18, 2023
Given the hydrophilic structure of lysophospholipids (LPLs), their dietary inclusion translates into a better emulsifying capacity components. The present study aimed to understand mechanisms underlying growth-promoting effect LPL supplementation by undertaking deep analyses proximal intestine and liver interactomes. Atlantic salmon (Salmo salar) was selected as main aquaculture species model. animals were divided two groups: one fed control diet (C-diet) other feed (LPL-diet) supplemented with an LPL-based digestive enhancer (0.1% AQUALYSO®, Adisseo). LPL-diet had positive on fish increasing final weight 5% reducing total serum lipids, mainly due decrease in plasma phospholipid (p < 0.05). In intestine, upregulated interactome suggests more robust capacity, improving vesicle-trafficking-related proteins, complex sugar hydrolysis, lipid metabolism. liver, promotes nutrients, several metabolic pathways. downregulation responses stress stimuli could be related reduced proinflammatory state. This benefits modes action LPLs opens new window nutrition extended productive species.
Language: Английский
Citations
6
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 263, P. 115397 - 115397
Published: Aug. 23, 2023
ATP-binding cassette (ABC) transporters are believed to protect aquatic organisms by pumping xenobiotics out, and recent investigation has suggested their involvement in the detoxification efflux of nanoparticles (NPs), but roles fish embryos poorly understood. In this regard, paper summarizes advances research pertaining development ABC transporter-mediated multi-xenobiotic resistance (MXR) mechanism potential interaction between NPs. The focuses on: (1) Expression, function, modulation proteins embryos; (2) Potential NPs cell models embryos. could be maternally transferred thus play an important role various chemical pollutants There is a need understand specific benefit protection resources.
Language: Английский
Citations
6
Aquaculture, Journal Year: 2023, Volume and Issue: 569, P. 739338 - 739338
Published: Feb. 16, 2023
Language: Английский
Citations
4
Biology, Journal Year: 2023, Volume and Issue: 12(12), P. 1454 - 1454
Published: Nov. 21, 2023
Fish primary cell culture has emerged as a valuable tool for investigating the physiological roles and responses of various types found in fish species. This review aims to provide an overview advancements applications techniques, focusing on profiling exhibited by cells vitro. involves isolation cultivation directly derived from tissues, maintaining their functional characteristics enabling researchers study behavior under controlled conditions. Over years, significant progress been made optimizing conditions, establishing standardized protocols, improving characterization techniques cultures. The highlights diverse that have successfully cultured different species, including gonad cells, pituitary muscle hepatocytes, kidney immune adipocyte myeloid brain fin gill other cells. Each type exhibits distinct functions, contributing vital processes such metabolism, tissue regeneration, response, toxin metabolism. Furthermore, this paper explores pivotal role elucidating mechanisms underlying processes. Researchers utilized cultures effects environmental factors, toxins, pathogens, pharmaceutical compounds cellular providing insights into health, disease pathogenesis, drug development. also discusses application aquaculture research, particularly growth, nutrition, reproduction, stress responses. By mimicking vivo conditions vitro, proven instrumental identifying key factors influencing health performance, thereby development sustainable practices.
Language: Английский
Citations
4
Published: Jan. 1, 2024
Language: Английский
Citations
1