Gut microbiota in colorectal cancer development and therapy

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(7), P. 429 - 452

Published: May 11, 2023

Language: Английский

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A Perspective on High-Intensity Interval Training for Performance and Health

Sports Medicine, Journal Year: 2023, Volume and Issue: 53(S1), P. 85 - 96

Published: Oct. 7, 2023

Language: Английский

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A Comparative Analysis of High-Intensity Technique-Specific Intervals and Short Sprint Interval Training in Taekwondo Athletes: Effects on Cardiorespiratory Fitness and Anaerobic Power

Journal of Sports Science and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 672 - 683

Published: Aug. 20, 2024

Technique-specific high-intensity interval training (HIITTS) has been proven to be an effective method enhance the sport-specific bio-motor abilities of taekwondo athletes. However, studies regarding its effects on comprehensive measures cardiorespiratory fitness are limited. Furthermore, there is a lack clarity extent individual adaptations this compared HIIT in form repeated sprints (HIITRS). This study HIITRS and HIITTS anaerobic power trained athletes (age = 19.8 ± 1.3 years; body mass 75.4 9.1 kg; height 1.73 0.0 .m). All participants completed three sessions per week 60-minute regular training. Following training, 3 sets 10 × 4 s all-out or same kicks with both legs over 6-week period. In groups, rest intervals were set at 15 seconds between efforts one minute sets. Before after period, underwent series lab- field-based tests evaluate abilities. Both interventions resulted significant improvements maximum oxygen uptake (V̇O2max), O2 pulse (V̇O2/HR), first ventilatory threshold (VT1), second (VT2), cardiac output (Q̇max), stroke volume (SV), peak (PPO), average (APO), squat jump (SJ), countermovement (CMJ). linear speed (20-m time) taekwondo-specific agility test (TSAT) only responded HIITRS. greater changes V̇O2max, V̇O2/HR, VT2, Q̇max, higher percentage responders measured parameters than HIITTS. addition, elicited lower inter-individual variability (CV) percent from pre- post-training all variables. These results suggest that incorporating into significantly more homogenized among

Language: Английский

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Effectiveness and safety of the combination of sodium–glucose transport protein 2 inhibitors and glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 18, 2024

Abstract Background Randomized controlled trials and real-world studies suggest that combination therapy with sodium–glucose transport protein 2 inhibitors (SGLT2is) glucagon-like peptide-1 receptor agonists (GLP-1RAs) is associated improvement in fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), body mass index (BMI), total cholesterol levels. However, a systematic review of available evidence may facilitate clinical decision-making the scenario. This meta-analysis assessed safety effectiveness combinations SGLT2is + GLP-1RAs focus on their cardioprotective effects along glucose-lowering ability patients type diabetes mellitus (T2DM) setting. Methods Electronic searches were performed PubMed/MEDLINE, PROQuest, Scopus, CINAHL, Google Scholar databases. Qualitative analyses meta-analyses using Joanna Briggs Institute SUMARI software package Review Manager v5.4, respectively. Results The initial database search yielded 1445 articles; these, 13 included this study. indicated significantly lower all-cause mortality when compared individual therapies (odds ratio [95% confidence interval [CI] 0.49 [0.41, 0.60]; p < 0.00001). Significant reductions BMI (− 1.71 [− 2.74, − 0.67]; = 0.001), SBP 6.35 10.17, 2.53]; HbA1c levels 1.48 1.75, 1.21]; 0.00001), FPG 2.27 2.78, 1.76]; 0.00001) simultaneous administration combination. Changes differences between sequential for outcome not significant. Conclusion based data suggests favorable improvements cardiovascular, renal, glycemic measurements. findings drive call-to–action to incorporate early simultaneously managing T2DM achieve potential cardiovascular benefits renal protection. Graphical

Language: Английский

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Adaptations to Optimized Interval Training in Soccer Players: A Comparative Analysis of Standardized Methods for Individualizing Interval Interventions

Journal of Sports Science and Medicine, Journal Year: 2023, Volume and Issue: unknown, P. 760 - 768

Published: Nov. 15, 2023

Accurately prescribing supramaximal interval training facilitates targeting desired physiological adaptations. This study compared the homogeneity of adaptations in cardiorespiratory parameters to [i.e., intensities beyond maximal aerobic speed (MAS)] interventions prescribed using anaerobic reserve (ASR), attained at end 30-15 Intermittent Fitness Test (VIFT), and MAS. Using repeated-measures factorial design, during off-season phase athletes’ yearly cycle, thirty national-level soccer players (age = 19 ± 1.6 years; body mass 78.9 kg; height 179 4.7 cm; Body fat 11 0.9%) were randomized consisting 2 sets 6, 7, 8, 9-min intervals (from 1st 6th week), including 15 s running Δ%20ASR (MAS + 0.2 × ASR), 120%MAS, or 95%VIFT followed by passive recovery. All ASR, VIFT, MAS programs sufficiently stimulated adaptive mechanisms, improving relative oxygen uptake [V̇O2max (p < 0.05; ES 1.6, 1.2, 1.1, respectively)], absolute V̇O2max 1.5, 0.7), ventilation [V̇E 1.1)], O2 pulse [V̇O2/HR 1.4, 0.6)], first second ventilatory threshold [VT1 0.7, 0.8, 0.7) VT2 0.8)], cardiac output [Q̇max 1.0, 0.7)], stroke volume [SVmax 0.9, 0.5)]. Although there was no between-group difference for change abovementioned variables over time, ASR VIFT resulted a lower coefficient variation [CV (inter-individual variability)] exercise intensity determined as proportion Expressing according athlete’s would assist accurately facilitate imposing mechanical related stimulus ceiling. Such an approach leads identical stimulation across athletes with differing profiles potentially more homogenized

Language: Английский

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Adaptive responses of cardiorespiratory system and hormonal parameters to individualized high-intensity interval training using anaerobic power reserve in well-trained rowers

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: April 24, 2023

The current study investigated the efficacy of individualizing exercise intensity according to anaerobic power reserve (APR) on hormonal, physiological, and performance adaptations in athletes with different profiles. Sixteen highly-trained male rowers (age = 22 ± 3 years, height 183 6 cm, weight 83 7 kg, body fat 11 2%, experience 12 5 years) were randomized a high-intensity interval training consisting 2 × (6, 6, 8, 10, 10 repetitions from 1st 6th week, respectively) 60 s intervals using rowing ergometer at ∆%30 APR (APR ) or same sets 130% maximal aerobic (MAP ). In both groups, relief set 1:1 min rest between sets. On four occasions separated by 24 h recovery, participants attended laboratory assess 2000-m performance, oxygen uptake (V̇O max) related physiological adaptations, hormonal parameters. Significant increases observed V̇O max, ventilation first second ventilatory threshold, MAP sprinting (MSP), total testosterone, testosterone cortisol ratio response weeks protocols. coefficient variation (inter-subject variability) adaptive cardiorespiratory parameters HIIT performed protocol was lower than those group. However, this is not case for changes. Prescribing based an athlete’s may help create more consistent level mechanical stimulus relative capacity, potentially leading similar across varying Mechanisms influencing are multifactorial affected approach.

Language: Английский

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Individualizing Basketball-Specific Interval Training Using Anaerobic Speed Reserve: Effects on Physiological and Hormonal Adaptations

International Journal of Sports Physiology and Performance, Journal Year: 2024, Volume and Issue: 19(4), P. 365 - 374

Published: Jan. 18, 2024

Purpose : We compared the adaptive responses to supramaximal high-intensity interval training (HIIT) individualized according anaerobic speed reserve (ASR), 30-15 Intermittent Fitness Test ( V IFT ), and velocity associated with maximum oxygen uptake (MAS) determine which approach facilitates more identical adaptations across athletes different profiles. Methods Thirty national-level basketball players (age = 28.4 [5] y; body mass 88.9 [6.3] kg; height 190 [4.8] cm) were randomly assigned 3 groups performing 2 sets of 4, 6, 8, 10-minute runs (from first sixth week, respectively), consisting 15-second running at Δ%20ASR (MAS + 0.2 × ASR), 95% , 120%MAS, 15 seconds recovery between efforts a 3-minute relief sets. Results All interventions significantly P < .05) enhanced pulse second ventilatory threshold (VT 1 VT cardiac output stroke volume, peak average power output, testosterone levels, testosterone-to-cortisol ratio following period. Different values interindividual variability (coefficient variation) for percentage changes measured variables observed in response HIIT ASR v MAS (8.7%, 18.8%, 34.6%, (9.5%, 15.0%, 28.6%), (9.6%, 19.6%, 34.6%), (21.8%, 32.4%, 56.7%), (8.2%, 16.9%, 28.8%), volume (7.9%, 15.2%, 23.5%), (20%, 22%, 37.3%), (21.1%, 21.3%, 32.5%), (52.9%, 61.6%, 59.9%), (55.1%, 59.5%, 57.8%). Conclusions Supramaximal performed resulted uniform physiological than prescribed using or MAS. Although hormonal do not follow this approach, all approaches induced an anabolic effect.

Language: Английский

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Performance Prediction Criteria Based on Yearling Training Cycle Data for World-Class Athletes’ Tiny 1000-Meter Kayak Teams: A Case Study

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 476 - 476

Published: March 16, 2025

This research aimed to identify optimal performance needs based on physiological tests of kayakers, revealing body adaptations and critical training periods within a yearly cycle. It sought develop selection protocols for teams provide evidence-based strategies future training. Methods: The male athletes underwent routine testing, considering medical limitations. A preparation year plan was established: six months preparation, one month the first competition, two further second competitor, transition. faced twelve at start each month. Results: certain intensity duration effort during preparatory cycles (approximately 22–42% in third zone, 24–28% fourth 3–4% fifth zone) were necessary achieve high level aerobic metabolism (64.00 69.40 mL·min−1·kg−1). Heart rate, work capacity ventilatory threshold, limit, maximum oxygen consumption all shown be vital indicators predicting competition results. Conclusions: identified physical development functional could aid forming team capable reaching an elite future.

Language: Английский

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Supramaximal interval training using anaerobic speed reserve or sprint interval training in rowers

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Objective This study aimed to compare the consistency of physiological adaptations and inter-individual variability in response three distinct high-intensity interval training (HIIT) protocols—anaerobic power reserve (APR), maximal aerobic (MAP), sprint (SIT)—among elite male rowers. By exploring impact individualized intensity prescriptions, we sought identify most effective protocol for enhancing consistency, as well improving both anaerobic performance while minimizing individual responses. Methods Thirty well-trained rowers (mean age: 24.9 ± 3.1 years; height: 185 4.4 cm; body mass: 86 7.9 kg; fat: 12.5% 2.4%) participated study. All participants were members a national rowing team with an average 6 years competitive experience regular participation international championships. The intervention involved weeks HIIT, performed times per week, pre- post-tests assessing VO 2 max, cardiovascular efficiency (Qmax), (MSP, CP), 2,000-m performance. Results interventions resulted significant improvements Qmax, MSP, time trial (p &lt; 0.05). SIT group exhibited largest relative improvements, max increasing by 6.3% (from 51.9 3.2 55.2 3.3 mL·kg -1 ·min , Cohen’s d = 1.05, 95% CI [0.57, 1.53]), Qmax 6.4% (Cohen’s 1.15, [0.66, 1.64]), 3.7% reduction 0.86, [0.39, 1.33]). Notably, demonstrated lowest across all measured outcomes, evidenced reduced coefficients variation narrower confidence intervals. Conclusion protocol, emphasizing exertion, led consistent greatest key metrics, including These results suggest that may be optimal approach maximizing Future research should explore long-term applicability potential integration other modalities further enhance

Language: Английский

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Uniform Homeostatic Stress Through Individualized Interval Training Facilitates Homogeneous Adaptations Across Rowers With Different Profiles

International Journal of Sports Physiology and Performance, Journal Year: 2024, Volume and Issue: 19(3), P. 232 - 241

Published: Jan. 2, 2024

This study compared the effects of individualizing supramaximal interval rowing interventions using anaerobic power reserve (APR [high-intensity training (HIIT) prescribed according to individual APR (HIITAPR)]) and associated with maximal oxygen uptake (WV˙O2max [HIIT based on WV˙O2max (HIITW)]) homogeneity physiological performance adaptations.

Language: Английский

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