Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy DOI Creative Commons

Jinjing Zhang,

Penghui Wang, Jiafeng Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107185 - 107185

Published: April 12, 2024

Microbes, including bacteria, viruses, fungi, and other eukaryotic organisms, are commonly present in multiple organs of the human body contribute significantly to both physiological pathological processes. Nowadays, development sequencing technology has revealed presence composition intratumoral microbiota, which includes Fusobacterium, Bifidobacteria, Bacteroides, shed light on significant involvement progression colorectal cancer (CRC). Here, we summarized current understanding microbiota CRC outline potential translational clinical applications diagnosis, prevention, treatment CRC. We focused reviewing microbial therapies targeting improve efficacy safety chemotherapy immunotherapy for identify biomarkers diagnosis prognosis Finally, emphasized obstacles solutions translating knowledge into practice.

Language: Английский

Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

81
Cardiovascular disease and cancer: shared risk factors and mechanisms DOI
Nicholas S. Wilcox,

Uri Amit,

Jacob B. Reibel

et al.

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(9), P. 617 - 631

Published: April 10, 2024

Language: Английский

Citations

75
The regulatory effect of polysaccharides on the gut microbiota and their effect on human health: A review DOI
Hongkun Xue,

Beimeng Liang,

Yu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132170 - 132170

Published: May 9, 2024

Language: Английский

Citations

32
Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation DOI Creative Commons
Jian Gu, Xiaozhang Xu, Xiangyu Li

et al.

Oncogene, Journal Year: 2024, Volume and Issue: 43(31), P. 2389 - 2404

Published: June 18, 2024

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter macrophages, thereby reducing its transcription. This loss affected immunosuppressive activities regulatory T cells (Tregs) antitumor CD8

Language: Английский

Citations

22
Opening the doors of precision medicine: novel tools to assess intestinal barrier in inflammatory bowel disease and colitis-associated neoplasia DOI Creative Commons
Marietta Iacucci, Giovanni Santacroce, Snehali Majumder

et al.

Gut, Journal Year: 2024, Volume and Issue: 73(10), P. 1749 - 1762

Published: June 8, 2024

Mounting evidence underscores the pivotal role of intestinal barrier and its convoluted network with diet microbiome in pathogenesis inflammatory bowel disease (IBD) colitis-associated colorectal cancer (CRC). Moreover, bidirectional association liver brain, known as gut-brain axis, plays a crucial developing complications, including extraintestinal manifestations IBD CRC metastasis. Consequently, healing represents therapeutic target these inflammatory-dependent disorders, assessment predicting outcomes, response to therapy manifestations.New advanced technologies are revolutionising our understanding paradigm, enabling accurate aiding unravelling complexity axis. Cutting-edge endoscopic imaging techniques, such ultra-high magnification endocytoscopy probe-based confocal laser endomicroscopy, new allowing real-time exploration 'cellular' barrier. Additionally, novel spatial technology platforms, multispectral imaging, upconversion nanoparticles, digital profiling, optical spectroscopy mass cytometry, enable deep comprehensive 'molecular' 'ultrastructural' In this promising landscape, artificial intelligence standardising integrating tools, thereby contributing prediction outcomes.Looking ahead, integrated approach holds promise uncovering targets, breaking ceiling IBD. Novel molecules, dietary interventions modulation strategies aim restore, reinforce, or modulate These advancements have potential for transformative personalised approaches managing

Language: Английский

Citations

19
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer DOI Creative Commons
Xueliang Wang, Y. Q. Fang, Wei Liang

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(10), P. 1729 - 1746.e8

Published: Sept. 19, 2024

Language: Английский

Citations

17
Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis DOI Creative Commons

Yong Sun,

Qiwen Wang, Yao Jiang

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 8, 2025

Gut microbes play a crucial role in regulating the tumor microenvironment (TME) of colorectal cancer (CRC). Nevertheless, deep mechanism between microbiota-TME interaction has not been well explored. In this study, we for first time discovered that Lactobacillus intestinalis (L. intestinalis) effectively suppressed growth both AOM/DSS-induced CRC model and ApcMin/+ spontaneous adenoma model. Our investigation revealed L. increased infiltration immune cells, particularly dendritic cells (DC), TME. Mechanically, tumor-derived CCL5 induced by recruited DC chemotaxis through NOD1/NF-κB signaling pathway. clinical samples datasets, found positive correlation intestinalis, level, DC-related genes. study provided new strategy microbial intervention deepened understanding modulated gut microbes.

Language: Английский

Citations

2
Interactions of non-starch polysaccharides with the gut microbiota and the effect of non-starch polysaccharides with different structures on the metabolism of the gut microbiota: A review DOI
Yujiao Sun, Jun Yao, Rui Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139664 - 139664

Published: Jan. 9, 2025

Language: Английский

Citations

2
Long-read 16S rRNA amplicon sequencing reveals microbial characteristics in patients with colorectal adenomas and carcinoma lesions in Egypt DOI Creative Commons
Asmaa A. El Leithy, Amira Salah El-Din Youssef, Auhood Nassar

et al.

Gut Pathogens, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 2, 2025

Language: Английский

Citations

2
Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies DOI Creative Commons

D.Y. Luo,

Jing Zhou, Shuiliang Ruan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

Abstract Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as promising therapeutic approach. However, significant proportion patients exhibit primary or acquired resistance, limiting the overall efficacy immunotherapy. This review provides comprehensive analysis mechanisms underlying immunotherapy resistance GC, including role tumor microenvironment, dynamic PD-L1 expression, compensatory activation other checkpoints, and genomic instability. Furthermore, explores GC-specific factors such molecular subtypes, unique evasion mechanisms, impact Helicobacter pylori infection. We also discuss emerging strategies to overcome combination therapies, novel immunotherapeutic approaches, personalized based on genomics microenvironment. By highlighting these key areas, this aims inform future research directions clinical practice, ultimately improving outcomes for GC undergoing

Language: Английский

Citations

2