Polyethylene microplastics induced gut microbiota dysbiosis leading to liver injury via the TLR2/NF-κB/NLRP3 pathway in mice

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170518 - 170518

Published: Jan. 28, 2024

Language: Английский

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Changes in the Progression of Chronic Kidney Disease in Patients Undergoing Fecal Microbiota Transplantation

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1109 - 1109

Published: April 10, 2024

Chronic kidney disease (CKD) is a progressive loss of renal function in which gut dysbiosis involved. Fecal microbiota transplantation (FMT) may be promising alternative for restoring and treating CKD. This study evaluated the changes CKD progression patients treated with FMT. Patients diabetes and/or hypertension clinical stages 2, 3, 4 this single-center, double-blind, randomized, placebo-controlled trial (NCT04361097) were randomly assigned to receive either FMT or placebo capsules 6 months. Laboratory stool metagenomic analyses performed. A total 28 included (15 13 placebo). Regardless stages, responded similarly treatment. More (53.8%) from group progressed than (13.3%). The maintained stable parameters (serum creatinine urea nitrogen) compared group. Adverse events after treatment mild moderate gastrointestinal symptoms. abundance Firmicutes Actinobacteria decreased whereas Bacteroidetes, Proteobacteria Roseburia spp. increased showed less administration. administration oral safe strategy, does not represent risk, has potential benefits.

Language: Английский

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Iridoids modulate inflammation in diabetic kidney disease: A review

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(3), P. 210 - 222

Published: March 28, 2024

Language: Английский

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Gut microbiota profiling reflects the renal dysfunction and psychological distress in patients with diabetic kidney disease

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 15, 2024

Background The gut microbiota plays a pivotal role in the development of diabetes and kidney disease. However, it is not clear how intestinal microecological imbalance involved context diabetic disease (DKD), leading cause renal failure. Objectives To elucidate microbial signatures associated with DKD progression towards end-stage (ESRD) explore whether they could reflect dysfunction psychological distress. Methods A cross-sectional study was conducted to 29 non-ESRD patients 19 ESRD compared 20 healthy controls. Differential analysis performed detect distinct alterations diversities taxon abundance without ESRD. Renal estimated by urea, creatinine, glomerular filtration rate. Psychological distress assessed using Self-Rating Anxiety Scale, Depression Hamilton Rating Scale. Results Alpha diversity indexes were reduced patients, particularly those Beta revealed that compositions different individuals whereas similar observed patients. Taxon differential showed when controls, exhibit profiles including abundances butyrate-produced, anti-inflammatory bacteria Faecalibacterium , Lachnospira Roseburia Lachnoclostridium increased pro-inflammatory Collinsella Streptococcus etc. These distinctive genera presented consistent associations dysfunction, as well distress, especially Conclusions who have progressed ESRD, unique characteristics their are both may be significant factor deterioration its eventual

Language: Английский

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Perspective: Multi-omics and Artificial Intelligence for Personalized Nutritional Management of Diabetes in Patients Undergoing Peritoneal Dialysis

Advances in Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100378 - 100378

Published: Jan. 1, 2025

Managing diabetes in patients on peritoneal dialysis (PD) is challenging due to the combined effects of dietary glucose, glucose from dialysate, and other medical complications. Advances technology that enable continuous biological data collection are transforming traditional management approaches. This review explores how multi-omics technologies artificial intelligence (AI) enhancing this patient population. Continuous monitoring (CGM) offers significant advantages over markers like hemoglobin A1c (HbA1c). Unlike HbA1c, which reflects an average level, CGM provides real-time, dynamic allow clinicians make timely adjustments, leading better glycemic control outcomes. Multi-omics approaches valuable for understanding genetic factors influence susceptibility diabetic complications, particularly those related advanced glycation end-products (AGEs). Identifying polymorphisms modify a patient's response AGEs allows personalized treatments, potentially reducing severity diabetes-related pathologies. Metabolomic analyses effluent also promising, as they help identify early biomarkers metabolic dysregulation. Early detection can lead interventions more tailored treatment strategies, improving long-term care. AI integration revolutionizing PD by processing vast datasets CGM, genetic, microbiome profiles. patterns predict outcomes may be difficult humans detect, enabling highly recommendations diet, medication, management. Furthermore, assist automating interpretation, plans education. Despite promise these technologies, there limitations. require investment infrastructure, training validation studies. Additionally, integrating into clinical practice presents logistical financial challenges. Nevertheless, personalized, data-driven strategies offer great potential patients.

Language: Английский

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Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 29, 2025

Metformin (MET) is a commonly used drug for the treatment of type 2 diabetes in department endocrinology. In recent years, due to few clinically effective options including glioma, some scholars have proposed possibility metformin and studies shown that has certain inhibitory effect on this tumor. This review explores multiple mechanisms through which exerts its antitumor effects, focusing signaling pathways such as AMPK/mTOR, ferroptosis, autophagy, apoptosis chloride ion channels (CLIC1). Metformin’s inhibition glioma proliferation involves complex cellular processes, mitochondrial dysfunction, increased reactive oxygen species (ROS) production, modulation immune responses. Additionally, affects stem cells by inhibiting key pathways, STAT3, mTOR, AKT, altering tumor microenvironment. While preclinical suggest enhances radiosensitivity reduces recurrence, clinical application remains early stages, with further needed optimize dosing regimens understand full therapeutic potential. provides comprehensive analysis metformin’s molecular highlights potential novel strategy, especially treatment-resistant gliomas.

Language: Английский

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The impact of gut microbiome on immune and metabolic homeostasis in type 1 diabetes: Clinical insights for prevention and treatment strategies

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 151, P. 103371 - 103371

Published: Jan. 29, 2025

Language: Английский

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Advances in understanding and managing diabetic kidney disease: An updated review

Ukrainian Journal of Nephrology and Dialysis, Journal Year: 2025, Volume and Issue: 1(85), P. 66 - 80

Published: Feb. 19, 2025

Chronic kidney disease (CKD) and end-stage (ESKD) are common complications of diabetes. Proteinuria is an early indicator glomerular basement membrane damage caused by diabetes, leading to diabetic (DKD). Edema, hypoproteinemia, proteinuria characteristics DKD. Blood sugar blood pressure control, along with detection, the primary strategies for preventing DKD slowing its progression. This review examines updates epidemiology, pathogenesis, prevention Various keywords phrases used search Google, EMBASE, PubMed, Scopus, Google Scholar most recent articles published from January 2023 December 2024. Despite advancements in understanding pathogenesis development novel therapies, remains highly prevalent poor outcomes. The pathophysiology still not fully understood, gaps treatment strategies. Therefore, this aims explore these propose potential new therapies future research directions.

Language: Английский

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Iron Metabolism and Ferroptosis in Diabetic Kidney Disease

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(4)

Published: April 1, 2025

ABSTRACT Diabetic kidney disease (DKD) is a major diabetic microvascular complication that still lacks effective therapeutic drugs. Ferroptosis recently identified form of programmed cell death triggered by iron overload. It characterized unrestricted lipid peroxidation and subsequent membrane damage found in various diseases. Accumulating evidence has highlighted the crucial roles overload ferroptosis DKD. Here, we review metabolism biology ferroptosis. The role aberrant inducing diverse renal intrinsic death, oxidative stress, fibrosis DKD summarized, elaborate on critical regulatory factors related to Finally, focused significance treatment highlight recent data regarding novel activities some drugs as inhibitors DKD, aiming provide new research targets strategies

Language: Английский

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Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 29, 2024

Objective To evaluate the quality of evidence, potential biases, and validity all available studies on dietary intervention diabetic nephropathy (DN). Methods We conducted an umbrella review existing meta-analyses randomized controlled trials (RCTs) that focused effects DN incidence. The literature was searched via PubMed, Embase, Web Science, Cochrane Database Systematic Reviews. According to Grading Recommendations, Assessment, Development Evaluation (GRADE), evidence each outcome evaluated graded as “high”, “moderate”, “low” or “very low” draw conclusions. Additionally, we classified outcomes into 4 categories. Results identified 36 RCTs 55 clinical from 395 unique articles. Moderate-quality suggested probiotic supplementation could significantly improve blood urea nitrogen (BUN), total cholesterol (TC) low-density lipoprotein (LDL-C) levels in patients. Low-quality indicated improved serum creatinine concentration, urinary albumin–creatinine ratio (UACR), fasting glucose (FBG), HbA1c high-density (HDL-C) In addition, low-quality a salt restriction diet clearance rate (CrCl) patients with DN. vitamin D UACR has soy isoflavone BUN, FBG, (TC), triglyceride (TG) LDL-C Furthermore, coenzyme Q10 HbA1c, TC HDL-C DN, polyphenols also Finally, antioxidant vitamins systolic pressure, level Given small sample size, associated were class IV evidence. Conclusion Moderate low amounts suggest probiotics, D, isoflavones, Q10, polyphenols, vitamins, salt-restricted diets may Review Registration https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD42024512670.

Language: Английский

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