Microplastics and Nanoplastics as Environmental Contaminants of Emerging Concern: Potential Hazards for Human Health DOI Open Access
Rita Khanna, Abhilash P. Chandra,

Shaundeep Sen

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(19), P. 8704 - 8704

Published: Oct. 9, 2024

With nearly 40% of the total plastics produced being used for packaging, up to five trillion plastic bags are consumed in world annually. The inadequate disposal waste and its persistence has become a serious challenge/risk environment, health, well-being living creatures, including humans. natural degradation is extremely slow; large pieces may break down into microplastics (MPs) (1 μm–5 mm) or nanoplastics (NPs) (<1000 nm) after protracted physical, chemical, and/or biological degradations. A brief overview transport micro- aquatic, terrestrial, atmospheric environments presented. Details provided on exposure routes these materials their entry humans other biota through ingestion, inhalation, dermal contact. greatest concern cumulative impact heterogeneous secondary MPs NPs planetary human health. Inhaled have been shown affect upper respiratory tract, lower alveoli; prolonged can lead chronic inflammatory changes systemic disease. These also autoimmune diseases health conditions, atherosclerosis malignancy. Sustainable mitigation strategies reduce MPs/NPs include source reduction, material substitution, filtration purification, transformation value-added materials, technological innovations, etc. Multidisciplinary collaborations across fields medicine, public environmental science, economics, policy required help limit detrimental effects widespread environment.

Language: Английский

Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences DOI Creative Commons
Charlotte E. Sofield, Ryan S. Anderton, Anastazja M. Gorecki

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4186 - 4202

Published: April 30, 2024

As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion is important exposure route for human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well gut inflammation dysfunction suggests they are more noxious than first thought. More alarmingly, there evidence permeating from throughout body, with adverse effects on immune nervous systems. Coupled now-accepted role gut-brain axis in neurodegeneration, these findings support hypothesis that this ubiquitous pollutant contributing rising incidence neurodegenerative diseases, like Alzheimer’s disease Parkinson’s disease. This comprehensive narrative review explores consequences gut-brain-axis by considering current gastrointestinal uptake disruption, activation, translocation neurological effects. now a permanent feature global environment, understanding gut, brain, whole body will facilitate critical further research inform policy changes aimed at reducing any consequences.

Language: Английский

Citations

10
Co-exposure of polystyrene nanoplastics and copper induces development toxicity and intestinal mitochondrial dysfunction in vivo and in vitro DOI

Jinyu Rong,

Chenwei Yuan,

Yin Xiang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 930, P. 172681 - 172681

Published: April 24, 2024

Language: Английский

Citations

9
High-fat diet disrupts the gut microbiome, leading to inflammation, damage to tight junctions, and apoptosis and necrosis in Nyctereutes procyonoides intestines DOI Creative Commons

Chengwei Wei,

Tianchao Xu,

Yuan Geng

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(4)

Published: Feb. 20, 2024

ABSTRACT Given the burgeoning Nyctereutes procyonoides breeding industry and its growing scale, it is imperative to investigate impact of high-fat diets on health these animals. This study involved 30 male comparable weights (3 kg ±0.5), randomly assigned either a control group or diet ( n = 15 each). The latter was fed mixture lard basal in 2:5 ratio, establishing model procyonoides. induced diarrhea histopathological changes Analysis small intestine contents using 16S rRNA sequencing revealed diet-induced disruption gut microbiota. Specifically, Escherichia-Shigella emerged as biomarker P 0.049), while Vagococcus prevalent indicating significant increase harmful bacteria group. Furthermore, this disrupted flora correlated with inflammation oxidative stress, evidenced by marked increases TNF-α < 0.01), IL-1β 0.05), IL-6 0.05) levels, measured via q-PCR, Western blot, stress assays. In addition, q-PCR analysis upregulation apoptosis necrosis markers, including Bax, Caspase3, Caspase9, Caspase12, RIPK3, RIPK1 0.01 0.001), concurrent downregulation anti-apoptotic gene Bcl-2 0.01) group, consistent protein expression trends. These findings suggest that alters microbiome toward more bacterial composition, escalating inflammatory responses intestinal tissue permeability, culminating cell necrosis. IMPORTANCE examines Our research established diet, revealing impacts, such diarrhea, histological anomalies, alterations emphasize importance preventing issues promoting sustainable growth. They highlight microbiota overall animal health.

Language: Английский

Citations

8
Green tea polyphenols inhibit TBBPA-induced lung injury via enhancing antioxidant capacity and modulating the NF-κB pathway in mice DOI

Hongli Lv,

Jingjing Wang, Yuan Geng

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(7), P. 3411 - 3419

Published: Jan. 1, 2024

Tetrabromobisphenol A (TBBPA) is a global pollutant. When TBBPA absorbed by the body through various routes, it can have wide range of harmful effects on body. Green tea polyphenols (GTPs) act as antioxidants, resisting toxic animals. The and mechanisms GTP oxidative stress, inflammation apoptosis in mouse lung are unknown. Therefore, we established vivo vitro models exposure antagonism using C57 mice A549 cells examined expression factors related to autophagy, apoptosis. results study showed that increase reactive oxygen species (ROS) levels after decreased autophagy-related Beclin1, LC3-II, ATG3, ATG5, ATG7 ATG12 increased p62; stress inhibits autophagy levels. pro-inflammatory IL-1β, IL-6 TNF-α anti-inflammatory factor IL-10 activation NF-κB p65/TNF-α pathway. Bax, caspase-3, caspase-7 caspase-9 Bcl-2 activate apoptosis-related pathways. addition attenuated levels, restored inhibition reduced Our suggest attenuate modulating ROS, reducing increasing attenuating cells. These provide fundamental information for exploring antioxidant mechanism further studying TBBPA.

Language: Английский

Citations

7
Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Y J Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

7
Sonicated polyethylene terephthalate nano- and micro-plastic-induced inflammation, oxidative stress, and autophagy in vitro DOI
Walison Augusto da Silva Brito, Mehdi Ravandeh,

Fariba Saadati

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 355, P. 141813 - 141813

Published: April 3, 2024

Language: Английский

Citations

6
Unraveling the spoilage characteristics of refrigerated pork using high-throughput sequencing coupled with UHPLC-MS/MS-based non-targeted metabolomics DOI

Zhengkai Yi,

Xingning Xiao, Wei Cai

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140797 - 140797

Published: Aug. 8, 2024

Language: Английский

Citations

6
Gut microbiota, a key to understanding the knowledge gaps on micro-nanoplastics-related biological effects and biodegradation DOI
Jiping Wang, Yutong Wang, Zhenyu Li

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 944, P. 173799 - 173799

Published: June 11, 2024

Language: Английский

Citations

5
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis via the ROS/NF-κB pathway in a mouse model DOI
Xiaoran Sun, Shuang Xu, Tianjing Liu

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(13), P. 7136 - 7147

Published: Jan. 1, 2024

Zinc (Zn) is an important trace element; it involved in the regulation and maintenance of many physiological functions organisms has anti-inflammatory antioxidant properties.

Language: Английский

Citations

5
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer DOI Open Access
Annalisa Bruno, Melania Dovizio, Cristina Milillo

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3079 - 3079

Published: Sept. 4, 2024

Micro- and nano-plastics (MNPLs) can move along the food chain to higher-level organisms including humans. Three significant routes for MNPLs have been reported: ingestion, inhalation, dermal contact. Accumulating evidence supports intestinal toxicity of ingested their role as drivers increased incidence colorectal cancer (CRC) in high-risk populations such inflammatory bowel disease (IBD) patients. However, mechanisms are largely unknown. In this review, by using leading scientific publication databases (Web Science, Google Scholar, Scopus, PubMed, ScienceDirect), we explored possible effects related MNPL exposure on gut epithelium healthy conditions IBD The summarized idea that oral may contribute epithelial damage, thus promoting sustaining chronic development inflammation, mainly Colonic mucus layer disruption further facilitate passage into bloodstream, contributing toxic different organ systems platelet activation, which may, turn, inflammation CRC development. Further exploration threat human health is warranted reduce potential adverse risk.

Language: Английский

Citations

5