Cited by SARS-CoV-2 infection leads to sustained testicular injury and functional impairments in K18 hACE2 mice

SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone DOI

Stefanos Giannakopoulos,

Jin Pak,

Jackson Bakse

et al.

PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(1), P. e1012804 - e1012804

Published: Jan. 7, 2025

Compromised male reproductive health, including reduced testosterone and sperm count, is one of the long COVID symptoms in individuals recovering from mild-severe disease. COVID-19 patients display testicular injury acute stage altered serum fertility markers recovery phase, however, long-term implications on testis remain unknown. This study characterized consequences SARS-CoV-2 function. The K18-hACE2 mice that survived infection were followed for month after function assessed at different stages recovery. impact key testes function-related hormones was measured. efficacy inflammation-suppressing drug preventing also evaluated. morphological defects like sloughing spermatids into lumen increased apoptotic cells sustained 2–4 weeks correlated with inflammation immune cell infiltration. Transcriptomic analysis revealed dysregulation inflammatory, death, steroidogenic pathways. Furthermore, levels associated a transient reduction count fertility. Most impairments resolved within infection. Importantly, dexamethasone treatment attenuated damage, inflammation, Our results implicate virus-induced cytokine storm as major driver functional impairments, timely prevention which limits damage. These findings serve model evaluating therapeutics may guide clinical strategies to improve health outcomes post-SARS-CoV-2

Language: Английский

Citations

Changes in environmental exposures over decades may influence the genetic architecture of severe spermatogenic failure DOI

Miriam Cerván‐Martín, Sara González‐Muñoz, Andrea Guzmán‐Jiménez

et al.

Human Reproduction, Journal Year: 2024, Volume and Issue: 39(3), P. 612 - 622

Published: Feb. 1, 2024

Abstract STUDY QUESTION Do the genetic determinants of idiopathic severe spermatogenic failure (SPGF) differ between generations? SUMMARY ANSWER Our data support that component SPGF is impacted by dynamic changes in environmental exposures over decades. WHAT IS KNOWN ALREADY The form has a multifactorial etiology wherein an interaction genetic, epigenetic, and factors leads to disease onset progression. At level, genome-wide association studies (GWASs) allow analysis millions variants across genome hypothesis-free manner, as valuable tool for identifying susceptibility risk loci. However, little known about specific role non-genetic their influence on this type conditions. DESIGN, SIZE, DURATION Case-control analyses were performed including total 912 cases 1360 unaffected controls. PARTICIPANTS/MATERIALS, SETTING, METHODS All participants had European ancestry (Iberian German). diagnosed during last decade either with non-obstructive azoospermia (n = 547) or oligozoospermia 365). logistic regression models considering generation covariate silico functional characterization genomic regions. MAIN RESULTS AND THE ROLE OF CHANCE This revealed 13 novel signals SPGF, eight them being independent. observed associations mostly explained each lead variant age-group. Additionally, we established links these loci diverse factors, such toxic dietary habits, respiratory disorders, autoimmune diseases, which might potentially architecture SPGF. LARGE SCALE DATA GWAS are available from authors upon reasonable request. LIMITATIONS, REASONS FOR CAUTION Additional independent involving large cohorts ethnically populations warranted confirm our findings. WIDER IMPLICATIONS FINDINGS Overall, study proposes innovative strategy achieve more precise understanding conditions interactions variable exposome through different generations predisposition complex diseases. FUNDING/COMPETING INTEREST(S) work was supported “Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020)” (ref. PY20_00212, P20_00583), Spanish Ministry Economy Competitiveness National Plan Scientific Technical Research Innovation PID2020-120157RB-I00 funded MCIN/ AEI/10.13039/501100011033), ‘Proyectos I+D+i del Programa Operativo FEDER 2020’ B-CTS-584-UGR20). ToxOmics-Centre Toxicogenomics Human Health, Genetics, Oncology Toxicology, also partially Portuguese Foundation Science Technology (Projects: UIDB/00009/2020; UIDP/00009/2020). declare no competing interests. TRIAL REGISTRATION NUMBER N/A.

Language: Английский

Citations

Effects of semen inflammation on embryo implantation, placentation, pregnancy outcomes and offspring health DOI

María Santos Martínez,

Yair A. Chocobar,

Yamila Fariz

et al.

Placenta, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

Fertility dynamics through historical pandemics and COVID-19 in Switzerland, 1871–2022 DOI

Katarina L. Matthes, Mathilde Le Vu, Kaspar Staub

et al.

Population Studies, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 11, 2025

We follow general fertility rates (GFRs) in Switzerland up to 2022, with a focus on their dynamics during and after pandemics. Historical influenza pandemics (1889–90, 1918–20, 1957) have consistently led temporary declines births between six nine months the pandemic peak. High of miscarriage may explain these findings. After 1889–90 1918–20 pandemics, short-term baby booms occurred. For recent Covid-19 pandemic, appear more complex. The GFR had already been declining since 2018, before hit Switzerland. During shortly first two waves 2020, there was an increase conceptions, leading higher 2021: shutdown measures brought planned pregnancies forwards. Subsequently, declined from February 2022; one possible explanation is that were intentionally postponed until vaccination. Following population-level observations, in-depth studies are needed understand better why affected by

Language: Английский

Citations

The sperm quality change in 6 months recovery from COVID-19 : a retrospective observational study DOI

Xiaoli Zhao,

Yu Zhao, Nan Jiang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract XZ and YZ performed the data analyses drafted manuscript. NJ, KL JX participated in collection. design of study coordination. ZL TX had main responsibility for design, analyses, interpretation, writing All authors read approved final Background The COVID-19 pandemic has yielded substantial evidence indicating that virus may possess reproductive toxicity effects adversely affect sperm quality. Given sex-specific implications these findings, it is imperative to reliably assess reversibility this damage, determine precise recovery time, evaluate male health parameters post-infection. Methods Male patients who underwent analysis prior infection were enrolled a observational trial changes quality during 6-month period from COVID-19. Sperm dynamic collected at five consecutive time points: before 1, 2, 3, 6 months following infection. Quality life, psychological status, sexual function patients, evaluated with questionnaires, first month after primary outcomes concentration (Con) progressive motility rate (PR%). Generalized Estimating Equations (GEEs) was used perform statistical comparisons on repeatedly measured variables. Kaplan-Meier survival employed observe trend over time. Results 1,009 subjects widespread COVID-19, April 2022 January 2023. Of 139 eligible have completed infection, 92 (66%) testing second month, 72 (52%) third 64 (46%) sixth month. Con [39·22 (95%CI, 32·02–46·41)] PR [36·41 3229-40·53)] significantly decreased post-infection compared pre-infection. demonstrated gradual At end our six-month observation period, continue be lower than levels observed Survival curve indicated that, average, duration 4·37 required achieve an 80% level During no significant adverse impacts participants' diverse scores. Discussion indeed influenced by but temporary, 4–5 months. Furthermore, notable alterations men's psychological, urinary symptoms, or initial

Language: Английский

Citations

Alterations in Semen Quality and Immune‐Related Factors in Men with Infertility who Recovered from COVID‐19 DOI

Ying Zhang,

Feiyin Zhu,

Zhe Zhang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 24, 2025

ABSTRACT The emergence of coronavirus disease 2019 (COVID‐19) has triggered research into its impact on male reproductive health. However, studies exploring the effects severe acute respiratory syndrome 2 (SARS‐CoV‐2) semen quality in infertile men remain limited. Herein, we enrolled 781 patients who recovered from COVID‐19 and analyzed their blood samples collected at different time points. We found that SARS‐CoV‐2 RNA was undetectable samples. Compared with pre‐COVID‐19 status, total sperm count, concentration, vitality, motility, percentage cells normal morphology decreased significantly first month post‐COVID‐19. these alterations were reversed third month. Furthermore, seminal plasma exhibited reduced proinflammatory cytokine levels notable changes amino acid, nucleic carbohydrate metabolism by compared those By contrast, no significant hormone found. Vitality, progressive motility negatively correlated body temperature when it above 38°C. In conclusion, initially decreases post‐COVID‐19 but reverses after approximately 3 months, a decline related to inflammatory fever. These findings may provide guidance need assisted technology.

Language: Английский

Citations

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis DOI

Peng Ge, Yalan Luo, Jie Liu

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(12)

Published: Dec. 1, 2023

Abstract The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development pancreatitis is a subject ongoing debate within academic discourse. Establishing causal link between COVID‐19 and may not be fully supported by relying only retrospective studies or case reports. This study examined relationship phenotypes Mendelian randomization (MR) method. identification instrumental variables (single nucleotide polymorphisms) that exhibit robust association with was accomplished through meticulous process rigorous screening procedures. We included chronic (CP) as outcomes in MR analysis, even though no definitive exist CP. A direct genetically predicted risk cannot established. There an over designation cause pancreatitis.

Language: Английский

Citations

Sperm quality and sexual function after the first COVID-19 infection during the omicron surge: an observational study in southwest China DOI

Tingting Yang, Bo Liu, Xiaohong Luo

et al.

Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(9), P. 1835 - 1846

Published: Sept. 1, 2024

As the Omicron variant became dominant coronavirus disease 2019 (COVID-19) strain and threat to human health decreased, impact of COVID-19 on male reproductive semen quality may have changed. In this prospective observational study, we aimed investigate changes in sexual function before after infection by self-controlled study explore influence health.

Language: Английский

Citations

The remarkable ups and downs of birth rate in Switzerland 2020 to 2023 in a historical context DOI

Mathilde Le Vu, Katarina L. Matthes, Kaspar Staub

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 5, 2023

Abstract We follow population trends in the monthly birth rate Switzerland almost up to present and place latest developments a historical context. Birth rates 2022 were lowest since 1870s, trend is continuing 2023. The decline had already begun 1-2 years before Covid-19. Previous pandemics (1890, 1918, 1920, 1957) led temporary births ∽9 months after epidemic peaks. With Covid-19, this appears more complex. During shortly first two waves shutdowns 2020, there conceptions thus excess 2021, all available subgroups except Italian-speaking Switzerland, somewhat pronounced among >30-year-old mothers second parities. Possible reasons for mini-boom include: increased time at home during has – planned or not which brought pregnancies forward; corona virus was still circulat-ing too infrequently 1st phase of pandemic have negative impact on fertility; end shutdowns, perceived threat could an optimistic mood also conceptions. subsequent from January stronger than in-crease before. part most likely due rebound advance-ment 2020/2021 deliberately postponed start vaccination pro-gram. associated with large Omicron wave winter 2021/2022, when many people fell ill. In addition, prices been rising real wages falling global political situation become unstable, general change values regarding willingness children may be underway. Following these observations level (with limited depth variables), in-depth studies must now better under-stand dynamic ups downs recent years.

Language: Английский

Citations

Age-Related COVID-19 Influence on Male Fertility DOI

Anastasiia D. Shcherbitskaia, Evgeniia M. Komarova, Yu. P. Milyutina

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15742 - 15742

Published: Oct. 30, 2023

The impact of coronavirus on the reproductive health men attracts special attention many researchers. While studies suggest changes in sperm parameters and possibility testicular inflammation, further are needed to elucidate any potential age-related these findings, which is purpose present study. semen quality parameters, cytokine concentration, markers pro- antioxidant system were assessed 60 five seven months after infection 77 controls (without a history infection). Additionally, participants divided into two age groups: less than 35 years or older. Notably increased round cell count ejaculate reduced hyaluronan binding ability observed among post-infection patients younger years. In same group, decline seminal plasma zinc levels nitrotyrosine fraction was found. over age, Coronavirus Disease 2019 (COVID-19) led DNA fragmentation, decrease total capacity, an elevation interleukin-1β interleukin-10. concentration decreased time following recovery all affected patients. data obtained adverse male health; however, effects appear be age-dependent.

Language: Английский

Citations