Autonomic Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 103231 - 103231
Published: Nov. 1, 2024
Language: Английский
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 21, 2024
The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) function is regulated by stiffness solid tumors often associated with poor prognosis. ECM stiffness-induced mechanical cues can activate cell membrane mechanoreceptors corresponding mechanotransducers the cytoplasm, modulating phenotype of TAMs. Currently, tuning TAM polarization through stimulation has received increasing attention, whereas its effect on fate rarely been summarized. A better understanding relationship between will contribute to development new strategies for cancer therapy. In this review, we first introduced overall stiffness, analyzed changes mediated tumor progression, finally summarized effects targeting prognosis provide insight into field.
Language: Английский
Citations
20
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 273, P. 116502 - 116502
Published: May 14, 2024
The cation channel Piezo1, a crucial mechanotransducer found in various organs and tissues, has gained considerable attention as therapeutic target recent years. Following this trend, several Piezo1 inhibitors have been discovered studied for potential pharmacological properties. This review provides an overview of the structural functional importance well discussing biological activities based on their mechanism action. compounds addressed include toxin GsMTx4, Aβ peptides, certain fatty acids, ruthenium red gadolinium, Dooku1, natural products tubeimoside I, salvianolic acid B, jatrorrhzine, escin. findings revealed that misexpression can be associated with number chronic diseases, including hypertension, cancer, hemolytic anemia. Consequently, inhibiting subsequent calcium influx beneficial effects pathological processes, shown by many vitro vivo studies. However, development is still its beginnings, opportunities challenges remaining to explored.
Language: Английский
Citations
12
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 6, 2024
The intestine is the largest mechanosensitive organ in human body whose epithelial cells, smooth muscle neurons and enteroendocrine cells must sense respond to various mechanical stimuli such as motility, distension, stretch shear regulate physiological processes including digestion, absorption, secretion, motility immunity. Piezo channels are a newly discovered class of ion consisting two subtypes, Piezo1 Piezo2. widely expressed involved pathological processes. present review summarizes current research progress on expression, function regulation intestine, with aim providing reference for future development therapeutic strategies targeting channels.
Language: Английский
Citations
7
Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102058 - 102058
Published: Jan. 1, 2025
Language: Английский
Citations
0
PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(4), P. e1013105 - e1013105
Published: April 23, 2025
Trypanosoma cruzi , the causative agent of Chagas disease, is a parasitic protist that affects millions people worldwide. Currently there are no fully effective drugs or vaccines available. Contact T. infective forms with their host cells extracellular matrix increases intracellular Ca 2+ concentration suggesting mechano-transduction process. We report here possesses two distinct mechanosensitive Piezo channels, named TcPiezo1 and TcPiezo2, different subcellular localizations but similarly essential for normal proliferation, differentiation, infectivity. While localizes to plasma membrane, TcPiezo2 lysosomes. Downregulation expression by novel ligand-regulated hammerhead ribozyme (HHR) significantly inhibited entry in expressing genetically encoded indicator while downregulation release from lysosomes, which now identified as acidic stores trypanosomes. The channels activated contact hypoosmotic stress. results establish essentiality life cycle homeostasis lysosomal localization channel eukaryotes.
Language: Английский
Citations
0
Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10
Published: Oct. 12, 2023
Fibrosis could happen in every organ, leading to organic malfunction and even organ failure, which poses a serious threat global health. Early treatment of fibrosis has been reported be the turning point, therefore, exploring potential correlates pathogenesis how reverse become pressing issue. As mechanism-sensitive cationic calcium channel, Piezo1 turns on response changes lipid bilayer plasma membrane. exerts multiple biological roles, including inhibition inflammation, cytoskeletal stabilization, epithelial-mesenchymal transition, stromal stiffness, immune cell mechanotransduction, interestingly enough. These processes are closely associated with development fibrotic diseases. Recent studies have shown that deletion or knockdown attenuates onset fibrosis. Therefore, this paper we comprehensively describe biology gene, focusing its relevance pulmonary fibrosis, renal pancreatic cardiac diseases, except for role drugs (agonists), increased intracellular mechanical stress using gene alleviating
Language: Английский
Citations
8
British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 181(23), P. 4714 - 4732
Published: Oct. 14, 2024
Abstract PIEZO1 is a eukaryotic membrane protein that assembles as trimers to form calcium‐permeable, non‐selective cation channels with exquisite capabilities for mechanical force sensing and transduction of into effect in diverse cell types include blood cells, endothelial epithelial fibroblasts stem cells systems bone, lymphatics muscle. The channel has wide‐ranging roles considered target novel therapeutics ailments spanning cancers cardiovascular, dental, gastrointestinal, hepatobiliary, infectious, musculoskeletal, nervous system, ocular, pregnancy, renal, respiratory urological disorders. identification modulators its infancy but useful experimental tools emerged activating, lesser extent inhibiting, the channels. Elementary structure–activity relationships are known Yoda series small molecule agonists, which show potential physicochemical pharmacological properties. Intriguing effects Yoda1 stimulated removal excess cerebrospinal fluid. Despite PIEZO1's broad expression, opportunities suggested selective positive or negative modulation without intolerable adverse effects. Here we provide focused, non‐systematic, narrative review progress this pharmacology discuss future directions research area.
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112684 - 112684
Published: July 14, 2024
The human immune system is capable of defending against, monitoring, and self-stabilizing various cells. Differentiation, proliferation, development these cells are regulated by biochemical signals. Moreover, biophysical signals, such as mechanical forces, have been found to affect cell function, thus introducing a new area immunological research. Piezo1, mechanically sensitive ion channel, was awarded the Nobel Prize for Physiology Medicine in 2021. This channel present on surface many cells, when stimulated force, it controls calcium (Ca
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Oct. 23, 2024
The endothelial cells of the blood circulation are exposed to hemodynamic forces, such as cyclic strain, hydrostatic and shear stress caused by fluid’s frictional force. Endothelial perceive mechanical forces via mechanosensors thus elicit physiological reactions alterations in vessel width. considered comprise ion channels, structures linked plasma membrane, cytoskeletal spectrin scaffold, mechanoreceptors, junctional proteins. This review focuses on how they alter vascular functions cells. current state knowledge dysregulation mechanosensitivity disease is briefly presented. interplay perception between smooth muscle outlined. Finally, future research avenues highlighted, which necessary overcome existing limitations.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 177 - 188
Published: Nov. 1, 2024
Citations
0