Translational Cancer Research,
Journal Year:
2024,
Volume and Issue:
13(7), P. 3898 - 3903
Published: July 1, 2024
The
skin
is
a
complex
organ
that
serves
as
critical
barrier
against
external
pathogens
and
environmental
impact.
Recent
advances
in
immunometabolism
have
highlighted
the
intricate
link
between
cellular
metabolism
immune
function,
particularly
context
of
cancers.
This
review
aims
to
provide
comprehensive
overview
key
metabolic
pathways
adaptations
occur
cells
during
homeostasis
activation,
explore
how
reprogramming
contributes
pathogenesis
specific
We
discuss
interplay
tumor
infiltrating
cells,
which
shapes
microenvironment
influences
disease
outcomes.
delves
into
role
various
pathways,
such
glycolysis,
oxidative
phosphorylation,
lipid
metabolism,
regulation
cell
function
their
impact
on
development
progression
Furthermore,
we
examine
potential
targeting
therapeutic
strategy
cancers
challenges
future
perspectives
this
rapidly
evolving
field.
By
understanding
basis
responses,
can
develop
novel,
personalized
therapies
for
treatment
cancers,
ultimately
improving
patient
outcomes
quality
life.
insights
gained
from
will
contribute
growing
body
knowledge
its
application
management
paving
way
more
effective
targeted
interventions
future.
The EPMA Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Association
of
both
intrinsic
and
extrinsic
risk
factors
leading
to
accelerated
skin
ageing
is
reflected
in
excessive
ROS
production
ir/reversible
mitochondrial
injury
burnout,
as
abundantly
demonstrated
by
accumulating
research
data.
Due
the
critical
role
stress
pathophysiology
disorders,
maintained
(primary
care)
restored
(secondary
health,
rejuvenation
homoeostasis
are
considered
most
effective
holistic
approach
advance
dermatological
treatments
based
on
systemic
health-supportive
stimulating
measures.
Per
evidence,
an
anti-ageing
protection,
wound
healing
scarring
quality
-
all
strongly
depend
sustainable
functionality
well-balanced
homoeostasis.
The
latter
can
be
objectively
measured
and,
if
necessary,
a
manner
pre-
rehabilitation
algorithms
tailored
individualised
patient
profiles.
entire
spectrum
corresponding
innovations
area
includes
natural
rejuvenation,
aesthetic
reconstructive
medicine,
protection
targeted
disorders.
Contextually,
mitochondria-centric
dermatology
instrumental
for
advanced
3PM-guided
which
makes
good
use
predictive
multi-level
diagnostics
against
health-to-disease
transition
progression
relevant
Cost-effective
new
treatment
avenues
focused
health
physiologic
proposed
article
including
in-depth
analysis
cases
exemplified
care
with
detailed
mechanisms
expert
recommendations
presented.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1803 - 1803
Published: Feb. 20, 2025
Skin
aging
is
the
most
prominent
phenotype
of
host
and
consequence
a
combination
genes
environment.
Improving
skin
essential
for
maintaining
healthy
physiological
function
mental
health
human
body.
Mitochondria
are
vital
organelles
that
play
important
roles
in
cellular
mechanisms,
including
energy
production
free
radical
balance.
However,
mitochondrial
metabolism,
dynamics,
biogenesis,
degradation
processes
vary
greatly
various
cells
skin.
It
well
known
dysfunction
can
promote
its
associated
diseases
skin,
resulting
damage
physiology
occurrence
pathology.
In
this
review,
we
summarize
role
mitochondria
cells,
review
responses
to
steps
quality
regulation,
phagocytosis,
describe
their
importance
specific
pathways
aging.
Medicine,
Journal Year:
2025,
Volume and Issue:
104(17), P. e42032 - e42032
Published: April 25, 2025
Osteonecrosis
of
the
femoral
head
(ONFH)
is
a
condition
caused
by
venous
stasis,
impaired
arterial
blood
flow,
or
destruction
head,
often
resulting
in
localized
death
bone
cells
and
marrow
components,
leading
to
joint
collapse.
Although
pathogenesis
ONFH
complex,
recent
attention
has
focused
on
role
TAR
DNA-binding
protein
(TARDBP)
gene
its
encoded
protein,
TDP-43,
disease
process.
which
plays
neurodegenerative
diseases,
may
also
regulate
apoptosis,
oxidative
stress,
immune
responses
ONFH.
This
study
utilized
GSE74089
GSE123568
datasets
from
expression
omnibus
database
analyze
differentially
expressed
genes
between
normal
samples.
Through
batch
effect
correction,
enrichment
analysis
(gene
ontology,
Kyoto
Encyclopedia
Genes
Genomes,
set
analysis),
protein–protein
interaction
network
construction,
weighted
co-expression
analysis,
key
were
identified.
Additionally,
infiltration
was
analyzed
using
CIBERSORT,
neural
model
developed
assess
importance
these
The
revealed
that
TARDBP
significantly
elevated
samples
correlated
with
monocytes
M1
macrophages.
Gene
ontology
Genomes
analyses
suggested
metabolism
repair
via
Wnt/β-catenin
signaling
pathway.
Protein–protein
identified
9
core
genes,
scoring
highest
model,
indicating
pivotal
regulation.
highly
ONFH,
possible
regulating
response
provide
new
ideas
for
molecular
mechanism
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1110 - 1110
Published: Sept. 14, 2024
Oxidative
stress
caused
by
reactive
oxygen
species
(ROS)
is
one
of
the
major
causes
senescence.
Strategies
to
reduce
ROS
are
known
be
important
factors
in
reversing
senescence,
but
effective
strategies
have
not
been
found.
In
this
study,
we
screened
substances
commonly
used
as
cosmetic
additives
find
with
antioxidant
effects.
Polygonum
cuspidatum
(P.
cuspidatum)
extract
significantly
reduced
levels
senescent
cells.
A
novel
mechanism
was
discovered
which
P.
ROS,
a
byproduct
inefficient
oxidative
phosphorylation
(OXPHOS),
increasing
OXPHOS
efficiency.
The
reduction
restored
senescence-associated
phenotypes
and
enhanced
skin
protection.
Then,
identified
polydatin
active
ingredient
that
exhibited
Polydatin,
contains
stilbenoid
polyphenols
act
singlet
scavengers
through
redox
reactions,
increased
efficiency
subsequently
phenotypes.
summary,
our
data
confirmed
effects
on
senescence
rejuvenation
protection
reduction.
This
finding
may
treatment
clinical
fields.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101210 - 101210
Published: Aug. 28, 2024
Skin
aging
is
the
phenomenon
of
degenerative
changes
in
structure
and
function
skin
tissues
over
time
manifested
by
a
gradual
loss
elasticity
firmness,
an
increased
number
wrinkles,
hyperpigmentation.
anti-aging
refers
to
reduction
through
medical
cosmetic
technologies.
In
recent
years,
new
biomaterials
have
been
continuously
developed
for
improving
appearance
mechanical
tissue
filling,
regulating
collagen
synthesis
degradation,
inhibiting
pigmentation,
repairing
barrier.
This
review
summarizes
mechanisms
associated
with
aging,
describes
that
are
commonly
used
aesthetics
their
possible
modes
action,
discusses
application
strategies
this
area.
Moreover,
synergistic
effects
such
other
active
ingredients,
as
stem
cells,
exosomes,
growth
factors,
antioxidants,
on
regeneration
evaluated.
Finally,
challenges
development
prospects
field
discussed,
novel
ideas
future
innovations
area
summarized.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5226 - 5226
Published: Nov. 5, 2024
Skin
photoaging,
primarily
caused
by
ultraviolet
(UV)
radiation,
leads
to
skin
metabolic
disorders,
which
have
adverse
psychological
and
physiological
effects
on
individuals.
However,
traditional
medications
for
repairing
photoaging
cause
side
effects.
Natural
bioactive
compounds
been
shown
prevent
treat
with
fewer
Epigallocatechin
gallate
(EGCG),
the
main
substance
in
tea
polyphenols,
is
a
natural
compound
range
of
properties.
This
review
summarizes
beneficial
mechanisms
EGCG,
as
well
application
forms
EGCG
photoaged
skin.
Results
indicated
that
has
repair
effects,
including
improving
elasticity,
enhancing
moisturization,
inhibiting
damage,
reducing
pigmentation
It
also
demonstrated
delivery
systems,
modified
combinations
other
substances
could
be
used
due
its
poor
stability
low
bioavailability.
effectively
repairs
various
types
damage
UV
radiation
while
maintaining
normal
structure
function.
is,
therefore,
an
effective
candidate
These
results
provide
references
development
products
treatment
