Food deprivation is associated with telomere elongation during hibernation in a primate
Biology Letters,
Journal Year:
2025,
Volume and Issue:
21(2)
Published: Feb. 1, 2025
Telomeres,
the
protective
ends
of
chromosomes,
progressively
shorten
due
to
incomplete
mitotic
replication
and
oxidative
stress.
In
some
organisms,
transient
telomere
elongation
may
occur,
for
example,
when
individuals
have
an
energy
surplus
counter
stress-induced
life
events
or
elongating
telomeres
is
a
last
chance
increase
fitness.
Mammalian
hibernators
are
good
models
test
dynamics,
as
they
cycle
between
prolonged
bouts
metabolic
depression
(torpor)
punctuated
by
short
surges
euthermia
(arousals).
We
studied
captive
fat-tailed
dwarf
lemurs
(
Cheirogaleus
medius
),
strepsirrhine
primate
hibernators,
that
were
food-deprived
n
=
8)
fed
daily
7)
during
hibernation
(4.5
months).
compared
lengths,
assayed
via
qPCR
from
oral
swabs,
at
five
strategic
time
points
span
full
year.
Food-deprived
subjects
underwent
multi-day
torpor/arousal
cycles,
lost
considerable
body
mass
elongated
but
shortened
them
upon
emergence.
contrast,
food-provisioned
ate
daily,
more
slowly,
shallower
shorter
torpor
experienced
little
change
in
lengths
same
periods.
Our
results
highlight
complex
relationship
balance
expression.
Further
investigation
warranted
elucidate
regulation
mechanisms
these
hibernators.
Language: Английский
Understanding seasonal telomere length dynamics in hibernating species
Journal of Thermal Biology,
Journal Year:
2024,
Volume and Issue:
123, P. 103913 - 103913
Published: July 1, 2024
Oxidative
stress
is
thought
to
be
one
of
the
main
causes
ageing
as
it
progressively
damages
cell
components
throughout
life,
eventually
causing
cellular
failure
and
apoptosis.
In
many
organisms,
telomeres
shorten
life
under
effect
of,
amongst
other
factors,
oxidative
stress,
are
therefore
commonly
used
marker
biological
ageing.
However,
hibernators,
which
regularly
exposed
acute
when
rewarming
from
torpor,
unexpectedly
long-lived.
this
review,
we
explore
associated
with
hibernation
its
impact
on
telomere
dynamics
in
different
taxa,
focussing
hibernating
rodents.
We
then
speculate
adaptive
mechanisms
hibernators
compensate
for
effects
may
explain
their
increased
longevity.
Because
winter
appears
high
particularly
rodents,
periodically
invest
repair
antioxidant
defences,
resulting
seasonal
variations
lengths.
This
research
shows
how
species
a
slow
life-history
strategy
deal
large
changes
unifying
evolutionary
physiological
theories
marked
variation
length,
also
draw
attention
using
markers
aging
heterotherms
possibly
highly
species.
Language: Английский