Wintering molecular changes in the brain of Calidris pusilla at lower latitude DOI Creative Commons
Patrick Douglas Corrêa Pereira, Ediely Pereira Henrique, Emanuel Ramos da Costa

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 29, 2022

Abstract Background: Migrant birds prepare differently to fly north for breeding in spring and the flight lower latitudes during autumn avoiding cold food shortages of hemisphere's harsh winter. The molecular events associated with these fundamental stages life history migrants include differential gene expression different tissues. Semipalmated sandpipers ( Calidris pusilla) are Artic shorebirds that migrate coast South America non-breeding season. Thus, adaptive changes brain at have not yet been investigated detail. Results: Here, we searched semipalmated sandpiper, recent arrived (RA) from autumnal migration individuals premigratory period (PM) spring. All were collected tropical coastal northern Brazil. We generated a De novo neurotranscriptome C. pusilla compared across libraries neurotranscriptome. To end mapped RNA-seq reads total 4 samples each group. A 266,414 transcripts reconstructed yielded 615 differentially expressed genes both groups. Conclusions: present report revealed remarkable recently individuals. It also recovering 5 days long-distance uninterrupted Atlantic Ocean preparation multiple stopover migration.

Language: Английский

Associations Between Esports Participation and Health: A Scoping Review DOI
Ana Monteiro Pereira, Júlio A. Costa, Evert Verhagen

et al.

Sports Medicine, Journal Year: 2022, Volume and Issue: 52(9), P. 2039 - 2060

Published: April 29, 2022

Language: Английский

Citations

44
Time trees and clock genes: a systematic review and comparative analysis of contemporary avian migration genetics DOI Creative Commons
Louis‐Stéphane Le Clercq, Gaia Bazzi, Jacopo G. Cecere

et al.

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2023, Volume and Issue: 98(4), P. 1051 - 1080

Published: March 6, 2023

Timing is a crucial aspect for survival and reproduction in seasonal environments leading to carefully scheduled annual programs of migration many species. But what are the exact mechanisms through which birds (class: Aves) can keep track time, anticipate changes, adapt their behaviour? One proposed mechanism regulating behaviour circadian clock, controlled by highly conserved set genes, collectively called 'clock genes' well established controlling daily rhythmicity physiology behaviour. Due diverse patterns observed within among species, seemingly endogenously programmed manner, field genetics has sought tested several candidate genes clock circuitry that may underlie differences breeding Among others, length polymorphisms such as Clock Adcyap1 have been hypothesised play putative role, although association fitness studies various species yielded mixed results. To contextualise existing body data, here we conducted systematic review all published relating seasonality phylogenetically taxonomically informed manner. This was complemented standardised comparative re-analysis gene 76 bird 58 migrants 18 residents, along with population analyses 40 available allele data. We genetic diversity estimates, used Mantel tests spatial analyses, evaluated relationships between averages geographic range (breeding- non-breeding latitude), distance, timing migration, taxonomic relationships, divergence times. Our combined analysis provided evidence (i) variation autumn spring migratory species; (ii) these not diagnostic markers distinguish from sedentary birds; (iii) correlated variability both potentially reflecting ancestrally inherited genotypes rather than contemporary changes driven selection. These findings highlight tentative attributes constraints on evolutionary adaptation.

Language: Английский

Citations

12
Genetics and Evolution of Bird Migration DOI

Zhongru Gu,

Andrew Dixon,

Xiangjiang Zhan

et al.

Annual Review of Animal Biosciences, Journal Year: 2023, Volume and Issue: 12(1), P. 21 - 43

Published: Oct. 31, 2023

Bird migration has long been a subject of fascination for humankind and is behavior that both intricate multifaceted. In recent years, advances in technology, particularly the fields genomics animal tracking, have enabled significant progress our understanding this phenomenon. review, we provide an overview latest advancements genetics bird migration, with particular focus on genomics, examine various factors contribute to evolution behavior, including climate change. Integration research from ecology, can enhance comprehension complex mechanisms involved inform conservation efforts rapidly changing world.

Language: Английский

Citations

8
Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering DOI Creative Commons
Lina Maria Delgado‐García, Ana Cristina Ojalvo‐Sanz, Thabatta Karollynne Estevam Nakamura

et al.

Biological Research, Journal Year: 2024, Volume and Issue: 57(1)

Published: Aug. 14, 2024

Abstract Brain damage triggers diverse cellular and molecular events, with astrocytes playing a crucial role in activating local neuroprotective reparative signaling within damaged neuronal circuits. Here, we investigated reactive using multidimensional approach to categorize their responses into different subtypes based on morphology. This utilized the StarTrack lineage tracer, single-cell imaging reconstruction multivariate data analysis. Our findings identified three profiles of astrocyte responses, categorized by effects cell size- shape- related morphological parameters: “moderate”, “strong,” “very strong”. We also examined heterogeneity reactivity, focusing spatial clonal distribution. research revealed notable enrichment protoplasmic fibrous “strong” strong” response subtypes. Overall, our study contributes better understanding an injury. By characterizing among subpopulations, provide insights that could guide future aimed at identifying novel therapeutic targets mitigate brain promote neural repair. Graphical

Language: Английский

Citations

2
Birds of a feather flock together: a dataset for Clock and Adcyap1 genes from migration genetics studies DOI Creative Commons
Louis‐Stéphane Le Clercq, Gaia Bazzi, Joan Ferrer

et al.

Scientific Data, Journal Year: 2023, Volume and Issue: 10(1)

Published: Nov. 9, 2023

Abstract Birds in seasonal habitats rely on intricate strategies for optimal timing of migrations. This is governed by environmental cues, including photoperiod. Genetic factors affecting intrinsic timekeeping mechanisms, such as circadian clock genes, have been explored, yielding inconsistent findings with potential lineage-dependency. To clarify this evidence, a systematic review and phylogenetic reanalysis was done. descriptor outlines the methodology sourcing, screening, processing relevant literature data. PRISMA guidelines were followed, ultimately 66 studies, 34 focusing candidate genes at genotype-phenotype interface. Studies clustered using bibliographic coupling citation network analysis, alongside scientometric analyses publication year location. Data retrieved allele data from databases, article supplements, direct author communications. The dataset, version 1.0.2, encompasses 52 species, 46 species Clock gene 43 Adcyap1 gene. featuring over 8000 birds, constitutes most extensive cross-species collection these used studies investigating polymorphisms bird migration.

Language: Английский

Citations

3
Urbanization is associated with non‐coding polymorphisms in candidate behavioural genes in the Eurasian coot DOI Creative Commons
Amelia Chyb, Radosław Włodarczyk, Joanna Drzewińska‐Chańko

et al.

Ecology and Evolution, Journal Year: 2023, Volume and Issue: 13(10)

Published: Oct. 1, 2023

Abstract Extensive transformation of natural land cover into urbanized areas enhances accumulation phenotypic differences between animals from urban and nonurban populations, but there is little information on whether these changes, especially in terms animal behaviour circadian rhythm, have a genetic basis. The aim this study was to investigate background behavioural four pairs populations common waterbird, the Eurasian coot Fulica atra . For purpose, we quantified polymorphisms personality‐related candidate genes, previously reported be associated with avian rhythms traits that may crucial for life. We found general associations landscape urbanization level 3′UTR region CREB1 gene encoding transcriptional factor, which participates development cognitive functions regulation rhythm. also significant differentiation intronic CKIɛ responsible clock. Although lacked evidence linkage variation coding polymorphisms, significantly stronger at intron compared neutral microsatellite markers, suggesting possible local adaptations expression specific sites. Our results indicate effect habitat‐specific selective pressure resulting environment supporting microevolutionary scenario. These adaptations, however, prevailed non‐coding regulatory rather than regions showed either or patterns, revealing high complexity birds.

Language: Английский

Citations

1
Dissecting Reactive Astrocyte Responses: Lineage Tracing and Morphology-based Clustering DOI Creative Commons
Lina M. Delgado-García, Ana Cristina Ojalvo‐Sanz, Thabatta Karollynne Estevam Nakamura

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Abstract Figure Graphical Brain damage triggers diverse cellular and molecular events, with astrocytes playing a crucial role in activating local neuroprotective reparative signaling within damaged neuronal circuits. Here, we investigated reactive using multidimensional approach to categorize their responses into different subtypes based on morphology the StarTrack lineage tracer, single-cell imaging reconstruction multivariate data analysis. Our findings revealed three profiles of astrocyte affecting cell size- shape-related morphological parameters: “moderate,” “strong,” “very strong”. We also explored heterogeneity reactivity, particular emphasis spatial clonal distribution. research highlights importance relationships between subpopulations responses, showing an enrichment protoplasmic fibrous “strong” strong” subtypes. Overall, our study contributes better understanding response injury. By elucidating among subpopulations, pave way for future aimed at uncovering novel therapeutic targets mitigating effects brain promoting neural repair.

Language: Английский

Citations

0
Molecular Changes in the Brain of the Wintering Calidris pusilla in the Mangroves of the Amazon River Estuary DOI Open Access
Patrick Douglas Corrêa Pereira, Ediely Pereira Henrique, Emanuel Ramos da Costa

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12712 - 12712

Published: Aug. 12, 2023

Migrant birds prepare differently to fly north for breeding in the spring and flight lower latitudes during autumn, avoiding cold food shortages of Northern Hemisphere's harsh winter. The molecular events associated with these fundamental stages life history migrants include differential gene expression different tissues. Semipalmated sandpipers (

Language: Английский

Citations

0
Genetic Disruption of System xc- Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat DOI Open Access
Evan Hess,

Sara N. Kassel,

Gregory Simandl

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 17, 2022

Abstract The impact of CNS disorders is exacerbated by the difficulty in developing safe, effective glutamatergic therapeutics. Synaptic glutamate transmission vital for neural physiology throughout brain, which contributes to vast therapeutic potential and safety risk Here, we created a genetically modified rat (MSxc) survey range brain functions impacted loss release from astrocytes involving system xc- (Sxc). Eliminating Sxc activity was not lethal did alter growth patterns, states, novel object recognition or performance other simple tasks. In contrast, MSxc rats differed WT Pavlovian Conditioned Approach cocaine self-administration/reinstatement paradigms. Both readily learned that cue predicted food delivery during training. However, were more likely approach tray (i.e., goal tracking) whereas food-predicted sign even when this behavior punished. paradigm, had higher levels cocaine-primed drug seeking absence altered extinction self-administration. These data demonstrate Sxc-mediated regulates non-reinforced negative-outcome behaviors without altering learning forms basic function.

Language: Английский

Citations

0
Wintering molecular changes in the brain of Calidris pusilla at lower latitude DOI Creative Commons
Patrick Douglas Corrêa Pereira, Ediely Pereira Henrique, Emanuel Ramos da Costa

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 29, 2022

Abstract Background: Migrant birds prepare differently to fly north for breeding in spring and the flight lower latitudes during autumn avoiding cold food shortages of hemisphere's harsh winter. The molecular events associated with these fundamental stages life history migrants include differential gene expression different tissues. Semipalmated sandpipers ( Calidris pusilla) are Artic shorebirds that migrate coast South America non-breeding season. Thus, adaptive changes brain at have not yet been investigated detail. Results: Here, we searched semipalmated sandpiper, recent arrived (RA) from autumnal migration individuals premigratory period (PM) spring. All were collected tropical coastal northern Brazil. We generated a De novo neurotranscriptome C. pusilla compared across libraries neurotranscriptome. To end mapped RNA-seq reads total 4 samples each group. A 266,414 transcripts reconstructed yielded 615 differentially expressed genes both groups. Conclusions: present report revealed remarkable recently individuals. It also recovering 5 days long-distance uninterrupted Atlantic Ocean preparation multiple stopover migration.

Language: Английский

Citations

0