Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: June 7, 2022

Abstract Cognitive impairment and function post-acute mild to moderate COVID-19 are poorly understood. We report findings of 128 prospectively studied SARS-CoV-2 positive patients. Cognition olfaction were assessed at 2-, 4- 12-months post-diagnosis. Lung function, physical mental health 2-month post diagnosis. Blood cytokines, neuro-biomarkers, kynurenine pathway (KP) metabolites measured 4-, 8- 12- months. Mild cognitive (demographically corrected) was present in 16%, 23%, 26%, diagnosis, respectively. Overall performance mildly, but significantly (p<.001) declined. more common those with anosmia (p=.05), only 2 KP quinolinic acid, 3-hydroxyanthranilic associated decline. The as a unique biomarker offers potential therapeutic target for COVID-19-related impairment.

Language: Английский

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Subjective and Objective Cognitive Deficits in Patients with Post-COVID Syndrome

Zeitschrift für Neuropsychologie, Journal Year: 2023, Volume and Issue: 34(2), P. 99 - 110

Published: May 24, 2023

Abstract: Cognitive impairment is a prominent symptom of the post-COVID syndrome (PCS). However, correspondence between subjective cognitive complaints (SCC) and objective results inconsistent. Here, we investigated this discrepancy. This longitudinal study included N = 42 individuals who reported SCC as PCS after mild infection at inclusion. Data collection comprised questionnaires neuropsychological assessment baseline follow-up (FU). At FU – on average 15 months acute COVID-19 88 % patients persisting SCC. There was an approx. 40 discrepancy report test both visits. Patients with indicated elevated fatigue reduced quality life compared to without FU. A growing number anticipated request assessments even infections.

Language: Английский

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Post-COVID-19 physical and cognitive impairments and associations with quality of life: a cross-sectional study

Frontiers in Sports and Active Living, Journal Year: 2024, Volume and Issue: 6

Published: March 5, 2024

Background and objective This study aimed to compare physical cognitive functions between post-coronavirus disease 2019 (COVID-19) participants healthy matched controls investigate associations impairments with quality of life. Methods Twenty-three post-COVID-19 23 age sex-matched people without a history COVID-19 were included. Physical function was assessed using the Medical Research Council Sum Score (MRC-SS), 2 min Step Test, Modified Borg Scale, Short Performance Battery (SPPB) Test. Cognitive Montreal Assessment (MoCA), Trail Making Test (TMT), Stroop test, life evaluated Euro Quality Life-5 Dimensions-3 Levels (EQ-5D-3l) questionnaire. Assessments performed by therapist in one session. Results Mann-Whitney U test showed that group, compared control number steps ( p &lt; 0.001, ES = 0.57) scores SPPB 0.03, 0.32), MoCA 0.003, 0.44), 0.75), EQ-5D-3l visual analog scale 0.027, 0.32) significantly lower. In addition, Scale score 0.6), TMT-A 0.013, 0.36) TMT-B 0.016, 0.35) times, time 0.61) higher group. There no significant between-group differences MRC-SS 0.055, 0.28). Furthermore, there moderate high participants. Conclusions On average 4 months after symptomatic COVID-19, had correlated These findings highlight need for comprehensive assessment plan appropriate management strategies.

Language: Английский

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Neuropsychiatric disturbances in mild cognitive impairment: A scientometric analysis

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102129 - 102129

Published: Nov. 20, 2023

Language: Английский

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COVID-19 and cognitive function: Evidence for increased processing speed variability in COVID-19 survivors and multifaceted impairment with long-COVID symptoms

European Psychiatry, Journal Year: 2023, Volume and Issue: 66(1)

Published: Jan. 1, 2023

There is increasing evidence for cognitive function to be negatively impacted by COVID-19. is, however, limited research evaluating pre- and post-COVID-19 using objective measures.We examined processing speed, attention, working memory, executive memory in adults (≤69 years) with a history of COVID-19 (n = 129, none acutely unwell), compared those no known 93). We also changes sub-group COVID 30) non-COVID 33) participants, their pre-COVID-19 pandemic level.Cross-sectionally, the group showed significantly larger intra-individual variability group. The pre-COVID level; significant change occurred participants over same time scale. Other indices were not cross-sectional or within-subjects investigations, but 20) who had needed hospitalisation due poor attention relative required 109). Poor health long-COVID symptoms correlated across domains group.The findings indicate impact only speed being an adult UK sample. However, severity and/or experience display multifaceted impairment may benefit from repeated assessments remediation efforts.

Language: Английский

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Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

BMJ Open Respiratory Research, Journal Year: 2023, Volume and Issue: 10(1), P. e001647 - e001647

Published: July 1, 2023

Objective Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19. Design Multicentre prospective observational cohort study using questionnaire data at visit 1 (2–7 months post discharge) 2 (10–14 from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations. Setting 64 UK acute hospital Trusts. Participants Adults aged >18 years, discharged an admissions unit or ward a with Main outcome measures Self-reported compromise. Results Compromised swallowing intensive care (post-ICU) admission reported 20% (188/955); 60% swallow problems received invasive mechanical ventilation were more likely have undergone proning (p=0.039). Voice 34% (319/946) post-ICU who (p<0.001) non-invasive (p=0.001) been proned (p<0.001). Communication 23% (527/2275) univariable identified associations younger age (p<0.001), female sex social deprivation being healthcare worker (p=0.010). Cognitive issues by 70% (1598/2275), consistent both visits, respondents higher baseline comorbidities associated greater Conclusion Swallow, prevalent COVID-19, alongside whole system including reduced mobility overall health scores. Research testing rehabilitation interventions are required pace explore these issues.

Language: Английский

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Cognitive impairment after recovery from COVID-19: Frequency, profile, and relationships with clinical and laboratory indices

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 79, P. 22 - 31

Published: Dec. 7, 2023

Cognitive impairment (CI) is regarded as a remarkable burden in COVID-19 survivors. Its prevalence and profile, relationships with the disease clinical laboratory indices, remain unclear. The present study investigated, large sample of patients recovered from COVID-19, frequency CI both face-to-face screening tool comprehensive test battery (MCCB). also evaluated profile its indices psychopathological features. Out 1344 subjects assessed for eligibility, 736 completed phase 11 months after infection; 402 participated baseline an depth cognitive, assessment about one month later. More than third screened presented (COG+); it was associated to age, education, male gender, severity, presence anosmia, dyspnea at rest exertional during acute phase. COG+ showed higher severity depression, anxiety post-traumatic distress, worse global functioning, without CI. MCCB that 45% had involving attention, working memory, verbal learning, visual reasoning problem solving. Finally, neurocognitive functioning inversely correlated LDH blood levels, potential biomarker severity. According our findings, cognitive should be routinely periodically patients, especially older subjects, who experienced more severe symptoms. In case persisting dysfunctions training programs considered treatment strategies.

Language: Английский

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SARS-CoV-2 infection is associated with self-reported post-acute neuropsychological symptoms within six months of follow-up

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0297481 - e0297481

Published: April 16, 2024

Background Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term impairment, it is important to characterize frequency predictors this post-infection phenotype. Methods The Epidemiology, Immunology, Clinical Characteristics Emerging Infectious Diseases with Pandemic Potential (EPICC) study longitudinal assessing infection in U.S. Military Healthcare System (MHS) beneficiaries, i.e. those eligible for care MHS active duty servicemembers, dependents, retirees. Four broad areas symptoms were assessed cross-sectionally among subjects 1–6 months post-infection/enrollment, including: depression (Patient Health Questionnaire-9), anxiety (General Anxiety Disorder-7), fatigue (PROMIS® Fatigue 7a), function Cognitive Function 8a PROMIS® abilities 8a). Multivariable Poisson regression models compared participants without history on these measures, adjusting sex, ethnicity, active-duty status, age, post-first positive or enrollment questionnaire completion (MPFP/E); also adjusted scores. Results population included 2383 who completed all five instruments within six MPFP/E, whom 687 (28.8%) had at least one test. Compared never tested SARS-CoV-2, group was more likely meet instrument-based criteria (15.4% vs 10.3%, p<0.001), (20.1% 8.0%, impaired (15.7% 8.6%, (24.3% 16.3%, p<0.001). In multivariable models, participants, an average 2.7 after increased risk moderate severe (RR: 1.44, 95% CI 1.12–1.84), 2.07, 1.62–2.65), 1.64, 1.27–2.11), 1.41, 1.15–1.71); MPFP/E not significant. Conclusions Participants up twice as report impairment prior infection. These findings underscore continued importance preventing while time since infection/enrollment significant through 6 follow-up, highlights need additional research into impacts COVID-19 mitigate reverse outcomes.

Language: Английский

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What We Know About Neurocognitive Outcomes in Long-/Post-COVID-19 Adults

Zeitschrift für Neuropsychologie, Journal Year: 2024, Volume and Issue: 35(2), P. 63 - 76

Published: May 1, 2024

Abstract: This review assesses neurocognitive studies on long-/post-COVID-19 adult patients, highlighting the research gaps. We categorize populations by infection severity, demographics, inclusion of controls, and psychological/biological factors. Methodologically, we analyzed 73 (95,600 subjects) from December 2019 to October 2022 using PRISMA-ScR guidelines PICO framework. Our findings revealed that most lacked control groups (88 %) reported unclear overall cognitive outcomes (73 %). While frequently assessed executive functions (86 attention (85 %), there were few longitudinal studies. Varied reporting sample sizes further complicated analysis. The identified gaps encompass convenience sampling, limited studies, inadequate use test batteries, leading a discrepancy between expected outcomes. absence standardized comparisons inconsistent statistical methods exacerbated these

Language: Английский

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Evaluation of cognitive functions in adult individuals with COVID-19

Neurological Sciences, Journal Year: 2022, Volume and Issue: 44(3), P. 793 - 802

Published: Dec. 27, 2022

Language: Английский

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