Depressive Disorders

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 149 - 178

Published: Jan. 1, 2025

---

Sexual assault experience, depression, and heavy substance use among German adults: an exploratory mediation analysis

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 10, 2025

Abstract Background The experience of sexual assault may be associated with numerous adverse outcomes, including depressive disorders and heavy substance use. We aimed to examine the relationship between use depression in victims assault. Methods used nationally representative data from German Health Sexuality Survey (GeSiD) N = 4,955 women men aged 18–75 years. assessed (i) potential effect on mediated through hazardous alcohol, tobacco, frequent cannabis (ii) using logistic regression analysis estimate proportion (PM). Results found some evidence mediation as a lifetime event by tobacco (PM 1.6%) 14.7%) among women. also observed alcohol 35.5%) 48.6%) who experienced childhood Focusing mediator, we 17.6%) 13.3%), 26.9%) Conclusions Our findings suggest that public health specialists, clinicians, therapists should develop early interventions prevent addiction development after experiencing

Language: Английский

---

Youth cannabis use in Canada post-legalization: service providers’ perceptions, practices, and recommendations

Substance Abuse Treatment Prevention and Policy, Journal Year: 2023, Volume and Issue: 18(1)

Published: June 22, 2023

Abstract Background In 2018, Canada legalized recreational cannabis use with the purpose of protecting youth and restricting access. However, concerns have been raised that this objective has not met as rates among aged 16–24 declined. Youth is associated various adverse effects including psychosis, anxiety, depression, suicidality, respiratory distress, cannabinoid hyperemesis syndrome, intoxications. Service providers play a crucial role in addressing use. This study aimed to understand Ontario service providers’ perceptions, practices, recommendations on Methods mixed method included survey two focus groups. The was distributed mental health serving across who were given option participate group. closed open-ended questions regarding recommendations, while groups explored these categories greater depth. Descriptive statistics used analyze close-ended interpretative content analysis applied for questions. Focus group data analyzed using thematic analysis. Results completed by 160 12 participated Regarding 60% participants agreed legalization, 26% had strong understanding medical versus cannabis, 84% believed physical risks, 49% perceived stigmatization. Less than half reported screening or assessing use, 16% stated they are highly familiar treating 67% rarely work families. Subthemes identified under perceptions normalization stigmatization, harms youth, stigma, racism, discrimination. practice being primary focus, challenges screening, assessment, intervention, referral specialized services. Both recommended increasing public education, enhancing provider training, improving regulation policies, reducing stigma minimization, access, providing more culturally responsive Conclusion remains significant concern, necessitating comprehensive plan protect reduce harms.

Language: Английский

---

The psychedelic effects of cannabis: A review of the literature

Journal of Psychopharmacology, Journal Year: 2023, Volume and Issue: 38(1), P. 49 - 55

Published: Nov. 10, 2023

Cannabis and classic psychedelics are controlled substances with emerging evidence of efficacy in the treatment a variety psychiatric illnesses. has largely not been regarded as having psychedelic effects contemporary literature, despite many examples historical use along to attain altered states consciousness. Research into “psychedelic” cannabis, delta-9-tetrahydrocannabinol (THC) particular, could prove helpful for assessing potential therapeutic indications elucidating mechanism action both cannabis psychedelics. This review aggregates evaluates literature capacity yield perceptual changes, aversiveness, mystical experiences more typically associated such psilocybin. also provides brief contrast neuroimaging findings acute The available suggests that high-THC may be able elicit effects, but these have observed recent research studies due doses, set, settings commonly used. is needed investigate high doses THC context utilized aimed occasion and/or experiences. If can reliably generate under conditions, dose treatments should explored adjunctive disorders considered an active comparator clinical trials involving traditional medications.

Language: Английский

---

Mental health problems, substance use, and perceived risk as pathways to current cannabis use among high school seniors in the United States

Children and Youth Services Review, Journal Year: 2024, Volume and Issue: 158, P. 107456 - 107456

Published: Jan. 21, 2024

Language: Английский

---

Synthesis and Evaluation of Natural and Unnatural Tetrahydrocannabiorcol for Its Potential Use in Neuropathologies

Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(2), P. 167 - 175

Published: Feb. 14, 2024

(−)-trans-Δ9-Tetrahydrocannabinol (trans-(−)-Δ9-THC) has shown neuroprotective potential, but its medicinal benefits are not fully exploited due to the limitations of psychoactive properties. The lower homologues non-psychoactive in nature lack comprehensive scientific validation regarding potential. present study describes synthesis THC-type compounds and their Both natural tetrahydro-cannabiorcol (trans-(−)-Δ9-THCO) unnatural Δ9-tetrahydrocannabiorcol (trans-(+)-Δ9-THCO) were successfully synthesized starting from R-limonene S-limonene, respectively, investigated for potential cellular models. structures both enantiomers confirmed by NMR, HMBC, HQSC, NOESY, COSY experiments. Results indicated that nontoxic cells treated up 50 μM. Neuroprotective properties showed treatments could significantly reverse corticosterone-induced toxicity SH-SY5Y simultaneously cause elevated expression brain-derived neurotrophic factor (BDNF). It was also observed trans-(+)-Δ9-THCO displayed better activity than enantiomer can be further explored use neuropathological ailments.

Language: Английский

---

The Role of Sex and Coping Styles on the Relationship Between Depression and Cannabis Use

International Journal of Mental Health and Addiction, Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Language: Английский

---

Avatar Intervention for Cannabis Use disorder in Individuals with Severe Mental Disorders: Results from a one-year pilot clinical trial (Preprint)

JMIR Mental Health, Journal Year: 2024, Volume and Issue: 11, P. e58499 - e58499

Published: Sept. 28, 2024

Abstract Background The dual diagnosis of cannabis use disorder (CUD) and severe mental (SMD) results in clinically complex individuals. Cannabis is known to have negative consequences on psychiatric symptoms, medication compliance, disease prognosis. Moreover, the effectiveness currently available psychotherapeutic treatments limited this population. In context, our research team developed avatar intervention, an approach using virtual reality as a therapeutic tool treat CUD individuals with SMD. Objective This pilot clinical trial aimed evaluate, until 1-year follow-up, efficacy intervention for among 32 participants SMD CUD. Methods Over course 8 sessions, were given opportunity enter dialogue representing person significant role their consumption, who was animated real time by therapist. primary outcomes quantity consumed frequency use. Secondary included severity problematic use, motivation change, protective strategies quality life. Changes reported during assessment periods before intervention; postintervention; 3, 6, 12 months after end assessed linear mixed-effects model. Results Significant reductions observed consumed, these maintained 12-month follow-up visit ( d =0.804; P <.001; confirmed urine quantification). Frequency showed small reduction at 3-month =0.384; =.03). improvements CUD, cannabis-related consequences, change used mitigate harms related Finally, moderate benefits life symptoms. Conclusions Overall, unique shows promising that seem be up intervention. With aim overcoming methodological limitations study, single-blind randomized controlled underway compare conventional addiction

Language: Английский

---

Reducing the harms of cannabis use in youth post-legalization: insights from Ontario youth, parents, and service providers

Harm Reduction Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 6, 2024

Abstract Background Canada has one of the highest prevalence cannabis use globally, particularly among young adults aged 20–24 (50%) and youth 16–19 (37%). In 2018, legalized recreational with aim protecting by restricting their access raising public awareness health risks. However, there been limited qualitative research on perceptions harms associated since legalization, which is crucial for developing effective harm reduction strategies. This study examined from perspectives youth, parents, service providers. We explored how participants described perceived risks or use, as well they own others’ approaches to reducing cannabis-related harms. Methods used a community-based participatory approach in partnership Families Addiction Recovery (FAR), national charity founded parents addiction issues. Virtual semi-structured interviews were conducted, data analyzed using thematic analysis. Results The included 88 three key groups ( n = 31 26 providers). Two main themes emerged regarding use: (1) concerns about harms, including addiction, brain development, impact family, various adverse effects areas such motivation, concentration, finances, employment, education, physical mental health; (2) minimization featuring conflicting messages, normalization, being less harmful than other substances. Additionally, two related identified: implementation reduction, challenges implementing approach. Specific each participant group noted, along structural barriers unavailable inaccessible services, easy cannabis, inadequate insufficient information lower-risk guidelines. Conclusions Youth significant concern that requires multi-pronged Developing youth-centered strategies recognize developmental needs vulnerabilities important role families, imperative.

Language: Английский

---

<i>Cannabis</i>: Drug of abuse and therapeutic agent, two sides of the same coin

Revista de investigaci�n Cl�nica, Journal Year: 2023, Volume and Issue: 75(3)

Published: July 5, 2023

The consumption of Cannabis sativa plant, known as marijuana in the Western world, for different purposes (therapeutic, intoxicating, and spiritual) due to its psychoactive effects, can be traced back ancient times.Cannabis is most used illicit drug worldwide; however, legal status changing rapidly.Cannabis regulation will allow a better understanding effects misused drug, including new challenges, such availability highly potent extracts.Furthermore, scientific research making significant efforts take advantage potential therapeutic uses active compounds.The science derivatives started with identification phytocannabinoids Δ 9 -tetrahydrocannabinol (Δ -THC) cannabidiol (CBD), allowing formal study complex set triggered by deciphering pharmacology.Δ -THC recognized compound responsible intoxicating Cannabis.Its led discovery endocannabinoid system, neuromodulatory system widespread human body.CBD does not induce intoxication that reason, it focus search cannabinoid clinical applications.This review examines current state knowledge about contrasting perspectives on Cannabis, -THC, CBD: their abuse liability use; two sides same coin.

Language: Английский

---