Journal of Oral Biology and Craniofacial Research,
Journal Year:
2023,
Volume and Issue:
13(2), P. 210 - 217
Published: Jan. 21, 2023
Diseases
such
as
periodontitis
and
osteoporosis
are
expected
to
rise
tremendously
by
2050.
Bone
formation
remodeling
complex
processes
that
disturbed
in
a
variety
of
diseases
influenced
various
hormones.This
study
aimed
review
present
the
roles
hormones
regulate
bone
craniofacial
complex.A
literature
search
was
conducted
on
PubMed
Google
Scholar
for
studies
related
jawbone.
Search
strategies
included
combinations
("name
hormone"
+
"dental
term")
following
terms:
"hormones",
"oxytocin",
"estrogen",
"adiponectin",
"parathyroid
hormone",
"testosterone",
"insulin",
"angiotensin",
"cortisol",
"erythropoietin",
combined
with
dental
term
"jaw
bone",
"alveolar
implant",
regeneration,
healing
or
repair",
"dentistry",
"periodontitis",
"dry
socket",
"osteoporosis"
"alveolitis".
The
papers
were
screened
according
inclusion
criteria
from
January
1,
2000
March
31,
2021
English.
Publications
reviews,
book
chapters,
original
research
papers;
vitro
studies,
vivo
animal,
human
including
clinical
meta-analyses.Bone
is
continuous
process
involving
many
hormones.
volume
reduction
tooth
extractions
diseases,
osteoporosis,
cause
serious
problems
require
great
understanding
process.Hormones
us
all
time,
shape
our
development
homeostasis.
Newly
discovered
effects
influencing
open
possibilities
using
therapeutics
combat
bone-related
diseases.
Journal Of Clinical Periodontology,
Journal Year:
2023,
Volume and Issue:
50(5), P. 642 - 656
Published: Jan. 16, 2023
Abstract
Aim
To
explore
the
potential
mechanisms
of
neuroinflammation
(microglia,
blood–brain
barrier
[BBB]
permeability,
and
sphingosine‐1‐phosphate
[S1P]
pathways)
resulting
from
association
between
periodontitis
depression
in
rats.
Materials
Methods
This
pre‐clinical
vivo
experimental
study
used
Wistar
rats,
which
(P)
was
induced
by
using
oral
gavages
with
Porphyromonas
gingivalis
Fusobacterium
nucleatum.
Then,
a
chronic
mild
stress
(CMS)
model
implemented
to
induce
depressive‐like
behaviour,
four
groups:
P
CMS
(P+CMS+),
without
(P+CMS−),
(P−CMS+),
control
(P−CMS−).
After
harvesting
brain
samples,
protein/mRNA
expression
analyses
fluorescence
immunohistochemistry
were
performed
frontal
cortex
(FC).
Results
analysed
ANOVA.
exposure
increased
number
microglia
(an
indicator
neuroinflammation)
FC.
In
combined
there
decrease
tight
junction
proteins
(zonula
occludens‐1
[ZO‐1],
occludin)
an
increase
intercellular
vascular
cell
adhesion
molecules
(ICAM‐1,
VCAM‐1)
matrix
metalloproteinase
9
(MMP9),
suggesting
more
severe
disruption
BBB.
The
enzymes
receptors
S1P
also
differentially
regulated.
Conclusions
Microglia,
BBB
pathways
could
be
relevant
explaining
depression.
Frontiers in Psychiatry,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 10, 2022
Background
Growing
evidence
supports
that
alterations
in
the
gut
microbiota
play
an
essential
role
etiology
of
anxiety,
depression,
and
other
psychiatric
disorders.
However,
potential
effect
oral
on
mental
health
has
received
little
attention.
Methods
Using
latest
genome-wide
association
study
(GWAS)
summary
data
microbiome,
polygenic
risk
scores
(PRSs)
285
salivary
microbiomes
309
tongue
dorsum
were
conducted.
Logistic
linear
regression
models
applied
to
evaluate
relationship
between
salivary-tongue
microbiome
interactions
with
anxiety
depression.
Two-sample
Mendelian
randomization
(MR)
was
utilized
compute
causal
effects
Results
We
observed
significant
related
depression
traits.
Significantly,
one
common
interaction
be
associated
both
score
score,
Centipeda
periodontii
SGB
224
×
Granulicatella
uSGB
3289
(P
depressionscore
=
1.41
10
−8
,
P
anxietyscore
5.10
).
Furthermore,
we
detected
Importantly,
identified
UKB
database
Finngen
public
database,
Eggerthia
IVW
−
majordepression
2.99
−6
Self
reportedanxiety/panicattacks
3.06
−59
3.16
,-16
1.14
−115
Conclusion
This
systematically
explored
which
could
help
improve
our
understanding
disease
pathogenesis
propose
new
diagnostic
targets
early
intervention
strategies.
npj Biofilms and Microbiomes,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Dec. 7, 2023
Abstract
The
gut–brain
axis
is
a
bidirectional
communication
system
between
the
gut
and
central
nervous
system.
Many
host-related
factors
can
affect
microbiota,
including
oral
bacteria,
making
brain
vulnerable
target
via
axis.
Saliva
contains
large
number
of
periodontitis,
common
disease,
change
composition
salivary
microbiota.
However,
role
mechanism
periodontitis
microbiota
(PSM)
on
remain
unclear.
Herein,
we
investigated
nature
mechanisms
this
relationship
using
mice
with
dextran
sulfate
sodium
salt
(DSS)-induced
anxiety-like
behavior.
Compared
healthy
PSM
worsened
behavior;
it
significantly
reduced
normal
neurons
activated
microglia
in
DSS
mice.
Antibiotic
treatment
eliminated
effect
behavior,
transplantation
fecal
from
PSM-gavaged
exacerbated
These
observations
indicated
that
anxiety-exacerbating
was
dependent
Moreover,
behavior
not
present
non-DSS
mice,
indicating
prerequisite
for
to
exacerbate
anxiety.
Mechanistically,
altered
histidine
metabolism
both
metabolomics.
Supplementation
histidine-related
metabolites
had
similar
as
PSM,
suggesting
may
be
critical
pathway
process.
Our
results
demonstrate
colitis-induced
by
directly
affecting
host
emphasizing
importance
diseases
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
204, P. 107214 - 107214
Published: May 17, 2024
Studies
have
shown
that
the
microbiota-gut-brain
axis
is
highly
correlated
with
pathogenesis
of
depression
in
humans.
However,
whether
independent
oral
microbiome
do
not
depend
on
gut
microbes
could
affect
progression
human
beings
remains
unclear,
neither
does
presence
and
underlying
mechanisms
microbiota-oral-brain
development
condition.
Hence
this
study
encompasses
clinical
animal
experiments
aims
at
investigating
correlation
between
microbiota
onset
via
mediating
axis.
We
compared
microbial
compositions
metabolomes
87
patients
depressive
symptoms
versus
70
healthy
controls.
found
metabolic
signatures
were
significantly
different
two
groups.
Significantly,
germ-free
(GF)
mice
transplanted
saliva
from
exposing
to
chronic
restraint
stress
(CRS)
displayed
depression-like
behavior
dysbiosis.
This
was
characterized
by
a
significant
differential
abundance
bacterial
species,
including
enrichment
Pseudomonas,
Pasteurellaceae,
Muribacter,
as
well
depletion
Streptococcus.
Metabolomic
analysis
showed
alternation
metabolites
plasma
CRS-exposed
GF
mice,
especially
Eicosapentaenoic
Acid.
Furthermore,
barrier
dysfunction
caused
CRS-induced
dysbiosis
may
be
associated
increased
blood-brain
permeability.
Pseudomonas
aeruginosa
supplementation
exacerbated
behavior,
while
Acid
treatment
conferred
protection
against
states
mice.
These
results
suggest
function
relevant
pathophysiology
depression.
The
proposed
provides
new
way
targets
for
us
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 22, 2022
Background
Observational
and
in-vivo
research
suggested
a
bidirectional
relationship
between
depression
periodontitis.
We
estimated
the
genetic
correlation
examined
directionality
of
causation.
Methods
The
study
used
summary
statistics
from
published
genome
wide
association
studies,
with
sample
sizes
ranging
45,563
to
797,563
individuals
European
ancestry.
performed
linkage
disequilibrium
score
regression
(LDSC)
estimate
global
Heritability
Estimation
Summary
Statistics
(ρ-HESS)
further
examine
local
correlation.
Latent
Heritable
Confounder
Mendelian
randomization
(LHC-MR),
Causal
Analysis
using
Effect
estimates
(CAUSE),
conventional
MR
approaches
assessed
Results
LDSC
observed
only
weak
(r
g
=
0.06,
P-Value
0.619)
ρ-HESS
did
not
reveal
loci
significant
covariance.
LHC-MR,
CAUSE
models
provided
no
support
for
causation
periodontitis,
odds
ratios
1.00
1.06
in
either
direction.
Conclusions
do
shared
heritability
or
causal
connection
Physiological Research,
Journal Year:
2022,
Volume and Issue:
71(6), P. 719 - 738
Published: Nov. 25, 2022
Hundreds
of
studies
in
last
decades
have
aimed
to
compare
the
microbiome
patients
suffering
from
diverse
diseases
with
that
healthy
controls.
The
microbiome-related
component
was
additionally
identified
pathophysiology
many
formerly
considered
depend
only
on
host
physiology.
This,
however,
opens
important
questions
like:
“What
is
microbiome?”
or
“Is
it
possible
define
unequivocally?”.
In
this
review,
we
describe
main
hindrances
complicating
definition
“healthy
microbiome”
terms
microbiota
composition.
We
discuss
human
perspective
classical
ecology
and
advocate
for
shift
stress
composition
functions
ensures
host.
Finally,
propose
leave
concept
ideal
replace
by
focus
advantageous
host,
which
always
depends
specific
context
like
age,
genetics,
dietary
habits,
body
site
physiological
state.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 3, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
and
periodontitis
share
common
risk
factors
such
as
obesity,
insulin
resistance
(IR),
dyslipidemia,
which
contribute
to
systemic
inflammation.
It
has
been
suggested
that
a
bidirectional
relationship
exists
between
NAFLD
periodontitis,
indicating
one
condition
may
exacerbate
the
other.
is
characterized
by
excessive
fat
deposition
in
associated
with
low-grade
chronic
There
are
several
for
development
of
NAFLD,
including
gender,
geriatric
community,
race,
ethnicity,
poor
sleep
quality
deprivation,
physical
activity,
nutritional
status,
dysbiosis
gut
microbiota,
increased
oxidative
stress,
overweight,
higher
body
mass
index
(BMI),
IR,
type
2
diabetes
mellitus
(T2DM),
metabolic
syndrome
(MetS),
dyslipidemia
(hypercholesterolemia),
sarcopenia
(decreased
skeletal
muscle
mass).
This
inflammation
can
progression
impairing
immune
responses
exacerbating
inflammatory
processes
periodontal
tissues.
Furthermore,
individuals
often
exhibit
altered
lipid
metabolism,
affect
oral
microbiota
composition,
leading
susceptibility
disease.
Conversely,
linked
through
mechanisms
involving
stress.
Chronic
release
pro-inflammatory
cytokines
bacterial
toxins
into
bloodstream,
contributing
hepatic
steatosis.
Moreover,
periodontitis-induced
stress
promote
accumulation
further
aggravating
NAFLD.
The
interplay
underscores
importance
comprehensive
management
strategies
targeting
both
conditions.
Lifestyle
modifications
regular
exercise,
healthy
diet,
proper
hygiene
practices
crucial
preventing
managing
these
interconnected
diseases.
Additionally,
interdisciplinary
collaboration
hepatologists
periodontists
essential
optimizing
patient
care
improving
outcomes
periodontitis.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(18), P. 3206 - 3206
Published: Sept. 22, 2024
Background:
The
oral
microbiota
is
the
second
largest
microbial
community
in
humans.
It
contributes
considerably
to
diversity
and
health
effects,
much
like
gut
microbiota.
Despite
physical
chemical
barriers
separating
cavity
from
gastrointestinal
tract,
bidirectional
transmission
occurs
between
two
regions,
influencing
overall
host
health.
Method:
This
review
explores
intricate
interplay
of
oral–gut–brain
axis,
highlighting
pivotal
role
systemic
ageing,
how
it
can
be
influenced
by
diet.
Results:
Recent
research
suggests
a
relationship
diseases,
such
as
periodontitis,
problems,
broader
significance
oral–gut
axis
well
neurological
disorders
mental
Diet
influences
gut.
While
certain
diets/dietary
components
improve
both
health,
others,
fermentable
carbohydrates,
promote
pathogens
while
boosting
Conclusions:
Understanding
these
dynamics
key
for
promoting
healthy
through
dietary
interventions
that
support
mitigate
age-related
risks.
