bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: March 10, 2023
Abstract
Sugar
bingeing
has
been
shown
to
induce
withdrawal
effects
when
sugar
is
no
longer
available
in
the
diet.
In
this
study,
we
investigated
sex
differences
sugar-addiction-like
behaviour
and
of
ketogenic
diet
on
these
outcomes.
We
used
two-bottle
sucrose
choice
paradigm
as
a
pre-clinical
overeating
model.
Female
mice
consumed
more
than
males
given
free
access
water
10%
for
four
weeks.
One
week
after
weeks
consecutive
showed
anxiety-like
male
mice.
However,
did
not
affect
overconsumption
females
but
prevented
withdrawal-induced
with
concomitant
increase
cFos
mRNA
prefrontal
cortex.
These
findings
provide
evidence
addiction-like
also
indicate
that
may
prevent
males.
further
research
needed
explore
underlying
molecular
mechanisms
driving
anxiolytic
Current Obesity Reports,
Journal Year:
2024,
Volume and Issue:
13(2), P. 214 - 223
Published: May 18, 2024
Detail
recent
advancements
in
the
science
on
ultra-processed
food
(UPF)
addiction,
focusing
estimated
prevalence
rates
and
emerging
health
disparities;
progress
towards
identifying
biological
underpinnings
behavioral
mechanisms;
implications
for
weight
management.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(6), P. 965 - 965
Published: March 10, 2025
With
the
prevalence
of
obesity
and
overweight
increasing
at
an
alarming
rate,
more
researchers
are
focused
on
identifying
effective
weight
loss
strategies.
The
ketogenic
diet
(KD),
used
as
a
treatment
in
epilepsy
management
for
over
100
years,
is
additionally
gaining
popularity
method.
Although
its
efficacy
well
documented,
areas
where
it
may
be
beneficial
to
other
dietary
approaches
need
carefully
examined.
objective
this
paper
identify
potential
benefits
KD
alternative
strategies
based
comprehensive
literature
review.
It
has
been
shown
that
bioenergetically
efficient
than
strategies,
inter
alia
owing
effect
curtailing
hunger,
improving
satiety
decreasing
appetite
(influence
hunger
hormones
sensation
hunger),
inducing
faster
initial
(associated
with
lower
glycogen
levels
reduced
water
retention),
controlling
glycaemia
insulinemia
(directly
attributable
low-carbohydrate
nature
indirectly
described).
These
effects
accompanied
by
improved
insulin
sensitivity,
inflammation
(through
ketone
bodies
avoidance
pro-inflammatory
sugars),
pharmacological
control
(the
diet’s
mechanisms
similar
those
medication
but
without
side
effects),
positive
impacts
psychological
factors
food
addiction.
Based
authors’
review
latest
research,
reasonable
conclude
that,
due
these
many
additional
health
benefits,
advantageous
diet-based
This
important
hypothesis
deserves
further
exploration,
which
could
achieved
including
outcome
measures
future
clinical
trials,
especially
when
comparing
different
diets
equal
caloric
value.
Appetite,
Journal Year:
2024,
Volume and Issue:
195, P. 107211 - 107211
Published: Jan. 11, 2024
There
is
a
substantial
research
base
for
addictive
eating
with
development
of
interventions.
The
current
3-arm
RCT
aimed
to
investigate
the
efficacy
TRACE
(Targeted
Research
Addictive
and
Compulsive
Eating)
program
decrease
symptoms
improve
mental
health.
Participants
(18-85
yrs)
endorsing
≥3
were
randomly
allocated
1)
active
intervention,
2)
passive
or
3)
control
group.
Primary
outcome
was
change
in
3-months
post-baseline
measured
by
Yale
Food
Addiction
Scale.
Depression,
anxiety
stress
also
assessed.
A
total
175
individuals
randomised.
Using
Linear
Mixed
Models,
from
baseline
3-months,
there
significant
improvement
symptom
scores
all
groups
mean
4.7
(95%
CI:
−5.8,
−3.6;
p
<
0.001),
3.8
−5.2,
−2.4;
0.001)
1.5
−2.6,
−0.4;
=
0.01)
respectively.
Compared
group,
participants
intervention
five
times
more
likely
achieve
clinically
scores.
reduction
depression
groups,
but
not
group
[-2.9
−4.5,
−1.3);
−2.3
−4.3,
−0.3);
0.5
−1.1,
2.1),
respectively];
within
[-1.3
−2.2,
−0.5);
−1.0
−2.1,
0.1);
0.4
−0.5,
1.2),
over
time
similar
groups.
dietitian-led
telehealth
adults
effective
than
condition
reducing
6
months.
Trial
registration:
Australia
New
Zealand
Clinical
Registry
ACTRN12621001079831.
Journal of Eating Disorders,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: April 10, 2025
Designing
interventions
to
change
addictive
eating
behaviours
is
a
complex
process
and
understanding
the
treatment
effect
on
co-occurring
disordered
of
importance.
This
study
aimed
explore
effects
TRACE
(Targeted
Research
for
Addictive
Compulsive
Eating)
intervention
disorder
psychopathology,
binge
eating,
reward
driven
grazing
behaviours.
involved
secondary
analysis
data
from
randomised
control
trial
among
175
participants
(18-85
yrs)
endorsing
≥
3
Yale
Food
Addiction
Scale
(YFAS)
symptoms
who
were
randomly
allocated
(1)
active
intervention,
(2)
passive
or
(3)
group.
Change
in
YFAS,
EDE-Q
6.0,
Binge
Eating
Scale,
RED-X5
Short
Inventory
Grazing
scores
assessed
at
3-months
(immediate
post-intervention)
6-months
(3-months
follow-up.
Using
Linear
Mixed
Models,
baseline
there
was
significant
reduction
global
[mean
decrease
-
0.6
(95%
CI:
-0.8,
-0.4)],
but
not
[-0.2
-0.5,
0.1)]
groups
[-0.1
-0.3,
0.1)].
In
reductions
[-3.8
-4.9,
-2.7;
-2.5
-3.9,
-1.1),
respectively],
compulsive
(-1.8
-2.4,
-1.3);
-1.1
-1.7,
-0.5),
respectively]
non-compulsive
(-1.4
-1.9,
-1.0);
-0.4),
The
over
time
similar
all
groups.
positively
associated
with
scores,
(rs
ranged
0.23
0.69).
dietitian-led
which
adopted
weight-neutral,
harm
approach
management
adults
demonstrated
positive
some
Importantly
did
cause
any
adverse
changes
pathologies
measured.
Australia
New
Zealand
Clinical
Trial
Registry
ACTRN12621001079831.
Frontiers in Psychiatry,
Journal Year:
2025,
Volume and Issue:
16
Published: April 14, 2025
The
topic
of
ultra-processed
food
addiction
has
been
the
subject
many
peer-reviewed
publications.
Although
on
average
14%
adults
may
meet
criteria
for
in
prevalence
studies,
it
is
not
a
recognized
clinical
diagnosis,
hence
lack
published
evidence-based
treatment
protocols
and
outcome
data.
In
2022,
we
reported
outcomes
pre-
post-intervention
from
an
online,
real
food-based,
low-carbohydrate
educational
program
with
psychosocial
support
related
to
recovery.
intervention
was
delivered
across
three
locations,
offering
common
approach.
programs
comprised
weekly
online
sessions
10–14
weeks,
followed
by
monthly
groups.
previously
data
were
relating
symptoms
measured
modified
Yale
Food
Addiction
Scale
2.0,
ICD-10
substance
use
disorder
(CRAVED),
mental
well-being
as
short
version
Warwick
Edinburgh
Mental
Wellbeing
Scale,
post-intervention.
current
report
focuses
same
cohort’s
6-
12-month
follow-up
show
significant,
sustained
improvement
well-being.
These
are
first
long-term
results
be
program.
Research
now
needed
evaluate
compare
other
interventions
this
impairing
increasingly
prevalent
biopsychosocial
condition.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: June 6, 2024
Background
Evidence
suggests
that
a
ketogenic
diet
(KD)
may
help
to
alleviate
psychiatric
symptoms,
including
depression
and
anxiety.
Positive
changes
have
been
reported
such
as
improvements
in
cognition,
concentration,
sleep,
reduction
hunger,
an
increase
well-being,
energy,
confidence,
resilience.
This
research
aims
understand
the
impact
of
non-calorie-restricted
KD
on
aspects
psychological
well-being
those
with
varying
degrees
depressive
symptoms.
Though
there
are
few
studies
directly
exploring
experiences
following
KD,
this
will
be
first
study
explore
narrative
from
mental
health
viewpoint.
Method
A
sample
nine
participants
who
had
followed
non-calorie
restricted
intervention
50
g
carbohydrates
or
less
per
day
for
at
least
12
weeks
were
recruited.
Participants
split
into
‘healthy
adults’
group
no
low
symptoms
‘depressive
symptoms’
mild
moderate
reflexive
thematic
analysis
was
considered
suitable
study.
Findings
Five
core
themes
24
subthemes
created.
These
were,
(1)
Poor
prior
program;
(2)
Hunger
cravings-the
food
mood
connection;
(3)
Psychological
improvements;
(4)
It
becomes
lifestyle;
(5)
Implementation
difficulties.
experienced
increased
self-esteem,
motivation,
achievement.
Some
more
control
life
greater
sense
reward.
Those
initially
self-worth
hopelessness
later
self-esteem
renewed
meaning
purpose
life.
The
findings
reflect
previous
reports
implementation
can
difficult
initially,
but
soon
easy
follow
turns
lifestyle.
Conclusion
In
literature,
very
qualitative
accounts
lived
KD.
From
participants’
study,
it
appears
benefits
positive
outcomes
outweigh
any
negative
side-effects
experienced.
is
encouraging
looking
adjunctive
therapies
address
improve
their
overall
health.
Journal of Human Nutrition and Dietetics,
Journal Year:
2024,
Volume and Issue:
37(4), P. 978 - 994
Published: April 23, 2024
Abstract
Background
Few
interventions
for
food
addiction
(FA)
report
on
dietary
intake
variables.
The
present
study
comprised
a
three‐arm
randomised
controlled
trial
in
adults
with
symptoms
of
FA.
aim
was
to
evaluate
intake,
sleep
and
physical
activity
resulting
from
dietitian‐led
telehealth
intervention
at
3
months.
Methods
Adults
≥3
FA
body
mass
index
>
18.5
kg/m
2
were
recruited.
Dietary
including
energy,
nutrients
diet
quality
assessed
by
validated
frequency
questionnaire
addition
(total
min)
compared
between
groups
over
time.
Personalised
goals
set
participants
examined
determine
whether
improvements
percent
energy
core
non‐core
foods
reported.
Results
active
group
superior
the
passive
control
(6.4%/day
[95%
confidence
interval
(CI)
−0.0
12.9],
p
=
0.049),
(−6.4%/day
CI
−12.9
0.0],
sweetened
drinks
(−1.7%/day
−2.9
−0.4],
0.013),
takeaway
(−2.3%/day
−4.5
−0.1],
0.045)
sodium
(−478
mg/day
−765
−191
mg],
0.001).
Conclusions
A
Australian
found
significant
Setting
personalised
around
nutrition
eating
behaviours
beneficial
lifestyle
change.
INNOSC Theranostics and Pharmacological Sciences,
Journal Year:
2024,
Volume and Issue:
7(2), P. 1472 - 1472
Published: April 30, 2024
The
Carter
Center
has
estimated
that
the
addiction
crisis
in
United
States
(US),
if
continues
to
worsen
at
same
rate,
may
cost
country
approximately
16
trillion
dollars
by
2030.
In
recent
years,
well-being
of
youth
been
compromised
not
only
coronavirus
disease
2019
pandemic
but
also
alarming
global
opioid
crisis,
particularly
US.
Each
year,
deadly
drugs
claim
hundreds
thousands
lives,
contributing
an
ever-rising
death
toll.
addition,
maternal
usage
opioids
and
other
during
pregnancy
could
compromise
neurodevelopment
children.
A
high
rate
DNA
polymorphic
antecedents
compounds
occurrence
epigenetic
insults
involving
methylation
specific
essential
genes
related
normal
brain
function.
These
genetic
antecedent
affect
healthy
mRNA
transcription,
leading
a
loss
proteins
required
for
development
function
youth.
Myelination
frontal
cortex,
process
known
extend
until
late
20s,
delays
proficient
executive
decision-making
abilities.
Understanding
this
delay
development,
along
with
presence
potential
high-risk
variants
or
alleles
generational
epigenetics,
provides
clear
rationale
embracing
Brain
Research
Commission’s
suggestion
mimic
fitness
programs
adaptable
health
check
(BHC).
Implementing
BHC
within
educational
systems
US
countries
serve
as
effective
initiative
proactive
therapies
aimed
reducing
juvenile
mental
problems
eventually
criminal
activities,
addiction,
behaviors
associated
reward
deficiency
syndrome.
BMJ Open,
Journal Year:
2023,
Volume and Issue:
13(6), P. e064151 - e064151
Published: June 1, 2023
Introduction
Approximately
15%–20%
of
the
adult
population
self-report
symptoms
addictive
eating.
There
are
currently
limited
options
for
management.
Motivational
interviewing-based
interventions,
containing
personalised
coping
skills
training,
have
been
found
to
be
effective
behaviour
change
in
disorders
(eg,
alcohol).
This
project
builds
upon
foundations
an
eating
feasibility
study
previously
conducted
and
co-design
process
involving
consumers.
The
primary
aim
this
is
examine
efficacy
a
telehealth
intervention
targeting
Australian
adults
compared
with
passive
control
groups.
Methods
analysis
three-arm
randomised
controlled
trial
will
recruit
participants
18–85
years,
endorsing
≥3
on
Yale
Food
Addiction
Scale
(YFAS)
2.0,
body
mass
index
>18.5
kg/m
2
.
Addictive
assessed
at
baseline
(pre-intervention),
3
months
(post-intervention)
6
months.
Other
outcomes
include
dietary
intake
quality,
depression,
anxiety,
stress,
quality
life,
physical
activity
sleep
hygiene.
Using
multicomponent
clinician-led
approach,
active
consists
five
sessions
(15–45
min
each)
delivered
by
dietitian
over
uses
feedback,
skill-building
exercises,
reflective
activities
goal
setting.
Participants
provided
workbook
website
access.
group
receives
via
self-guided
approach
access
(no
telehealth).
written
feedback
advised
follow
their
usual
pattern
offered
after
endpoint
YFAS
symptom
scores
A
cost–consequence
determine
costs
alongside
mean
outcomes.
Ethics
dissemination
Human
Research
Committee
University
Newcastle,
Australia
approval
(H-2021-0100).
Findings
disseminated
publication
peer-reviewed
journals,
conference
presentations,
community
presentations
student
theses.
Trial
registration
number
New
Zealand
Clinical
Trials
Registry
(ACTRN12621001079831).
Journal of Eating Disorders,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: June 9, 2024
Abstract
Background
Weight
suppression
has
been
defined
as
diet-induced
weight
loss,
traditionally
operationalized
the
difference
between
one’s
highest
and
current
weight.
This
concept
studied
in
context
of
eating
disorders,
but
its
value
predicting
treatment
outcomes
inconsistent,
which
may
be
partially
attributed
to
calculation.
Method
The
study
operationalizes
a
novel
score,
reflecting
midpoint
lowest
adult
weights
among
adults
(N
=
287,
ages
21–75,
73.9%
women)
seeking
outpatient
for
disordered
eating.
report
compared
traditional
calculation
score
simulated
dataset
model
their
differential
distributions.
Next,
we
analyzed
shared
distinct
clinical
correlates
versus
using
intake
data.
Results
was
significantly
associated
with
meeting
criteria
both
disorders
ultra-processed
food
addiction
more
sensitive
detecting
clinically
relevant
disorder
symptomatology.
However,
(vs.
suppression)
fewer
symptoms.
Conclusion
particularly
those
addiction,
relevance
individual
Consideration
future
research
on
behaviors
should
extend
beyond
just
diagnosed
disorders.