The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106799 - 106799

Published: May 19, 2023

Depression is the most prevalent mental disorder in world associated with huge socio-economic consequences. While depressive-related symptoms are well known, molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) emerging as a key regulator of central nervous system homeostasis by exerting fundamental immune metabolic functions. In turn, brain influences intestinal microbial composition through neuroendocrine signals, within so-called microbiota-brain axis. balance this bidirectional crosstalk important to ensure neurogenesis, preserve integrity blood-brain barrier avoid neuroinflammation. Conversely, dysbiosis permeability negatively affect development, behavior, cognition. Furthermore, although not fully defined yet, changes GM depressed patients reported influence pharmacokinetics common antidepressants affecting their absorption, metabolism, activity. Similarly, neuropsychiatric drugs may shape turn an impact on efficacy toxicity pharmacological intervention itself. Consequently, strategies aimed at re-establishing correct homeostatic (i.e., prebiotics, probiotics, fecal transplantation, dietary interventions) represent innovative approach improve pharmacotherapy depression. Among these, probiotics Mediterranean diet, alone or combination standard care, hold promise for clinical application. Therefore, disclosure intricate network between depression will give precious insights diagnostic therapeutic approaches towards depression, profound implications drug development practice.

Language: Английский

---

Association between diet quality scores and risk of overweight and obesity in children and adolescents

BMC Pediatrics, Journal Year: 2023, Volume and Issue: 23(1)

Published: April 13, 2023

This study examined the associations of diet quality assessed by Healthy Eating Index 2015 (HEI-2015), Alternative 2010 (AHEI-2010), Mediterranean Diet (MedDiet) and overweight/obesity in children adolescents.This cross-sectional used data participants aged 2-19 years from National Health Nutrition Examination Survey (NHANES) 2005-2018. The weighted logistic regression model was adopted to explore association between scores overweight, obesity adolescents. Subgroup analysis also performed based on sex.A total 9,724 were included group (2-11 old), 5,934 adolescent (12-19 old). All divided into BMI-for-age: underweight normal, overweight groups. After adjusting for age, race, poverty-income ratio, maternal smoking during pregnancy energy, HEI-2015 MedDiet related risk children, only remained associated with a decreased children. adolescents, respectively, after sex, cotinine, energy physical activity. similar results male found.Higher lower obesity, particularly higher

Language: Английский

---

Sleep disorder, Mediterranean diet, and all-cause and cause-specific mortality: a prospective cohort study

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: May 18, 2023

There is a bidirectional effect between sleep disorders and Mediterranean diet (MED), but the joint of MED on mortality unclear. The aim this study was to investigate whether there synergistic adherence all-cause cause-specific mortality.The included 23,212 individuals in National Health Nutrition Examination Survey (NHANES) from 2005 2014. A 9-point evaluation score, alternative (aMED) index used assess MED. Sleep disorder hours were assessed by structured questionnaires. Cox regression models relationship disorders, aMED mortality, (cardiovascular-related death, cancer-related death). interaction with further assessed.Results showed that participants lower presence had significantly higher risk cardiovascular-related (HR, 2.16, 95% CI, 1.49-3.13, P < 0.0001; HR, 2.68, 1.58-4.54, = 0.0003). significant found cardiovascular (p for 0.033). No existed 0.184) 0.955).Poorer synergistically increased long-term NHANES population.

Language: Английский

---

The moderating effect of alternate Mediterranean diet on the association between sedentary behavior and insomnia in postmenopausal women

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

The study aimed to explore the moderating role of alternate Mediterranean diet (aMED) adherence on association between sedentary behavior and insomnia symptoms in postmenopausal women. Data regarding women were obtained for this cross-sectional from National Health Nutrition Examination Survey (NHANES) 2005-2008. Sedentary assessed using questionnaire. aMED was evaluated according 24-h dietary recalls. Weighted univariate logistic regression models utilized screen potential covariates. relationship behavior, adherence, explored weighted multivariate models. All results expressed as odds ratios (ORs) 95% confidence intervals (CIs). A total 1,793 included final analysis. Of them, 643 (37.56%) reported experiencing symptoms. Among women, time >8 h associated with (OR = 1.41, CI 1.01-1.96), prolonged nocturnal awakening 1.38, 1.06-1.79), undesired early morning 1.59, 1.09-2.30). No observed 1.05, CI: 0.77-1.44). lower aMED, higher those ≥8 1.63, 1.02-2.62). Similarly, participants low also 1.90, 1.27-2.83) 1.85, 1.09-3.16). Adherence modulates Interventions targeting patterns may improve sleep quality overall health

Language: Английский

---

Association between Healthy Eating Index-2020, alternative Mediterranean Diet scores, and gastrointestinal cancer risk in NHANES 2005–2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Diet quality is closely related to the occurrence of gastrointestinal (GI) cancers; however, few studies have investigated association between Healthy Eating Index (HEI-2020) and alternative Mediterranean diet (aMED) scores GI cancers. This study aims assess HEI-2020, aMED Information from a total 26,320 participants was included in National Health Nutrition Examination Survey (NHANES). In our sub-analysis, we focused on with complete dietary health data, specifically assessing relationship cancers outcomes. The 24-hour recall questionnaire used collect participants' average intake. Diagnoses were based self-reported medical history confirmed through physician interviews or linked cancer registry ensuring diagnostic reliability. Logistic regression models, restricted cubic splines (RCS), subgroup analysis, interaction methods employed fully evaluate associations scores, Mediation analysis also conducted identify potential mediators this relationship. Even after adjusting for confounders, high adherence HEI-2020-2020 significantly associated reduced risk Compared lowest tertile highest had 30% (OR 0.70, 95% CI 0.50 0.98, p = 0.037). 37% 0.63, 0.44 0.92, 0.014). RCS indicated that both HEI-2020 no significant non-linear observed. primary findings confirm higher lower These results suggest maintaining high-quality may play crucial role prevention management these Further research needed elucidate mechanisms effects healthy diets

Language: Английский

---

Associations of cMIND Diet with depressive and anxiety symptoms among old people in China: a nationwide study

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(3)

Published: March 12, 2025

Language: Английский

---

Correlation of cognitive impairment with Mediterranean diet and mortality: a prospective cohort study

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 9, 2025

Long-term adherence to the Mediterranean Diet has been shown improve cognitive function in patients. However, there is a lack of evidence regarding impact diet and impairment on long-term mortality outcomes. This study aims explore whether an interaction between degree The included 2,520 participants from National Health Nutrition Examination Survey (NHANES) conducted 2011 2014. was assessed using 9-point alternative index (aMED index). Cognitive Consortium Establish Registry for Alzheimer's disease (CERAD), Animal Fluency Test (AFT), Digital Symbol Substitution (DSST). By accessing public records Death Index (NDI), NHANES participants' information linked death certificate determine causes during follow-up period, up December 31, 2019, with specified according ICD-10. Participants were categorized based median aMED score into low (scores 0-3), moderate (score 4), high 5-9) groups. by calculating arithmetic mean standardized scores (Z-scores) each test. below first quartile considered have impairment. Cox proportional hazards regression models used assess relationship impairment, aMED, all-cause cardiovascular Additionally, these outcomes evaluated. participants, 481 deaths which 129 (26.8%) cardiovascular-related. population 4, 632 individuals (25.1%) A higher associated reduced risk cardiovascular-related (HR, 0.65; 95% CI, 0.52-0.81, p < 0.001; HR, 0.73; 0.47-0.91, = 0.039). increased 1.78; 1.46-2.18, 1.80; 1.22-2.64, 0.003). Individuals both lower had risks mortality. Subgroup analysis indicates that only subgroup There increasing (p 0.028). concerning mortality, but not Among more significant

Language: Английский

---

Impact of Mediterranean diet on mortality in vertebral compression fracture patients

Arthritis Research & Therapy, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 16, 2025

Vertebral compression fractures (VCF) is a common fragility fracture with high mortality worldwide. The management and prevention of VCF start proper nutrition. Mediterranean diet (MD) rich in balanced nutrients has been shown to be beneficial for several chronic diseases. However, the association adherence (aMED) prognosis patients remains unclear. To explore between aMED all-cause cardiovascular disease (CVD)-cause morality patients. In present study, aged ≥ 40 years old measurement were extracted from National Health Nutrition Examination Survey (NHANES) 2013-2014. bone mineral density (BMD) dual-energy X-ray absorptiometry (DXA) was used diagnose VCF. We weighted univariable Cox proportional hazards model screen covariates related utilized multivariable models risk patients, described as hazard ratios (HRs) 95% confidence intervals (CIs). Subgroup analyses based on different complications further assessed association. A total 2,730 eligible included. Until 12 December 2019, 218 (7.99%) deaths documented. After adjusting all VCFs, we found (HR = 1.75, 95%CI: 1.13-2.73, P 0.041) CVD-cause 2.35, 1.12-4.91, 0.038); however, no significant or (all > 0.05). Compared without score 6, < 6 higher 2.27, 1.25-4.13, 0.025) 4.25, 1.64-11.06, 0.013). Our study also suggested that compared those 2.26, 1.22-4.17, 0.002) 3.31, 1.28-8.57, 0.018), this results may have moderating effect mortality. Subgroups analysis remain robust, especially dyslipidemia (HR: 2.49, 1.29-4.80, 0.009), CVD 3.48, 1.56-7.74, 0.001) CKD 3.64, 1.50-8.78, 0.001). research supports importance MD potentially healthy eating pattern.

Language: Английский

---

Effects of dietary patterns on the all‐cause mortality and cardiovascular disease mortality in patients with hypertension: A cohort study based on the NHANES database

Clinical Cardiology, Journal Year: 2023, Volume and Issue: 46(11), P. 1353 - 1370

Published: Aug. 16, 2023

Hypertension (HTN) patients have higher risk of all-cause and cardiovascular disease (CVD)-specific mortality. Dietary patterns been reported related to the mortality, but their roles in HTN is unclear.To explore relationships between different dietary all-cause/CVD-specific mortality provide guidance for patients' prognosis improvement.Data 27 618 were extracted from National Health Nutrition Examination Survey (NHANES) database this retrospective cohort study. The associations Healthy Eating Index (HEI)-2015, Alternate (AHEI)-2010, Approaches Stop (DASH), Mediterranean (MED) diet CVD-specific explored using univariate multivariate Cox regression analyses with hazard ratios (HRs) 95% confidence intervals (CIs). Subgroup age, gender, body mass index, comorbidity also performed.The median follow-up time was 83 months. A total 3462 died 1064 due CVD. After adjusting covariates, we found that high adherence AHEI-2010 (HR = 0.84 all-cause; HR 0.72 CVD), MED 0.77 CVD) associated decreased risks both In who aged ≥65 years old, normal/overweight, without complications, different.High scores may be HTN.

Language: Английский

---

Comparison of Associations between MIND and Mediterranean Diet Scores with Patient-Reported Outcomes in Parkinson’s Disease

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 5185 - 5185

Published: Dec. 6, 2022

The Mediterranean (MEDI) and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets have been associated with a reduced risk of Parkinson’s disease (PD) diagnosis. However, studies evaluating whether these are progression in those patients already diagnosed lacking. objective this study was to evaluate MIND MEDI scores were improved patient-reported outcomes. Additionally, we sought explore which questions on the scales more strongly correlated PD symptom severity. Data obtained from ongoing Modifiable Variables Parkinsonism study, using outcomes (PRO-PD) as primary measure severity, diet score. After adjusting age, gender, income, years since diagnosis, each 1-point increase scores, PRO-PD 52.9 points lower (95%CI: −66.4, −39.4; p < 0.001) 25.6 −37.2, −14.0; 0.001), respectively (N = 1205). This suggests fewer symptoms over time, point being twice strong reducing Future dietary intervention trials should consider therapeutic strategy improving long-term

Language: Английский

---