The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder

Journal of Neural Transmission, Journal Year: 2023, Volume and Issue: 130(8), P. 1057 - 1076

Published: May 5, 2023

Language: Английский

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The global, regional, and national late-life depression burden and trends from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105758 - 105758

Published: Jan. 14, 2025

Language: Английский

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Ginkgo biloba L. leaf extract (EGb 761) alleviates reserpine-induced depression-like symptoms in aged rats by enhancing serotonin/norepinephrine levels and reducing oxidative/nitrosative stress

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Along with accelerated aging, the prevalence of late-life depression (LLD) exacerbates. Older people are more vulnerable to adverse effects antidepressants than young. Therefore, creating from medicinal herbs that effective and safer is inevitable. Ginkgo biloba L. leaf extract (EGb761) broadly applied for treating various neuronal dysfunctions. The present study aimed evaluate ameliorative antidepressant EGb761 against reserpine (RES)-induced like symptoms associated comorbidities in aged female rats. Besides, it compared its efficacy duloxetine (DULX), offering a comprehensive understanding therapeutic potential EGb 761. Rats grouped into control group, 761-H RES plus either 761-L, 761-H, or DULX groups. 761 were evaluated through series behavioral tests, measurement biochemical markers, performing histopathology immunohistochemical analyses. significantly attenuated deficits open field test reduced immobility time forced swimming test. Moreover, exerted antidepressant-like actions by ameliorating neurotransmitter imbalances, restoring redox homeostasis cortical region. Also, increased level ATP, diminished DNA fragmentation, decreased caspase-3 immunoreactivity synaptophysin cerebral cortex, besides enhanced histological architecture this Overall, has manage LLD focus on role both serotonergic noradrenergic systems mediating these effects, alongside impact oxidative/nitrosative stress.

Language: Английский

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The mediating effects of sleep quality in the relationship between loneliness and depression among middle-aged and older adults

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 24, 2025

Loneliness has long been recognized as a key predictor of depression in older adults, and both are related to sleep quality. However, this day, less is known about whether quality mediates their relationship. This study aimed examine the relationship between loneliness, quality, depressive symptoms, further explore loneliness symptoms. Using random cluster sampling method, 1016 permanent residents aged 45 above Ankang City, Shaanxi Province were selected. The symptoms was analyzed using binary logistic regression, mediating role PROCESS macro SPSS 25.0 software. average age participants 60.39 ± 8.50. Regression analyses showed that individuals with (OR 7.161, 95%CI: 4.889–10.490, P < 0.001) those poor 4.777, 3.301–6.913, more likely experience than without good also found significant effect [effect value = 0.066, bootstrap 95% CI: (0.037, 0.093)] an size 13.31%. may lead reduced individuals, which turn or exacerbate Therefore, highlights importance assessing improving lonely people.

Language: Английский

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Global, regional, and national burden of geriatric depressive disorders in people aged 60 years and older: an analysis of the Global Burden of Disease Study 2021

Annals of General Psychiatry, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 5, 2025

Late-life depression (LLD) stands as a prevalent mental health issue among older adults, frequently intertwined with cardiovascular and cerebrovascular diseases well cognitive decline. The occurrence of LLD in the who often present multiple aging-related conditions, results this disorder being overlooked. However, astronomical treatment costs considerable societal burden associated necessitate urgent sustained attention. Utilizing data from Global Burden Diseases, Injuries, Risk Factors Study 2021 (GBD 2021), we extracted incidence rates disability-adjusted life years (DALYs) individuals aged 60 older. underwent rigorous evaluation through application age-period-cohort models, inequality concentration index, frontier analysis. From 1990 to 2021, global increase was observed both age-standardized rate (ASIR) DALY LLD. Specifically, ASIR ascended by 0.01 per 100,000 annually, while rose 0.03 each year. Notably, statistically significant inverse relationship identified between Socio-demographic Index (SDI) (p < 0.001). Additionally, notable linear correlation discerned death (ASDR) SDI, albeit without discernible downward trend According Estimated average percentage change (EAPC) five SDI districts showed no or decrease. Globally, an upward high middle low-middle regions, high-middle region, decrease low region. In analysis, found that increased age regions compared were opposite regional characteristics. period effect analysis revealed irrespective gender, trends remained relatively unchanged globally 1992 2021. As levels rose, SDI-adjusted disparities tended stabilize. A comparative highlighted relative decline inequalities. This comprehensive assessment disease population underscores accomplishments simultaneously emphasizing areas requiring ongoing vigilance. context relentless growth aging, favorable downturns reflect tangible advancements managing

Language: Английский

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Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential

Dialogues in Clinical Neuroscience, Journal Year: 2025, Volume and Issue: 27(1), P. 98 - 111

Published: May 6, 2025

The global population is ageing rapidly, with the number of individuals aged 60 and older reaching 1 billion in 2019 expected to double by 2050. As people age, neuropsychological health often deteriorates, leading a higher prevalence age-related depression. Symptoms may include anxiety, apathy, mood instability, sadness, and, severe cases, suicidal thoughts. Depression elderly widespread concern, conventional treatments such as antidepressants are limited side effects, reduced efficacy, complications arising from polypharmacy. In response, novel therapeutic approaches being explored, including psychedelic interventions. Recent clinical preclinical studies suggest that psychedelics could offer promising treatment for major depressive disorder (MDD) adults. These compounds, known their profound neurobiological have gained attention potential address depression where traditional therapies fall short. This review aims examine promise substances, focusing on those show treating MDD elderly. We also explore underlying mechanisms through which exert effects highlight models support use. Finally, we safety considerations propose strategies enhance effectiveness future trials, offering new hope disorders.

Language: Английский

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A scoping review of functional near-infrared spectroscopy biomarkers in late-life depression: Depressive symptoms, cognitive functioning, and social functioning

Psychiatry Research Neuroimaging, Journal Year: 2024, Volume and Issue: 341, P. 111810 - 111810

Published: March 26, 2024

Language: Английский

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Association between Dietary Antioxidant Capacity in Midlife and Depressive Symptoms in Late Life: The Singapore Chinese Health Study

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 576 - 576

Published: May 8, 2024

Preclinical and limited epidemiological studies suggest that oxidative stress may be implicated in geriatric depression. Our study investigated the association between midlife dietary total antioxidant capacity (TAC) depressive symptoms late life among 13,712 participants a population-based cohort of Chinese Singapore. At baseline (1993-1998), intake antioxidants from diet supplements at mean age 52.4 years was estimated using validated food frequency questionnaire to derive two TAC indices vitamins C E, carotenoids flavonoids: Comprehensive Dietary Antioxidant Index (CDAI) Vitamin Equivalent Capacity (VCEAC). follow-up 3 (2014-2016), when were 72.5 years, assessed Geriatric Depression Scale, depression, defined as having ≥5 symptoms, presented 3173 (23.1%) participants. Both CDAI VCEAC inversely associated with odds stepwise manner: OR (95% CI) comparing extreme quartiles 0.73 (0.64-0.83;

Language: Английский

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Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links Through Daily Activity Patterns and Brain Connectivity Analysis

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(7), P. 639 - 649

Published: April 13, 2024

Better understanding apathy in late-life depression (LLD) would help predicting poor prognosis of the disease such as dementia. Actimetry provides an objective and ecological measure from patients' daily motor activity. We aimed to determine if patterns activity were associated with brain connectivity networks underlying goal-directed behaviors. Resting-state functional MRI diffusion collected 38 non-demented LLD subjects. Apathy was evaluated using diagnostic criteria for apathy, evaluation scale (AES) motivation index (AMI). Functional principal components (fPC) derived actimetry recordings 72 hours. Associations between fPC estimated by linear regression. Subnetworks whose significantly identified via threshold-free network-based statistics. The relationship microstructure metrics along fibers tensor imaging a multicompartment model called neurite orientation dispersion density tractometry. found two apathy: mean diurnal activity, negatively AES, early chronotype, AMI. Mean increased default-mode, cingulo-opercular frontoparietal networks, while chronotype more heterogenous pattern same networks. did not find significant associations microstructural fPCs. Our findings suggest that could provide indirect ambulatory measures LLD, modified

Language: Английский

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Choice intention for the national volume-based procurement drug and its associated factors: a cross-sectional study on patients with late-life depression in China

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 27, 2024

The national volume-based procurement (NVBP) policy has significantly decreased prices and increased the accessibility of NVBP drugs. Nevertheless, issues such as heightened adverse reactions suboptimal efficacy have arisen. Concerns regarding quality low-cost medications absence long-term research been widely recognized. This led to caution among patients with late-life depression (LLD) due their delicate health severity condition. study evaluated choice intention for drugs associated factors in older LLD. A weighted sample 408 participants between December 2022 March 2023 were included. Data collected via face-to-face interviews questionnaires. To identify significant intention, a multilevel logistic regression model was employed. Over half (53.68%) LLD intended choose Associated included self-assessed poor economy, higher out-of-pocket expenses, monthly household income exceeding CNY 6000, other non-communicable chronic diseases, ordinary registration, urban employee medical insurance, no requirements brand-name drugs, after using rejection physicians' recommendation interaction effect real economic condition economy influences Among 124 75 showed use In these patients, age, insurance reimbursement, brand awareness intention. Economic factors, physical conditions, needs, physician recommendations influenced can be improved by strengthening physician-patient communication, increasing scope proportion improving substitution studies, conducting post-marketing re-evaluations

Language: Английский

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