Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1352 - 1352

Published: April 30, 2024

In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed examine the efficacy psychobiotics—probiotics beneficial mental health via gut–brain axis—in adults with psychiatric and cognitive disorders. Out 51 studies involving 3353 patients where half received psychobiotics, there notably high measurement effectiveness specifically in treatment depression symptoms. Most participants were older female, treatments commonly utilizing strains Lactobacillus Bifidobacteria over periods ranging 4 24 weeks. Although general agreement on variability approaches presentations limits comparability generalization findings. This underscores need for more personalized optimization deeper investigation into mechanisms through which psychobiotics act. The research corroborates therapeutic potential represents progress management

Language: Английский

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Human Gut Microbiota for Diagnosis and Treatment of Depression

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5782 - 5782

Published: May 26, 2024

Nowadays, depressive disorder is spreading rapidly all over the world. Therefore, attention to studies of pathogenesis disease in order find novel ways early diagnosis and treatment increasing among scientific medical communities. Special drawn a biomarker therapeutic strategy through microbiota–gut–brain axis. It known that symbiotic interactions between gut microbes host can affect mental health. The review analyzes mechanisms action microbiota on pathophysiology depression. possibility using knowledge about taxonomic composition metabolic profile patients with depression select gene compositions (metagenomic signature) as biomarkers evaluated. use silico technologies (machine learning) for based given. Alternative approaches are being considered by balancing microbial dietary modifications additives, namely probiotics, postbiotics (including vesicles) prebiotics psychobiotics, fecal transplantation. bacterium Faecalibacterium prausnitzii under consideration promising new-generation probiotic auxiliary diagnostic analysis conducted this may be useful clinical practice pharmacology.

Language: Английский

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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of gut microbiome as a tractable therapeutic target for gastrointestinal, mental brain health. Current research is still marked by many open questions that undermine widespread application humans. For example, lack mechanistic understanding probiotic effects means it remains unclear why even apparently closely related strains exhibit different in vivo. live microbial psychobiotics, consensus on their adjunct treatments conventional neuromodulators, use unmedicated populations or at‐risk cohorts with sub‐clinical symptomatology warranted. This missing information both sides equation when treating central nervous system (CNS) conditions makes psychobiotic challenging, especially compared other pharmaceutical functional food approaches. Expediting transition from positive preclinical data proven benefits humans includes interpreting promises pitfalls animal behavioural assays, well navigating mechanism‐informed decision making select right microbe(s) job. In this review, we consider how these decisions can be supported light accrued range clinical studies across healthy, pathological study populations, where specific have been evaluated context gastrointestinal physiology, function behaviour. Examples successful, partial unsuccessful translation bench bedside are considered. We also discuss developments silico analyses enhanced our moved towards pinpointing host–microbe interactions most important optimal gut–brain function. Combining assays vitro ex vivo domains incorporating model organisms prime discovery pipelines promising rationally selected candidates.

Language: Английский

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Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 126 - 147

Published: March 1, 2024

Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.

Language: Английский

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Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2260 - 2260

Published: July 13, 2024

We conducted a 12-week randomized double-blind placebo-controlled clinical trial to investigate the potential impact of Bifidobacterium bifidum (Bf-688) supplementation on attention-deficit/hyperactivity disorder (ADHD). Children with ADHD who were already receiving stable dose methylphenidate (MPH) treatment enrolled and randomly assigned two groups: one add-on Bf-688 (daily bacterial count 5 × 109 CFUs) (n = 51) other placebo 51). All participants underwent assessments using Conners’ Continuous Performance Test (CPT) Auditory Attention (CATA). Additionally, fecal samples collected at beginning (week 0) endpoint 12). Remarkably, group supplementation, but not group, exhibited significant improvements in omission errors CPT as well Hit reaction time both CATA. Gut microbiome analysis revealed increase Firmicutes Bacteroidetes ratio (F/B ratio) only group. Furthermore, we identified negative correlations between N-Glycan biosynthesis Our results demonstrate that probiotic supplement can enhance neuropsychological performance children ADHD, possibly by altering composition gut microbiota, ultimately leading reduced biosynthesis.

Language: Английский

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Psychobiotics for Mitigation of Neuro‐Degenerative Diseases: Recent Advancements

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 68(13)

Published: Sept. 15, 2023

Abstract Ageing is inevitable and poses a universal challenge for all living organisms, including humans. The human body experiences rapid cell division metabolism until approximately 25 years of age, after which the accumulation metabolic by‐products cellular damage leads to age‐related diseases. Neurodegenerative diseases are concern due their irreversible nature, lack effective treatment, impact on society economy. Researchers interested in finding drugs that can effectively alleviate ageing without side‐effects. Psychobiotics novel class probiotic organisms prebiotic interventions confer mental health benefits host when taken appropriately. Psychobiotic strains affect functions related central nervous system (CNS) behaviors mediated by Gut‐Brain‐Axis (GBA) through various pathways. There an increasing interest researchers these microbial‐based psychopharmaceuticals. have been reported reduce neuronal ageing, inflammation, oxidative stress, cortisol levels; increase synaptic plasticity levels neurotransmitters antioxidants. present review focuses manifestation elderly neurodegenerative disorders, particularly Alzheimer's disease (AD), Parkinson's (PD), depression, current status potential alleviation psychobiotic interventions, highlighting possible mechanisms action.

Language: Английский

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Evaluating the scientific evidence to support mental health and well-being claims made on probiotic products

Nutrition and Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Background Increasing interest in probiotics for mental health has led to products marketed consumers claiming psychological benefits. This study aimed identify claims on probiotic supplements and provide a narrative review of the scientific evidence support these claims. Methods Probiotic with product label were identified. A search literature was performed using Google Scholar, PubMed Cochrane Central Register Controlled Trials. Studies included if primary outcome or biomarker health, they investigated exact strain combination strains as present product, trial conducted either humans animals. Included studies assessed risk bias. Results Fourteen identified containing five different combinations. Eighteen relevant investigating outcomes met inclusion criteria. Ten same provided made. Statistically significant results not universally all products. Conclusion The amount quality benefits made is variable. need grading system facilitate informed consumer decision-making when choosing supplement health.

Language: Английский

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Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Language: Английский

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Microbial diversity and fitness in the gut–brain axis: influences on developmental risk for Alzheimer’s disease

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 10, 2025

The gut-brain axis (GBA) denotes the dynamic and bidirectional communication system that connects gastrointestinal tract central nervous (CNS). This review explored this axis, focusing on role of microbial diversity fitness in maintaining health preventing neurodegeneration, particularly Alzheimer's disease (AD). Gut dysbiosis, characterized by imbalance populations beneficial harmful bacteria, has been associated with increased systemic inflammation, neuroinflammation, progression AD through pathogenic mechanisms involving amyloid deposition, tauopathy, blood-brain barrier (BBB) permeability. Emerging evidence highlighted therapeutic potential probiotics, dietary interventions, intermittent fasting restoring balance, reducing minimizing neurodegenerative risks. Probiotics synbiotics are promising helping improve cognitive function metabolic health, while patterns like Mediterranean diet were linked to decreased neuroinflammation enhanced communication. Despite significant advancement, further research is needed elucidate specific strains, metabolites, influencing brain health. Future studies employing longitudinal designs advanced omics technologies essential developing targeted microbiome-based therapies for managing AD-related disorders.

Language: Английский

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Intestinal dysbiosis leads to the reduction in neurochemical production in Parkinson’s disease (PD)

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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