Frontiers in Psychiatry,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 4, 2024
Premenstrual
dysphoric
disorder
(PMDD),
a
more
severe
manifestation
of
premenstrual
syndrome
(PMS),
is
characterized
by
emotional,
behavioral,
and
physical
symptoms
that
begin
in
the
mid-to-late
luteal
phase
menstrual
cycle,
when
estradiol
progesterone
levels
precipitously
decline,
remit
after
onset
menses.
Remotely
monitoring
physiologic
variables
associated
with
PMDD
depression
symptoms,
such
as
heart
rate
variability
(HRV),
sleep,
activity,
holds
promise
for
developing
an
affective
state
prediction
model.
Switching
into
out
depressive
states
increased
risk
suicide,
therefore,
periods
switching
may
help
mitigate
risk.
Management
other
chronic
health
conditions,
including
cardiovascular
disease
diabetes,
has
benefited
from
remote
digital
paradigms
enable
patients
physicians
to
monitor
real-time
make
behavioral
medication
adjustments.
condition
benefit
real-time,
monitoring.
However,
clinical
practice
not
advanced
real-time.
Identifying
can
detect
within-person
change
facilitate
later
research
on
timely
efficacious
interventions
individuals
PMDD.
This
narrative
review
synthesizes
current
literature
physiological
correlates
suitable
during
cycle.
The
reliable
measurement
existing
wearable
technology,
suggests
potential
paradigm
disorders.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 20, 2025
Female
gonadal
hormones,
particularly
estrogen
and
progesterone,
are
not
only
central
to
reproductive
health
but
also
play
a
crucial
role
in
regulating
mood,
cognition,
overall
brain
health.
These
hormones
have
significant
impact
on
the
nervous
system,
influencing
key
processes
such
as
neurotransmission,
neuroplasticity,
development.
Increasing
evidence
shows
that
hormonal
fluctuations
contribute
onset
progression
of
mental
disorders
disproportionately
affect
women,
premenstrual
dysphoric
disorder
(PMDD),
postnatal
depression
(PND),
menopausal
depression.
This
paper
explores
current
regarding
neurobiological
effects
female
discusses
therapeutic
approaches
conditions
PMDD,
PND,
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 28, 2025
Premenstrual
syndrome
(PMS)
and
premenstrual
dysphoric
disorder
(PMDD)
are
prevalent
emotional
disorders
in
females,
characterized
by
cyclic
variations
physiological
stress
responses
symptoms
that
correspond
with
the
menstrual
cycle.
Despite
extensive
research,
underlying
causes
of
these
remain
elusive.
This
review
delves
into
neurobiological
mechanisms
connecting
stress-induced
neuroinflammation
PMS/PMDD.
Additionally,
it
traces
conceptual
development
historical
context
The
further
evaluates
clinical
evidence
on
association
between
PMS/PMDD
stress,
along
findings
from
both
animal
studies
link
to
inflammatory
processes.
pathways
which
may
play
a
role
pathogenesis
were
elucidated,
including
their
interactions
hypothalamic-pituitary-ovary
(HPO)
axis,
serotonin-kynurenine
(5-HT-KYN)
system,
GABAergic
brain-derived
neurotrophic
factor
(BDNF),
hypothalamic-pituitary-adrena(HPA)axis
and.
Future
research
is
encouraged
investigate
through
perspective
neuroinflammatory
responses.
Psychoneuroendocrinology,
Journal Year:
2024,
Volume and Issue:
166, P. 107081 - 107081
Published: May 13, 2024
Allopregnanolone
(ALLO)
is
a
metabolite
of
progesterone
and
neuroactive
steroid
hormone.
As
positive
allosteric
modulator
gamma-aminobutyric
acid
(GABA)
receptors,
ALLO
seems
to
have
antidepressant
anxiolytic
effects,
was
therefore
approved
as
specific
medication
for
the
treatment
postpartum
depression
in
2019.
Despite
growing
number
publications
investigating
levels,
results
on
biological
psychological
correlates
peripartum
period
remain
inconsistent,
possibly
due
methodological
challenges
regarding
measurement.
To
date,
however,
there
no
systematic
review
examining
correlates,
concentrations,
measuring
women.
The Journal of Steroid Biochemistry and Molecular Biology,
Journal Year:
2024,
Volume and Issue:
243, P. 106590 - 106590
Published: July 23, 2024
Neuroactive
steroids
(i.e.,
sex
steroid
hormones
and
neurosteroids)
are
important
physiological
regulators
of
nervous
function
potential
neuroprotective
agents
for
neurodegenerative
psychiatric
disorders.
Sex
is
an
component
such
effects.
However,
even
if
fluctuations
in
hormone
level
during
the
menstrual
cycle
associated
with
neuropathological
events
some
women,
neuroactive
pattern
brain
across
ovarian
has
been
poorly
explored.
Therefore,
we
assessed
levels
pregnenolone,
progesterone,
its
metabolites
dihydroprogesterone,
allopregnanolone
isoallopregnanolone),
dehydroepiandrosterone,
testosterone
dihydrotestosterone,
3α-diol
17β-estradiol)
rat
to
determine
whether
their
plasma
similar
those
occurring
central
hippocampus
cerebral
cortex)
peripheral
sciatic
nerve)
system.
Data
obtained
indicate
that
these
molecules
generally
does
not
fully
reflect
In
addition,
levels,
identical
between
two
regions
nerves.
Indeed,
exception
all
other
here
showed
peculiar
regional
differences
fluctuation
system
estrous
cycle.
These
observations
may
have
diagnostic
therapeutic
consequences
influenced
by
Psychopharmacology,
Journal Year:
2024,
Volume and Issue:
241(9), P. 1923 - 1935
Published: May 14, 2024
Clinical
and
preclinical
studies
have
demonstrated
that
estradiol
withdrawal
after
delivery
is
one
of
important
factors
involved
in
the
pathogenesis
postpartum
depression
(PPD).
The
infralimbic
cortex
(IL)
related
to
anxiety
mood
disorders.
Whether
IL
neurons
mediate
PPD
still
unclear.
