medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 4, 2023
Abstract
Background
Studies
in
old
adults
showed
bidirectional
interconnections
between
amnestic
mild
cognitive
impairment
(aMCI)
and
affective
symptoms
that
adverse
childhood
experiences
(ACE)
may
affect
both
factors.
Nevertheless,
these
associations
be
confined
to
older
with
clinical
depression.
Aims
To
delineate
the
relationship
of
aMCI
without
major
depression
(MDD)
or
dysfunctions
activities
daily
living
(ADL).
Methods
This
case-control
study
recruited
61
participants
(diagnosed
using
Petersen’s
criteria)
59
excluded
subjects
MDD
ADL
dysfunctions.
Results
We
uncovered
2
distinct
dimensions,
namely
distress
age
(DSOA)
comprising
anxiety,
depression,
perceived
stress
neuroticism
scores,
(mCoDy)
episodic
memory
test
total
Mini-Mental
State
Examination
(MMSE)
Montreal
Cognitive
Assessment
(MoCA)
scores.
A
large
part
variance
(37.9%)
DSOA
scores
was
explained
by
ACE,
negative
life
events
(health
financial
problems),
a
subjective
feeling
decline,
education
(all
positively).
While
ACE
NLE
have
highly
significant
impact
on
DSOA,
they
are
not
associated
mCoDy
Cluster
analysis
diagnosis
is
overinclusive
because
some
incorrectly
classified
as
aMCI.
Conclusions
The
clinicians
should
carefully
screen
for
after
excluding
MDD.
might
misinterpreted
Journal of Affective Disorders,
Journal Year:
2024,
Volume and Issue:
350, P. 728 - 740
Published: Jan. 21, 2024
The
binary
major
depressive
disorder
(MDD)
diagnosis
is
inadequate
and
should
never
be
used
in
research.
study's
objective
to
explicate
our
novel
precision
nomothetic
strategy
for
constructing
depression
models
based
on
adverse
childhood
experiences
(ACEs),
lifetime
current
phenome,
biomarker
(atherogenicity
indices)
scores.
This
study
assessed
recurrence
of
illness
(ROI:
namely
episodes
suicidal
behaviors),
behaviors
the
phenome
depression,
neuroticism,
dysthymia,
anxiety
disorders,
lipid
biomarkers
(including
ApoA,
ApoB,
free
cholesterol
cholesteryl
esters,
triglycerides,
high
density
lipoprotein
cholesterol)
67
normal
controls
66
MDD
patients.
We
computed
atherogenic
reverse
transport
indices.
were
able
extract
one
factor
from
a)
comprising
ROI,
traits
such
as
dysthymia
b)
acute
phase
(based
quality
life
scores).
PLS
analysis
showed
that
55.7
%
variance
+
was
explained
by
increased
atherogenicity,
neglect
sexual
abuse,
while
atherogenicity
partially
mediated
effects
neglect.
Cluster
generated
a
cluster
patients
with
dysmood
disorder,
which
externally
validated
characterized
scores
all
clinical
features.
outcome
not
represented
variable
(MDD
or
not),
but
rather
multiple
dimensional
biomarkers,
subclinical
traits,
including
behaviors.
Frontiers in Psychiatry,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 22, 2023
We
found
that
neuroticism
may
be
identified
as
a
subclinical
manifestation
of
the
phenome
depression,
comprising
depressive
and
anxiety
symptoms,
suicidal
behaviors.
Rumination
is
positively
associated
with
depression
mediate
effects
on
depression.
This
study
aimed
to
determine
whether
rumination
or
its
components,
including
brooding
reflection,
or,
alternatively,
both
are
manifestations
Psychology Research and Behavior Management,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 101 - 116
Published: Jan. 1, 2024
Background:
Studies
in
old
adults
showed
bidirectional
interconnections
between
amnestic
mild
cognitive
impairment
(aMCI)
and
affective
symptoms
that
adverse
childhood
experiences
(ACE)
may
affect
both
factors.
Nevertheless,
these
associations
be
confined
to
older
with
clinical
depression.
Aim:
To
delineate
the
relationship
of
aMCI
without
major
depression
(MDD)
or
dysfunctions
activities
daily
living
(ADL).
Methods:
This
case-control
study
recruited
61
participants
(diagnosed
using
Petersen's
criteria)
59
excluded
subjects
MDD
ADL
dysfunctions.
Results:
We
uncovered
2
distinct
dimensions,
namely
distress
age
(DSOA),
comprising
symptoms,
perceived
stress
neuroticism,
dysfunctions,
episodic
memory
test
scores,
total
Mini-Mental
State
Examination
(MMSE)
Montreal
Cognitive
Assessment
(MoCA)
scores.
A
large
part
variance
(37.9%)
DSOA
scores
was
explained
by
ACE,
negative
life
events
(health
financial
problems),
a
subjective
feeling
decline,
education
(all
positively).
ACE
NLE
have
highly
significant
impact
on
score
are
not
associated
its
severity.
Cluster
analysis
diagnosis
is
overinclusive
because
some
incorrectly
classified
as
aMCI.
Conclusion:
The
clinicians
should
carefully
screen
for
after
excluding
MDD.
might
misinterpreted
Keywords:
depression,
experiences,
impairments,
disorders,
events,
neurocognitive
deficits
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 5, 2024
Abstract
Background
Major
depressive
disorder
(MDD)
is
considered
to
be
a
neuroimmune
disorder.
However,
there
are
no
data
regarding
the
association
between
comprehensive
immune
profiles
and
their
interactions
with
metabolic
syndrome
(MetS)
in
predicting
neuroticism,
suicidal
behaviors,
severity
of
outpatient
MDD
(OMDD).
Methods
We
assayed
48
serum
cytokines,
chemokines,
growth
factors
using
multiplex
assay
67
healthy
controls
66
OMDD
patients.
Around
50%
control
participants
had
diagnosis
MetS.
Results
Ten
differentially
expressed
proteins
(DEPs)
were
upregulated
(i.e.,
CXCL12,
TNFB,
PDGF,
CCL11,
IL9,
IL4,
CCL5,
CCL2,
CCL4,
IL1RN),
indicating
an
immune,
defense
stress
response.
Six
DEPs
downregulated
(VEGFA,
IL12,
CCL3,
CSF1,
IL1B,
NGF),
lowered
neurogenesis
regulation
neuron
death.
Significant
MetS
caused
a)
substantial
increases
TNF
signaling,
upregulation
IL17,
TNF,
IL1RN;
b)
downregulation
VEGFA
FGF.
A
large
part
variance
neuroticism
(26.6%),
behaviors
(23.6%),
phenome
(31.4%)
was
predicted
by
immunological
TNFB
or
VEGFA.
Discussion
characterized
immunoneurotoxic
profile
which
partly
explains
phenome’s
severity.
Lowered
IL-10
increased
neurotoxicity
characteristics
other
depression
phenotypes,
including
severe
first-episode
inpatient
MDD.
The
presence
considerably
exacerbates
immunoneurotoxicity.
Consequently,
studies
should
always
performed
subjects
without
Asian Journal of Social Health and Behavior,
Journal Year:
2025,
Volume and Issue:
8(1), P. 21 - 28
Published: Jan. 1, 2025
Introduction:
This
study
delves
into
the
association
between
adverse
childhood
experiences
(ACEs)
and
development
of
health
issues
behavior
in
adolescents.
The
objective
is
to
refine
our
understanding
trajectory
problems
associated
with
ACE
exposure
among
this
demographic.
Methods:
Data
from
2022
round
Bangkok
Behavior
Surveillance
Survey
were
scrutinized
cross-sectional
study.
Participants,
comprising
5740
students
36
educational
institutions
Bangkok,
responded
an
online
questionnaire.
questionnaire,
consisting
15
items,
explored
various
ACEs.
Multiple
regression
analysis
was
employed
examine
relationship
levels
indicators.
Results:
Findings
revealed
that
78.1%
participants
reported
at
least
one
ACE,
a
higher
prevalence
females.
(0
[ref],
1,
2,
3,
4,
5+)
behavioral
indicators
compared
no
including
substance
use
(conventional
cigarettes
odds
ratio
[OR]
1.94–4.51,
e-cigarettes
OR
2.16–2.80,
alcohol
1.46–3.44,
marijuana
2.18–3.09,
Kratom
2.05–3.93,
illicit
drugs
2.61–3.01),
engagement
sexual
activity
1.55–3.26,
mental
concerns
(anxiety
OR:
2.39–10.11,
depression
1.98–14.26,
suicidal
thoughts
2.03–13.21,
self-harm
2.98–8.09,
stress
1.65–6.88).
Female
histories
exhibited
poorer
health,
whereas
male
demonstrated
propensity
for
abuse.
Conclusion:
underscores
compelling
correlation
spectrum
negative
effects
risky
behaviors
Those
reporting
five
or
more
exposures
heightened
vulnerability
conditions.
BMC Psychiatry,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 15, 2025
Significant
associations
exist
between
major
depressive
disorder
(MDD),
metabolic
syndrome
(MetS),
and
cardiovascular
disease,
potentially
attributable
to
heightened
atherogenicity.
This
study
aimed
ascertain
if
MDD,
depression
severity,
suicidal
behaviors,
neuroticism
associate
with
elevated
pro-atherogenic
indices
reduced
anti-atherogenic
indices,
including
a
reverse
cholesterol
transport
(RCT)
index.
comprised
34
healthy
controls
33
MDD
patients
without
MetS,
35
31
MetS.
It
assessed
total
(TC)
free
(FC),
high-density
lipoprotein
(HDLc),
low-density
(LDLc),
triglycerides
(TG),
apolipoprotein
(ApoA),
ApoB,
esterification
rate,
RCT
composite.
No
significant
lipids
were
seen
in
the
group
that
combined
individuals
In
devoid
of
is
significantly
correlated
(a)
FC,
TG,
Castelli
risk
index
1,
ApoB/ApoA,
(b)
diminished
HDLc,
ApoA,
there
are
notable
correlations
severity
depression,
tendencies,
neuroticism,
risk,
indices.
The
link
features
cannot
be
adequately
estimated
by
combining
participants
should
examined
sample
excludes
subjects
phenome,
correlate
atherogenicity,
which
likely
implicated
pathophysiology
MDD.
Increased
atherogenicity
lowered
may
represent
novel
drug
targets
for
treatment
prevention
behaviors.
BMJ Mental Health,
Journal Year:
2024,
Volume and Issue:
27(1), P. e300982 - e300982
Published: Jan. 1, 2024
Background
Increasing
data
suggest
emergent
affective
symptoms
during
the
COVID-19
pandemic.
Objectives
To
study
impact
of
pandemic
on
and
suicidal
ideation
in
Thai
adults.
Methods
The
Collaborative
Outcomes
Study
Health
Functioning
Infection
Times
uses
non-probability
sampling
(chain
referring
voluntary
response
sampling)
stratified
probability
to
identify
risk
factors
mental
health
problems
potential
treatment
targets
improve
outcomes
pandemics.
Findings
Analysing
14
271
adult
survey
participants
across
all
four
waves
Thailand,
covering
77
provinces
from
1
June
2020
30
April
2022,
suicidality
increased
Affective
were
strongly
predicted
by
(feelings
isolation,
fear
COVID-19,
loss
social
support,
financial
loss,
lack
protective
devices)
non-pandemic
(female
sex,
non-binary
individuals,
adverse
childhood
experiences
(ACEs),
negative
life
events,
student
status,
multiple
medical
conditions,
physical
pain)
factors.
ACEs,
prior
conditions
pain
top
three
associated
with
both
Partial
least
squares
analysis
showed
that
ACEs
most
important
factor
as
they
impacted
Clinical
implications
Rational
policymaking
a
should
aim
groups
at
highest
(those
psychiatric
disease,
women,
individuals)
implement
immediate
long-term
strategies
mitigate
while
effectively
addressing
conditions.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 21, 2024
Abstract
Background
Major
depressive
disorder
(MDD)
is
considered
to
be
a
neuroimmune
disorder.
However,
there
are
no
data
regarding
the
association
between
comprehensive
immune
profiles
and
their
interactions
with
metabolic
syndrome
(MetS)
in
predicting
neuroticism,
suicidal
behaviors,
severity
of
outpatient
MDD
(OMDD).
Methods
We
assayed
48
serum
cytokines,
chemokines,
growth
factors
using
multiplex
assay
67
healthy
controls
66
OMDD
patients.
Around
50%
control
participants
had
diagnosis
MetS.
Results
Ten
differentially
expressed
proteins
(DEPs)
were
upregulated
(i.e.,
CXCL12,
TNFB,
PDGF,
CCL11,
IL9,
IL4,
CCL5,
CCL2,
CCL4,
IL1RN),
indicating
an
immune,
defense
stress
response.
Six
DEPs
downregulated
(VEGFA,
IL12,
CCL3,
CSF1,
IL1B,
NGF),
lowered
neurogenesis
regulation
neuron
death.
Significant
MetS
caused
a)
substantial
increases
TNF
signaling,
upregulation
IL17,
TNF,
IL1RN;
b)
downregulation
VEGFA
FGF.
A
large
part
variance
neuroticism
(26.6%),
behaviors
(23.6%),
phenome
(31.4%)
was
predicted
by
immunological
TNFB
or
VEGFA.
Discussion
characterized
immunoneurotoxic
profile
which
partly
explains
phenome’s
severity.
Lowered
IL-10
increased
neurotoxicity
characteristics
other
depression
phenotypes,
including
severe
first-episode
inpatient
MDD.
The
presence
considerably
exacerbates
immunoneurotoxicity.
Consequently,
studies
should
always
performed
subjects
without
