Elucidating the pivotal molecular mechanisms, therapeutic and neuroprotective effects of lithium in traumatic brain injury

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(6)

Published: June 1, 2024

Traumatic brain injury (TBI) refers to damage tissue by mechanical or blunt force via trauma. TBI is often associated with impaired cognitive abilities, like difficulties in memory, learning, attention, and other higher functions, that typically remain for years after the injury. Lithium an elementary light metal only utilized salt form due its high intrinsic reactivity. This current review discusses molecular mechanisms therapeutic neuroprotective effects of lithium TBI.

Language: Английский

An Effect of Chronic Negative Stress on Hippocampal Structures and Functional Connectivity in Patients with Depressive Disorder [Letter]

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 1153 - 1154

Published: May 1, 2024

Effect of Chronic Negative Stress on HippocampalStructures and Functional Connectivity in Patients with Depressive Disorder. 1 We congratulate all authors who have provided valuable information regarding the relationship between hippocampal structure functional connectivity (FC) depressed patients experiencing chronic negative stress.Depressive disorder is a condition that causes to symptoms poor mood, increased fatigue anhedonia deficits neurocognitive functions, such as impaired memory, visuo-spatial processing attention. 2The hippocampus brain involved stress also depressive disorders if they experience changes volume are therefore very important improve our understanding mental related hippocampus. 3he study conducted by Lili Zhang et al used Diagnostic Statistical Manual Mental Disorders 5th diagnose major disorder, Life Events Scale (LES) evaluate from collected fMRI data look at volume. All instruments accordance objectives be achieved, but we would like recommend one tool, namely magnetization-prepared rapid gradient echo (MPRAGE) for structural analysis brain, which can help researchers estimate total intracranial covariate order determine whether There differences subfields so it differentiate post-traumatic (PTSD) (MDD) patients.In addition, additional duration symptoms, psychopharmacological treatment previous psychotherapy themselves.3 In this research, found experienced had volume, while decreased.The opposite do not stress. However, should noted pattern stress, PTSD MDD may indicate represent different phenotype than traditional diagnostic strategies know patient's history treatment.During treatment, illness drug interventions reflect pathophysiology mechanisms psychiatric disorders.4 conclusion, agree depression disruption connectivity, diagnosis medical personnel highly dependent patient report integration neuroimaging data, routine inpatient MRI scans, some health control added research increase well long-term Disorder patients.3

Language: Английский

The interplay of Genetic and Environmental Factors on the Morphology of the Limbic Cortex and Hippocampal Subfields: Insights from an MRI Twin Study

Psychiatry Research Neuroimaging, Journal Year: 2024, Volume and Issue: 345, P. 111909 - 111909

Published: Oct. 5, 2024

Language: Английский