Cannabidiol for treatment of Irritability and Aggressive Behavior in Children and Adolescents with ASD: Background and Methods of the CAnnabidiol Study in Children with Autism Spectrum DisordEr (CASCADE) Study DOI Open Access
Elise M. Sannar,

Joan R. Winter,

Ronda K. Franke

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

ABSTRACT Introduction Autism spectrum disorder (ASD) is a neurodevelopmental commonly associated with behavioral challenges. There are few evidence based pharmacological interventions available for the treatment of symptoms ASD. Cannabidiol (CBD), non-psychoactive component cannabis, has potential neuroprotective, antiepileptic, anxiolytic, and antipsychotic effects may be useful in treating Methods We describe research methods 27-week double-blind placebo-controlled cross-over trial cannabidiol irritability aggression ASD, utilizing subscale Aberrant Behavior Checklist-2nd edition (ABC-2) as primary outcome measure. Adverse safety monitoring protocols included. Several secondary exploratory outcomes measures also include anxiety, communication, repetitive behaviors, attention, hyperactivity, autism family experience, telehealth functional behavior assessment. Conclusion significant need clinical exploring alternative medications (CBD) being studied management irritability, aggression, other problem behaviors

Language: Английский

Endocannabinoid System Changes throughout Life: Implications and Therapeutic Potential for Autism, ADHD, and Alzheimer’s Disease DOI Creative Commons
Kamila Gabrieli Dallabrida, Jeane Maria de Oliveira,

Ellen Schavarski Chade

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 592 - 592

Published: June 10, 2024

The endocannabinoid system has been linked to various physiological and pathological processes, because it plays a neuromodulator role in the central nervous system. In this sense, cannabinoids have used off-label for neurodevelopmental disorders, such as autism spectrum disorder (ASD) attention-deficit/hyperactivity (ADHA), well Alzheimer's disease (AD), more prevalent neurodegenerative disease. Thus, study aims, through comprehensive literature review, arrive at better understanding of impact therapeutic treatment patients with ASD, ADHD, (AD). Overall, cannabis products rich CBD displayed higher potential ASD children, while THC tested AD therapy. For clinical studies are incipient inconclusive, but promising. general, main limitations lack standardization cannabis-based consumed by participants, scientific rigor, small number participants.

Language: Английский

Citations

6
Cannabinoid treatment for the symptoms of autism spectrum disorder DOI
Adi Aran,

Dalit Cayam Rand

Expert Opinion on Emerging Drugs, Journal Year: 2024, Volume and Issue: 29(1), P. 65 - 79

Published: Jan. 2, 2024

Introduction Autism spectrum disorder (ASD) is a neurodevelopmental affecting approximately 3% of school-age children. The core symptoms are deficits in social communication and restricted repetitive patterns behavior. Associated problems cognition, language, behavior, sleep mood prevalent. Currently, no established pharmacological treatment exists for ASD symptoms. Risperidone aripiprazole used to manage associated irritability, but their effectiveness limited adverse events common.

Language: Английский

Citations

6
Therapeutic potential of CBD in Autism Spectrum Disorder DOI
João Francisco Cordeiro Pedrazzi, Lucas Hassib, Frederico Rogério Ferreira

et al.

International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 149 - 203

Published: Jan. 1, 2024

Language: Английский

Citations

5
Análise da utilização da Cannabis sativa na prática da clínica veterinária de pequenos animais: uma visão atual DOI Creative Commons
Hellen Thawane Duarte, Luciana Sandra Bastos de Souza

PubVet, Journal Year: 2025, Volume and Issue: 19(01), P. e1718 - e1718

Published: Jan. 7, 2025

In the current scenario, Cannabis sativa has been highlighted due to increasing use of its components in treatment various pathologies, both human and veterinary medicine. The present study aims identify ways which is used Veterinary Medical Clinics today. For this, a methodology for bibliographic review. Finally, data found was compared proven, where Clinic verified chronic atopic dermatitis, epilepsy, travel-induced stress urothelial cancer dogs, addition as analgesics osteoarthritis. cats.

Language: Английский

Citations

0
Clinical Uses of Cannabinoids: What Does the Evidence Say? DOI
Leah Sera,

Carrie Hempel‐Sanderoff

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cannabidiol for treatment of irritability and aggressive behavior in children and adolescents with autism spectrum disorder: background and methods of the cannabidiol study in children with autism spectrum disorder study DOI Open Access
Elise M. Sannar,

Joan Winter,

Ronda K. Franke

et al.

International Journal of Clinical Trials, Journal Year: 2025, Volume and Issue: 12(1), P. 29 - 37

Published: Jan. 28, 2025

Background: Autism spectrum disorder (ASD) is a neurodevelopmental commonly associated with behavioral challenges. There are few evidence based pharmacological interventions available for the treatment of symptoms ASD. Cannabidiol (CBD), non-intoxicating component cannabis, has known neuroprotective, antiepileptic, anxiolytic, and antipsychotic effects may be useful in treating Methods: We describe research methods 27-week randomized placebo-controlled crossover trial to evaluate safety efficacy oral CBD irritability aggression ASD, as measured by subscale aberrant behavior checklist-2nd edition (ABC-2) children adolescents. Conclusions: significant need clinical exploring alternative medications Upcoming results from this will help answer question whether intervention management Clinical registry: NCT04520685.

Language: Английский

Citations

0
Eating Disorders and the Endocannabinoid System DOI
Marialuisa de Ceglia, Juan Decara, Maria Vittoria Micioni Di Bonaventura

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Emerging autism and Fragile X syndrome treatments DOI

Michael David Parkhill,

Natalina Salmaso, Amedeo D’Angiulli

et al.

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Clinical and Family Implications of Cannabidiol (CBD)-Dominant Full-Spectrum Phytocannabinoid Extract in Children and Adolescents with Moderate to Severe Non-Syndromic Autism Spectrum Disorder (ASD): An Observational Study on Neurobehavioral Management DOI Creative Commons

Jeanne Alves de Souza Mazza,

Lisiane Seguti Ferreira,

Alice de Faria Martins-Vieira

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 686 - 686

Published: May 27, 2024

Autism Spectrum Disorder (ASD) encompasses a wide range of neurodevelopmental conditions characterized by deficits in social interaction, communication and behavior. Current pharmacological options are limited feature significant side effects. In this study, we conducted retrospective, observational, cross-sectional cohort study to evaluate the effects Cannabidiol (CBD)-dominant, full-spectrum cannabis extract, containing Tetrahydrocannabinol (THC) ratio 33:1 (CBD:THC), on non-syndromic children adolescents (5–18 years old) with moderate severe ASD. Thirty volunteers were recruited, underwent neuropsychological evaluations treated individualized doses CBD-dominant extract. Clinical assessments designated clinician. Additionally, parents or caregivers independently interviewed assess perceived treatment We found improvements various symptomatic non-symptomatic aspects ASD, minimal untoward effects, as reported both clinical parental perceptions. The observed included increased communicative skills, attention, learning, eye contact, diminished aggression irritability, an overall increase patient’s family’s quality life. Despite its limitations, our findings suggest that extract may be safe effective option for core comorbid symptoms it also life individuals ASD their families.

Language: Английский

Citations

3
Abordagens Terapêuticas no Transtorno do Espectro Autista: Uma Revisão Atualizada DOI Creative Commons

Mayra Luana Fernandes Sousa,

Luisa Dos Santos Vieira,

Letícia Azeredo Bittencourt Tavora

et al.

Brazilian Journal of Implantology and Health Sciences, Journal Year: 2024, Volume and Issue: 6(1), P. 139 - 152

Published: Jan. 4, 2024

Esta revisão científica oferece uma abordagem abrangente e atualizada sobre as terapias aplicadas em Transtornos do Espectro Autista (TEA). Dada a natureza complexa diversificada TEA, torna-se imperativo analisar minuciosamente estratégias terapêuticas disponíveis para compreensão mais profunda eficaz dessa condição. O espectro autista abrange variedade de sintomas desafios, este estudo visa oferecer visão holística das práticas terapêuticas, desde intervenções comportamentais intensivas até modalidades farmacológicas, proporcionando assim um panorama cenário atual. Destaca-se não apenas diversidade abordagens disponíveis, mas também enfatiza importância crucial da intervenção personalizada precoce. Reconhecendo heterogeneidade autista, salienta como adaptadas às características individuais dos pacientes podem ser fundamentais maximizar os resultados. Essa personalização reconhece singularidade cada indivíduo, destaca necessidade multifacetada integrativa no tratamento TEA. Explorando últimas descobertas desenvolvimentos na área, se limita consolidar informações existentes, busca fomentar reflexão crítica atuais TEA. Ao fazer isso, o trabalho insights valiosos profissionais saúde, pesquisadores familiares, promovendo e, consequentemente, contribuindo melhoria contínua qualidade vida indivíduos com

Citations

2