Mitigating the Impact of High-Fat Diet: The Role of Metformin and Exercise Interventions in Alleviating Autism-Like Behaviors and Insulin Resistance in Mice

Journal of Science in Sport and Exercise, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

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Intestinal Barrier Dysfunction and Gut Microbiota in Non-Alcoholic Fatty Liver Disease: Assessment, Mechanisms, and Therapeutic Considerations

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 243 - 243

Published: April 6, 2024

Non-alcoholic fatty liver disease (NAFLD) is a type of metabolic stress injury closely related to insulin resistance (IR) and genetic susceptibility without alcohol consumption, which encompasses spectrum disorders ranging from simple hepatic lipid accumulation, known as steatosis, the more severe form steatohepatitis (NASH). NASH can progress cirrhosis hepatocellular carcinoma (HCC), posing significant health risks. As multisystem disease, NAFLD associated with systemic resistance, central obesity, disorders, contribute its pathogenesis development extrahepatic complications, such cardiovascular (CVD), 2 diabetes mellitus, chronic kidney certain cancers. Recent evidence highlights indispensable roles intestinal barrier dysfunction gut microbiota in onset progression NAFLD/NASH. This review provides comprehensive insight into role NAFLD, including function assessment, inflammatory factors, TLR4 signaling, gut–liver axis. Finally, we conclude discussion on potential therapeutic strategies targeting permeability individuals NAFLD/NASH, interventions medications/probiotics, fecal transplantation (FMT), modifications lifestyle, exercise diet.

Language: Английский

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A network meta-analysis of the effect of physical exercise on core symptoms in patients with autism spectrum disorders

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Objective To compare the effects of various sports exercise programs on core symptoms patients with autism spectrum disorder (ASD). Methods We searched China National Knowledge Infrastructure, VIP databases, Wanfang Cochrane Library, PubMed, EMBASE, and Web Science databases from their inception to February 2023 for randomized controlled trial that investigated effect ASD. The overall risk bias in included literature was summarized using revised Randomized Trial Risk Bias Tool (ROB2), network meta-analysis used intervention effects. Results A total 30 studies involving 1,375 participants were included. results showed programs, including 8–12 weeks ball (SMD = −5.35, 95%CI: −7.57, −3.23), horse riding −3.71, −6.18, −1.13), comprehensive −2.17, −3.99, −0.44), more than 12 −3.75, −6.33, −1.24), significantly improved social interaction disorders. Furthermore, −4.36, 2.04, 6.73) 3.65, 1.40, 6.08) repetitive behaviors restricted interests. Conclusion Sports can improve ASD patients, different show a selective response elements. Systematic review registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42023455806.

Language: Английский

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Parental perspectives on table tennis as an inclusive physical activity for children with autism: a qualitative means-end chain analysis

International Journal of Developmental Disabilities, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: May 4, 2025

Language: Английский

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Effects of mini-basketball training program on social communication impairments and regional homogeneity of brain functions in preschool children with autism spectrum disorder

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2024, Volume and Issue: 16(1)

Published: April 24, 2024

Abstract Background Social communication impairments (SCI) is a core symptom of autism spectrum disorder (ASD) and marked by challenges in social interaction. Although physical exercise has been shown to improve SCI, this finding not supported comprehensive scientific evidence. Existing research established strong link between the SCI children with ASD abnormalities regional homogeneity (ReHo). Therefore, investigating effects on Reho patients may help elucidate neurological mechanisms involved. Methods The present study included 30 preschool diagnosed ASD, 15 participants each group (experimental control). experimental underwent 12-week mini-basketball training program (MBTP) based routine behavioral rehabilitation, while control only received rehabilitation. Responsiveness Scale-Second Edition (SRS-2) was employed assess both groups. Resting-state functional magnetic resonance imaging technology used evaluate ReHo Results After MBTP, significant × time interactions were observed groups total SRS-2 scores ( F = 14.514, p < 0.001, η 2 0.341), as well domains cognition 15.620, 0.358), 12.460, 0.01, 0.308), autistic mannerisms 9.970, 0.263). No statistical difference found for awareness subscale motivation interaction (all > 0.05). exhibited increased right Cerebellum_Crus1 parahippocampal gyrus, coupled decreased left middle frontal gyrus (orbital part), superior (dorsolateral), postcentral parietal gyrus. Furthermore, decrease positively correlated changes behaviors Conclusions Our underscores effectiveness MBTP ameliorating among ASD. Trial registration trial retrospectively registered Chinese Clinical Registry (ChiCTR1900024973; August 5, 2019).

Language: Английский

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Effects of Sensory Integration to Manage Behavior Problems of Children with Autism Spectrum Disorder

Allied Medical Research Journal, Journal Year: 2024, Volume and Issue: unknown, P. 203 - 212

Published: Jan. 30, 2024

Background: Play is an occupation that promote learning and socializing among children, physical play involves different gross motor skills stimulate sensory processing specifically proprioception vestibular. The objective of the study to evaluate impact based sports on pattern children discover effect smart vestibular for behavior management. Methods: 62 Children with ASD mild moderate were enrolled in from rehab institutes Karachi such as psyche care, hands exceptional mind. participants have definite probable score at their component profile poor emotional regulation. They involved six months than reassessed same domain check Results: Significant mean variance was obtained between pre post range leading. Conclusion: Sensory integration therapy always being use therapeutic tool one most effective intervention management Autism. implementation ideation through games culturally intact can be applied developand sustain interest, focus above all develop good behavior. Keywords: Integration Therapy, Autism, Proprioception, Vestibular, Behavior, Smart Sport.

Language: Английский

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Exploring Physical Activity in Children and Adolescents with Disabilities: A Bibliometric Review of Current Status, Guidelines, Perceived Barriers, and Facilitators and Future Directions

Healthcare, Journal Year: 2024, Volume and Issue: 12(9), P. 934 - 934

Published: May 1, 2024

Background: Physical activity contributes to both physiological and psychosocial benefits for children adolescents with disabilities. However, the prevalence of physical inactivity is notably higher among disabled young people compared their healthy peers. Despite this, there a lack constructed knowledge structure, evolutionary path, research hotspots, frontiers in studies related disabilities.Methods: The literature disabilities was retrieved from core collection Web Science. annual publication numbers timing, frequency, centrality co-occurrence network respect journals, countries, institutions, authors, references, keywords were analyzed. Additionally, clustering analysis burst performed on references keywords. All analyses conducted using CiteSpace. Results: A total 1308 articles included. structure adolescents, including numbers, influencing along respective collaborative networks, has been constructed. Furthermore, foundation, current hot topics, have identified by analyzing Conclusions: Current hotspots include interventions, therapies, programs aimed at enhancing specific skills, as well addressing satisfaction competence improve motivation effectiveness activity. There also focus development scales quantitative studies. Future directions may be toward personalized interventions or enhance levels youth

Language: Английский

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Body Composition and Anthropometric Measurements in Children and Adolescents with Autism Spectrum Disorder: A Case–Control Study in Lebanon

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 847 - 847

Published: March 15, 2024

The occurrence of overweight and obesity among individuals with Autism Spectrum Disorder (ASD) has become a worldwide epidemic. However, there is limited research on this topic in the Lebanese population. Therefore, study aimed to assess differences anthropometric measurements body composition variables children, pre-adolescents, adolescents diagnosed ASD contrast typically developing peers across various developmental stages. Additionally, it investigate prevalence within A total 86 participants controls were involved case–control study, conducted between June 2022 2023. Anthropometric assessed, followed by statistical analyses examine these two groups. results revealed significantly higher ASD, particularly evident during childhood pre-adolescence. group exhibited fat mass percentage compared controls. no significant observed groups adolescence. These findings emphasize significance monitoring addressing weight status improve their overall health outcomes. Future directions could focus investigating underlying mechanisms contributing heightened population, ultimately enhancing quality life well-being.

Language: Английский

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Metabolomic changes in children with autism

World Journal of Clinical Pediatrics, Journal Year: 2024, Volume and Issue: 13(2)

Published: June 7, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. Metabolomic profiling has emerged as valuable tool for understanding the underlying metabolic dysregulations associated with ASD.

Language: Английский

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The neurobiological mechanisms underlying the effects of exercise interventions in autistic individuals

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Autism spectrum disorder is a pervasive and heterogeneous neurodevelopmental condition characterized by social communication difficulties rigid, repetitive behaviors. Owing to the complex pathogenesis of autism, effective drugs for treating its core features are lacking. Nonpharmacological approaches, including education, social-communication, behavioral psychological methods, exercise interventions, play important roles in supporting needs autistic individuals. The advantages intervention, such as low cost, easy implementation, high acceptance, have garnered increasing attention. Exercise interventions can effectively improve co-occurring conditions but underlying neurobiological mechanisms unclear. Abnormal changes gut microbiome, neuroinflammation, neurogenesis, synaptic plasticity may individually or interactively be responsible atypical brain structure connectivity, leading specific experiences characteristics. Interestingly, affect these biological processes reshape network connections, which explain how alleviates In this review, we describe definition, diagnostic approach, epidemiology, current support strategies autism; highlight benefits interventions; call individualized programs different subtypes Finally, possible improves comprehensively summarized inform development optimal targets meet

Language: Английский

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