Sertraline in depressed patients with or at risk for coronary heart disese: a systemic review DOI

Kiana Seifouri,

Reza Kahdemi,

Fatemeh Ahmadi Hajikolaei

et al.

American Journal of Cardiovascular Disease, Journal Year: 2024, Volume and Issue: 14(6), P. 318 - 329

Published: Jan. 1, 2024

Depression is a prevalent comorbidity among patients with coronary heart disease (CHD). While recent studies have hinted at possible association between CHD and antidepressant medications like sertraline, the existing evidence remains inconclusive. To investigate this potential link, we conducted comprehensive systematic review. We systematically searched PubMed, Google Scholar, Scopus for relevant articles published up to March 2023. After thorough screening of titles abstracts, 12 were included in our The studies, spanning from 1999 2021, comprised 11 randomized controlled trials (RCTs) one pilot study. A total 2767 participants major depressive disorder history cardiovascular or risk such events included. majority these demonstrated improvements mood status treated serotonin-targeting antidepressants reduced events, as measured by various outcomes. some cardiac adverse effects observed serotonin treatment, did not reach statistical significance. Our findings provide supporting beneficial both symptoms prevention These results highlight value serotonin-based treatments depression high-risk populations.

Language: Английский

Development and external validation of a risk prediction model for depression in patients with coronary heart disease DOI
Xin-Zheng Hou, Qian Wu,

Qianyu Lv

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 367, P. 137 - 147

Published: Sept. 2, 2024

Language: Английский

Citations

6
Connecting the Dots: NLRP3 Inflammasome as a Key Mediator in the Intersection of Depression and Cardiovascular Disease – A Narrative Review DOI Creative Commons
Ghazaleh Ghaffaripour Jahromi, Nima Rezaei

Heart and Mind, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and frequently coexist with depressive disorders. The consequence their concurrence is exacerbation both conditions. Numerous studies seek to understand pathophysiological connection between this mental disorder CVDs, theories such as autonomic dysfunction, endocrine dysregulation, platelet inflammation have been suggested. However, in review, we propose that these all related etiology can be explained by involvement nucleotide-binding oligomerization domain-, leucine-rich repeat-, pyrin domain-containing protein 3 (NLRP3) inflammasome-mediated inflammation. To elucidate, investigate inflammasome contribution central nervous system (CNS), vasculature, heart, system. We presented evidence neurotransmitter imbalances, hypothalamic pituitary adrenal axis microglial activation, inflammatory damage CNS. put forward research on NLRP3 activation showing vascular could alter brain blood barrier, endothelial lipid metabolism, hypertension, atherosclerosis, aneurisms, hypercoagulable states. Similarly, explore its development heart failure, cardiac remodeling, myocardial infarction, arrythmias, hyperactive tuning sympathetic response.

Language: Английский

Citations

0
Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review) DOI Open Access

Shijie Zheng,

Linlin Yang,

Qiuting Dai

et al.

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(3)

Published: Jan. 14, 2025

Depression and coronary heart disease (CHD) are two interconnected diseases that profoundly impact global health. is both a complex psychiatric disorder an established risk factor for CHD. Sirtuin 1 (SIRT1) enzyme requires the cofactor nicotinamide adenine dinucleotide (NAD+) to perform its deacetylation function, involvement crucial in reducing cardiovascular risks associated with depression. SIRT1 exerts cardioprotective effects via modulating oxidative stress, inflammation metabolic processes, all of which central pathogenesis CHD individuals Through influencing these pathways, helps reduce endothelial dysfunction, prevent formation atherosclerotic plaques stabilize existing plaques, thereby decreasing overall The present review underscores important role serving as therapeutic intervention molecule tackling complications stemming from Furthermore, it highlights need further studies clarify how influences depression at molecular level. ultimate goal this research will be translate findings into practical clinical strategies.

Language: Английский

Citations

0
Explainable Machine learning model for assessing health status in patients with comorbid coronary heart disease and Depression: Development and validation study DOI
Jiqing Li, Shuo Wu,

Jianhua Gu

et al.

International Journal of Medical Informatics, Journal Year: 2025, Volume and Issue: 196, P. 105808 - 105808

Published: Jan. 23, 2025

Language: Английский

Citations

0
The Role of Digital Biomarkers in Physiological Signal-Based Depression Assessment: A Systematic Review DOI

H. Lee,

Seung‐Gul Kang, Seon Heui Lee

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis DOI Creative Commons
Jun Zeng, Yuting Qiu,

Chengying Yang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Features of short-term heart rate variability in internally displaced people with type 2 diabetes mellitus DOI Creative Commons
Victoria Serhiyenko, Володимир Сегін, V.І. Pankiv

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(3), P. 243 - 252

Published: May 22, 2025

Background. Internally displaced people (IDP) often face many problems, both physical and psychological. Anxiety depression inherent in IDP predict slow recovery increase the risk of post-traumatic stress disorder mortality. Dysfunction autonomic nervous system is combined with type 2 diabetes mellitus (T2DM) cardiac neuropathy (CAN). The aim study was to analyze peculiarities short-term heart rate variability (HRV) T2DM. Materials methods. looked at three groups: 16 practically healthy individuals (group 1, controls), patients T2DM subclinical CAN (Lviv region, group 2, n = 16) 3, 16). No clinical symptoms were detected patients, age, sex, duration T2DM, body mass index, HbA1c did not differ significantly (p > 0.05). Subclini­cal diagnosed according results cardiovascular reflex tests Composite Assessment Symptom Score 31. HRV lasting 5 min studied analyzed. Results. A statistically significant rise wase CAN. At same time, there a decrease median RR interval (mRR); percentage adjacent NN intervals that deviate from one another by more than 50 ms (pNN50%); levels high frequency power (HF) normalized unit (HFnorm). In CAN, compared further signifi­cant observed: 86.19 ± 82.30 [69.0; 121.0] bpm; mRR: 709.56 93.45 [496.0; 871.0] ms; root mean square successive differences between intervals: 17.56 9.06 [5.0; 41.0] pNN50%: 2.56 4.66 [0; 17] %; low (LF): 626.56 428.50 [156.0; 1358.0] ms2; HF: 143.81 111.68 [10.0; 363.0] HF total spectrum: 10.44 8.15 [2.0; 26.0], as well growth LF unit: 79.81 14.25 [54.0; 96.0] n.u.; very 47.50 18.69 [12.0; 86.0] %. Conclusions. It found went down, sympathetic component became much stronger. This indicates activation body’s adaptive reactions response stressful situations. use analysis can be cost-effective scientifically sound approach for early diagnosis data obtained become basis development effective prevention strategies, new methods timely therapy

Language: Английский

Citations

0
Impaired Modulation of the Autonomic Nervous System in Adult Patients with Major Depressive Disorder DOI Creative Commons

Elise Böttcher,

Lisa Sofie Schreiber,

David F. Wozniak

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1268 - 1268

Published: June 6, 2024

Patients with major depressive disorder (MDD) have an increased risk for cardiac events. This is partly attributed to a disbalance of the autonomic nervous system (ANS) indicated by reduced vagal tone and (relative) sympathetic hyperactivity. However, in most studies, heart rate variability (HRV) was only examined while resting. So far, it remains unclear whether dysbalance ANS patients MDD restricted resting or also evident during parasympathetic activation. The aim this study compare responses challenges that stimulated and, respectively, systems MDD. Forty-six (female 27 (58.7%), mean age 44 ± 17 years) 46 healthy controls 26 (56.5%), 20 underwent measurement time- frequency-dependent domains HRV at rest, standing (sympathetic challenge), slow-paced breathing (SPB, vagal, i.e., challenge). showed higher rate, HRV, diminished resting, standing, SPB compared controls. responded similarly extent modulation impaired MDD, who decrease but increase activity when switching from standing. Assessing changes activation via respective might serve as future biomarker help allocate therapies like biofeedback psychotherapy were recently found modulate tone.

Language: Английский

Citations

3
Sotagliflozin attenuates cardiac dysfunction and depression-like behaviors in mice with myocardial infarction through the gut-heart-brain axis DOI Creative Commons

Lei Liao,

Lu Zhang,

Chengying Yang

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106598 - 106598

Published: July 11, 2024

Myocardial infarction (MI) and depression are leading causes of mortality morbidity globally, these conditions increasing recognized as being fundamentally interconnected. The recently gut-heart-brain axis offers insights into following MI, but effective treatments for this comorbidity remain lacking. To address medical need, we employed an animal model MI to investigate the potential repurposing sotagliflozin (SOTA), approved sodium-glucose cotransporter 1 2 (SGLT1/2) inhibitor diabetes, managing identifying SOTA-associated microbial mechanisms. SOTA treatment improved cardiac dysfunction alleviated depression-like behaviors induced by accompanied alterations in gut microbiota composition, such changes Prevotellaceae NK3B31 group, Alloprevotella, UCG-001. Moreover, fecal transplantation (FMT) using samples from SOTA-treated mice demonstrated that contributed beneficial effects on mice. Intriguingly, FMT-based intervention concordance analysis before after FMT suggested UCG-001 were associated with SOTA. Furthermore, functional prediction correlation support significance dynamic communities. In conclusion, findings suggest could serve a drug ameliorate depressive symptoms patients via through axis.

Language: Английский

Citations

3
Association between depression and vascular aging: a comprehensive analysis of predictive value and mortality risks DOI
Yuntao Feng,

Jing-Yin Pei,

Yuepeng Wang

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 367, P. 632 - 639

Published: Aug. 30, 2024

Language: Английский

Citations

2