Published: April 12, 2023
In the wake of Covid-19 crisis, a need has arisen to prevent and treat two related conditions, Covid vaccine injury long Covid, both which have significant vascular component. Therefore, management these conditions require development strategies or dissolve blood clots restore circulatory health. This review summarizes evidence on that can be applied injuries based similar mechanisms action.
Language: Английский
Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 94(7), P. 2986 - 3005
Published: March 12, 2022
Numerous variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have evolved. Viral may evolve with harmful susceptibility to immunity established existing COVID-19 vaccination. These are more transmissible, induce relatively extreme illness, evasive immunological features, decrease neutralization using antibodies from vaccinated persons, and susceptible re-infection. The Centers for Disease Control Prevention (CDC) has categorized SARS-CoV-2 mutations as interest (VOI), concern (VOC), high consequence (VOHC). At moment, four VOC many been defined require constant observation. This review article summarizes various surfaced special emphasis on VOCs that spreading across world, well several viral mutational impacts how these modifications alter properties virus.
Language: Английский
Citations
113
Cells, Journal Year: 2023, Volume and Issue: 12(2), P. 300 - 300
Published: Jan. 12, 2023
Diabetic retinopathy, one of the most devastating complications diabetes, is a multifactorial progressing disease with very complex etiology. Although many metabolic, molecular, functional and structural changes have been identified in retina its vasculature, exact molecular mechanism pathogenesis still remains elusive. Sustained high-circulating glucose increases oxidative stress also activates inflammatory cascade. Free radicals increase mediators, inflammation can production free radicals, suggesting positive loop between them. In addition, diabetes facilitates epigenetic modifications that influence transcription gene without changing DNA sequence. Several genes associated diabetic retinopathy are influenced by modifications. This review discusses cross-talks stress, epigenetics retinopathy. Since external factors such as environment lifestyle, they be reversed, this opens up possibilities for new strategies to inhibit development/progression sight-threatening disease.
Language: Английский
Citations
48
Acta Neuropsychiatrica, Journal Year: 2022, Volume and Issue: 34(3), P. 109 - 126
Published: Feb. 11, 2022
Long COVID refers to the lingering symptoms which persist or appear after acute illness. The dominant long in two years since pandemic began (2020-2021) have been depression, anxiety, fatigue, concentration and cognitive impairments with few reports of psychosis. Whether other will later on is not yet known. For example, dopamine-dependent movement disorders generally take many before first are seen. Post-stroke depression anxiety may explain early cases. Hemorrhagic, hypoxic inflammatory damages central nervous system, unresolved systematic inflammation, metabolic impairment, cerebral vascular accidents such as stroke, hypoxia from pulmonary fibrotic changes among major causes COVID. Glucose brain issues likely predispose subjects pre-existing diabetes, cardiovascular lung problems well. Preliminary data suggest that psychotropic medications be a danger but could instead beneficial combating COVID-19 infection. same true for diabetes metformin. Thus, focus sigma-1 receptor ligands glucose metabolism expected useful new drug development well repurposing current drugs. reported protective effects psychotropics antihistamines against COVID-19, earlier reduced number receptors post-mortem schizophrenic brains, antidepressant antipsychotic drugs being significant affinity receptor, support role sigma histamine neuroinflammation viral infections. Literature all these areas accumulating at fast rate. We reviewed discussed relevant important literature.
Language: Английский
Citations
47
Nature Immunology, Journal Year: 2022, Volume and Issue: 23(3), P. 360 - 370
Published: Feb. 24, 2022
Language: Английский
Citations
40
Cell Death and Differentiation, Journal Year: 2021, Volume and Issue: 28(12), P. 3199 - 3213
Published: Oct. 18, 2021
SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to develop our understanding of the nature disease and its effects on human immunity. Previously, suggested that a dysregulated STAT3 pathway following SARS-Co-2 infection ultimately leads PAI-1 activation cascades pathologies. The major COVID-19-associated metabolic risks (old age, hypertension, cardiovascular diseases, diabetes, obesity) share high levels could predispose certain groups severe complications. In this review article, describe common profile is shared between all these high-risk COVID-19. This not only involves as previously described, also includes low glutamine NAD+, coupled with overproduction hyaluronan (HA). exacerbates imbalance predisposes patients pathophysiologies COVID-19, including involvement NETs (neutrophil extracellular traps) HA in lung. While hyperinflammation due proinflammatory cytokine has been frequently documented, it recently recognized immune response markedly suppressed some cases by expansion activity MDSCs (myeloid-derived suppressor cells) FoxP3+ Tregs (regulatory T cells). metabolomics profiles advanced cancer are similar, patients, aberrant activation, which promotes cancer-like metabolism. We propose deficiency overproduced central characteristic groups. suggest usage supplementation repurposing drugs prevent development pneumonia.
Language: Английский
Citations
48
Epidemiology and Psychiatric Sciences, Journal Year: 2023, Volume and Issue: 32
Published: Jan. 1, 2023
Abstract Aims It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and be disproportionally affected by disease 19 (COVID-19) once infected. We aimed analyse the COVID-19 infection rate, course outcome, including mortality long COVID, in anxiety, depressive, neurodevelopmental, schizophrenia spectrum substance use relative control subjects without these disorders. Methods This study constitutes a preregistered systematic review random-effects frequentist Bayesian meta-analyses. Major databases were searched up until 27 June 2023. Results Eighty-one original articles included reporting 304 cross-sectional prospective effect size estimates (median n per effect-size = 114837) regarding associations of interest. Infection was not significantly increased for any disorder we investigated samples The COVID-19, however, is relatively severe, COVID COVID-19-related hospitalization are more likely all patient investigated. odds dying from high most types disorders, except those anxiety neurodevelopmental non-patient (pooled ORs range, 1.26–2.57). analyses confirmed findings approach complemented them strength evidence. Conclusions Once infected, pre-existing at mortality, despite increased.
Language: Английский
Citations
20
Frontiers in Science, Journal Year: 2024, Volume and Issue: 2
Published: May 23, 2024
The COVID-19 pandemic accelerated research and innovation across numerous fields of medicine. It emphasized how disease concepts must reflect dynamic heterogeneous interrelationships between physical characteristics, genetics, co-morbidities, environmental exposures, socioeconomic determinants health throughout life. This article explores scientists other stakeholders collaborate in novel, interdisciplinary ways at these new frontiers medicine, focusing on communicable diseases, precision/personalized systems data science. highlighted the critical protective role vaccines against current emerging threats. Radical efficiency gains vaccine development (through mRNA technologies, public private investment, regulatory measures) be leveraged future together with continued area monoclonal antibodies, novel antimicrobials, multisectoral, international action diseases. Inter-individual heterogeneity pathophysiology prompted targeted therapeutics. Beyond COVID-19, medicine will become increasingly personalized via advanced omics-based technologies biology—for example targeting gut microbiome specific mechanisms underlying immunoinflammatory diseases genetic conditions. Modeling proved to strengthening risk assessment supporting decision-making. Advanced computational analytics artificial intelligence (AI) may help integrate epidemic modeling, clinical features, genomics, immune factors, data, anthropometric measures into a “systems medicine” approach. also digital giving telehealth therapeutics roles system resilience patient care. New methods employed during including decentralized trials, could benefit evidence generation decision-making more widely. In conclusion, shaped by multistakeholder collaborations that address complex molecular, clinical, social interrelationships, fostering precision while improving health. Open science, innovative partnerships, patient-centricity key success.
Language: Английский
Citations
6
Expert Systems with Applications, Journal Year: 2024, Volume and Issue: 252, P. 124028 - 124028
Published: May 8, 2024
The COVID-19 pandemic has changed the research agendas of most scientific communities, resulting in an overwhelming production articles a variety domains, including medicine, virology, epidemiology, economy, psychology, and so on. Several open-access corpora literature hubs were established; among them, Open Research Dataset (CORD-19) systematically gathered contributions for 2.5 years, by collecting indexing over one million articles. Here, we present CORD-19 Topic Visualizer (CORToViz), method associated visualization tool inspecting textual corpus abstracts. Our is based upon careful selection up-to-date technologies (including large language models), architecture clustering along orthogonal dimensions extraction techniques temporal topic mining. inspection supported interactive dashboard, providing fast, one-click contents as word clouds trends time series, equipped with easy-to-drive statistical testing analyzing significance emergence arbitrarily selected windows. processes data preparation results are completely general virtually applicable to any documents - thus suited effective adaptation other contexts.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Aug. 18, 2023
Abstract Prostate cancer (PCa) development and progression relies on the programming of glucose lipid metabolism, this involves alterations in androgen receptor expression signalling. Defining molecular mechanism that underpins metabolic will have direct significance for patients with PCa who a poor prognosis. Here we show there is dynamic balance between sortilin syndecan-1, reports different phenotypes. Using tissue microarrays, demonstrated by immunohistochemistry was highly expressed low-grade cancer, while syndecan-1 upregulated high-grade disease. Mechanistic studies prostate cell lines revealed androgen-sensitive LNCaP cells, enhanced metabolism regulating GLUT1 GLUT4, binding progranulin lipoprotein lipase (LPL) to limit metabolism. In contrast, androgen-insensitive PC3 upregulated, interacted LPL colocalised β 3 integrin promote addition, androgen-deprived cells had decreased reduced glucose-metabolism, but increased expression, facilitating interactions possibly integrin. We report hitherto unappreciated PCa, which may disease how androgen-deprivation therapy might castration-resistant PCa.
Language: Английский
Citations
11
Infectious Medicine, Journal Year: 2025, Volume and Issue: 4(1), P. 100162 - 100162
Published: Jan. 16, 2025
In the context of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2), metabolic research has become crucial for in-depth exploration viral infection mechanisms and in searching therapeutic strategies. This paper summarizes interrelationships between carbohydrate, lipid, amino acid metabolism COVID-19 infection, discussing their roles progression. SARS-CoV-2 leads to insulin resistance increased glycolysis, reducing glucose utilization shifting use fat as an energy source. Fat is replication, imbalances may interfere with immune regulation. Consequently, changes such hyperglycemia, hypolipidemia, deficiency certain acids following can contribute progression toward conditions. These pathways not only have potential value prediction diagnosis but also provide new perspectives development By monitoring changes, severity be predicted early, modulating these help reduce inflammatory responses, improve risk thrombosis. Research on relationship provides important scientific basis addressing global challenge posed COVID-19, however, further studies are needed validate findings more effective strategies control.
Language: Английский
Citations
0