Analyzing COVID-19 progression with Markov multistage models: insights from a Korean cohort DOI Creative Commons

Frank Aimee Rodrigue Ndagijimana,

Taesung Park

Genomics & Informatics, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 27, 2025

Abstract Background Understanding the progression and recovery process of COVID-19 is crucial for guiding public health strategies developing targeted interventions. This longitudinal cohort study aims to elucidate dynamics severity evaluate impact underlying conditions on these transitions, providing critical insights more effective disease management. Methods Data from 4549 patients admitted Seoul National University Boramae Medical Center between February 5th, 2020, October 30th, 2021, were analyzed using a 5-state continuous-time Markov multistate model. The model estimated instantaneous transition rates different levels severity, predicted probabilities state determined hazard ratios associated with comorbidities. Results analysis revealed that most stabilized in their initial state, 72.2% moderate symptoms remaining moderate. Patients hypertension had 67.6% higher risk progressing severe, while those diabetes an 89.9% deteriorating severe critical. Although death low early hospitalization, comorbidities significantly increased likelihood worsening conditions. Conclusion highlights utility models assessing among hospitalized patients. findings indicate are likely recover than experience However, increase outcomes, underscoring importance managing

Language: Английский

Exploring the Challenges of Industry 4.0 Adoption in the FMCG Sector: Implications for Resilient Supply Chain in Emerging Economy DOI Creative Commons
Md Shihab Shakur, Maishat Lubaba, Binoy Debnath

et al.

Logistics, Journal Year: 2024, Volume and Issue: 8(1), P. 27 - 27

Published: March 5, 2024

Background: Fast-moving consumer goods (FMCG) supply chains are experiencing various challenges due to the interactions between consumers and decision-makers during physical distribution, manufacturing, wholesale retail. One possible strategy address these for smoothing chain (SC) logistics operations is adopt Industry 4.0 (I4.0) based technologies in FMCG business processes. In this regard, digitalization automation of can be strengthened by alluring properties I4.0 technologies. Methods: This study identified nine significant through a literature review expert validation. Later, were evaluated using novel multicriteria decision-making (MCDM) framework, Bayesian best worst method (BWM). Results: The findings indicated that “requirement substantial investment resources”, “incompatible technological infrastructure” “poorly structured value chain” most implementing industry. Conclusions: expected significantly contribute improving chain’s resilience, sustainability, visibility, traceability responsiveness. Additionally, research provide industrial practitioners valuable insights into similar sectors thus promote SC sustainability resilience those industries.

Language: Английский

Citations

21
Price reaction of global economic indicators: evidence from the COVID-19 pandemic and the Russia–Ukraine conflict DOI
Ahmed Mohamed Habib, Umar Nawaz Kayani

SN Business & Economics, Journal Year: 2024, Volume and Issue: 4(1)

Published: Jan. 3, 2024

Language: Английский

Citations

13
Bibliometric Analysis of Financial and Economic Implications during the COVID-19 Pandemic Crisis DOI Open Access

Bojan Obrenovic,

Goran Oblaković,

Asa Romeo

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(7), P. 2897 - 2897

Published: March 30, 2024

A bibliometric study was performed to explore the financial and economic implications of COVID-19 pandemic. The SCOPUS database sourced, VOSviewer version 1.6.20 used generate visualizations. Articles published between 2020 2024 were targeted, resulting in 1257 papers analysis. comprehensive analysis conducted this paper guided by keywords “COVID-19”, “pandemic”, “financial crisis”, impact”, “economic which revealed critical insights that contribute body knowledge on outputs belong topical areas economics, finance, business, management. Keyword mapping clustering methods employed analyze links crisis, impact, themes. co-occurrence network identified key thematic clusters, including analysis; research impact; social, environmental, corporate responsibility; regional studies disease-related research; challenges policy responses. This reveals an annual publication decline 62.94% average citation rate 20.13 per document. findings suggest abundance global collaboration networks authorships. contributes a better understanding multifaceted impact pandemic from perspective, offering foundation for future application strategies effective crisis

Language: Английский

Citations

11
From Acute Infection to Prolonged Health Consequences: Understanding Health Disparities and Economic Implications in Long COVID Worldwide DOI Open Access
Jaleel Jerry G. Sweis, Fatima Alnaimat,

Valeria Flórez Esparza

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(3), P. 325 - 325

Published: March 11, 2024

The COVID-19 pandemic has resulted in a growing number of patients experiencing persistent symptoms and physiological changes after recovering from acute SARS-CoV-2 infection, known as Long COVID. COVID is characterized by recurring inflammation across multiple organ systems. Diagnosis can be challenging, influenced factors like demographics, comorbidities, immune responses. impacts various systems have neuropsychological effects. Health disparities, particularly related to race, contribute higher burden infection ongoing minority populations. Managing entails addressing spectrum that encompass physical, cognitive, psychological aspects. recovery period for with vary significantly, the severity disease, hospitalization, age. Currently, there are no universally effective treatments, although certain interventions show promise, necessitating further research. Self-management rehabilitation programs provide relief, but more research needed establish their effectiveness. Preventive measures such vaccination use antiviral medications metformin. It imperative conduct develop evidence-based guidelines gain better understanding long-term implications COVID-19. could substantial economic impact on labor market, productivity, healthcare expenditures, overall growth. To address challenges complications face, focus strategies promoting telework flexible work arrangements accommodate diverse symptoms, chronic fatigue other In conclusion, this review emphasizes multifaceted complexity need its potential health impacts.

Language: Английский

Citations

8
New evidence on the real role of digital economy in influencing public health efficiency DOI Creative Commons
Zhao Xiongfei,

Shansong Wu,

Bin Yan

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 26, 2024

Abstract In recent years, the rapid advancement of digital technology has supported growth economy. The transformation towards digitization in public health sector serves as a key indicator this economic shift. Understanding how economy continuously improves efficiency services and its various pathways influence become increasingly important. It is essential to clarify impact mechanism on optimize expenditures advance construction. This study investigates development from novel perspective, considering social media usage urban–rural healthcare disparities while constructing comprehensive index development. findings indicate that reduces primarily through two transmission mechanisms: promotion widening gap. Moreover, these impacts exhibit spatial heterogeneity. unveils intrinsic connection mechanisms interaction between services, providing theoretical basis reference for government policy formulation. However, it also prompts further considerations achieving synergy services.

Language: Английский

Citations

8
Inhibitors of SARS-CoV-2 Main Protease (Mpro) as Anti-Coronavirus Agents DOI Creative Commons
Agnieszka Zagórska, Anna Czopek,

Monika Fryc

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 797 - 797

Published: July 4, 2024

The main protease (Mpro) of SARS-CoV-2 is an essential enzyme that plays a critical part in the virus’s life cycle, making it significant target for developing antiviral drugs. inhibition Mpro has emerged as promising approach therapeutic agents to treat COVID-19. This review explores structure protein and analyzes progress made understanding protein–ligand interactions inhibitors. It focuses on binding kinetics, origin, chemical these provides in-depth analysis recent clinical trials involving covalent non-covalent inhibitors emerging dual targeting Mpro. By integrating findings from literature ongoing trials, this captures current state research into inhibitors, offering comprehensive challenges directions their future development anti-coronavirus agents. information new insights inspiration medicinal chemists, paving way more effective novel COVID-19 therapies.

Language: Английский

Citations

8
COVID-19 Vaccine Distribution Patterns for Prioritized Age Group: Analysis of European Nations DOI Open Access

Ogbonnaya Ezichi,

Victor Okpanachi,

Joy Jibunoh

et al.

Open Journal of Epidemiology, Journal Year: 2025, Volume and Issue: 15(01), P. 1 - 18

Published: Jan. 1, 2025

The emergence of the SARS-CoV-2 virus resulted in a health and economic crisis worldwide. Although everyone is susceptible to COVID-19, elderly have compromised immune systems often suffer from chronic underlying diseases, which makes them more vulnerable. This study aims assess variation COVID-19 vaccine distribution patterns across different age groups European countries understand extent prioritized vulnerable (age > 70) their vaccination programs. utilized open data Center for Disease Prevention Control (ECDC) employed an observational, retrospective design examine among various several September 2021 2023. Results reveal that rates increase with age, peaking at 25 - 49 group (1.34 × 10−4), after there was decline rate. Analysis variance (ANOVA) used investigate equality 29 Europe, p-value during period as no country achieved 70% coverage aimed by WHO. Continuous efforts must be made ensure larger this population order protect severe outcomes region.

Language: Английский

Citations

1
Turning Over a New Leaf: Post-Covid Infrastructure Development Planning and Financing Strategies in the Organizational Environment of Bandung City DOI Creative Commons
Asep Sumaryana, Ahmad Zaini Miftah, Ida Widianingsih

et al.

Regional Science Policy & Practice, Journal Year: 2025, Volume and Issue: unknown, P. 100170 - 100170

Published: Jan. 1, 2025

Language: Английский

Citations

1
Nanobody-Based Lateral Flow Immunoassay for Rapid Antigen Detection of SARS-CoV-2 and MERS-CoV Proteins DOI
Yuli Peng, Ya-Ning Huang, Fabian Kießling

et al.

ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

The COVID-19 pandemic has highlighted the critical need for pathogen detection methods that offer both low limits and rapid results. Despite advancements in simplifying enhancing nucleic acid amplification techniques, immunochemical remain preferred mass testing. These eliminate specialized laboratories highly skilled personnel, making home testing feasible. Here, we developed nanobody-based lateral flow assays (LFAs) of SARS-CoV-2 MERS-CoV single dual formats as point-of-care diagnostic tools. LFAs are sensitive successfully detected analytes at clinically relevant cutoff values. Additionally, our results confirmed have a long shelf life can be produced cost-effectively with ease.

Language: Английский

Citations

1
Two sides of the same coin: heat shock proteins as biomarkers and therapeutic targets for some complex diseases DOI Creative Commons
Xolani Henry Makhoba

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 20, 2025

Heat shock proteins are molecular chaperones that play crucial roles in the folding and unfolding of complex polypeptides within cellular system. These molecules involved various processes, including vesicular transport, prevention protein aggregation cytosol, cell signaling. They also linked to autoimmunity, infection immunity, tumor immunology. Stressors like heat shock, exposure heavy metals, cytokines, reactive oxygen species, inflammation, viruses can influence production these molecules. In diseases such as cancer, malaria, COVID-19, considered both biomarkers drug targets. The upregulation small hsp27 major 70/90 has been recognized therapeutic targets for cancer. Additionally, it reported invasion Plasmodium falciparum, causative agent leads hsp40, hsp70, hsp90. This sudden increase is a protective mechanism from human host enhances parasite's growth, making significant malarial presence SARS-CoV-2 virus system correlates with substantial 70 cells. Furthermore, our research group demonstrated hijacks host's proteins, we currently developing tools prevent utilizing review aims highlight role selected refractory diseases, focusing on COVID-19. A fundamental docking study was performed investigate interaction between non-structural chosen molecules, which emphasized this review.

Language: Английский

Citations

1