The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106799 - 106799

Published: May 19, 2023

Depression is the most prevalent mental disorder in world associated with huge socio-economic consequences. While depressive-related symptoms are well known, molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) emerging as a key regulator of central nervous system homeostasis by exerting fundamental immune metabolic functions. In turn, brain influences intestinal microbial composition through neuroendocrine signals, within so-called microbiota-brain axis. balance this bidirectional crosstalk important to ensure neurogenesis, preserve integrity blood-brain barrier avoid neuroinflammation. Conversely, dysbiosis permeability negatively affect development, behavior, cognition. Furthermore, although not fully defined yet, changes GM depressed patients reported influence pharmacokinetics common antidepressants affecting their absorption, metabolism, activity. Similarly, neuropsychiatric drugs may shape turn an impact on efficacy toxicity pharmacological intervention itself. Consequently, strategies aimed at re-establishing correct homeostatic (i.e., prebiotics, probiotics, fecal transplantation, dietary interventions) represent innovative approach improve pharmacotherapy depression. Among these, probiotics Mediterranean diet, alone or combination standard care, hold promise for clinical application. Therefore, disclosure intricate network between depression will give precious insights diagnostic therapeutic approaches towards depression, profound implications drug development practice.

Language: Английский

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Global trends of purinergic receptors and depression: A bibliometric analysis from 2003 to 2023

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(2)

Published: Jan. 14, 2025

BACKGROUND Depression significantly threatens human health. Purinergic receptors are reported to be associated with depression. However, there is no bibliometric research in this field have been published. AIM To provide some reference for the further of purinergic and depression utilizing analysis. METHODS Relevant researches were retrieved from Web Science Core Collection database. The period search was January 1, 2003 December 31, 2023. CiteSpace (6.2.R7) VOSviewer (1.6.19) applied identify main contributors countries, authors, institutions, references journals. Besides, we evaluate keywords assess hotspots trends over previous 2 decades. RESULTS Totally, 247 articles identified, showing an increasing trend time. most productive country, institution, journal China, Harvard University, Biological Psychiatry, respectively. Liang SD Rodrigues, Ana Lucia S prolific authors. Burnstock G ranked first among cited cooperation countries disciplines crucial. P2X7 receptor provides promising prospects treating studies warranted validate scope significance therapeutic strategies. CONCLUSION This study overview worldwide status future considered appropriate target treatment depression, as well neurological diseases. It implied that based on system, interventions aimed at promising, way both augmentation strategies new drug treatments context pharmacology

Language: Английский

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Exploring the gut-brain axis in a large cohort of patients with irritable bowel syndrome: Is there a link between depression and intestinal and extra-intestinal symptoms?

Gastroenterología y Hepatología, Journal Year: 2025, Volume and Issue: unknown, P. 502370 - 502370

Published: Feb. 1, 2025

Language: Английский

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Exploration of the mechanism of Traditional Chinese Medicine for anxiety and depression in patients with diarrheal irritable bowel syndrome based on network pharmacology and meta-analysis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 21, 2024

Background The efficacy of Chinese herbal medicine (CHM) in managing irritable bowel syndrome with diarrhea (IBS-D) accompanied by anxiety and depression remains uncertain. Thus, a systematic review was carried out employing meta-analysis network pharmacology to ascertain the underlying mechanisms CHM therapy. Methods By conducting review, including literature search, screening, data extraction, we identified 25 randomized controlled trials assess CHM’s effectiveness treating alongside depression. Network utilized scrutinize metabolite utility addressing this condition. Potential primary were synthesized using information sourced from PubMed database. Results Twenty-five studies, 2055 patients, analyzed, revealing significant treatment for IBS-D trial group compared controls [OR = 4.01, 95% CI (2.99, 5.36), I 2 0%] Additionally, [SMD −1.08, (-1.30, −0.86), p < 0.00001, 68%; SDS: SMD -1.69, (-2.48, −0.90), 0.0001, 96%] [HAMA: -1.29, (-1.68, −0.91), 89%; SAS: -1.75, (-2.55, −0.95), significantly improved group. Furthermore, exhibited lower disease relapse rate 0.30, (0.20, 0.44), 0%]. consistently IBS severity (IBS-SSS) symptom scores. analysis key chemical metabolites traditional formulations, Beta-sitosterol, Stigmasterol, Quercetin, Naringenin, Luteolin, Kaempferol, Nobiletin, Wogonin, Formononetin, Isorhamnetin. Utilizing STRING database Cytoscape v3.9.0 software, protein-protein interaction (PPI) revealed top eight targets: IL-6, TNF, PPARG, PTGS2, ESR1, NOS3, MAPK8, AKT1, implicated anti-inflammatory responses, antioxidant stress modulation, neurotransmitter homeostasis maintenance. Conclusion Herbal Medicine offers promising safe approach patients dealing Diarrheal Irritable Bowel Syndrome depression; thus, indicating its potential practical implementation. most active could simultaneously act on pathological targets IBS-D, anxiety, depression.The diverse scope therapeutic role includes various aspects objectives, underscoring broad utilization.

Language: Английский

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Effect of Acupuncture on Anxiety, Depression, and Quality of Life in Patients with Irritable Bowel Syndrome: A Meta-Analysis

International Journal of Behavioral Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

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Depression in Diarrhea-Predominant IBS Patients: Exploring the Link Between Gut Barrier Dysfunction and Erythrocyte Polyunsaturated Fatty Acid Levels

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2483 - 2483

Published: April 5, 2025

Background: Patients with irritable bowel syndrome (IBS) often experience comorbid psychological conditions, notably depression and anxiety. Evidence suggests that these conditions are linked to gut barrier dysfunction, dysbiosis, chronic inflammation. All factors central IBS pathophysiology mood disturbances. Polyunsaturated fatty acids (PUFAs) play crucial roles in modulating inflammation depression. This study examined the associations among intestinal permeability, PUFA profiles, low-grade inflammation, severity patients diarrhea (IBS-D). Methods: Forty-three IBS-D (7 men, 36 women; 44.56 ± 1.52 years) were categorized into depressed (IBS-D(d+)) non-depressed (IBS-D(d-)) groups according scores on subscale of Symptom Checklist-90-Revised (SCL-90-R). Biomarkers small permeability (s-IP) assessed urine blood, alongside erythrocyte membrane composition, indices. Results: (d+) exhibited elevated s-IP altered metabolism compared their (d-) counterparts. Additionally, first group, omega-3 concentrations inversely correlated biomarkers, while omega-6/omega-3 ratio showed a positive correlation. Moreover, is significantly associated markers levels. Lastly, higher levels dysbiosis pro-inflammatory cytokines than patients. Conclusions: These findings highlight interplay between integrity depression, suggesting profiles could represent novel therapeutic targets for managing this population. was registered ClinicalTrials.gov (NCT03423069), date registration 30 January 2018.

Language: Английский

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Transcriptomic analysis and experiment to verify the mechanism of Xiaoyao San in the treatment of irritable bowel syndrome with depression

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119732 - 119732

Published: April 1, 2025

Language: Английский

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Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight – An integrated bibliometric and science mapping approach

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 8, 2023

Objectives This study aims to perform a bibliometric analysis of functional dyspepsia (FD), which includes visualizing bibliographic information, in order identify prevailing themes, topics interest, contributing journals, countries, institutions, and authors as well co-citation patterns. Methods The Web Science™ Core Collection Database was used retrieve all peer-reviewed scientific publications related FD research. validated search terms were entered into the “title” “author keywords” fields, results sorted by publication year from 2006 2022. There no restrictions on language. On 12 February 2023, manual export complete metadata for each original review article performed. CiteSpace reveal co-authorship, publication, patterns find prominent authors, organizations, journals research author keywords with strong citation bursts, could indicate an emerging area. VOSviewer build co-occurrence indicator (co-word) main previous studies focused induce clustered landscape two consecutive periods intriguing areas future Results A database retrieved 2,957 documents. wave-like pattern number until 2017, after there spike volume. USA, China, Japan provided majority contributions. In institution, Mayo Clin, Univ Newcastle, Katholieke Leuven found be prolific institutions. Additionally, that eastern Asian researchers contributed significantly global knowledge literature led other countries; however, Canada, Australia, England, Germany have highest degree betweenness centrality. Nicholas J. Talley, Jan Tack, Gerald Holtmann, Michael Camilleri, Ken Haruma, Paul Moayyedi occupied top positions based productivity centrality indicators. Six thematic clusters emerged ( Helicobacter pylori infection; pathophysiological mechanisms FD; extraintestinal co-morbidities overlap syndromes associated herbal medicine diabetic gastroparesis; dietary factors FD). “Acupuncture,” “duodenal eosinophilia,” “gut microbiota,” others among rising prevalence. Conclusion research, countries established themselves major contributors publishing productivity; has primarily been driven North America, Europe, where cooperation is generally more active highly influential are produced. Our suggests increased investments, training human resources, improved infrastructures, expanded collaborations essential improving quality Asia. keyword eosinophil-mast cell axis, gut microbiota, mental disorders, acupuncture key attract researchers’ attention boulevards. skewed distribution output across Asia, most focus complementary alternative (CAM) coming Chinese, Japanese, South Korean centers. However, CAM remains underexplored area context FD, it deserves greater efforts obtain evidence. Furthermore, we propose framework should not limited dysmotility; rather, interpreted within holistic brain-gut-microbiota novel concepts such duodenitis, mucosal permeability, infiltration activation eosinophils mast cells, others. Overall, bibliometrics-based overviews relevant different backgrounds healthcare professionals provide in-depth overview trends

Language: Английский

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Bibliometric analysis of the 100 most-cited papers about the role of gut microbiota in irritable bowel syndrome from 2000 to 2021

Clinical and Experimental Medicine, Journal Year: 2022, Volume and Issue: 23(6), P. 2759 - 2772

Published: Dec. 15, 2022

Language: Английский

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Prevalence of Irritable Bowel Syndrome in Saudi Arabia: A Systematic Review and Meta-Analysis

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 16, 2023

Irritable bowel syndrome (IBS) is a commonly found global functional pathology with no detectable structural changes. It affects the quality of life and often coexists psychiatric somatic issues. We reviewed all articles published between 1990 April 2023. The databases used for data search were Google Scholar, Web Science, Cochrane Library, PubMed/MEDLINE. Ovid engine was also to broaden strategy. Predefined keywords, including "Irritable syndrome" (MeSH) OR "IBS" (all fields), along "Saudi Arabia" "Middle East," avoid loss ambiguity. Any cross-sectional study that reported prevalence IBS in any gender, age, group Saudi population included. Data extraction independently performed duplicate mitigate bias loss. Statistical analysis proportion conducted by using Miller (Freeman-Tukey double arcsine - exact inverse). Out 350 records identified, only 38 studies included quantitative synthesis. total number participants 26,567, on basis predefined inclusion criteria study. StatsDirect software statistical parameters. Based identified studies, calculated pooled 20.7% (95% confidence interval (CI) = 17.8% 23.7% applying random effects (DerSimonian-Laird method). 21% CI 16.7% 25.7%) general population, 22% 17.6% 26.7%) students, 18.3% 13.3% 23.9%) healthcare workers. among 20.7%. pathophysiology complexed significantly affected genetics, diet, cultural characteristics, anxiety, depression, stress, sleep disorders. This fills gap understanding Arabia, contributing valuable this region.

Language: Английский

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