“A Cross Sectional Study on Association between Serum Vitamin D Status and Insulin Resistance in Polycystic Ovarian Syndrome” DOI Open Access

J Sreeja Shraddha,

Anupama Hari

Scholars International Journal of Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: 6(10), P. 378 - 387

Published: Oct. 11, 2023

Polycystic ovarian syndrome is a common cause of dysfunction in women with anovulation world wide.50-70% patients PCOS exhibit metabolic abnormalities, including poor glucose tolerance and hyperinsulinemia. The prevalence vitamin D deficiency about 67-85 per cent, serum concentrations 25(OH) <20 ng/ml. It suggested that there an association between levels parameters PCOS, fasting levels, insulin, insulin resistance, high blood pressure, lipid disorders, obesity, fertility other clinical laboratory- related associated PCOS. Given the south Indian population, less number studies, inconclusive especially population as well evidence from recent studies indicating link lab parameters, this study aimed to assess relationship resistance Pearsons correlation showed 0.034 HOMA IR d more values, resistance. 0.05 No significant relation seen (Pearsons value >0.05). In study, it was found percentage were deficient. also difference values some such waist circumference, HOMA-IR, BMI without deficiency; however, no linear baseline variables, except for BMI, G120. conclusion, our data confirm Insulin Thus, supplementation could be beneficial treatment abolish regulate menstrual irregularities.

Language: Английский

Unraveling intestinal microbiota’s dominance in polycystic ovary syndrome pathogenesis over vaginal microbiota DOI Creative Commons
Yu Xia,

XiaoQin Li,

Hui Yang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: March 28, 2024

Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disease in women, intricately linked to hormonal imbalances. The microbiota composition plays pivotal role influencing levels within the body. In this study, we utilized murine model investigate how intestinal and vaginal interact with hormones development of PCOS. Methods Twenty female mice were randomly assigned normal group (N) (P), where latter received daily subcutaneous injections 0.1 mL DHEA (6 mg/100 g). Throughout experiment, evaluated PCOS mouse by estrus cycle, serum total testosterone (T), prolactin (PRL) luteinizing hormone (LH) levels, ovarian pathological morphology. microbial both content studied 16S rRNA gene high-throughput sequencing. Results Compared N group, P showed significant increases body weight, T, PRL, decrease LH. Ovaries exhibited polycystic changes, estrous cycle was disrupted. result shows that Chao1, ACE, Shannon Simpson indexes decreased, Desulfobacterota Acidobacteriota increased, Muribaculaceae , Limosilactobacillus Lactobacillus decreased group. T significantly positively correlated Enterorhabdus LH Lactobacillus. analysis revealed no changes Shannon, indices. However, there increased Firmicutes, Bacteroidota, Actinobacteriota, Streptococcus . Particularly, Rodentibacter displayed robust negative correlation other components microbiota. Conclusion Therefore, response more than likely involved through its participation regulation.

Language: Английский

Citations

2
Molecular role of non-exonic variants in CALPAIN 10 gene in polycystic ovarian syndrome in Saudi women DOI Creative Commons

Arwa A. Alageel,

Amal F. Alshammary, Imran Ali Khan

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 27, 2023

Non-diabetic women with polycystic ovarian syndrome (PCOS) often have abnormal insulin regulation. Calpain 10 (CALP10) is a biomarker of type 2 diabetes mellitus, some its single-nucleotide polymorphisms (SNPs) influencing PCOS development.

Language: Английский

Citations

4
Mapping the knowledge structure of research on insulin resistance and metabolic syndrome: a global perspective DOI Creative Commons
Sa’ed H. Zyoud,

Muna Shakhshir,

Amani S. Abushanab

et al.

Translational Medicine Communications, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 2, 2024

Abstract Background Insulin resistance is a major pathogenic factor that plays crucial role in the development of metabolic syndrome and has been proposed as one its underlying causes. Most diagnostic criteria for do not directly include insulin resistance. Furthermore, research on continues to provide information treatment syndromes related health conditions. Therefore, this bibliometric analysis aimed investigate current status identify possible future hotspots area by analyzing Scopus-based studies. Methods To collect published data resistance, study used Scopus database source without particular starting date but including records up December 31, 2022. The gathered documents were then exported VOSviewer v.1.6.18 analyze visualize country collaborations areas high interest. Results presents an overview 1932 between 1988 2022, focusing Of these records, 77.33% original journal articles, while 13.30% review articles. Additionally, 9.35% fall under other types publication, letters, notes, editorials. United States came out top with 463 items, accounting 23.96% contributions field, followed Japan second place 119 items (6.16%). China ( n = 113, 5.85%) Kingdom ranked third. publications focus key terms pathogenesis syndrome, use waist circumference clinical indicator evaluate risk association oxidative stress pro-inflammatory state. Conclusions This first findings offer comprehensive global perspective carried can be invaluable research.

Language: Английский

Citations

1
Positive association of the anti-aging protein α-Klotho with insulin resistance and its inverse L-shaped relationship with glycaemic control in the middle-aged and elderly population DOI
Kai Wang, Jianing Liu

Endocrine, Journal Year: 2024, Volume and Issue: 86(1), P. 143 - 155

Published: May 18, 2024

Language: Английский

Citations

1
Multiomics in polycystic ovarian syndrome DOI
Farhat Jabeen, Rais Ahmad,

Seerat Rasool

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 219 - 252

Published: Jan. 1, 2024

Language: Английский

Citations

1
Recent status and trends of innate immunity and the gut-kidney aixs in IgAN: A systematic review and bibliometric analysis DOI
Xun� Li, Chao Li, Pei Wu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113335 - 113335

Published: Oct. 17, 2024

Language: Английский

Citations

1
Gut microbiota in insulin resistance: a bibliometric analysis DOI

Weiwei Tian,

Li Liu, Ruirui Wang

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2024, Volume and Issue: 23(1), P. 173 - 188

Published: Feb. 14, 2024

Language: Английский

Citations

1
A bibliometric and visual analysis of obesity and polycystic ovary syndrome from 2012 to 2022 DOI Creative Commons

Ping Luo,

Jiake Li, Pengzhou Li

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 2, 2022

Background Obesity is associated with polycystic ovary syndrome (PCOS). We aimed to elucidate the research status and explore trends future directions of on obesity PCOS. Methods A bibliometric analysis published papers in field PCOS between 2012 2022 was conducted basis Web Science Core Collection database. The collaboration networks, trends, literature sources, citation analysis, co-citation keywords were statistically analyzed visualized using VOSviewer software. Results retrieved 2843 records from 681 journals by 12307 authors 2942 institutes 99 countries. number citations had a roughly increasing trend annually. United States China contributed majority records. Monash University, Shanghai Jiaotong Aristotle University Thessaloniki, Karolinska Institute, São Paulo, Tehran Medical Sciences biggest nodes their cluster network map, Moran LJ, Teede HJ, Joham AE, Escobar-Morreale HF, Macut D prolific authors. Research hotspots identified this focused insulin resistance (IR), metabolic syndrome, metformin, inflammation. Bariatric surgery, mitochondrial dysfunction, binding globulins, comorbidities may be frontiers research. Conclusions concluded better understanding patterns, hotspots, useful for researchers.

Language: Английский

Citations

6
A bibliometric analysis of the effects of sex hormone profiles in women with polycystic ovary syndrome DOI Creative Commons
Bo Li, Shuang Li,

Zibo Duan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract Background：Polycystic ovary syndrome (PCOS) is one of the common causes infertility in pregnant women, which regulated by sex hormones. This has had a serious negative impact on quality life women childbearing age and placed burden families society. Therefore, study hormones PCOS important research value, social value practical significance. The objective this to evaluate published articles through utilization bibliometrics, generate comprehensive methodical overview current status emerging subjects field, predict trajectory future focus area. Methods: investigation utilized Web Science Core Collection (WoSCC) database locate relevant prior November 24, 2023. CiteSpace, Biblimetric, VOSViewer were applications bibliometric analysis process. Results: incorporated 1835 publications from 2013 institutions 80 countries, with China United States being most prominent. aforementioned field experienced period exponential growth since 2017. Journal Gynecological Endocrinology publishes greatest number concerning effects PCOS.The factor FERTILITY AND STERILITY among leading ten journals. A total 10605 authors credited for these works, Ricardo Azziz cited Legro prolific. principal areas discipline pertain pathological processes complications. Current usage includes terms "insulin resistance," "women," "prevalence," "polycystic syndrome," "obesity," "risk," "expression," "testosterone" denote trends hotspots. Conclusion: Research hormone polycystic possesses both societal scientific merit. rate its progress accelerating, growing cohort scholars are devoting their attention field. By employing analysis, identified hot topics predicted development trend, summarized analyzed influence PCOS, including spots, trends,

Language: Английский

Citations

0
Research status of polycystic ovary syndrome treatment: a mini review and a bibliometric analysis from 2010 to 2023 DOI Creative Commons

Yu‐Xin Jin,

Hang-Qi Hu,

Jia-Cheng Zhang

et al.

Gynecological Endocrinology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Sept. 19, 2024

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in premenopausal women, often linked to abdominal obesity, insulin resistance, issues. With its heterogeneous nature, PCOS treatment should be tailored individual symptoms patient preferences. This study examines collaboration networks among countries, institutions, authors, references, journals related treatment.

Language: Английский

Citations

0