Long-term trends in the burden of pulmonary arterial hypertension in China and worldwide: new insights based on GBD 2021

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Pulmonary arterial hypertension (PAH) poses a significant health challenge globally, with China experiencing notable increase in its burden. Understanding the trends and factors contributing to PAH is crucial for developing effective public strategies. This study utilized data from Global Burden of Disease (GBD) 2021 database estimate burden worldwide 1990 2021. A Bayesian age-period-cohort (BAPC) model was employed analyze differences across age, gender, time periods, project global epidemiological until 2036. From 2021, incidence prevalence increased by 80.59% 86.74%, respectively. The age-standardized rate (ASIR) (ASPR) showed an annual percentage change (AAPC) -0.07% 0.25%, Conversely, disability-adjusted life year (DALY) mortality (ASMR) have been declining since 1990, AAPC -1.90% -1.26%, Females 50-70 years age group experienced higher compared males. Projections indicate that ASPR, ASMR, death (ASDR) will stabilize minimal variation over next decade. findings highlight age-related China, particularly affecting older populations women. projected stabilization metrics decade underscores need continued monitoring targeted interventions. study's comprehensive analysis three decades provides valuable insights policymakers healthcare providers, necessitating concerted efforts address this critical issue.

Language: Английский

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Tuberculosis disease burden in China: a spatio-temporal clustering and prediction study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

The primary aim of this study is to investigate and predict the prevalence determinants tuberculosis disease burden in China. Leveraging high-quality data sources employing a methodologically rigorous approach, endeavors enhance our understanding control efforts across different regions First, through nationwide spatio-temporal cluster analysis, we summarized status various China explore differences, thereby providing basis for formulating more targeted prevention policies regions; Subsequently, using time series-based forecasting model, conducted first-ever national trend forecast offer scientific guidance timely adjustments planning resource allocation. This research seeks contribute significantly China's existing system. draws upon publicly available pulmonary (PTB) incidence mortality statistics from 31 provinces municipalities mainland between 2004 2018. We organized classified these according province, month, year, patient age group. Overall, sample included 14,816,329 new instances PTB 42,465 PTB-related fatalities. used spatiotemporal analysis record epidemiological characteristics patterns during period. Additionally, series model was constructed analyze trends reveals significant regional variations Tibet (124.24%) Xinjiang (114.72%) western exhibited largest percentage change (TB) incidence, while Zhejiang Province (-50.45%) Jiangsu (-51.33%) eastern showed decreases. Regions with increases rates (>100%) four regions, six central five regions. relatively large decreases rate include Tianjin (-52.25%) Shanghai (-68.30%). These differences are attributed two main factors: (1) economic imbalances leading poor TB underdeveloped areas, (2) TB-related among causing uneven distribution risks. Consequently, may still face challenges achieving World Health Organization's 2030 goals. Nationwide, increased 2018 (percentage change: 105.35%, AAPC: 4.1), downward -20.59%, -2.1). Among groups, 0-19 group has smallest burden. While were primarily found adults 60 years or older, TB, highlighting obvious characteristics. It predicted that will continue increase. In summary, epidemic been largely controlled due implementation many public health programs targeting specific groups geographical areas. Finding supporting effective make it possible achieve goal controlling

Language: Английский

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Global burden and trends of norovirus-associated diseases from 1990 to 2021 an observational trend study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

Norovirus remains a significant viral cause of waterborne and foodborne gastroenteritis outbreaks epidemics worldwide. The burden norovirus extends across different income settings. Leveraging secondary data from the 2021 Global Burden Diseases Study, our analysis spanned period 1990 to assess norovirus-associated diseases (NADs). We utilized descriptive statistics examine global mortality rates disability-adjusted life years (DALYs). For trend analysis, we employed annual percentage change (EAPC) through linear regression applied Joinpoint identify changes over time. A comprehensive age-period-cohort model evaluated key risk factors. Furthermore, Bayesian was conducted forecast trends up 2035, providing valuable insights for policy formulation resource allocation. In 2021, age-standardized rate (ASMR) NADs 1.62 per 100,000 population (95% UI: 0.35 2.91), while DALY (ASDR) 79.02 26.61 132.26). downward observed in most regions countries, with EAPC -4.29% -4.53 -4.05) ASMR -4.40% -4.62 -4.19) ASDR 2021. Notably, children under 5 old had considerably higher ASDR: 475.52 160.73 893.72) males 335.44 112.29 623.48) females. Mortality escalated age, peak 69.27 CI: 64.04 74.92) under-five age group, 11.38 10.59 12.22) individuals 95 years. Age-Period Cohort projections indicate continued decline 2035. Between significantly declined due public health interventions, vaccination, improved sanitation. However, highly contagious, especially among older adult. Projections suggest decrease such by To further reduce this burden, preventive measures like vaccination infection control strategies are essential high-risk populations, alongside ongoing research into epidemiology transmission dynamics.

Language: Английский

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Global temporal trends and projections of hepatitis B-related cirrhosis among adolescents and young adults from 1990 to 2035: an analysis based on the global burden of disease study 2021

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Chronic hepatitis B and cirrhosis pose significant global health threats. Few studies have explored the disease burden mortality trend of caused by virus infection among adolescents young adults (AYAs, aged 15-39 years). This study aimed to assess trends. Publicly available data were obtained from 2021 GBD database. The rates incidence, mortality, disability-adjusted life years calculated at global, regional, national levels. Temporal trends assessed using joinpoint regression analysis, while Bayesian age-period-cohort model was used predict future From 1990 2021, incidence rate B-related decreased 111.33 (95% uncertainty interval: 89.18 134.98) 67.75 (54.06 82.71) per 100,000 with an average annual percentage change -1.58 confidence -1.66 -1.51, p < 0.001). However, between numbers in 30-34 35-39 age groups increased 23.75 21.24%, respectively. number deaths low low-middle Socio-demographic Index (SDI) areas 79.51 20.62%, Moreover, it is predicted that incidences will continue rise SDI. At regional level, Central Sub-Saharan Africa had highest rates. In Somalia Democratic Republic Congo rates, whereas Kiribati Cambodia overall AYAs has over past three decades. Nevertheless, there a slight increase individuals 30-39 years. substantial SDI underscore need for sustained targeted public interventions.

Language: Английский

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Therapeutic Potential of Vanillic Acid in Ulcerative Colitis Through Microbiota and Macrophage Modulation

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

This study investigated the protective effects of dietary polyphenol vanillic acid (VA) on dextran sulfate sodium-induced acute ulcerative colitis (UC) in mice, focusing its impact gut microbiota and inflammatory responses. VA was supplemented following sodium administration, key indicators, including body weight, disease activity index, colon length, spleen markers, were assessed. supplementation significantly alleviated UC symptoms, preserved intestinal barrier integrity, reduced pro-inflammatory cytokine levels. Additionally, positively altered composition, promoting beneficial bacteria such as Akkermansia muciniphila while suppressing arachidonic metabolism pathway. Fecal transplantation confirmed that VA-modified contributed to these effects. also facilitated macrophage polarization from M1 phenotype anti-inflammatory M2 phenotype, further mitigating inflammation. These findings highlight potential a natural intervention for UC, emphasizing role regulating pathways, which may have significant nutritional relevance managing bowel diseases.

Language: Английский

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Psoriasis Burden: Global Burden of Disease Study 2021

Published: Jan. 1, 2025

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Dissecting the rising tide of inflammatory bowel disease among youth in a changing world: insights from GBD 2021

International Journal of Colorectal Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Feb. 18, 2025

This study investigates the alarming epidemiological trends of inflammatory bowel disease (IBD) among children and young adults, highlighting associated burden on global health. Utilizing data from Global Burden Disease (GBD) 2021, we conducted a comprehensive analysis age-standardized incidence rates (ASIR), mortality (ASMR), disability-adjusted life years (DALYs), estimated annual percentage changes (EAPC). Future were forecasted using Bayesian age-period-cohort model. From 1990 to IBD DALY remained persistently high, with concerning upward trend noted adults. While men experienced decline in rates, women faced increasing burdens. In high-income regions, particularly North America, reported highest contrasting sharply Central Latin which exhibited lowest ASIR. Southeast Asia presented most favorable rates. A notable negative correlation was identified between socio-demographic index (SDI) at national level, high high-middle SDI countries continuing bear substantial burden, while low middle nations rising challenges. The persistent adults signifies critical public health concern. marked geographical gender disparities underscore urgent need for tailored regional population-based strategies aimed primary prevention effective management. illuminates pressing necessity policy interventions address growing epidemic vulnerable populations.

Language: Английский

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Respiratory infections and nutritional deficiencies in Chadian children under five years between 1990 to 2021: Incidence, DALYs, risk factors and policies performance

Journal of Global Health Economics and Policy, Journal Year: 2025, Volume and Issue: 5

Published: March 10, 2025

Background The burden of lower respiratory infections (LRI), upper (URI), and nutritional deficiencies (ND) among children under five in low-income countries has remained critically high for decades. Methods Data, expressed as rates per 100,000 people from the Global Burden Diseases, were analyzed to investigate trends, maternal risk factors, performance health policies related LRI, URI, ND incidence well disability-adjusted life years (DALYs) Chadian five. Findings Over study period, LRI declined boys girls Additionally, DALYs all exhibited decreasing trends. Moreover, an increase prevalence gynecological diseases, disorders, HIV/AIDS, tuberculosis, deficiencies, malaria, alcohol use hepatitis B was associated with Consequently, enacted Chad since 2015 improve children’s resulted only decline DALYs, incidence. Conclusions URI requires particular attention. Furthermore, many conditions have been identified being ND. Since existing did not effectively decrease three conditions, implementing specific targeting might substantially alleviate such Chad.

Language: Английский

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Comparison of trend analysis of varicella zoster disease burden between China and the world 1990–2021 and disease burden forecast 2030

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 10, 2025

Objectives This study aims to analyze temporal trends in the age- and sex-specific burdens of varicella zoster virus (VZV), including incidence, prevalence, mortality, disability-adjusted life years (DALYs) China from 1990 2021, predict burden for 2030 by comparing with global disease. Methods Data Global Burden Disease database (1990–2021) were used characteristics (VZV) globally, (DALYs). The average annual percentage change (AAPC) its corresponding 95% confidence interval (95% CI) calculated using Joinpoint assess VZV trends. A comprehensive comparative analysis differences between population was conducted across multiple dimensions, age, gender, time period. Additionally, an autoregressive integrated moving (ARIMA) model trend 2021 2030. Results Between age-standardized incidence rate (ASIR) decreased 1,274.93/100,000 1,270.58/100,000, while ASIR increased 1,244.05/100,000 1,248.59/100,000. In China, prevalence (ASPR) slightly 72.27/100,000 72.03/100,000, whereas ASPR rose 66.67/100,000 67.16/100,000. year (ASDR) significantly, 17.68/100,000 4.66/100,000, ASDR 19.28/100,000 12.31/100,000. Similarly, China’s mortality (ASMR) declined 0.40/100,000 0.05/100,000, ASMR 0.35/100,000 0.19/100,000. Over same period, ASIR, ASPR, ASMR, −0.0056, −0.0131%, −6.84%, −4.24%, respectively, AAPC these metrics 0.0119, 0.0183, −1.97%, −1.42%, respectively. age gender had a significant impact on zoster. notably influenced exhibited increasing age. Projections indicate that will continue decrease 2030, are expected remain stable. Conclusion DALYs demonstrated declining trend, reflecting relative reduction burden. Women more susceptible infection face higher risk than men. contrast, disease remains China. suggest slight However, due country’s large aging population, pose public health challenge.

Language: Английский

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Global trends in staphylococcus aureus-related lower respiratory infections from 1990 to 2021: findings from the 2021 global burden of disease report

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Language: Английский

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