Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance: A visualization and bibliometric study

World Journal of Hepatology, Journal Year: 2024, Volume and Issue: 16(6), P. 951 - 965

Published: June 19, 2024

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a condition that prevalent worldwide and associated with significant health risks economic burdens. As it has been linked to insulin resistance (IR), this study aimed perform bibliometric analysis visually represent the scientific literature on IR NAFLD. AIM To map research landscape underscore critical areas of focus, influential studies, future directions NAFLD IR. METHODS This conducted indexed in SciVerse Scopus database from 1999 2022. The search strategy used terms medical subject headings, focusing related VOSviewer software was visualize trends, collaborations, key thematic areas. examined publication type, annual output, contributing countries institutions, funding agencies, journal impact factors, citation patterns, highly cited references. RESULTS identified 23124 documents NAFLD, revealing increase number publications between retrieved 715 papers including 573 (80.14%) articles 88 (12.31%) reviews. most productive were China (n = 134; 18.74%), United States 122; 17.06%), Italy 97; 13.57%), Japan 41; 5.73%). leading institutions included Università degli Studi di Torino, 29; 4.06%), Consiglio Nazionale delle Ricerche, 19; 2.66%). top agencies National Institute Diabetes Digestive Kidney Diseases 48; 6.71%), Natural Science Foundation 37; 5.17%). active journals field Hepatology (27 publications), Journal (17 Clinical Endocrinology Metabolism (13 publications). main hotspots “therapeutic approaches for NAFLD” “inflammatory high-fat diet impacts NAFLD”. CONCLUSION first examine relationship In response escalating global challenge highlights an urgent need better understanding development intervention strategies. Policymakers prioritize address increasing prevalence

Language: Английский

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Research trends and hotspots in exercise interventions for liver cirrhosis: A bibliometric analysis via CiteSpace

Medicine, Journal Year: 2024, Volume and Issue: 103(28), P. e38831 - e38831

Published: July 12, 2024

Cirrhosis is a chronic liver disease with severe consequences for patient’s health and survival. Exercise an essential therapeutic strategy both cirrhosis prevention treatment. On the other hand, information regarding present status of exercise-related research in limited. Therefore, this study seeks to close gap scientific literature by using bibliometric techniques analyze trends, focal points, cutting-edge areas on exercise cirrhosis. September 22, 2023, articles reviews intervention were obtained downloaded from Web Science Core Collection (WoSCC). Subsequently, we employed CiteSpace (version 6.1.R6) conduct knowledge graph analyses. 588 papers 301 scholarly journals written 673 authors 460 institutions spread over 63 countries regions. The most productive nation among them United States. Not only Zobair M. Younossi 1 prolific writers, but he also receives co-citations. Most published University Michigan US, Alberta Canada coming second. Meanwhile, WORLD JOURNAL OF GASTROENTEROLOGY has articles, whereas HEPATOLOGY greatest number Apart theme words, frequently utilized keywords “quality life,” “insulin resistance,” “mortality.” Future may concentrate “obesity,” “sarcopenia,” “Mediterranean diet,” according analysis keyword emergence. used work visually represent topic cirrhosis, offering valuable researchers field’s current possible future direction.

Language: Английский

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Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1553 - 1553

Published: July 12, 2024

Metabolic dysfunctions are among the best documented hallmarks of ageing. Cardiovascular disease, Alzheimer’s cancer, type 2 diabetes mellitus, metabolic-dysfunction-associated steatosis liver and fragility fractures diseases hyperinsulinaemia that reduce life healthspan. We studied effect suppressing ketosis in 10 lean (BMI 20.5 kg/m2 ± 1.4), metabolically healthy, pre-menopausal women (age 32.3 8.9 years) maintaining nutritional (NK) for an average 3.9 years (± 2.3) who underwent three 21-day phases: (NK; P1), suppressed (SuK; P2), returned to NK (P3). Ketosis suppression significantly increased insulin, 1.83-fold (p = 0.0006); glucose, 1.17-fold 0.0088); homeostasis model assessment insulin resistance (HOMA-IR), 2.13-fold 0.0008); leptin, 3.35-fold 0.0010); total osteocalcin, 1.63-fold 0.0138); uncarboxylated 1.98-fold 0.0417) decreased beta-hydroxybutyrate, 13.50-fold 0.0012) glucagon-like peptide-1 (GLP-1), 2.40-fold 0.0209). Sustained showed no adverse health effects may mitigate hyperinsulinemia. All biomarkers basal P1 levels after removing intervention SuK, indicating metabolic flexibility was maintained with long-term euketonaemia.

Language: Английский

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A bibliometric and visual analysis of the research status and hotspots of seborrheic dermatitis based on web of science

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(9)

Published: Sept. 1, 2024

Abstract Background Seborrheic dermatitis (SD) is a common chronic inflammatory skin disease. In recent years, significant progress has been made in the field of SD, but there no bibliometric research yet. This study aims to use methods analyze current status and hot topics understand further trends future development prospects this field. Methods Retrieve core literature on SD from Web Science database conduct detailed analysis using CiteSpace VOSviewer software based factors such as publication volume, countries (regions), institutions, journals, authors, highly‐cited papers, keywords. Results From 1996 2024, total 1436 publications were included analysis. The number shown an increasing trend year by year. USA leading country research. University California System primary institution. International Journal Dermatology journal with highest publications. author Yang Won Lee publications, while article “Seborrheic Dermatitis” (2004) Gupta, A.K. cited most. dermatitis” most frequently occurring keyword. main hotspots frontiers are follows: (1) relationship between other diseases popular topic; (2) Malassezia inflammation SD; (3) Focusing antifungal anti‐inflammatory treatments for frontier direction Conclusion summary research, which helps clinical doctors researchers quickly insights valuable information provides reference decision‐making finding directions.

Language: Английский

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Global research trends and prospects on immune-related therapy in ischemic stroke: a bibliometric analysis

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 29, 2024

Following ischemic stroke, non-neuronal cells within the nervous system play a crucial role in maintaining neurovascular unit functions, regulating metabolic and inflammatory processes of system. Investigating functions regulation these cells, particularly immune deepens our understanding complex mechanisms neuroinflammation modulation after stroke provides new perspectives methods for immune-related therapy.

Language: Английский

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Insulin resistance, vulnerable plaque and stroke risk in patients with carotid artery stenosis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 12, 2024

Insulin resistance (IR) is linked to both the vulnerable plaque and stroke risk. However, precise extent of this correlation its impact on risk in carotid artery stenosis patients remain unclear. Therefore, study aims investigate relationship between IR mediating role with stenosis. This included 505 was assessed using triglyceride-glucose (TyG) index. The association TyG index investigated restricted cubic splines (RCS)and adjusted Logistic regression. Additionally, mediation analysis used explore A total 184 (36.4%) events were recorded. RCS curves revealed a positive linear among (P-value < 0.001 P for nonlinear = 0.860). After fully adjusting covariates, emerged as significant predictors events. Mediation indicated that mediated 18.3%, 15.8%, 13.9%, 11.6% different models, respectively. are associated higher In addition, plaques partially

Language: Английский

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Exploring the Role of Insulin Resistance in Fueling Stroke Vulnerability and Worsening Post-stroke Prognosis: A Narrative Review of Current Literature

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Stroke remains one of the world's greatest causes disability and death. Insulin resistance (IR) impairs insulin's beneficial effects on brain can change course illness in post-stroke patients. This review aims to find sufficient evidence support causal association IR ischemic stroke with prognosis (PSP). The will also list probable mechanisms better understand how affects pathology. Various articles from PubMed Central, MEDLINE, databases were reviewed, then after careful consideration, 17 selected. studies, using various genetic metabolic markers, have linked increased incidence stroke. Among types strokes investigated this standpoint, silent lacunar infarct stands out as a widely researched subtype. Even though exact pathogenesis is still unclear, current shows an interplay atherosclerosis, embolism, platelet dysfunction. development early neurological decline (END) patients has been used link poor PSP. It acknowledged contributed some way three-month outcomes. Modifying inflammatory pathways developing glucotoxicity are by which After reviewing significant was found role causing well Additional investigation required assess its influence significance subcategories.

Language: Английский

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Analysis of the Research Progress on Chinese Medicine Residue Using CiteSpace Knowledge Graph

Traditional Chinese Medicine, Journal Year: 2024, Volume and Issue: 13(07), P. 1697 - 1713

Published: Jan. 1, 2024

Language: Английский

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Study on the correlation between the level of insulin resistance and changes in the degree of cerebral atherosclerosis in non-diabetic patients

Technology and Health Care, Journal Year: 2024, Volume and Issue: 32(6), P. 4999 - 5007

Published: Nov. 8, 2024

BACKGROUND: Cerebral infarction is a health problem of global concern and brings particular burden to medical treatment. OBJECTIVE: To analyze the correlation between insulin resistance (IR) levels changes in cerebral atherosclerosis (AS) degree non-diabetic patients with infarction. METHODS: A total 134 who visited Department Neurology our hospital from May 2019 October 2020 were selected underwent MRA/CTA (Magnetic resonance angiography/Computed tomography angiography) arteries refine cerebrovascular imaging data, according results AS load, divided into mild group severe group, index was calculated HOMA-IR (homeostasis model assessment resistance) evaluate IR level compared two groups. Spearman used load. RESULTS: 54 individuals had 80 AS, an arteries. There significant difference (P< 0.05) difficult gentle link severity found using analysis (r= 0.850, P< 0.05). CONCLUSION: The phenomenon prevalent infarction, closely related AS.

Language: Английский

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Brain insulin resistance in neurological disorders of various genesis: current state and treatment approaches

Нейрохимия, Journal Year: 2024, Volume and Issue: 41(3), P. 215 - 230

Published: Nov. 28, 2024

Language: Английский

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