Correlates of never testing for HIV among men who have sex with men in Nepal DOI Creative Commons
Kiran Paudel, Kamal Gautam,

Anjila Pandey

et al.

PLOS Global Public Health, Journal Year: 2025, Volume and Issue: 5(5), P. e0004432 - e0004432

Published: May 12, 2025

Men who have sex with men (MSM) are disproportionately affected by HIV. Individuals accessed sexual health clinic services for sexually transmitted infections (STIs) and pre-exposure prophylaxis (PrEP) were less likely to engage in high-risk behaviors such as transactional condomless exhibited greater perceived importance of HIV testing. testing is considered the gateway both prevention treatment HIV, enabling timely intervention transmission. Therefore, this study aimed measure determine factors associated never among MSM Nepal. We conducted population-based bio-behavioral surveillance between October December 2022 using respondent-driven sampling (RDS) method. computed estimates bivariate multivariate analyses explore correlation participant characteristics Among 250 participants, over half participants (52.5%) had tested their lifetime, only 11.7% last 12 months. not engaged (aOR:4.5; 95% CI: 1.2-17.3), no daily internet access (aOR: 5.4; 1.4-21.3), prior diagnosis infection lifetime 8.4; 2.8-25.2), heard self-testing (aOR:6.7; 2.8-16.0), unaware that someone taking PrEP (aOR:44.9; 10.5-191.6) higher odds having been Conversely, single (aOR:0.3; 0.1-0.8) lower being This highlights a significant gap Nepal, particularly those an kit. The findings underscore need targeted interventions address multi-level barriers increase rates Nepali MSM.

Language: Английский

Climate warming, environmental degradation and pollution as drivers of antibiotic resistance DOI
Piotr Rzymski, Willis Gwenzi, Barbara Poniedziałek

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 346, P. 123649 - 123649

Published: Feb. 23, 2024

Language: Английский

Citations

21
Association of HIV infection and hospitalization among mpox cases: a systematic review and meta-analysis DOI Creative Commons
Muhammed Shabil, Shilpa Gaidhane,

R Roopashree

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 22, 2025

Mpox is a viral zoonotic disease that has seen resurgence in recent years, with outbreaks reaching beyond its traditional endemic zones Central and West Africa to parts of Europe North America. The relationship between human immunodeficiency virus (HIV) infection mpox outcomes, particularly hospitalization rates, remains underexplored despite the known immunosuppressive effects HIV. This systematic review meta-analysis aimed clarify association HIV likelihood cases. A literature search was conducted through PubMed, Embase, Web Science, Scopus, Cochrane Library up until August 10, 2024. eligibility criteria focused on observational studies evaluated rates among cases, distinguishing HIV-positive HIV-negative individuals. Newcastle-Ottawa Scale used for evaluating study quality. random-effects model accommodate expected heterogeneity using R software (V. 4.4). yielded 686 records, 14 meeting inclusion exclusion after screenings full-text assessments. pooled analysis revealed 56.6% increased risk cases compared individuals (95% CI: 18.0–107.7%). Notable (I² = 76%) observed, likely reflecting variations settings methodologies. Sensitivity confirmed robustness these findings, no significant publication bias detected (Egger's test p-value 0.733). associated statistically There critical need integrated care enhanced surveillance, especially populations high prevalence. Our findings emphasize importance ongoing research better understand co-infection refine management strategies this vulnerable group. Future should focus long-term outcomes effectiveness various across different healthcare settings.

Language: Английский

Citations

2
Dementia prevalence and risk factors in people with and without HIV in Malawi: A medical record review DOI Creative Commons
Haeok Lee,

Yohannie Mlombe,

Yeunjoo E. Song

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Sub-Saharan Africa (SSA) is experiencing a rapid increase in its aging population, including people living with human immunodeficiency virus (HIV) (PLHIV). The purpose of this study was to determine the prevalence dementia among PLHIV and without HIV (POHIV) Malawi. We conducted retrospective medical record review 400 consecutive patients from single tertiary health center (200 an clinic 200 POHIV outpatient clinic) Lilongwe, overall rate higher than that (22% vs 10%; p = 1.4e). Older age, unknown employment or unemployed, depression were significant risk factors for PLHIV, while older age POHIV. Our confirmed increased provides valuable groundwork future studies accurately examine SSA, Malawians, face double burden AD related dementias. assess factors. Dementia PLHIV. findings, reflecting current diagnosing documenting practice Malawi, provide research

Language: Английский

Citations

2
Infectious Causes of Death: An Autopsy-Based Study of 546 cases DOI Creative Commons

Soudabeh Eshaghi,

Fereshte Sheybani,

Aria Hedjazi

et al.

Open Forum Infectious Diseases, Journal Year: 2025, Volume and Issue: 12(2)

Published: Jan. 31, 2025

Abstract Background Diagnostic accuracy in cases of infectious diseases is crucial for appropriate patient management and public health interventions. This retrospective study aimed to evaluate the most common causes death caused by rate agreement between clinical diagnoses autopsy findings individuals diagnosed with Mashhad, Iran. Methods Autopsy reports from March 2009 February 2018 were analyzed patients diseases. Demographic data, diagnoses, results collected compared. Discrepancies assessed, potential predictors diagnostic discrepancy examined. Results Among 28 451 autopsied cases, 546 (1.9%) Pleuropulmonary infections cause (69.8%) as determined autopsy, followed bloodstream (14.1%) intra-abdominal (10.0%). identified 22.4% cases. had highest frequency discrepancies (29.1%), central nervous system (CNS) (15.8%). Conclusions underscores importance identifying improving practice They also highlight need ongoing efforts enhance capabilities, particularly challenging such pleuropulmonary CNS infections, reduce burden misdiagnosis improve outcomes.

Language: Английский

Citations

1
Targeting histone deacetylases: Emerging applications beyond cancer DOI
Yasir S. Raouf

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(9), P. 104094 - 104094

Published: July 11, 2024

Language: Английский

Citations

8
Resting Body Temperature and Long-Term Survival in Older Adults at a Mental Health Center: Cross-Sectional and Longitudinal Data DOI Open Access
Piotr Paweł Chmielewski, Bartłomiej Strzelec, Krzysztof Data

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 713 - 713

Published: Jan. 22, 2025

Background/Objectives: Elevated body temperature is a well-established biomarker of infection, increased disease risk, and adverse health outcomes. However, the relationship between resting long-term survival in older individuals complex. Emerging evidence suggests that higher basal associated with reduced accelerated aging non-obese adults. This study aimed to compare temperatures across different age groups hospitalized Methods: Data were retrospectively collected from 367 physically healthy residents mental center. Longitudinal data 142 (68 men 74 women), aged 45 70 years monitored continuously over 25 years, compared cross-sectional 225 (113 112 women) who underwent periodic clinical examinations measurements. The sample was stratified into four categories. Resting oral measured under conditions ensure protocol consistency. Age-related changes both sexes evaluated using standard regression analysis, Student’s t-tests, ANOVA, Generalized Linear Models. Results: analysis revealed an increase among women, while showed long-lived generally had lower their shorter-lived counterparts. Conclusions: These findings support hypothesis lifetime steady-state greater longevity further research needed determine whether observed linked specific advantages, such as enhanced immune function, absence detrimental factors or diseases, metabolic rate potentially influenced by caloric restriction.

Language: Английский

Citations

1
Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021 DOI Creative Commons
Xinchen Li, Yanyan Zhang, Qiyu Zhang

et al.

Infectious Diseases of Poverty, Journal Year: 2024, Volume and Issue: 13(1)

Published: Oct. 8, 2024

Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden these is not comprehensively quantified. This study aims to analyze six major vIDPs, including coronavirus disease 2019 (COVID-19), HIV/AIDS, acute hepatitis, dengue, rabies, and Ebola virus (EVD), using data from Global Burden Diseases, Injuries, Risk Factors Study 2021 (GBD 2021).

Language: Английский

Citations

5
Effects of Tenofovir Disoproxil Fumarate on Bone Quality beyond Bone Density—A Scoping Review of the Literature DOI Creative Commons
Tejpal Singh,

Tejpal Singh Jashwin Singh,

Kok‐Yong Chin

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(2), P. 146 - 146

Published: Jan. 23, 2024

Tenofovir disoproxil fumarate (TDF) is a widely used pharmacological agent for the treatment of human immunodeficiency virus infection. While prolonged exposure to TDF has been associated with decrease in bone mineral density (BMD) and increased fracture risk, limited discussion exists on its effects various aspects quality. This scoping review aims provide comprehensive overview impact quality beyond BMD. A literature search was conducted using PubMed Scopus databases identify studies investigating Original research articles written English, irrespective study type or publication year, were included review. Seven met inclusion criteria. Findings indicate that adversely affects microarchitecture strength, impeding healing skeletal microdamage repair. The observed suggest complex interplay involving cell signalling, cytokines remodelling processes as potential mechanisms underlying TDF's As conclusion, impairs by influencing dynamic behaviour signalling pathways. Future should delve deeper into understanding intricate negative explore strategies reversing these effects.

Language: Английский

Citations

3
Bending the Curve Through Innovations to Overcome Persistent Obstacles in HIV Prevention and Treatment DOI Creative Commons

Tamer A. Addissouky,

Ibrahim El Tantawy El Sayed,

Majeed M. A. Ali

et al.

Journal of AIDS and HIV Treatment, Journal Year: 2024, Volume and Issue: 6(1), P. 44 - 53

Published: Jan. 1, 2024

Background: HIV/AIDS remains a major global public health challenge despite significant progress in treatment. New infections and HIV-related deaths persist, fueled by disparities prevention care access. Purpose: This review synthesizes recent advances across key domains - from vaccine development to novel treatments omics approaches – that collectively hold promise for ending the pandemic. Main body: Multiple innovative HIV platforms are now early-phase trials, including mRNA vaccines as well conserved epitope mosaic constructs broader immunogenicity. Long-acting injectable antiretrovirals represent milestone treatment, while gene editing techniques offer future curative potential. Leveraging multi-omics data through genomics, transcriptomics, proteomics, metabolomics provides systems-level insights into viral persistence new therapeutic opportunities. The gut microbiome is increasingly recognized mediator of progression, spurring research probiotic/prebiotic supplementation fecal transplantation. Across these domains, integration artificial intelligence machine learning will likely accelerate discovery. Conclusion: Despite past setbacks, cure effort has renewed momentum. Translating emerging tools like long-acting profiling clinical application could bend pandemic’s trajectory. Innovation must be paired with ensuring equitable access maximize impact.

Language: Английский

Citations

3
Double-Edged Sword: Exploring the Mitochondria–Complement Bidirectional Connection in Cellular Response and Disease DOI Creative Commons

Jingfei Lin,

Sinwoo Hwang, Honglin Luo

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 431 - 431

Published: June 11, 2024

Mitochondria serve an ultimate purpose that seeks to balance the life and death of cells, a role extends well beyond tissue organ systems impact not only normal physiology but also pathogenesis diverse diseases. Theorized have originated from ancient proto-bacteria, mitochondria share similarities with bacterial including their own circular DNA, double-membrane structures, fission dynamics. It is no surprise, then, interact bacterium-targeting immune pathway known as complement system. The system sophisticated arm response serves body’s first line defense against microbial invaders. operates through complex cascade protein activations, rapidly identifying neutralizing pathogens, even aiding in clearance damaged cells complexes. This dynamic system, intertwining innate adaptive immunity, holds secrets understanding numerous In this review, we explore bidirectional interplay between mitochondrial dysfunction release damage-associated molecular patterns. Additionally, several mitochondria- complement-related diseases potential for new therapeutic strategies.

Language: Английский

Citations

3