PLOS Global Public Health,
Journal Year:
2025,
Volume and Issue:
5(5), P. e0004432 - e0004432
Published: May 12, 2025
Men
who
have
sex
with
men
(MSM)
are
disproportionately
affected
by
HIV.
Individuals
accessed
sexual
health
clinic
services
for
sexually
transmitted
infections
(STIs)
and
pre-exposure
prophylaxis
(PrEP)
were
less
likely
to
engage
in
high-risk
behaviors
such
as
transactional
condomless
exhibited
greater
perceived
importance
of
HIV
testing.
testing
is
considered
the
gateway
both
prevention
treatment
HIV,
enabling
timely
intervention
transmission.
Therefore,
this
study
aimed
measure
determine
factors
associated
never
among
MSM
Nepal.
We
conducted
population-based
bio-behavioral
surveillance
between
October
December
2022
using
respondent-driven
sampling
(RDS)
method.
computed
estimates
bivariate
multivariate
analyses
explore
correlation
participant
characteristics
Among
250
participants,
over
half
participants
(52.5%)
had
tested
their
lifetime,
only
11.7%
last
12
months.
not
engaged
(aOR:4.5;
95%
CI:
1.2-17.3),
no
daily
internet
access
(aOR:
5.4;
1.4-21.3),
prior
diagnosis
infection
lifetime
8.4;
2.8-25.2),
heard
self-testing
(aOR:6.7;
2.8-16.0),
unaware
that
someone
taking
PrEP
(aOR:44.9;
10.5-191.6)
higher
odds
having
been
Conversely,
single
(aOR:0.3;
0.1-0.8)
lower
being
This
highlights
a
significant
gap
Nepal,
particularly
those
an
kit.
The
findings
underscore
need
targeted
interventions
address
multi-level
barriers
increase
rates
Nepali
MSM.
BMC Infectious Diseases,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 22, 2025
Mpox
is
a
viral
zoonotic
disease
that
has
seen
resurgence
in
recent
years,
with
outbreaks
reaching
beyond
its
traditional
endemic
zones
Central
and
West
Africa
to
parts
of
Europe
North
America.
The
relationship
between
human
immunodeficiency
virus
(HIV)
infection
mpox
outcomes,
particularly
hospitalization
rates,
remains
underexplored
despite
the
known
immunosuppressive
effects
HIV.
This
systematic
review
meta-analysis
aimed
clarify
association
HIV
likelihood
cases.
A
literature
search
was
conducted
through
PubMed,
Embase,
Web
Science,
Scopus,
Cochrane
Library
up
until
August
10,
2024.
eligibility
criteria
focused
on
observational
studies
evaluated
rates
among
cases,
distinguishing
HIV-positive
HIV-negative
individuals.
Newcastle-Ottawa
Scale
used
for
evaluating
study
quality.
random-effects
model
accommodate
expected
heterogeneity
using
R
software
(V.
4.4).
yielded
686
records,
14
meeting
inclusion
exclusion
after
screenings
full-text
assessments.
pooled
analysis
revealed
56.6%
increased
risk
cases
compared
individuals
(95%
CI:
18.0–107.7%).
Notable
(I²
=
76%)
observed,
likely
reflecting
variations
settings
methodologies.
Sensitivity
confirmed
robustness
these
findings,
no
significant
publication
bias
detected
(Egger's
test
p-value
0.733).
associated
statistically
There
critical
need
integrated
care
enhanced
surveillance,
especially
populations
high
prevalence.
Our
findings
emphasize
importance
ongoing
research
better
understand
co-infection
refine
management
strategies
this
vulnerable
group.
Future
should
focus
long-term
outcomes
effectiveness
various
across
different
healthcare
settings.
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
21(3)
Published: March 1, 2025
Sub-Saharan
Africa
(SSA)
is
experiencing
a
rapid
increase
in
its
aging
population,
including
people
living
with
human
immunodeficiency
virus
(HIV)
(PLHIV).
The
purpose
of
this
study
was
to
determine
the
prevalence
dementia
among
PLHIV
and
without
HIV
(POHIV)
Malawi.
We
conducted
retrospective
medical
record
review
400
consecutive
patients
from
single
tertiary
health
center
(200
an
clinic
200
POHIV
outpatient
clinic)
Lilongwe,
overall
rate
higher
than
that
(22%
vs
10%;
p
=
1.4e).
Older
age,
unknown
employment
or
unemployed,
depression
were
significant
risk
factors
for
PLHIV,
while
older
age
POHIV.
Our
confirmed
increased
provides
valuable
groundwork
future
studies
accurately
examine
SSA,
Malawians,
face
double
burden
AD
related
dementias.
assess
factors.
Dementia
PLHIV.
findings,
reflecting
current
diagnosing
documenting
practice
Malawi,
provide
research
Open Forum Infectious Diseases,
Journal Year:
2025,
Volume and Issue:
12(2)
Published: Jan. 31, 2025
Abstract
Background
Diagnostic
accuracy
in
cases
of
infectious
diseases
is
crucial
for
appropriate
patient
management
and
public
health
interventions.
This
retrospective
study
aimed
to
evaluate
the
most
common
causes
death
caused
by
rate
agreement
between
clinical
diagnoses
autopsy
findings
individuals
diagnosed
with
Mashhad,
Iran.
Methods
Autopsy
reports
from
March
2009
February
2018
were
analyzed
patients
diseases.
Demographic
data,
diagnoses,
results
collected
compared.
Discrepancies
assessed,
potential
predictors
diagnostic
discrepancy
examined.
Results
Among
28
451
autopsied
cases,
546
(1.9%)
Pleuropulmonary
infections
cause
(69.8%)
as
determined
autopsy,
followed
bloodstream
(14.1%)
intra-abdominal
(10.0%).
identified
22.4%
cases.
had
highest
frequency
discrepancies
(29.1%),
central
nervous
system
(CNS)
(15.8%).
Conclusions
underscores
importance
identifying
improving
practice
They
also
highlight
need
ongoing
efforts
enhance
capabilities,
particularly
challenging
such
pleuropulmonary
CNS
infections,
reduce
burden
misdiagnosis
improve
outcomes.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(3), P. 713 - 713
Published: Jan. 22, 2025
Background/Objectives:
Elevated
body
temperature
is
a
well-established
biomarker
of
infection,
increased
disease
risk,
and
adverse
health
outcomes.
However,
the
relationship
between
resting
long-term
survival
in
older
individuals
complex.
Emerging
evidence
suggests
that
higher
basal
associated
with
reduced
accelerated
aging
non-obese
adults.
This
study
aimed
to
compare
temperatures
across
different
age
groups
hospitalized
Methods:
Data
were
retrospectively
collected
from
367
physically
healthy
residents
mental
center.
Longitudinal
data
142
(68
men
74
women),
aged
45
70
years
monitored
continuously
over
25
years,
compared
cross-sectional
225
(113
112
women)
who
underwent
periodic
clinical
examinations
measurements.
The
sample
was
stratified
into
four
categories.
Resting
oral
measured
under
conditions
ensure
protocol
consistency.
Age-related
changes
both
sexes
evaluated
using
standard
regression
analysis,
Student’s
t-tests,
ANOVA,
Generalized
Linear
Models.
Results:
analysis
revealed
an
increase
among
women,
while
showed
long-lived
generally
had
lower
their
shorter-lived
counterparts.
Conclusions:
These
findings
support
hypothesis
lifetime
steady-state
greater
longevity
further
research
needed
determine
whether
observed
linked
specific
advantages,
such
as
enhanced
immune
function,
absence
detrimental
factors
or
diseases,
metabolic
rate
potentially
influenced
by
caloric
restriction.
Infectious Diseases of Poverty,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Oct. 8, 2024
Viral
infectious
diseases
of
poverty
(vIDPs)
remain
a
significant
global
health
challenge.
Despite
their
profound
impact,
the
burden
these
is
not
comprehensively
quantified.
This
study
aims
to
analyze
six
major
vIDPs,
including
coronavirus
disease
2019
(COVID-19),
HIV/AIDS,
acute
hepatitis,
dengue,
rabies,
and
Ebola
virus
(EVD),
using
data
from
Global
Burden
Diseases,
Injuries,
Risk
Factors
Study
2021
(GBD
2021).
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(2), P. 146 - 146
Published: Jan. 23, 2024
Tenofovir
disoproxil
fumarate
(TDF)
is
a
widely
used
pharmacological
agent
for
the
treatment
of
human
immunodeficiency
virus
infection.
While
prolonged
exposure
to
TDF
has
been
associated
with
decrease
in
bone
mineral
density
(BMD)
and
increased
fracture
risk,
limited
discussion
exists
on
its
effects
various
aspects
quality.
This
scoping
review
aims
provide
comprehensive
overview
impact
quality
beyond
BMD.
A
literature
search
was
conducted
using
PubMed
Scopus
databases
identify
studies
investigating
Original
research
articles
written
English,
irrespective
study
type
or
publication
year,
were
included
review.
Seven
met
inclusion
criteria.
Findings
indicate
that
adversely
affects
microarchitecture
strength,
impeding
healing
skeletal
microdamage
repair.
The
observed
suggest
complex
interplay
involving
cell
signalling,
cytokines
remodelling
processes
as
potential
mechanisms
underlying
TDF's
As
conclusion,
impairs
by
influencing
dynamic
behaviour
signalling
pathways.
Future
should
delve
deeper
into
understanding
intricate
negative
explore
strategies
reversing
these
effects.
Journal of AIDS and HIV Treatment,
Journal Year:
2024,
Volume and Issue:
6(1), P. 44 - 53
Published: Jan. 1, 2024
Background:
HIV/AIDS
remains
a
major
global
public
health
challenge
despite
significant
progress
in
treatment.
New
infections
and
HIV-related
deaths
persist,
fueled
by
disparities
prevention
care
access.
Purpose:
This
review
synthesizes
recent
advances
across
key
domains
-
from
vaccine
development
to
novel
treatments
omics
approaches
–
that
collectively
hold
promise
for
ending
the
pandemic.
Main
body:
Multiple
innovative
HIV
platforms
are
now
early-phase
trials,
including
mRNA
vaccines
as
well
conserved
epitope
mosaic
constructs
broader
immunogenicity.
Long-acting
injectable
antiretrovirals
represent
milestone
treatment,
while
gene
editing
techniques
offer
future
curative
potential.
Leveraging
multi-omics
data
through
genomics,
transcriptomics,
proteomics,
metabolomics
provides
systems-level
insights
into
viral
persistence
new
therapeutic
opportunities.
The
gut
microbiome
is
increasingly
recognized
mediator
of
progression,
spurring
research
probiotic/prebiotic
supplementation
fecal
transplantation.
Across
these
domains,
integration
artificial
intelligence
machine
learning
will
likely
accelerate
discovery.
Conclusion:
Despite
past
setbacks,
cure
effort
has
renewed
momentum.
Translating
emerging
tools
like
long-acting
profiling
clinical
application
could
bend
pandemic’s
trajectory.
Innovation
must
be
paired
with
ensuring
equitable
access
maximize
impact.
Biology,
Journal Year:
2024,
Volume and Issue:
13(6), P. 431 - 431
Published: June 11, 2024
Mitochondria
serve
an
ultimate
purpose
that
seeks
to
balance
the
life
and
death
of
cells,
a
role
extends
well
beyond
tissue
organ
systems
impact
not
only
normal
physiology
but
also
pathogenesis
diverse
diseases.
Theorized
have
originated
from
ancient
proto-bacteria,
mitochondria
share
similarities
with
bacterial
including
their
own
circular
DNA,
double-membrane
structures,
fission
dynamics.
It
is
no
surprise,
then,
interact
bacterium-targeting
immune
pathway
known
as
complement
system.
The
system
sophisticated
arm
response
serves
body’s
first
line
defense
against
microbial
invaders.
operates
through
complex
cascade
protein
activations,
rapidly
identifying
neutralizing
pathogens,
even
aiding
in
clearance
damaged
cells
complexes.
This
dynamic
system,
intertwining
innate
adaptive
immunity,
holds
secrets
understanding
numerous
In
this
review,
we
explore
bidirectional
interplay
between
mitochondrial
dysfunction
release
damage-associated
molecular
patterns.
Additionally,
several
mitochondria-
complement-related
diseases
potential
for
new
therapeutic
strategies.