Food Control, Journal Year: 2024, Volume and Issue: 169, P. 111002 - 111002
Published: Nov. 4, 2024
Language: Английский
Environmental Health Insights, Journal Year: 2023, Volume and Issue: 17
Published: Jan. 1, 2023
Along with expanding urbanization and industrialization, environmental pollution which negatively affects the surroundings, has been rising quickly. As a result, induces heavy metal contamination poses serious threat to living organisms of aquatic soil ecosystems. Therefore, they are need ameliorate effects cost by on environment. In this review, we explore methods employed mitigate caused metals Many techniques manage tedious very costly, necessitating use alternative management strategies resolve challenge. concept, bioremediation is viewed as future technique, due its friendliness cost-effective measures aligned sustainable or climate-smart agriculture contaminants in The technique involves entities such bacteria, fungi, plants deteriorate toxic substances from rhizosphere. Currently, thought be most practical, dependable, environmentally benign, long-lasting solution. Although different techniques, still find efficient method for removing This review focuses origins pollution, delves into green technological approaches eliminating pollutants environment, discusses impact these human health.
Language: Английский
Citations
77
Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 495, P. 117227 - 117227
Published: Jan. 7, 2025
Language: Английский
Citations
1
Food Frontiers, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
ABSTRACT Berries are widely regarded as beneficial foods, rich in polyphenols, flavonoids, and other bioactive compounds that could positively influence human health. Although the gut microbiota plays a crucial role metabolism physiology of humans, interaction between berries activity remains unclear. This review systematically summarizes antioxidant, anti‐inflammatory, microbiota‐regulating effects various berries. It focuses on impact several related metabolic diseases addition to adverse outcomes associated with environmental exposures from perspective modulation microbiota. Overall, may actively modulate microbiota, influencing composition especially production metabolites, thereby conferring health effects. aims provide comprehensive understanding via interactions offering insights into potential application maintaining
Language: Английский
Citations
1
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 264, P. 115447 - 115447
Published: Sept. 13, 2023
As emerging pollutants in the environment, nanoplastics (NPs) can cross biological barriers and be enriched organisms, posing a greatest threat to health of livestock humans. However, size-dependent toxic effects NPs higher mammals remain largely unknown. To determine potential toxicities NPs, we exposed mouse (AML-12) human (L02) liver cell lines vitro, 6-week-old C57BL/6 mice (well-known preclinical model) vivo five different sizes polystyrene (PS-NPs) (20, 50, 100, 200 500 nm). We found that ultra-small (20 nm) induced highest cytotoxicity lines, causing oxidative stress mitochondrial membrane loss on AML-12 cells. Unexpectedly vivo, after long-term oral exposure PS-NPs (75 mg/kg), medium (200 large (500 significant hepatotoxicity, evidenced by increased stress, dysfunction, lipid metabolism disorders. Most importantly, or generated local immunotoxic via recruiting activating more numbers neutrophils monocytes intestine, which potentially resulted proinflammatory cytokine secretion tissue damage. The discrepancy vitro-in results might attributed properties biodistribution accumulation sized vivo. Our study provides new insights regarding hepatotoxicity immunotoxicity health, warranting us take immense measures prevent these NPs-associated
Language: Английский
Citations
20
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: May 10, 2024
Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite widespread lack awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing regulation triggering pro-inflammatory responses. The exposure to also leads alterations in gut microbiota with decreasing abundance beneficial microbes, such as short-chain fatty acid-producing bacteria, an overgrowth species. subsequent intestinal barrier dysfunction, together oxidative stress increased inflammatory responses, plays role pathogenesis gastrointestinal diseases. Moreover, encourage inflammation-dysplasia-carcinoma sequence various mechanisms, stress, dysregulation cellular signalling cell cycle impairment genomic instability. In this narrative review, we will describe interplay between pollutants, microbiota, system, focusing their relationship bowel diseases colorectal cancer. Understanding biological mechanisms underlying health-to-disease transition may allow design public health policies aimed at reducing burden disease pollutants.
Language: Английский
Citations
8
Journal of Crohn s and Colitis, Journal Year: 2024, Volume and Issue: 18(9), P. 1415 - 1429
Published: April 12, 2024
Epidemiological data regarding inflammatory bowel disease [IBD] are lacking, in particular for occupationally exposed populations. We investigated whether, among the entire French farm manager [FM] workforce, certain agricultural activities more strongly associated with IBD than others.
Language: Английский
Citations
6
Toxics, Journal Year: 2024, Volume and Issue: 12(1), P. 47 - 47
Published: Jan. 8, 2024
Emerging contaminants have been increasingly recognized as critical determinants in global public health outcomes. However, the intricate relationship between these and glucose metabolism remains to be fully elucidated. The paucity of comprehensive clinical data, coupled with need for in-depth mechanistic investigations, underscores urgency decipher precise molecular cellular pathways through which potentially mediate initiation progression diabetes mellitus. A profound understanding epidemiological impact emerging contaminants, well elucidation underlying pathways, is indispensable formulation evidence-based policy preventive interventions. This review systematically aggregates contemporary findings from investigations delves into correlates that tether exposure including endocrine disruptors, perfluorinated compounds, microplastics, antibiotics, glycemic dysregulation. nuanced exploration undertaken focusing on potential dietary sources consequential role gut microbiome their toxic effects. endeavors provide a foundational reference future complex interplay
Language: Английский
Citations
5
Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2302 - 2302
Published: July 17, 2024
Inflammatory bowel disease (IBD), a complex chronic inflammatory disorder that includes Crohn’s (CD) and Ulcerative Colitis (UC), has become globally increasing health concern. Nutrition, as an important factor influencing the occurrence development of IBD, attracted more attention. As most nutrient, protein can not only provide energy nutrition required by patients, but also help repair damaged intestinal tissue, enhance immunity, thus alleviate inflammation. Numerous studies have shown nutritional support plays significant role in treatment remission IBD. This article presents comprehensive review pathogenesis IBD analyzes summarizes potential mechanisms Additionally, it provides overview clinical effects its impact on complications. Research findings reveal demonstrates benefits improving symptoms, reducing risk complications, quality life patients. Therefore, is expected to new approach for
Language: Английский
Citations
4
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117705 - 117705
Published: Jan. 1, 2025
Persistent organic pollutants (POPs) are pervasive chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due their toxicity persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, chemistry, cellular immunity, shields host from external threats fosters symbiotic relationship bacteria. Sirtuin 6 (SIRT6), sirtuin family member, is pivotal in genome telomere stability, inflammation regulation, metabolic processes. Result shows POPs have been implicated diseases, particularly barrier dysfunction, through mechanisms such as damage, epigenetic alterations, inflammation, microbiota changes, disruptions. While impact of SIRT6 expression changes on functions has reviewed, linking remain elusive. This review summarized latest research results discussed role multiple perspectives, proposed new directions POPs, health, explored therapeutic potential SIRT6.
Language: Английский
Citations
0
Nanotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15
Published: Jan. 22, 2025
Introduction: Important cell-based models of intestinal inflammation have been advanced in hopes predicting the impact nanoparticles on disease. We sought to determine whether a high level and extended exposure nanoplastic might result added caused by reported mouse model irritable bowel Methods: The cell consist Transwell©-type insert with filter membrane upon which lies biculture monolayer Caco-2 HT29-MTX-E12 made up barrier cells (apical compartment). This was exposed digested 40 nm diameter polymethacrylate (PMA) surface-functionalized COOH (PMA-) or NH2 (PMA+) at 'low level' (143 µg/cm2 surface area) 'high (571 µg/cm2) for 24 48 h. Beyond apical compartment well tissue culture plate, macrophages, previously differentiated from THP-1 (basolateral Thus, immune competent tri-cultures were examined as two models: healthy inflamed. inflamed model, having activated IFN-γ macrophages LPS expressed greater secretion pro-inflammation cytokines. Results: Sedimentation, Diffusion Dosimetry (ISDD) simulated that 8%-12% PMA deposited onto 24-48-h. structure disorganized both PMA, level, 48-h experiments. While neither amount nor duration influenced lactate dehydrogenase (LDH) only levels PMA- PMA+ experiments resulted significantly increased LDH secreted compared control. study is first show an additive intestine.
Language: Английский
Citations
0