A retrospective analysis of the incidence and risk factors of perioperative urinary tract infections after total hysterectomy

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 29, 2024

Abstract Introduction Perioperative urinary tract infections (PUTIs) are common in the United States and a significant contributor to high healthcare costs. There is lack of large studies on risk factors for PUTIs after total hysterectomy (TH). Methods We conducted retrospective study using national inpatient sample (NIS) 445,380 patients from 2010 2019 analyze annual incidence associated with TH perioperatively. Results were found 9087 overall, showing 2.0% incidence. substantial differences based age group ( P < 0.001). Between two groups, there was consistently difference type insurance, hospital location, bed size, Patients exhibited significantly higher number comorbidities Unsurprisingly, had longer median length stay (5 days vs. 2 days; 0.001) in-hospital death rate (from 0.1 1.1%; Thus, overall hospitalization expenditures increased by $27,500 ($60,426 $32,926, as medical Elective hospitalizations less (66.8% 87.6%; According multivariate logistic regression study, following variables TH: over 45 years old; (≥ 1); size (medium, large); teaching hospital; region hospital(south, west); preoperative (alcohol abuse, deficiency anemia, chronic blood loss congestive heart failure, diabetes, drug hypertension, hypothyroidism, lymphoma, fluid electrolyte disorders, metastatic cancer, other neurological paralysis, peripheral vascular psychoses, pulmonary circulation renal solid tumor without metastasis, valvular disease, weight loss); complications (sepsis, acute myocardial infarction, deep vein thrombosis, gastrointestinal hemorrhage, pneumonia, stroke, wound infection, rupture, embolism, transfusion, postoperative delirium). Conclusions The findings suggest that identifying these can lead improved preventive strategies management patients. Counseling should be done prior surgery reduce PUTIs. manuscript adds current knowledge In practice, identification patient prevention treatment strategies. noted stay, cost, pre-existing comorbidities, hospital, hospitals, also play role UTI’s. Clinical topics Urogynecology

Language: Английский

New resorcylic acid derivatives of Lysimachia tengyuehensis against MRSA and VRE by interfering with bacterial metabolic imbalance

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 277, P. 116714 - 116714

Published: July 31, 2024

Language: Английский

Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens

Biotechnology Advances, Journal Year: 2024, Volume and Issue: unknown, P. 108492 - 108492

Published: Dec. 1, 2024

The prevalence of multidrug-resistant (MDR) ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, represents a critical global public health challenge. In response, mRNA vaccines offer an adaptable scalable platform for immunotherapy against pathogens by encoding specific antigens that stimulate B-cell-driven antibody production CD8

Language: Английский