Medicina,
Journal Year:
2024,
Volume and Issue:
60(1), P. 191 - 191
Published: Jan. 22, 2024
Background:
The
potential
positive
interaction
between
intermittent
fasting
(IF)
and
brain-derived
neurotrophic
factor
(BDNF)
on
cognitive
function
has
been
widely
discussed.
This
systematic
review
tried
to
assess
the
efficacy
of
interventions
with
different
IF
regimens
BDNF
levels
their
association
functions
in
humans.
Interventions
forms
such
as
caloric
restriction
(CR),
alternate-day
(ADF),
time-restricted
eating
(TRE),
Ramadan
model
(RIF)
were
targeted.
Methods:
A
was
conducted
for
experimental
observational
studies
healthy
people
patients
diseases
published
EMBASE,
Scopus,
PubMed,
Google
Scholar
databases
from
January
2000
December
2023.
We
followed
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analysis
statements
(PRISMA)
writing
this
review.
Results:
Sixteen
research
works
metabolic
disorders
met
inclusion
criteria
Five
showed
a
significant
increase
after
intervention,
while
five
reported
decrease
levels,
other
six
no
changes
due
regimens.
Moreover,
examined
RIF
protocol,
which,
three
reduction,
two
along
an
improvement
RIF.
Conclusions:
current
findings
suggest
that
varying
effects
healthy,
overweight/obese
individuals
conditions.
However,
few
human
have
shown
increases
controversial
results.
In
humans,
yet
be
fully
investigated
terms
its
long-term
effect
functions.
Large-scale,
well-controlled
high-quality
data
are
warranted
elucidate
impact
Biogerontology,
Journal Year:
2024,
Volume and Issue:
25(6), P. 899 - 922
Published: Aug. 23, 2024
The
gut
microbiota
(GM)
produces
various
molecules
that
regulate
the
physiological
functionality
of
brain
through
gut-brain
axis
(GBA).
Studies
suggest
alteration
in
GBA
may
lead
to
onset
and
progression
neurological
dysfunctions.
Moreover,
aging
is
one
prominent
causes
contribute
GBA.
With
age,
GM
undergoes
a
shift
population
size
species
microflora
leading
changes
their
secreted
metabolites.
These
also
hamper
communications
among
HPA
(hypothalamic-pituitary-adrenal),
ENS
(enteric
nervous
system),
ANS
(autonomic
system).
A
therapeutic
intervention
has
recently
gained
attention
improving
health
maintaining
communication
between
calorie
restriction
(CR),
which
plays
critical
role
autophagy
neurogenesis
processes.
However,
its
strict
regime
lifelong
commitment
pose
challenges.
need
produce
similar
beneficial
effects
CR
without
having
rigorous
compliance.
This
led
an
exploration
mimetics
(CRMs)
could
mimic
CR's
functions
limiting
diet,
providing
long-term
benefits.
CRMs
ensure
efficient
functioning
bacteria
metabolites
i.e.,
short-chain
fatty
acids,
bile
neurotransmitters.
particularly
for
elderly
individuals,
as
deteriorates
with
age
body's
ability
digest
toxic
accumulates
declines.
In
this
review,
we
have
explored
effect
extending
lifespan
by
enhancing
on
metabolite
production,
conditions,
dysfunctions
including
neurodegenerative
disorders.
Current Issues in Molecular Biology,
Journal Year:
2023,
Volume and Issue:
45(10), P. 8289 - 8308
Published: Oct. 12, 2023
The
hypothalamus
is
an
important
regulator
of
autonomic
and
endocrine
functions
also
involved
in
aging
regulation.
process
the
accompanied
by
disturbed
intracellular
signaling
including
insulin/insulin-like
growth
factor-1
(IGF-1)/growth
hormone
(GH),
phosphatidylinositol-4,5-bisphosphate
3-kinase
(PI3K)/protein
kinase
B
(AKT)/the
mammalian
target
rapamycin
(mTOR),
mitogen
activated
protein
(MAPK),
janus
(JAK)/signal
transducer
activator
transcription
(STAT),
AMP-activated
(AMPK),
nuclear
factor
kappa-light-chain-enhancer
cells
(NF-ĸB),
nitric
oxide
(NO).
In
current
review,
I
have
summarized
understanding
changes
above-mentioned
pathways
with
a
focus
on
hypothalamic
alterations.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10757 - 10757
Published: Oct. 6, 2024
With
the
aging
of
global
population,
neurodegenerative
diseases
are
emerging
as
a
major
public
health
issue.
The
adoption
less
sedentary
lifestyle
has
been
shown
to
have
beneficial
effect
on
cognitive
decline,
but
molecular
mechanisms
responsible
clear.
Here
we
provide
detailed
analysis
complex
molecular,
cellular,
and
systemic
underlying
age-related
decline
how
choices
influence
these
processes.
A
review
evidence
from
animal
models,
human
studies,
postmortem
analyses
emphasizes
importance
integrating
physical
exercise
with
cognitive,
multisensory,
motor
stimulation
part
multifaceted
approach
mitigating
decline.
We
highlight
potential
non-pharmacological
interventions
address
key
hallmarks,
such
genomic
instability,
telomere
attrition,
neuroinflammation,
underscore
need
for
comprehensive
personalized
strategies
promote
resilience
healthy
aging.
Cellular and Molecular Neurobiology,
Journal Year:
2024,
Volume and Issue:
44(1)
Published: Oct. 16, 2024
Aging,
an
inevitable
physiological
process
leading
to
a
progressive
decline
in
bodily
functions,
has
been
abundantly
researched
domain
with
studies
attempting
slow
it
down
and
reduce
its
debilitating
effects.
Investigations
into
the
cellular
molecular
pathways
associated
aging
have
allowed
formulation
of
therapeutic
strategies.
Of
these,
caloric
restriction
(CR)
implicated
for
role
promoting
healthy
by
modulating
key
targets
like
Insulin/IGF-1,
mTOR,
sirtuins.
However,
CR
requires
dedication
commitment
strict
regimen
which
poses
difficulty
maintaining
consistency.
To
maneuver
around
cumbersome
diets,
Caloric
Restriction
Mimetics
(CRMs)
emerged
as
promising
alternatives
mimicking
beneficial
effects
CR.
This
review
elucidates
foundations
enabling
CRMs
rapamycin,
metformin,
resveratrol,
spermidine,
many
more
function
suitable
anti-aging
molecules.
Moreover,
explores
clinical
trials
(retrieved
from
clinicaltrials.gov
database)
aimed
at
demonstrating
efficacy
effective
candidates
against
age-related
neurodegenerative
diseases
such
Alzheimer's
disease
Parkinson's
disease.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 24, 2024
Intermittent
fasting
(IF)
has
demonstrated
extensive
health
benefits
through
the
regulation
of
fatty
acid
metabolism
and
modulation
neuroimmune
microenvironment,
primarily
via
activation
key
signaling
pathways
such
as
AMP-activated
protein
kinase
(AMPK)
sirtuin
1
(SIRT1).
IF
not
only
facilitates
oxidation
improves
metabolic
health,
but
also
enhances
mitochondrial
function,
mitigates
oxidative
stress,
promotes
autophagy,
inhibits
apoptosis
ferroptosis.
These
mechanisms
contribute
to
its
substantial
preventive
therapeutic
potential
in
various
conditions,
including
neurodegenerative
disorders
Alzheimer’s
Parkinson’s
diseases,
autoimmune
neurotraumatic
conditions.
While
supportive
evidence
been
obtained
from
animal
models
preliminary
clinical
studies,
further
large-scale,
long-term
randomized
controlled
trials
are
imperative
establish
safety
evaluate
efficacy
comprehensively.
JCI Insight,
Journal Year:
2024,
Volume and Issue:
9(4)
Published: Jan. 16, 2024
AMP-activated
protein
kinase
(AMPK)
plays
a
crucial
role
in
maintaining
ATP
homeostasis
photoreceptor
neurons.
AMPK
is
heterotrimeric
consisting
of
α,
β,
and
γ
subunits.
The
independent
functions
the
2
isoforms
catalytic
α
subunit,
PRKAA1
PRKAA2,
are
uncharacterized
specialized
neurons,
such
as
photoreceptors.
Here,
we
demonstrate
mice
that
rod
photoreceptors
lacking
but
not
PRKAA1,
showed
altered
levels
cGMP,
GTP,
ATP,
suggesting
isoform-specific
regulation
metabolism.
Furthermore,
PRKAA2-deficient
displayed
visual
functional
deficits
on
electroretinography
outer
segment
structural
abnormalities
transmission
electron
microscopy
consistent
with
neuronal
dysfunction,
neurodegeneration.
Phosphoproteomics
identified
inosine
monophosphate
dehydrogenase
(IMPDH)
molecular
driver
PRKAA2-specific
inhibition
IMPDH
improved
function
Prkaa2
photoreceptor-knockout
mice.
These
findings
highlight
therapeutically
targetable
PRKAA2
regulating
metabolism
through
potentially
previously
mechanism
affecting
activity.
