BioMed Research International,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Aim:
This
systematic
review
was
aimed
at
addressing
the
focused
question:
What
is
protective
potential
of
biological
agents
against
alveolar
bone
resorption
during
progression
experimental
periodontitis
(EP)?
Material
and
Methods:
The
study
protocol
registered
in
Open
Science
Framework
database
(doi:
10.17605/OSF.IO/3P2HY
).
A
comprehensive
literature
search
conducted
across
PubMed,
Web
Science,
Cochrane
Library,
Scopus,
Embase
databases
up
to
December
2023.
Inclusion
criteria
consisted
preclinical
studies
animal
models
EP
that
examined
effects
on
preventing
periodontal
loss
reducing
tissue
inflammation.
Studies
were
excluded
if
they
(i)
used
non‐EP
models;
(ii)
antimicrobial
agents;
(iii)
centered
prebiotics
or
probiotics;
(iv)
evaluated
compounds
not
classified
as
biologicals;
(v)
included
randomized
clinical
trials,
studies,
reviews.
Eligibility
determined
based
PI/ECOs
framework,
quality
assessed
using
SYRCLE
risk‐of‐bias
tool.
Results:
After
screening
an
initial
pool
5236
records
from
databases,
registries,
hand
searches,
39
met
inclusion
criteria.
total
23
these
studies.
majority
employed
ligature‐induced
model
test
effectiveness
biologicals
preventive
therapeutic
interventions.
dosage
duration
disease
induction
varied
depending
model.
In
all
main
outcome—alveolar
loss,
a
hallmark
EP—was
significantly
inhibited
by
agents,
which
also
reduced
proinflammatory
mediators
when
compared
untreated
controls.
key
strength
this
high
number
included,
most
having
low
risk
bias.
However,
notable
limitation
absence
meta‐analysis,
short
follow‐up
periods
heterogeneity
among
compound
dosages
route
administration.
Conclusion:
demonstrates
are
effective
mitigating
inflammation
progression.
Randomized
trials
needed
confirm
findings
human
populations.
Frontiers in Clinical Diabetes and Healthcare,
Journal Year:
2023,
Volume and Issue:
4
Published: March 2, 2023
Gestational
diabetes
mellitus
(GDM)
is
one
of
the
most
frequent
endocrine
conditions
during
pregnancy.
GDM
linked
to
adverse
pregnancy
outcomes
and
has
implications
for
maternal
health.
Studies
have
demonstrated
link
between
pathogenic
periodontal
bacteria,
glycemic
control,
risk
diabetes.
The
objective
current
study
perform
a
mini-review
available
literature
on
potential
changes
in
oral
microbiota
women
with
GDM.
review
was
conducted
by
two
independent
reviewers
(LLF
JDC).
Indexed
electronic
databases
(PubMed/Medline,
Cochrane
Library,
Web
Science,
Scopus)
were
searched,
including
articles
published
English
Portuguese.
A
manual
search
also
performed
identify
related
articles.
microbial
community
pregnant
unique
from
that
healthy
women.
majority
alterations
found
point
pro-inflammatory
environment
high
levels
bacteria
associated
periodontitis
(
Prevotella,
Treponema
,
anaerobic
bacteria)
depletion
health
maintenance
(Firmicutes,
Streptococcus,
Leptotrichia).
More
well-designed
studies
differentiating
good
those
are
needed
ascertain
which
differences
due
or
periodontitis.
Frontiers in Dental Medicine,
Journal Year:
2024,
Volume and Issue:
5
Published: May 22, 2024
The
extensive
studies
on
Filifactor
alocis
(Fa)
show
a
positive
association
with
periodontitis,
demonstrating
elevated
Fa
levels
compared
to
traditional
periodontal
pathogens
in
severe
disease.
Periodontitis
is
chronic
multifactorial
disease
induced
by
dysbiotic
microbiota
susceptible
host
whilst
diabetes
an
established
risk
factor
for
periodontitis.
Diabetes
has
been
shown
alter
the
subgingival
into
distinct
microbial
communities
which
favours
shift
towards
It
these
very
that
are
believed
contribute
high
prevalence
and
severity
of
periodontitis
diabetic
patients.
This
constitute
include
among
others
red
complex
triad
(
Porphyromonas
gingivalis,
Treponema
denticola,
Tannerella
forsythia
),
Aggregatibacter
actinomycetemcomitans
,
orange
Fusobacterium
nucleatum,
Prevotella
intermedia
etc.)
other
emerging
such
as
were
previously
unrecognised
role
players
pathogenesis
asaccharolytic
anaerobic
gram-positive
rod
(AAGPR)
currently
considered
be
one
potential
drivers
progression
worsening
through
its
unique
virulence
characteristics.
Various
mechanisms
contributes
have
reported.
involved
bidirectional
relationship
between
continuously
being
explored
order
enhance
individualised
preventative
management
approaches
affected
review
aims
report
this
pathogen
capacity
influence
dysbiosis
within
community;
including
will
highlight
prognostic
indicator
worsening,
help
improve
protocols
diabetes.
Periodontal
disease,
a
multifactorial
inflammatory
condition
affecting
the
supporting
structures
of
teeth,
has
been
increasingly
recognized
for
its
association
with
various
systemic
diseases.
Understanding
molecular
comorbidities
periodontal
disease
is
crucial
elucidating
shared
pathogenic
mechanisms
and
potential
therapeutic
targets.
In
this
study,
we
conducted
comprehensive
literature
biological
database
mining
utilizing
tools
such
as
DisGeNET2R,
Romin,
Rentrez
R
libraries
to
identify
diseases
sharing
associated
genes,
proteins,
or
pathways
periodontitis.
Our
analysis
revealed
significant
overlaps
between
several
conditions,
including
cardiovascular
diseases,
diabetes
mellitus,
rheumatoid
arthritis,
bowel
Shared
implicated
in
pathogenesis
these
periodontitis
encompassed
dysregulation
mediators,
immune
response
pathways,
oxidative
stress
alterations
extracellular
matrix.
Furthermore,
network
unveiled
key
hub
genes
proteins
that
play
pivotal
roles
crosstalk
comorbidities,
offering
targets
intervention.
Insights
gained
from
integrative
approach
shed
light
on
intricate
interplay
health
well-being,
emphasizing
importance
interdisciplinary
collaboration
developing
personalized
treatment
strategies
patients
comorbidities.
BioMed Research International,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Aim:
This
systematic
review
was
aimed
at
addressing
the
focused
question:
What
is
protective
potential
of
biological
agents
against
alveolar
bone
resorption
during
progression
experimental
periodontitis
(EP)?
Material
and
Methods:
The
study
protocol
registered
in
Open
Science
Framework
database
(doi:
10.17605/OSF.IO/3P2HY
).
A
comprehensive
literature
search
conducted
across
PubMed,
Web
Science,
Cochrane
Library,
Scopus,
Embase
databases
up
to
December
2023.
Inclusion
criteria
consisted
preclinical
studies
animal
models
EP
that
examined
effects
on
preventing
periodontal
loss
reducing
tissue
inflammation.
Studies
were
excluded
if
they
(i)
used
non‐EP
models;
(ii)
antimicrobial
agents;
(iii)
centered
prebiotics
or
probiotics;
(iv)
evaluated
compounds
not
classified
as
biologicals;
(v)
included
randomized
clinical
trials,
studies,
reviews.
Eligibility
determined
based
PI/ECOs
framework,
quality
assessed
using
SYRCLE
risk‐of‐bias
tool.
Results:
After
screening
an
initial
pool
5236
records
from
databases,
registries,
hand
searches,
39
met
inclusion
criteria.
total
23
these
studies.
majority
employed
ligature‐induced
model
test
effectiveness
biologicals
preventive
therapeutic
interventions.
dosage
duration
disease
induction
varied
depending
model.
In
all
main
outcome—alveolar
loss,
a
hallmark
EP—was
significantly
inhibited
by
agents,
which
also
reduced
proinflammatory
mediators
when
compared
untreated
controls.
key
strength
this
high
number
included,
most
having
low
risk
bias.
However,
notable
limitation
absence
meta‐analysis,
short
follow‐up
periods
heterogeneity
among
compound
dosages
route
administration.
Conclusion:
demonstrates
are
effective
mitigating
inflammation
progression.
Randomized
trials
needed
confirm
findings
human
populations.
