Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 95 - 125
Published: Aug. 30, 2024
Language: Английский
The Lancet, Journal Year: 2024, Volume and Issue: 404(10448), P. 175 - 192
Published: June 20, 2024
Language: Английский
Citations
78
Journal of Diabetes and its Complications, Journal Year: 2023, Volume and Issue: 37(8), P. 108524 - 108524
Published: June 3, 2023
Language: Английский
Citations
14
Microbial Genomics, Journal Year: 2025, Volume and Issue: 11(4)
Published: April 15, 2025
Oral microbiome dysbiosis has been proposed as a potential contributing factor to rising rates of diabetes in pregnancy, with oral health previously associated an increased risk numerous chronic diseases and complications including gestational mellitus (GDM). However, whilst most studies examining the relationship between GDM identify significant differences, these differences are highly variable studies. Additionally, no previous research examined women pre-existing type 2 (T2DM), which greater risks both mother baby. In this study, we compared 11 pregnant T2DM 28 normoglycaemic controls. We used shotgun metagenomic sequencing examine buccal swab saliva rinse samples at two time points 26 38 weeks gestation. To reduce variation caused by choice differential abundance analysis tool, employed consensus approach taxa pathways due status. Differences were identified late point only. samples, there was Flavobacteriaceae , Capnocytophaga gingivalis SGB2479, leadbetteri SGB2492 Neisseria elongata SGB9447 well Shannon diversity richness. Haemophilus Pasteurellaceae Pasteurellales Proteobacteria . contrast or that use single our few without T2DM.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2217 - 2217
Published: Aug. 31, 2023
Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition associated with adverse maternal and neonatal outcomes including gestational hypertension, preeclampsia, placental abruption, preterm birth, stillbirth, fetal growth restriction. In the long-term, mothers children have an increased risk of developing metabolic diseases such as type 2 cardiovascular disease. Accumulating evidence suggest alterations in microbiome may play role pathogenesis GDM pregnancy outcomes. This review describes changes during physiological adaptations pregnancy, Findings from this highlight importance understanding link between GDM. Furthermore, new therapeutic approaches to prevent or better manage are discussed. Further research clinical trials necessary fully realize potential translate these findings into practice.
Language: Английский
Citations
9
Children, Journal Year: 2024, Volume and Issue: 11(4), P. 421 - 421
Published: April 2, 2024
Gestational diabetes mellitus (GDM) affects approximately 5–20% of pregnant women and is associated with adverse pregnancy outcomes. This review aimed to assess whether the oral microbiota infants their mothers GDM had a different composition from that found in unaffected offspring. PubMed, Embase, Scopus, Google Scholar were searched December 2023 after protocol registration International Prospective Register Systematic Reviews (CRD42023406505). Risk bias was assessed using Joanna Briggs Institute Critical Appraisal tools. Overall, 1113 articles identified; evaluating full texts, 12 papers included qualitative analysis. In six studies eight included, significant differences between M-GDM M-nGDM found. four studies, depletion Firmicutes an enrichment Proteobacteria infants. Since all judged have high risk bias, quantitative synthesis results not carried out. conclusion, although could be without GDM, there insufficient evidence clarify this aspect so far.
Language: Английский
Citations
1
Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 95 - 125
Published: Aug. 30, 2024
Language: Английский
Citations
1