Oxidative-Stress-Mediated Epigenetic Dysregulation in Spermatogenesis: Implications for Male Infertility and Offspring Health

Genes, Journal Year: 2025, Volume and Issue: 16(1), P. 93 - 93

Published: Jan. 17, 2025

Male reproductive health is governed by an intricate interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms—encompassing DNA methylation, histone modifications, non-coding RNA activity—are crucial both for spermatogenesis sperm maturation. However, oxidative stress, driven excessive reactive oxygen species, disrupts these processes, leading to impaired function male infertility. This disruption extends epigenetic resulting in abnormal gene expression chromatin remodeling that compromise genomic integrity fertilization potential. Importantly, oxidative-stress-induced alterations can be inherited, affecting the fertility offspring future generations. review investigates how stress influences regulation reproduction modifying RNAs, ultimately compromising spermatogenesis. Additionally, it discusses transgenerational implications disruptions their potential role hereditary infertility disease predisposition. Understanding mechanisms vital developing therapeutic strategies mitigate damage restore homeostasis germline. By integrating insights from molecular, clinical, research, this work emphasizes need targeted interventions enhance prevent adverse outcomes progeny. Furthermore, elucidating dose–response relationships between changes remains a critical research priority, informing personalized diagnostics interventions. In context, studies should adopt standardized markers damage, robust clinical trials, multi-omic approaches capture complexity Such rigorous investigations will reduce risk disorders optimize outcomes.

Language: Английский

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Effectiveness of exercise interventions on sperm quality: a systematic review and network meta-analysis

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Background Infertility affects about 10% to 15% of the world’s population, thus making it a global concern. Although there are large number studies develop treatment for infertility in men, no illustrate effect exercise on male sperm well rationalized and aggregated manner, therefore aim this study was validate comparative effectiveness different interventions treating quality men by using network Meta-analysis. Methods All randomized clinical trials (RCT) were obtained from PubMed, Cochrane Library, EMBASE, Web Science, CNKI, Wanfang, VIP databases, meta-analysis used assess quality. Results Fourteen with 1079 subjects finally included study. Compared physical inactivity group, indoor aerobic, outdoor resistance training significantly reduced density (P<0.05); necrotic spermatozoa active (P>0.05).Outdoor aerobic[MD=1.84,95%CI:(1.56,2.14),P<0.05], multi-component motion [MD=1.37,95%CI:(0.85,1.89),P<0.05],competitive sports[MD=1.04,95%CI:(0.46,1.60),P<0.05],indoor aerobic [MD=0.32, 95%CI:(0.21,0.44), P<0.05], effectively enhanced volume; other sports [MD=9.49,95%CI:(6.17,12.84),P<0.05], aerobic[MD=4.43,95%CI:(3.12,5.74),P<0.05],resistance [MD=3.93, 95%CI:(0.49,7.37), competitive [MD=5.44,95%CI:(0.10,10.79), bicycle aerobics[MD=27.29,95%CI:(22.45,32.06),P<0.05], motility; [MD=17.20,95%CI:(3.12,31.19), total count;resistance training[MD=10.90,95%CI:(8.44,13.36), P<0.05],other [MD=1.97,95%CI:(1.41,2.54),P<0.05], [MD=2.43,95%CI:(1.13,3.73), P<0.05],and [MD=12.18, 95%CI:(10.19,14.18),P<0.05], morphology; (MD=18.87, 95%CI:11.70,25.86, P<0.05), (MD=9.53, 95%CI:8.97,10.09, P<0.05),effectively concentration. Conclusion In conclusion, aerobics had significant improving volume infertile patients; enhancing motility count morphology patients, has impact concentration patients. Systematic review registration https://www.crd.york.ac.uk/prospero/#myprospero , identifier CRD42024534582.

Language: Английский

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Impact of physical activity on semen quality: a review of current evidence

Asian Journal of Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

A growing global trend indicates a decline in semen quality, with lack of physical activity identified as one the contributing factors. Exercise is medication, and numerous studies have explored its effects on quality. However, there no consensus most effective type intensity exercise for improving owing to inconsistent findings across studies. These discrepancies may be attributable variations study populations ( e.g. , healthy versus infertile individuals) research methodologies observational interventional studies). This paper reviews existing literature from databases PubMed, Web Science, Google Scholar, reclassifying articles their subject designs delineate relationship between It also summarizes mechanisms through which influences including hormonal regulation, oxidative stress, inflammatory

Language: Английский

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Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 478 - 478

Published: March 25, 2025

Oxidative stress is a significant factor that contributes to male infertility and sperm dysfunction. In this condition, an increase in ROS production exceeds the body's antioxidant defenses, resulting decline spermatozoa quality fertilizing capacity. Furthermore, excessive has been linked promotion of genomic damage, lipid peroxidation, inflammation, altered enzyme activity, ultimately, irreversible alterations, cell death, seminal parameters associated with infertility. It established physical activity (PA), acting on inflammatory improving defense, can alleviate negative effects caused by free radicals, offering numerous health benefits positively influencing quality. The objective review highlight mechanisms production, physiological pathophysiological roles relation reproductive system, recent knowledge impact some protocols PA these systems molecular involved.

Language: Английский

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