Possible role of exercise therapy on depression: Effector neurotransmitters as key players
Behavioural Brain Research,
Journal Year:
2023,
Volume and Issue:
459, P. 114791 - 114791
Published: Dec. 2, 2023
Language: Английский
Glutamatergic Neurotransmission in Aging and Neurodegenerative Diseases: A Potential Target to Improve Cognitive Impairment in Aging
Archives of Medical Research,
Journal Year:
2024,
Volume and Issue:
55(6), P. 103039 - 103039
Published: July 8, 2024
Language: Английский
Beyond the Handicap: A Cross-Sectional Study of Mental Health Amongst Registered Golfers in Spain
Sports,
Journal Year:
2025,
Volume and Issue:
13(3), P. 80 - 80
Published: March 7, 2025
The
prevalence
of
impaired
mental
health
(MH)
has
increased
in
recent
decades.
aim
the
study
was
to
analyze
MH
amongst
registered
Spanish
golfers
using
GHQ-28
questionnaire.
A
cross-sectional
online
survey
carried
out
Spain
between
March
and
August
2024
a
self-administered
questionnaire
on
298
adult
participants.
participants
were
mainly
men
(75.1%)
over
60
years
age
(50.7%)
who
married
or
with
partner
(79.5%),
active
job
market
(56%).
Of
participants,
73.5%
reported
an
improvement
levels
attributed
game,
77.2%
recommended
golf
as
way
improve
MH.
6.7%
(95%
confidence
interval
[CI]:
4.1–10.2%).
Differences
found
according
(<=45
years:
28.6%;
46–60
5.0%
>60
4.0%;
p
=
0.001),
marital
status
(married
partner:
4.6%
vs.
other:
14.8%;
0.009)
time
play
(morning:
3.3%
10.3%;
0.015).
detected
low
these
results
indicated
that
such
playing
habits
characteristics
may
have
positive
impact
wellbeing
players.
Language: Английский
A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters
Jie Song,
No information about this author
Aili Fu,
No information about this author
Chuan Wang
No information about this author
et al.
Behavioral and Brain Functions,
Journal Year:
2025,
Volume and Issue:
21(1)
Published: March 26, 2025
The
objective
of
this
review
study
is
to
examine
the
combined
antidepressant
effects
exercise
and
polyphenol
supplementation,
with
a
focus
on
specific
polyphenolic
compounds
such
as
crocin,
curcumin,
quercetin,
well
different
forms
physical
exercise,
including
aerobic
resistance
training.
research
examines
how
these
interventions
influence
depressive-like
behaviors,
cognitive
function,
neurochemical
markers
in
animal
models
human
participants.
findings
demonstrate
that
both
polyphenols
independently
contribute
mood
enhancement,
reduced
anxiety,
improved
function
through
mechanisms
neurogenesis,
neurotransmitter
modulation,
anti-inflammatory
effects.
Notably,
showed
synergistic
effect,
providing
more
significant
benefits
reducing
symptoms
depression
enhancing
performance,
supporting
overall
mental
well-being.
These
results
suggest
integrating
supplementation
could
be
promising
non-pharmacological
approach
managing
related
disorders.
Language: Английский
Neuroimaging biomarkers: a critical review of their role in neurological disease diagnosis and management
Brain Disorders,
Journal Year:
2025,
Volume and Issue:
18, P. 100222 - 100222
Published: April 21, 2025
Language: Английский
Effects of swimming exercise on neuropathic pain in a rat model: role of glutamate
Neurological Research,
Journal Year:
2024,
Volume and Issue:
46(4), P. 330 - 338
Published: Feb. 7, 2024
Objective
The
pain-reducing
effects
of
the
exercise
were
exerted
through
different
mechanisms.
Knowing
more
clear
mechanisms
helps
to
find
approach
that
is
therapeutic.
objective
present
study
evaluation
cerebrospinal
fluid
(CSF)
glutamate
level
alteration
in
neuropathic
pain
rats
and
whether
physical
activity
could
modulate
it.
Language: Английский
Current Understanding of the Roles of Gut–Brain Axis in the Cognitive Deficits Caused by Perinatal Stress Exposure
Cells,
Journal Year:
2023,
Volume and Issue:
12(13), P. 1735 - 1735
Published: June 28, 2023
The
term
‘perinatal
environment’
refers
to
the
period
surrounding
birth,
which
plays
a
crucial
role
in
brain
development.
It
has
been
suggested
that
dynamic
communication
between
neuro–immune
system
and
gut
microbiota
is
essential
maintaining
adequate
function.
This
interaction
depends
on
mother’s
status
during
pregnancy
and/or
newborn
environment.
Here,
we
show
experimental
clinical
evidence
indicates
perinatal
critical
window
stress-induced
immune
activation
altered
compositions
produce
lasting
behavioral
consequences,
although
clear
causative
relationship
not
yet
established.
In
addition,
discuss
potential
early
treatments
for
preventing
deleterious
effect
of
stress
exposure.
this
sense,
environmental
enrichment
exposure
(including
exercise)
melatonin
use
could
be
valuable
improving
negative
consequences
adversities.
presented
review
encourages
realization
studies
investigating
beneficial
administration
mitigating
cognitive
alteration
offspring
under
On
other
hand,
direct
restoration
as
main
mechanism
behind
effects
treatment
fully
demonstrated
should
explored
future
studies.
Language: Английский
Children with Autism Spectrum Disorder Exhibit Elevated Physical Activity and Reduced Sedentary Behavior
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1575 - 1575
Published: Nov. 9, 2023
According
to
previous
research,
individuals
with
autism
spectrum
disorder
(ASD)
have
lower
levels
of
physical
activity
than
their
typically
developed
(TD)
counterparts.
There
been
conflicting
reports
about
(PA)
in
people
ASD.
Given
the
evidence,
further
investigation
is
required.
We
believe
that
evaluating
PA
ASD
critical
order
offer
intervention
plans
aiming
at
increasing
health-related
fitness
on
a
daily,
systematic,
and
individualized
basis.
In
current
study,
an
ActiGraph
monitor
(GT3X+)
was
used
accurately
measure
sedentary
21
children
aged
6.43
±
2.29
years
30
TD
7.2
3.14
years.
Our
data
indicated
while
light
moderate
counts
were
not
significantly
different
between
two
groups,
vigorous
higher
compared
TD.
This
finding
attributed
characteristic
stereotypy
self-stimulating
behaviors.
The
discussed
relation
altered
neurochemistry,
oxidative
stress,
neuroinflammation
as
etiological
mechanisms
research
provides
better
understanding
status
participation
Language: Английский
Astrocytes mGluR3 deficiency and inhibition restores depressive-like behaviors in CSDS mice
Mingming Chen,
No information about this author
Yatao Liu,
No information about this author
Lingling Shi
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 8, 2024
Abstract
The
involvement
of
metabotropic
glutamate
receptors
(mGluR)
in
mood
regulation
has
been
widely
acknowledged.
However,
the
specific
changes
distribution
and
function
these
astrocytes
within
mood-related
brain
regions
during
depression
remain
unclear.
In
this
study,
we
conducted
an
analysis
isolated
from
(mPFC,
hippocampus,
amygdala,
NAc,
BNST,
VTA)
CSDS
mice
to
investigate
expression
mGluR3
mGluR5.
Surprisingly,
observed
upregulation
specifically
mPFC,
VTA,
but
not
neurons
or
microglia.
Additionally,
increase
astrocyte
reactivation
release
gliotransmitters
(such
as
glutamate,
D-serine,
GABA),
while
neuronal
activities
(represented
by
frequency
amplitude
sEPSC)
were
inhibited.
Furthermore,
found
that
knocking
out
Grm3
inhibiting
through
NAM
treatment
prior
CSDS,
depressive-like
behaviors
improved
mice.
These
findings
contribute
a
better
understanding
underlying
mechanisms
offer
new
perspectives
for
development
antidepressant
treatments.
Language: Английский
Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
After
infection
with
SARS-CoV-2,
patients
may
present
one
or
more
symptoms
that
appear
persist
over
time,
including
fatigue,
respiratory,
cardiovascular
and
neurological
disorders.
Neurological
include
anxiety,
depression
impaired
short-term
memory.
However,
the
exact
underlying
mechanisms
of
long
Covid
are
not
yet
decrypted.
Using
golden
hamster
as
a
model,
we
provide
further
evidence
SARS-CoV-2
is
neuroinvasive
can
in
central
nervous
system,
found
viral
RNA
replicative
virus
brainstem
after
80
days
infection.
Infected
hamsters
presented
neurodegenerative
signature
brainstem,
overexpression
innate
immunity
genes,
impacted
dopaminergic
glutamatergic
synapses,
altered
energy
metabolism.
Finally,
infected
manifested
persistent
signs
memory,
well
late-onset
valuable
model
to
study
Covid.
Conclusively,
virus-related
immunometabolic
coexist
contribute
manifestation
neuropsychiatric
cognitive
symptoms.
Highlights
infects
persists
intranasally-inoculated
Persistent
consequences
observed
SARS-CoV-2-infected
The
distinct
transcriptome
profiles
acute
systems
affected
affects
expression
genes
related
processes
Language: Английский