A Multiomics Evaluation of the Countermeasure Influence of 4-Week Cranberry Beverage Supplementation on Exercise-Induced Changes in Innate Immunity
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3250 - 3250
Published: Sept. 26, 2024
Objectives:
This
study
examined
the
effect
of
a
4-week
unsweetened
cranberry
beverage
(CRAN)
(317
mg
polyphenols)
versus
placebo
(PLAC)
ingestion
(240
mL/day)
on
moderating
exercise-induced
changes
in
innate
immunity.
Methods:
Participants
included
25
male
and
female
non-elite
cyclists.
A
randomized,
placebo-controlled,
double-blind
crossover
design
was
used
with
two
supplementation
periods
2-week
washout
period.
Supplementation
were
followed
by
an
intensive
2.25
h
cycling
bout.
Six
blood
samples
collected
before
after
(in
overnight
fasted
state)
at
0
h,
1.5
3
24
post-exercise.
Stool
urine
pre-
post-supplementation.
Outcome
measures
serum
creatine
kinase,
myoglobin,
cortisol,
complete
counts,
plasma
untargeted
proteomics,
plasma-targeted
oxylipins,
metabolomics,
stool
microbiome
composition
via
whole
genome
shotgun
(WGS)
sequencing.
Results:
Urine
CRAN-linked
metabolites
increased
significantly
supplementation,
but
no
trial
differences
alpha
or
beta
microbiota
diversity
found
samples.
The
bout
caused
significant
increases
arachidonic
acid
(ARA)
53
oxylipins
(FDR
q-value
<
0.05).
patterns
increase
for
ARA,
four
generated
from
ARA-cytochrome
P-450
(CYP)
(5,6-,
8,9-,
11,12-,
14,15-diHETrEs),
linoleic
(LA)
CYP
(9,10-DiHOME,
12,13-DiHOME),
LA
lipoxygenase
(LOX)
(9-HODE,
13-HODE)
slightly
higher
CRAN
PLAC
(all
interaction
effects,
p
proteomics
analysis
showed
that
protein
clusters
differed
between
trials,
CRAN-related
elevations
proteins
related
to
immune
activation
reduced
levels
regulation
complement
cascade,
platelet
activation,
binding
uptake
ligands
scavenger
receptors.
No
cortisol
muscle
damage
biomarkers.
Conclusions:
juice
resulted
gut
microbiome.
associated
transient
modest
post-exercise
elevation
selected
system.
Language: Английский
An In-Depth Assessment of Dietary Methods and Nutritional Treatments to Improve Female Athletes
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 35 - 66
Published: Oct. 14, 2024
A
female
athlete
needs
to
plan
her
diet
properly
in
order
provide
the
necessary
support
for
body
and
help
perform
optimally.
more
systematic
assessment
of
different
dietary
nutrient
approaches
is
required
successfully
enhance
nutrition,
health
conditions,
iron
status,
besides
optimizing
physical
functions.
This
includes
evaluating
several
effective
nutritional
determine
right
way
implement
changes.
Therefore,
studying
such
will
identify
ways
athletes'
performance,
ensuring
possibility
achieving
best
outcomes.
Language: Английский