Environmental Toxicology and Pharmacology,
Journal Year:
2023,
Volume and Issue:
100, P. 104157 - 104157
Published: May 22, 2023
Pharmaceuticals
have
been
classified
as
emerging
contaminants
in
the
aquatic
ecosystem,
mainly
due
to
their
increased
use
and
improper
disposal.
A
significant
range
of
pharmaceutical
compounds
metabolites
globally
detected
surface
waters
pose
detrimental
effects
non-target
organisms.
Monitoring
water
pollution
relies
on
analytical
approaches
for
detection,
however,
such
are
limited
by
sensitivity
limit
coverage
wide
compounds.
This
lack
realism
risk
assessment
is
bypassed
with
effect-based
methods,
which
complemented
chemical
screening
impact
modelling,
able
provide
mechanistic
insight
pollution.
Focusing
freshwater
this
study
we
evaluated
acute
daphnids
three
distinct
groups
pharmaceuticals;
antibiotics,
estrogens,
a
commonly
encountered
environmentally
relevant
pollutants.
Combining
several
endpoints
mortality,
biochemical
(enzyme
activities)
holistic
(metabolomics)
discovered
patterns
biological
responses.
In
study,
changes
enzymes
metabolism
e.g.
phosphatases
lipase,
well
detoxification
enzyme,
glutathione-S-transferase,
were
recorded
following
exposure
selected
pharmaceuticals.
targeted
analysis
hydrophilic
profile
revealed
up-regulation
metformin,
gabapentin,
amoxicillin,
trimethoprim
β-estradiol.
Whereas
gemfibrozil,
sulfamethoxazole
oestrone
resulted
down-regulation
majority
metabolites.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(46), P. 18259 - 18270
Published: Nov. 1, 2023
Machine
Learning
(ML)
is
increasingly
applied
to
fill
data
gaps
in
assessments
quantify
impacts
associated
with
chemical
emissions
and
chemicals
products.
However,
the
systematic
application
of
ML-based
approaches
still
limited,
their
potential
for
addressing
a
wide
range
unknown.
We
prioritized
chemical-related
parameters
toxicity
characterization
inform
ML
model
development
based
on
two
criteria:
(1)
each
parameter's
relevance
robustly
characterize
described
by
uncertainty
results
attributable
parameter
(2)
predict
values
availability
measured
data.
13
out
38
developing
approaches,
while
flagging
another
nine
critical
gaps.
For
all
parameters,
we
performed
space
analysis
assess
further
diverse
considering
structural
diversity
available
data,
showing
that
can
potentially
8–46%
marketed
1–10%
Our
systematically
future
efforts
address
characterization.
Chemical Research in Toxicology,
Journal Year:
2024,
Volume and Issue:
37(3), P. 465 - 475
Published: Feb. 26, 2024
To
modernize
genotoxicity
assessment
and
reduce
reliance
on
experimental
animals,
new
approach
methodologies
(NAMs)
that
provide
human-relevant
dose-response
data
are
needed.
Two
transcriptomic
biomarkers,
GENOMARK
TGx-DDI,
have
shown
a
high
classification
accuracy
for
genotoxicity.
As
these
biomarkers
were
extracted
from
different
training
sets,
we
investigated
whether
combining
the
two
in
human-derived
metabolically
competent
cell
line
(i.e.,
HepaRG)
provides
complementary
information
of
genotoxic
hazard
identification
potency
ranking.
First,
applicability
to
TempO-Seq,
high-throughput
technology,
was
evaluated.
HepaRG
cells
exposed
72
h
increasing
concentrations
10
chemicals
eight
known
Regulatory Toxicology and Pharmacology,
Journal Year:
2023,
Volume and Issue:
145, P. 105524 - 105524
Published: Nov. 2, 2023
Regulatory
science,
rooted
in
legal
requirements,
provides
a
mechanism
for
identifying,
assessing,
and
managing
harm
to
humans
the
environment
from
exposure
hazardous
substances.
A
challenge
regulatory
authorities
is
that
many
governing
laws
reflect
scientific
paradigm
of
mid-20th
century.
By
nature
legislative
processes,
most
are
not
able
readily
adapt
incorporate
advances
inherent
an
ever-evolving
paradigm.
Consequently,
issue
rigid
frameworks
has
become
prominent
global
discussions
related
incorporation
reliable
relevant
modern
technology
fulfill
needs.
To
explore
this
issue,
we
apply
Thomas
Kuhn's
The
Structure
Scientific
Revolutions
as
conceptual
framework
help
understand
natural
progression
paradigms
(from
normal
anomaly,
crisis,
revolution,
finally
new
normal),
identify
where
now
cycle,
path
towards
revolution
enables
timely
implementation
best
available
science
fulfil
requirements.
Environmental Toxicology and Pharmacology,
Journal Year:
2023,
Volume and Issue:
100, P. 104157 - 104157
Published: May 22, 2023
Pharmaceuticals
have
been
classified
as
emerging
contaminants
in
the
aquatic
ecosystem,
mainly
due
to
their
increased
use
and
improper
disposal.
A
significant
range
of
pharmaceutical
compounds
metabolites
globally
detected
surface
waters
pose
detrimental
effects
non-target
organisms.
Monitoring
water
pollution
relies
on
analytical
approaches
for
detection,
however,
such
are
limited
by
sensitivity
limit
coverage
wide
compounds.
This
lack
realism
risk
assessment
is
bypassed
with
effect-based
methods,
which
complemented
chemical
screening
impact
modelling,
able
provide
mechanistic
insight
pollution.
Focusing
freshwater
this
study
we
evaluated
acute
daphnids
three
distinct
groups
pharmaceuticals;
antibiotics,
estrogens,
a
commonly
encountered
environmentally
relevant
pollutants.
Combining
several
endpoints
mortality,
biochemical
(enzyme
activities)
holistic
(metabolomics)
discovered
patterns
biological
responses.
In
study,
changes
enzymes
metabolism
e.g.
phosphatases
lipase,
well
detoxification
enzyme,
glutathione-S-transferase,
were
recorded
following
exposure
selected
pharmaceuticals.
targeted
analysis
hydrophilic
profile
revealed
up-regulation
metformin,
gabapentin,
amoxicillin,
trimethoprim
β-estradiol.
Whereas
gemfibrozil,
sulfamethoxazole
oestrone
resulted
down-regulation
majority
metabolites.