Dietary Macleaya cordata extract supplementation improves the growth performance and gut health of broiler chickens with necrotic enteritis

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 7, 2023

Abstract Background The poultry industry needs effective antibiotic alternatives to control outbreaks of necrotic enteritis (NE) caused by Clostridium perfringens . Methods aim this study was investigate the effects dietary supplementation with Macleaya cordata extract (MCE) on immune function and gut microbiota broilers NE. A total 288 1-day-old broiler chicks were randomly assigned a 2 × factorial arrangement two concentrations MCE (0 or 350 mg/kg diet) disease challenge statuses (control NE). Results results revealed that NE significantly increased feed conversion rate (FCR), mortality, intestinal lesion score, levels IL-1β, IL-17 IFN-γ/IL-4 in serum IL-17/IL-10 jejunal mucosa, mRNA TLR2 , IFN-γ pIgR jejunum, cecum. decreased body weight (BW), gain (BWG), villus height, V/C, level AMPK-α1 IL-4 mucosa lactic acid bacteria abundance BW, BWG, occludin ZO-1 IgA IgG IL-10 NF-κB MHC-II jejunum. Additionally, FCR, crypt depth, cecum, Moreover, are associated inflammation, obesity depression ( Alistipes Barnesiella Intestinimonas RF39 UCG-005 ) short-chain fatty (SCFA)-producing Anaerotruncus Butyricicoccus Bacteroides SCFA-producing Streptococcus Ruminococcus_torques_group Lachnospiraceae_NK4A136_group reduced inflammation UCG-010 In cecum NE, relative higher Lachnoclostridium Shuttleworthia lower. Interestingly, these trends reversed addition diet. Spearman correlation analysis showed enhanced inhibited growth performance, whereas anti-inflammatory effects. Conclusions ameliorated loss performance chickens probably regulating barrier, function, microbiota.

Language: Английский

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Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 23, 2024

polysaccharide (YPF-P) is the main substance of alcohol deposition in

Language: Английский

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Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 14, 2023

Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control fed a basal diet the LPS+GCT group supplemented with 300 mg/kg GCT. intraperitoneally injected (1 body weight BW) at 17, 19, 21 days of age. results manifested that dietary GCT addition attenuated LPS-induced deleterious effects serum parameters significantly increased immunoglobulin complement C3 concentrations relative groups. Dietary supplementation inhibited increase hepatic inflammatory cytokines, caspases activities, TLR4/NF-κB pathway-related gene mRNA expression. Therefore, improved immune function inhibit inflammation by blocking TLR4/NF- κ B pathway. Our findings provide support application poultry production.

Language: Английский

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Effects of Clostridium butyricum as an Antibiotic Alternative on Growth Performance, Intestinal Morphology, Serum Biochemical Response, and Immunity of Broilers

Antibiotics, Journal Year: 2023, Volume and Issue: 12(3), P. 433 - 433

Published: Feb. 22, 2023

The current study aimed to investigate the effects of Clostridium butyiricum on growth performance, intestinal morphology, serum biochemical response, and immunity in broiler chickens. A total 330 commercial one-day-old, mixed-sex Ross 308 broilers were randomly divided into five treatment groups with six replicates per group. fed basal diet (CON), 150 mg/kg aureomycin (AM), C. butyricum at 2 × 108 CFU/kg (CBL), 4 (CBM), 8 (CBH). Results showed that final body weight (BW) (p < 0.01; p 0.05), ADG from day 22 39 1 0.05) improved a linear quadratic response inclusion butyricum. There no differences feed conversion rate (FCR) among all > 0.05). Supplementation quadratically reduced crypt depth 21 0.01), linearly villus height jejunum 0.001), increased (V/C) ratio 0.01) 0.001). Dietary affected thymus index (linear, bursa Fabricius (quadratic, Compared AM group, urea contents decreased but IgG CBL CBH 0.01); addition, albumin (ALB) concentrations butyricum-supplemented CBM group augmented In conclusion, dietary could enhance performance by improving jejunal morphology stimulating organ development broilers, be an alternative antibiotics poultry feeds.

Language: Английский

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Macleaya cordata isoquinoline alkaloids attenuate Escherichia coli lipopolysaccharide-induced intestinal epithelium injury in broiler chickens by co-regulating the TLR4/MyD88/NF-κB and Nrf2 signaling pathways

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 17, 2024

This study sought to explore the effects and potential mechanisms of dietary supplementation with isoquinoline alkaloids (IA) from Macleaya cordata alleviate lipopolysaccharide (LPS)-induced intestinal epithelium injury in broilers. A total 486 1-day-old broilers were assigned at random a control (CON) group, LPS LPS+IA group 21-d study. The CON groups received basal diet, while diet supplemented 0.6 mg/kg IA. At 17, 19, 21 days age, LPS+BP injected intraperitoneally LPS, was equivalent amount saline solution. results manifested that injection caused inflammation lipid peroxidation, disrupted barrier function, increased abundance harmful microorganisms. However, IA alleviated LPS-induced adverse changes morphology, apoptosis, mucosal integrity, cecum microorganisms, homeostasis disorder by decreasing inflammatory cytokines enhancing antioxidant-related genes expressions; inhibited increases TLR4 NF-κB expressions decreases Nrf2 GPX1 expressions. Our findings indicated addition attenuated anti-inflammatory antioxidant capacity broiler chickens possibly via co-regulating TLR4/MyD88/NF-κB signaling pathways.

Language: Английский

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Effect of a microencapsulated phyto/phycogenic blend supplementation on growth performance, processing parameters, meat quality, and sensory profile in male broilers

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: March 28, 2024

Powered by consumer taste, value, and preferences, natural products including phytogenics algae are increasingly separately used in the food systems where they have been reported to improve growth performance poultry livestock. The present study aimed determine effects of a new feed additive, microencapsulated NUQO© NEX, which contains combination phytogenic phycogenic, on broiler performance, blood chemistry, bone health, meat quality sensory profile. Male Cobb500 chicks (

Language: Английский

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Research on the metabolites and key metabolic enzymes of allocryptopine in chicken liver microsomes via stable isotope tracing technology

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 255, P. 116667 - 116667

Published: Jan. 6, 2025

Language: Английский

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Dietary supplementation with hydroxy-methionine manganese improves meat quality, antioxidant capacity, and lipid metabolism in Cherry Valley ducks (Anas platyrhynchos domesticus)

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Hydroxymethionine manganese (MnHMet), as a novel organic trace element additive, has demonstrated significant effects on improving meat quality, enhancing antioxidant capacity, and lipid metabolism. However, its specific Cherry Valley ducks remain unclear. This study explored the of dietary MnHMet metabolism in ducks. In 35-day study, 560 1-day-old male were randomly assigned to seven groups: six groups supplemented at 0, 30, 60, 90, 120, 150 mg/kg, group was 120 mg/kg MnSO 4 . Results showed that had significantly lower triglyceride (TG) levels than ( P &lt; 0.05). Serum high-density lipoprotein cholesterol increased compared 0 quadratic change increasing supplementation reduced drip loss, shear force, abdominal fat weight, percentage while intramuscular (IMF, Drip loss force decreased linearly, IMF response Fatty acid analysis revealed decrease hepatic C23:0 concentrations improved capacity by total (T-AOC), upregulating MnSOD mRNA expression liver breast muscle, levels, reducing malondialdehyde (MDA) T-AOC exhibited linear increases muscle liver, respectively, MDA quadratically Catalase higher Additionally, adipocyte area, downregulated fatty synthase acetyl-CoA carboxylase, upregulated peroxisome proliferator-activated receptor-γ, carnitine palmitoyltransferase-1α, lipase Based percentage, optimal 107.5 117.5 respectively. These results mass, composition, fat, enhanced quality regulating

Language: Английский

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Residue of allocryptopine and protopine in tissues and eggs of laying hens using ultra-high performance liquid chromatography–tandem mass spectrometry

Poultry Science, Journal Year: 2025, Volume and Issue: 104(6), P. 105124 - 105124

Published: April 5, 2025

The residues of allocryptopine (ALL) and protopine (PRO) in the eggs tissues laying hens from veterinary drug Bopp Total Alkali Powder® were evaluated. UPLC-MS/MS technology was used to accurately determine these components. study found that at a dose 400 mg/kg, PRO reached peak 2.8 µg/kg on seventh day administration undetectable five days after stopping medication. ALL not detected throughout study. At 2000 one medication, 16.72 8.61 µg/kg, respectively. Seven undetectable, but there still residue ALL. Tissue samples showed two hours concentrations both components significantly increased all rapidly declined within 24 h. no tissues. suggests risk is low when using mg/kg. However, mg/kg may increase residue, so it recommended stop medication for least seven ensure food safety.

Language: Английский

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Dietary Galla Chinensis tannic acid supplementation in the diets improves growth performance, immune function and liver health status of broiler chicken

Frontiers in Veterinary Science, Journal Year: 2022, Volume and Issue: 9

Published: Oct. 14, 2022

This experiment was conducted to investigate the effects of Galla Chinensis tannic acid (TA) on growth performance, immune function, and liver health status in broilers. A total 288 1-day-old Arbor Acres broiler chickens were randomly divided into two groups a 42-days study. The basal diet (CON group) supplemented with 300 mg/kg (TA group). results showed that TA group had significantly decreased feed-to-gain ratio (F/G) throughout (P < 0.05). levels protein, albumin, low density lipoprotein, high urea, cholesterol, glucose higher than CON In addition, serum immunoglobulin G, M, complements (C3, C4) those Compared group, hepatic interleukin-6, interleukin-18, NLRs family pyrin domain containing 3 (NLRP3), caspase-1, caspase-3 Besides, lower mRNA expression toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), nuclear factor-kappa B (NF-κB), NLRP3 Bcl-2 Moreover, tended decrease Bax/Bcl-2 0.10). To sum up, dietary microencapsulated from beneficial protective role broilers might be related inhibition apoptosis pyroptosis via inactivation TLR4/MyD88/NF-κB signaling pathway.

Language: Английский

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